|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prognostic evaluation of postoperative adjuvant therapy for operable cervical cancer:10 years'experience of National Cancer Center in China显示文摘Objective: The aim of this study was to investigate the prognostic factors and to evaluate the impact of adjuvant therapy on clinical outcome for early-stage cervical cancer.Methods: The clinical-pathological data of all 1,335 patients with the International Federation of Gynecology and Obstetrics(FIGO) Ib–IIa cervical cancer treated with primary radical surgery at the Chinese National Cancer Center between May 2007 and Dec 2013 were retrospectively reviewed.The median follow-up was 70 months.Results: Of all the patients,61.6% of the cases received adjuvant therapy,with 5-year disease-free survival(DFS)of 92.1% and 5-year overall survival(OS) of 95.0%.In multivariate analysis,differentiation of G3(P<0.05),lymph node metastasis(LNM,P<0.05) and lymphovascular space invasion(LVSI,P<0.05) were independent predictors for OS,while LNM(P<0.05),deep stroma invasion(DSI,P<0.05) and LVSI(P<0.05) were independent factors for DFS.The samples were stratified by histologic type,and cervical squamous cell carcinoma(SCC) was found to share the same independent factors except for differentiation of OS.As to patients with cervical adenocarcinoma/adenosquamous carcinoma(AC/ASC),differentiation was the independent predictor of OS(P<0.05); and LVSI of DFS(P<0.05).Of 236 patients with high-risk factors,there was no significant difference in survival between concurrent chemoradiotherapy(CCRT,n=195),radiotherapy(RT,n=24),and chemotherapy(CT,n=17).Among the 190 patients with LNM who underwent CCRT,124 cases showed improved DFS after sequential CT(P=0.118),with a recurrence rate decrease of 14%,though the difference was not statistically significant.Patients with single intermediate-risk factors like DSI or LVSI were found to partially benefit from adjuvant therapy,but the difference was not statistically significant.Conclusions: LNM,LVSI,DSI and differentiation were found to be independent prognostic factors for operable cervical cancer.Aggressive postoperative adjuvant therapy based on single risk factors in Chinese National Cancer Center could benefit survival.CCRT+CT outperformed CCRT in high-risk patients.For patients with single non-high-risk factor,the role of adjuvant therapy needs to be further discussed. | Tong Shu Dan Zhao Bin Li Yating Wang Shuanghuan Liu Pingping Li Jing Zuo Ping Ba i RongZhang Lingying Wu | 2017 | Chinese Journal of Cancer Research2017，29，6： | 12 |
| 2 | Overall scheme and on-orbit images of Chang’E-2 lunar satellite CCD stereo camera显示文摘The goals of engineering and scientific missions for Chang’E-2 lunar satellite require high detection sensitivity and large im-aging dynamic range for the onboard CCD cameras.The TDI CCD image sensor was adopted for the two linear CCD stereo cameras for the first time in the lunar reconnaissance of the world.The design argumentation is described in this paper.The analysis shows that the imagers meet the mission requirements.The satellite was launched on 1 October 2010 at zero window.The cameras obtained images of 7 m resolution on the 100 km orbit for the first time on 24 October 2010,and operated once again on 27 October 2010 to take stereo images of the Sinus Iridum with the resolution better than 1.5 m.On the near-moon-arc of 15 km×100 km elliptical orbit,the images are very clear and rich of grey scales,indicating successful com-pletion of the Chang’E-2 engineering mission.At the present the cameras are acquiring the full lunar surface stereo images with 7 m resolution on the 100 km circular orbit to complete their scientific mission. | ZHAO BaoChang YANG JianFeng WEN DeSheng GAO Wei CHANG LingYing SONG ZongXi XUE Bin ZHAO Wei | 2011 | Science China(Technological Sciences)2011，54，9： | 7 |
