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| 1 | Structural basis of Sphingosine-1-phosphate transport via human SPNS2显示文摘Dear Editor,Sphingosine 1-phosphate(S1P)plays crucial roles in various physiological processes,including immune response,vascular development,and neural system homeostasis1 through activating S1P receptors(S1PRs).Notably,a desirable concentration gradient of S1P which is achieved by S1P transporters,including spinster homolog 2 protein(SPNS2)and MFSD2B that transport S1P from the intracellular side to the extracellular side of cells,2,3 is essential for proper S1P signaling.SPNS2 and MFSD2B belong to the major facilitator superfamily(MFS),and specifically. | Yaning Duan Nancy C.P.Leong Jing Zhao Yu Zhang Dat T.Nguyen Hoa T.T.Ha Na Wang Ruixue Xia Zhenmei Xu Zhengxiong Ma Yu Qian Han Yin Xinyan Zhu Anqi Zhang Changyou Guo Yu Xia Long N.Nguyen Yuanzheng He | 2024 | Cell Research2024，34，2： | 0 |
| 2 | Identification of oleic acid as an endogenous ligand of GPR3显示文摘Although GPR3 plays pivotal roles in both the nervous system and metabolic processes,such as cold-induced thermogenesis,its endogenous ligand remains elusive.Here,by combining structural approach(including cryo-electron microscopy),mass spectrometry analysis,and functional studies,we identify oleic acid(OA)as an endogenous ligand of GPR3.Our study reveals a hydrophobic tunnel within GPR3 that connects the extracellular side of the receptor to the middle of plasma membrane,enabling fatty acids to readily engage the receptor.Functional studies demonstrate that OA triggers downstream Gs signaling,whereas lysophospholipids fail to activate the receptor.Moreover,our research reveals that cold stimulation induces the secretion of OA in mice,subsequently activating Gs/cAMP/PKA signaling in brown adipose tissue.Notably,brown adipose tissues from Gpr3 knockout mice do not respond to OA during cold stimulation,reinforcing the significance of GPR3 in this process.Finally,we propose a“born to be activated and cold to enhance”model for GPR3 activation.Our study provides a starting framework for the understanding of GPR3 signaling in cold-stimulated thermogenesis. | Yangjie Xiong Zhenmei Xu Xinzhi Li Yuqin Wang Jing Zhao Na Wang Yaning Duan Ruixue Xia Zhengbin Han Yu Qian Jiale Liang Anqi Zhang Changyou Guo Asuka Inoue Yu Xia Zheng Chen Yuanzheng He | 2024 | Cell Research2024，34，3： | 0 |
| 3 | Assessing the cost reduction potential of CCUS cluster projects of coal-fired plants in Guangdong Province in China显示文摘Carbon capture, utilization, and storage (CCUS) have garnered extensive attention as a target of carbon neutrality in China. The development trend of international CCUS projects indicates that the cluster construction of CCUS projects is the main direction of future development. The cost reduction potential of CCUS cluster projects has become a significant issue for CCUS stakeholders. To assess the cost reduction potential of CCUS cluster projects, we selected three coal-fired power plants in the coastal area of Guangdong as research targets. We initially assessed the costs of building individual CCUS projects for each plant and subsequently designed a CCUS cluster project for these plants. By comparing individual costs and CCUS cluster project costs, we assessed the cost reduction potential of CCUS cluster projects. The results show that the unit emission reduction cost for each plant with a capacity of 300 million tonnes per year is 392.34, 336.09, and 334.92 CNY/tCO_(2). By building CCUS cluster project, it could save 56.43 CNY/tCO_(2) over the average cost of individual projects (354.45 CNY/tCO_(2)) when the total capture capacity is 9 million tonnes per year (by 15.92%). Furthermore, we conducted a simulation for the scenario of a smaller designed capture capacity for each plant. We found that as the capture scale increases, the cost reduction potential is higher in the future. | Muxin LIU Yueze ZHANG Hailin LAN Feifei HUANG Xi LIANG Changyou XIA | 2023 | Frontiers of Earth Science2023，17，3： | 0 |
| 4 | Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity显示文摘Dear Editor,Omega(w)-3 fatty acids are known to have multiple beneficial effects on health,including anti-inflammation,enhancement of glucose uptake and promotion of brain development.'The effects of w-3 fatty acids are mainly mediated by free fatty acid receptor 4(FFAR4,also known as GPR120),a member of G protein-coupled receptor(GPCR)superfamily.FFAR4 plays crucial roles in main-taining metabolic homeostasis via regulating adipogenesis,insulin sensitivity and inflammation,and is a highly valuable target for treating metabolic diseases such as diabetes.Other FFARs include FFAR1(GPR40)which responds to long-chain FFAs(>12 carbons),and FFAR2(GPR43)and FFAR3(GPR41)that respond to short-chain FFAs(<6 carbons).FFAR4 responds to long-chain FFAs,and a common feature of FFAR4 ligands is the existence of multiple cis double-bonds on the acyl chain of the fatty acids,such as a-linolenic acid(18:3,aLa),stearidonic acid(18:4),eicosapentaenoic acid(20:5,EPA)and docosahexaenoic acid(22:6,DHA).'FFAR4 primarily couples to Gg pathway,but also has been reported to signal through Gs and G. | Han Yin Asuka Inoue Zhengxiong Ma Xinyan Zhu Ruixue Xia Zhenmei Xu Na Wang Yaning Duan Anqi Zhang Changyou Guo Yuanzheng He | 2023 | Cell Research2023，33，8： | 0 |
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