| 3 | Coral reef ecosystems in the South China Sea as a source of atmospheric CO_2 in summer显示文摘由空至海的 CO2 的领域大小在华南海的三个珊瑚礁石区域交换(即 Nansha 岛的 Yongshu 礁石环礁,南部的华南海(SCS ) ;Xisha 岛的 Yongxing 岛,北方中央的 SCS;并且在海南岛的 Sanya 的 Luhuitou Fringing 礁石,北 SCS ) 在 2008 和 2009 的夏天期间揭示了那 CO2 (pCO2 ) 的部分压力显示出的空气和表面海水常规日报周期。最小的价值在早上发生在晚上和最大的价值。在每三个学习区域的空气 pCO2 出现了小日报变化,当时大日报变化在海水 pCO2 被观察。日报海水 pCO2 的变化振幅是 70 摩尔摩尔? 1 在 Yongshu 礁石泻湖, 420619 摩尔摩尔? 1 在 Yongxing 岛礁石公寓,和 264579 摩尔摩尔上? 1 在 Luhuitou Fringing 礁石的礁石公寓上,并且 324492 摩尔摩尔? 1 在就在这 fringing 礁石外面的一个邻近的区域。关于空间关系,在越过华南海的由空至海的 CO2 流动有大差别(例如 0.4 mmol CO2 m ? 2 d ? 1 在 Yongshu 礁石, 4.7 mmol CO2 m ? 2 d ? 1 在 Yongxing 岛,并且 9.8 mmol CO2 m ? 2 d ? 1 在 Luhuitou Fringing 礁石)。然而,这些积极的值建议 SCS 的珊瑚礁石生态系统可以是到空气的 CO2 的网络来源。另外的分析显示了那日报在浅水礁石公寓的表面海水 pCO2 的变化主要被生物新陈代谢的过程控制,当那些被两个生物新陈代谢和水动力学因素更深的水泻湖和外部礁石区域调整时。不同于开的海洋,无机的新陈代谢在在珊瑚礁石生态系统影响海水 pCO2 变化起一个重要作用。 | YAN HongQiang YU KeFu SHI Qi TAN YeHui ZHANG HuiLing ZHAO MeiXia LI Shu CHEN TianRan HUANG LingYing WANG PinXian | 2011 | Chinese Science Bulletin2011，56，7： | 6 |
| 4 | Removing ammonia from air with a constant pH, slightly acidic water spray wet scrubber using recycled scrubbing solution显示文摘 | Ahmad Kalbasi Ashtari Amir M. Samani Majd Gerald L. Riskowski Saqib Mukhtar Lingying Zhao | 2016 | Frontiers of Environmental Science & Engineering2016，10，6： | 4 |
| 5 | Nomograms based on HPV load for predicting survival in cervical squamous cell carcinoma: An observational study with a longterm follow-up显示文摘Objective: To investigate the prognostic value of pretreatment human papillomavirus(HPV) viral load for cervical cancer, and to develop nomograms based on HPV load and other clinicopathological factors for long-term survival.Methods: We conducted a prospective study on cervical squamous cell carcinoma(SCC) patients diagnosed between January 2003 and December 2008. Cervical samples were tested for HPV viral load by the Hybrid Capture II(HCII) assay before treatment and 6 months after treatment. Clinical characteristics and follow-up information were also collected. A multivariable Cox proportional hazards model was used to adjust covariates in both the radical hysterectomy(RH) treatment group and concurrent chemoradiotherapy(CCRT) treatment group to identify relevant covariates, and then nomograms were constructed and used for internal validation.Results: A total of 520 SCC patients enrolled in this study with a median follow-up of 127 months, 360 patients received RH, whereas 160 patients received CCRT. The median HPV viral load in RH and CCRT groups was356.10 and 294.29, respectively. Tumor size was positively correlated with high pretreatment HPV load in both groups. In CCRT group, the advanced International Federation of Gynecology and Obstetrics(FIGO) stage and enlarged retroperitoneal lymph node status determined by computed tomography(LNSCT) were correlated with low HPV load group. Initial HPV viral load, FIGO stage and lymph node metastasis were prognostic factors for RH group, whereas HPV viral load, squamous cell carcinoma antigen(SCC-Ag) level and LNSCT were identified as prognostic factors for CCRT group. Nomograms incorporating these predictors for 10-year progression-free survival(PFS) were constructed [concordance index(C-index): 0.756, 0.749].Conclusions: A low pretreatment HPV viral load is an independent prognostic factor for poor prognosis of cervical SCC and is related to other clinicopathological factors. The survival nomogram based on HPV viral load could predict the long-term prognosis. | Jing Zuo Ying Huang Jusheng An Xi Yang Ning Li Manni Huang Lingying Wu | 2019 | Chinese Journal of Cancer Research2019，31，2： | 4 |
| 6 | Study on the Analysis System of Meteorological and Geological Disaster Grades Early Warning of WebGIS显示文摘The method of realizing meteorological and geological disaster forecast and early warning information system in Qixian County of Shanxi Province was studied. According to meteorological factor parameter of the geological disasters for many years in Qixian County Land Bureau,and data of average meteorological element parameters that corresponded by evolution of geological disaster region each year,evaluation algorithm model of the forecast and early warning of geological disasters in Qixian County was obtained,and the database of meteorological factor of geological disaster was established. On this basis,WebG IS geographic information system based on C / S and B / S which could real-time monitor geological disaster region was studied and designed. After data analysis system could evaluate the geological disaster forecast and early warning and make the real-time and accurate early warning,which greatly improved the timeliness of meteorological geological disasters forecast and early warning in Qixian County. System set of data processing and forecast and early warning issued in one,to realize the dynamic information release function of grade of geological disaster early warning,and had the characteristics of easy sharing,real-time dynamic update. | Wang Tao Li Qiang Hao Lingying Liu Jia | 2014 | Meteorological and Environmental Research2014，5，12： | 3 |
| 7 | Wuzi Yanzong prescription(五子衍宗丸)from Traditional Chinese Medicine for male infertility:a narrative review显示文摘Wuzi Yanzong prescription(WYP),as a classical prescription for male infertility with kidney essence deficiency,is composed of Gouqizi(Fructus Lycii),Tusizi(Semen Cuscutae),Wuweizi(Fructus Schisandrae Chinensis),Fupenzi(Fructus Rubi Chingii)and Cheqianzi(Semen Plantaginis).It has been used for hundreds of years in the treatment of male infertility,known as“the first prescription of ancient and modern seeds”,with convincing clinical evidence.At present,more than 100 chemical compounds have been isolated from WYP,including polysaccharide,fatty acids,flavonoids,phenylpropanoids,organic acids,alkaloids,terpenoids,etc.Pharmacological and clinical studies show that WYP has an obvious effect on reproductive system diseases,especially male infertility,which has a very wide application prospect.It also has effects on the nervous system,inhibiting liver injury,lowering blood sugar and blood lipid,anti-aging,improving immunity,resisting hypoxia and fatigue effects.This study reviewed the chemical constituents,quality control,pharmacology,and clinical application of WYP.There is no doubt about the clinical value of WYP,but its quality control system is not perfect,pharmacological mechanism is not fully explained,and clinical applications need to be reevaluated.Therefore,the follow-up researches should proceed from the theory of Traditional Chinese Medicine(TCM)and clinical applications,further explain the theoretical connotation,reveal the mechanism of action,and provide the basis for the secondary development of classic famous prescriptions.In addition,WYP is mostly used in combination with western medicines besides being used alone.Whether it can improve the efficacy and reduce side effects will also be a meaningful research direction in the future. | CHEN Zhimin AO Mingyue LIAO Yujiao YU Lingying YANG Zhuo HU Lin LI Wenbing HU Changjiang GAO Yongxiang | 2023 | Journal of Traditional Chinese Medicine2023，43，2： | 3 |
| 8 | Comparison of cellular responses across multiple passage numbers in Ba/F3-BCR-ABL cells induced by silver nanoparticles显示文摘With the rapid development of nanotechnology and increasingly broad bio-application of engineered nanomaterials, their biohazards have become a serious public concern. It is believed that the chemical nature, particle size, morphology, and surface chemistry of nanomaterials are key parameters that influence their toxicity. Although cultured cells have been widely used to evaluate nanomaterial toxicity, it remains unclear whether the passage of these cells affects the evaluation results. In the present study, Ba/F3 cells transfected with the BCR-ABL gene were subcultured to study the effect of passage number on cell stability and their cellular responses upon exposure to nanomaterials. The results demonstrated that proliferation, cellular senescence, BCR-ABL gene expression, cell cycle and apoptosis were stable across multiple passages. Senescence and BCR-ABL gene expression of cells from different passage cells were unchanged when treated with silver nanoparticles (AgNPs). In addition, the cells at multiple passage numbers were all arrested in the G 2 /M phase and apoptosis was induced by the AgNPs. These nanoparticles could enter cells via endocytosis and localize in the endosomes, which were also not influenced by passage number. These data suggest that short-term passage would not affect cultured cell stability and toxicity assessment using these cells would be consistent when maintained appropriately. | GUO DaWei ZHANG XiuYan HUANG ZhiHai ZHOU XueFeng ZHU LingYing ZHAO Yun GU Ning | 2012 | Science China(Life Sciences)2012，55，10： | 2 |
| 9 | Preparation and Thermal Properties of Shape-stabilized Paraffin/NPGDMA/BN Composite for Phase Change Energy Storage显示文摘of main observation and conclusion Paraffin,as an excellent phase change material(PCM),is limited by the leakage problem and low thermal conductivity.In this research,a novel paraffin/neopentyl glycol dimethacrylate/boron nitride(paraffin/NPGDMA/BN)composite PCM was successfully prepared via a physical mixing process.NPGDMA in paraffin/NPGDMA/BN composite PCM was cured by UV light under the action of photo initiator,which can improve the shape stability to avoid the leakage of paraffin in the process of phase change.By comparing the leakage rate,latent heat,and thermal conductivity,the optimal mass ratio of paraffin and NPGDMA was selected to be 7:3.It was showed that the presence of 5 wt%BN led to increasing in thermal conductivity by up to 59%.The microstructure of the composite PCMs was characterized by SEM,FTIR,and XRD.The composite PCMs can be processed into a variety of shapes by using molds.The paraffin/NPGDMA/BN composite PCM exhibited a significantly improved shape stability and large phase change enthalpy of 123.0 J/g.The leakage rate of paraffin/NPGDMA/BN was much improved after being soaked with petroleum ether. | Xuefeng Li Lingying Chen Weifang Han Chunhua Ge Hongyu Guan Rui Zhang Xiangdong Zhang | 2020 | Chinese Journal of Chemistry2020，38，12： | 2 |
| 10 | Papillary serous carcinoma of the uterine cervix:a clinicopathological analysis of 4 cases and a literature review显示文摘Objective To investigate the clinicopathological characteristics and clinical treatment outcomes of patients with papillary serous carcinoma of the uterine cervix(PSCC).Methods In this study, 4 patients with histologically confirmed papillary serous carcinoma of the uterine cervix were retrospectively investigated. Pap smears, human papillomavirus(HPV) screening, tumor marker status, biopsy analysis, and relevant imaging examinations were conducted for the confirmation of primary diagnosis and recurrence. Patients underwent surgery, chemotherapy, or radiotherapy, and survival were the main endpoint.Results The 4 patients were diagnosed with IB1, IB1, IIA, or IIIB disease. Two patients(2/4) presented with recurrence within 18 months after primary therapy. Compared with chemotherapy alone(progressionfree survival(PFS): 11 months), radiotherapy combined with adjuvant chemotherapy showed favorable PFS rates(PFS: 20, 36, 13 months in 3 cases), although valid statistical analysis was not feasible because of the small sample size. The 5-year survival rate was 0%, and the 3-year survival rate was 75%. Our data, in agreement with the literature evidence, showed that the number of moderate-risk and high-risk factors in patients diagnosed with PSCC at an early stage was higher than that in patients diagnosed with common adenocarcinoma/squamous carcinoma of the uterine cervix.Conclusion PSCC has a poor clinical prognosis, and compared with chemotherapy alone, radiotherapy combined with adjuvant chemotherapy may lead to improved PFS. | Li Ge Hongwen Yao Rong Zhang Xiaoguang Li Lingying Wu | 2017 | Oncology and Translational Medicine2017，3，5： | 2 |
| 11 | 显示文摘 | TangWeifen(唐卫芬) LingYing(凌瑛) ChenShanshan(陈珊珊) HuZhaoxia(胡朝霞) ChenShouwen(陈守文) | 2013 | 高等学校化学学报2013，34，： | 2 |
| 12 | Synchronous primary cancers of the endometrium and ovary: review of 43 cases显示文摘目的将调查子宫内膜和卵巢的同步原发癌的临床、病理学的特征,治疗方法,和预后。有子宫内膜和卵巢的同步原发癌的 43 个病人的临床的数据回顾地被考察的方法。幸存被 Kaplan-Meier 方法计算并且比较了使用木头等级测试。结果在诊断的病人的中部的年龄是 49 年(范围, 28 73 年) 。最普通的症状是反常阴道流血(69.8%) 并且腹或骨盆的疼痛(44.2%) 。骨盆的群众在 39.5% 病人被发现并且在药品检查在 27.9% 扩大了宫体,当骨盆的群众在 43 个病人(29 个案例) 中的 67.4% 个被发现并且变厚时或在 23.3% 的反常子宫内膜(10 个案例) 在超声检查期间。CT/MRI 检查的 25 个病人,骨盆的群众在 13 种情况中被发现并且在 11 种情况中扩大了子宫。经历了子宫内膜的活体检视的所有 15 个病人被证明有子宫内膜样癌。浆液 CA125 水平被发现与中部的价值在 34 个检验盒子(64.7%) 中的 22 个中被提高 500 U/mL (范围, 39 3439 U/mL ) 。子宫内膜的癌的 FIGO 阶段:IA 18 盒子, IB 20 盒子, IC 2 盒子,和 IIA 3 盒子;卵巢的癌的阶段:IA 19 大小写, IB 4 盒子, IC 7 盒子, II 4 盒子,和 IIIC 9 盒子。24 个病人(55.8%) 在舞台我子宫内膜、卵巢的癌。同时, 31 个病人与网膜切除术和阑尾切除术加双边的输卵管卵巢切除术经历了全部的子宫切除 12 个病人有骨盆的淋巴节点解剖。43 个病人(88.4%) 中的 38 个有一病理地证明的子宫内膜的腺癌。占优势的卵巢的组织学与子宫内膜样部件是子宫内膜样或混合瘤(30/43, 69.8%) 。手术后地, 26 个病人(60.5%) 独自收到了辅助化疗,加放射疗法的 12 有的化疗,仅仅一个病人有独自一个的放射并且留下 4 个盒子没收到辅佐疗法。这个组的 3 年、 5 年的幸存率分别地是 87.4% 和 71.1% 。有子宫内膜样癌在的病人的 3 年、 5 年的幸存率子宫内膜、卵巢比有 non-endometrioid 的那些的高或混合了 histologic 子类型(93.8% , 82% 对 79.7% , 69%) 。有早阶段疾病的病人的 3 年、 5 年的幸存率比另外的病人的那些好(93.3% , 93.3% 对 69.7% , 36.7%) 。复发在 15 个病人(34.9%) 发展了。它被降低加放射疗法的化疗显著地并且断然影响了的 CA125 水平,早 FIGO 阶段,和助手的 univariate 分析显示出 5 年的幸存评价,当加放射疗法的仅仅早的 FIGO 舞台和化疗被揭示由时多变量分析同样独立的预示的因素。子宫内膜和卵巢的结论同步原发癌与也不同主要子宫内膜或卵巢的癌症,当通常它能与好预后在早舞台被检测时。进一步的预后需要上的 CA125 水平的影响学习了。外科治疗可能独自为早阶段病人是足够的。化疗正放射疗法可能为先进病人是必要的。 | Shaokang Ma Hongtu Zhang Yangchun Sun Lingying Wu | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，2： | 2 |
| 13 | 20-Gbps optical LiFi transport system 显示文摘 | CHENG Lingying LU H H LI C Y | 2015 | Optics Letters2015，40，14： | 1 |
| 14 | Prevention of angiolensin Ⅱ -induced cardiac remodeling by angiotensin-(1-7) 显示文摘 | Grebe JL Mecca AP Lingis M | 2007 | Am J Physiol Heart Circ Physiol2007，292，2： | 1 |
| 15 | Prevent:ort of angiotensin 1I -induced cardiac remodeling by angiotensin-( 1-7 ) 显示文摘 | Grobe Jl Mecca Ap Lingis M | 2007 | Am J Physiol Heart Circ Physio12007，292，2： | 1 |
| 16 | Predictors for re- lapse after antiepileptic drug withdrawal in seizure-free pa- tients with epilepsy 显示文摘 | Lingying Su Qing Di Nian Yu | 2013 | J Clin Neurosci2013，20，： | 1 |
| 17 | Preparation and dielectric properties of barium strontium titanate glass-ceramices sintered from sol-gel derived powdwes显示文摘 | Jian ying Wang Xi Yao Lingying Zhang | 2004 | Ceramics International2004，30，： | 1 |
| 18 | Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7)显示文摘 | Grobe JL Mecca AP Lingis M | 2007 | Am J Physio! Heart Cite Physiol2007，292，2： | 1 |
| 19 | Prevention of anglotensin II-induced cardiac remodeling by angiotensin-(1-7) 显示文摘 | Grobe JL Mecca AP Lingis M | 2007 | Am J Physiol Heart Circ Physiol2007，292，： | 1 |
| 20 | Prevention of angiotensin II-induced cardiac remodeling by angiotensin(1-7)显示文摘 | GROBE J L MECCA A P LINGIS M | 2007 | Am J Physiol Heart Circ Physiol2007，292，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员