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| 1 | Analysis of viral amino acids sequences and the IL28B SNP influencing the development of hepatocellular carcinoma in chronic hepatitis C显示文摘 | Mika Miura Shinya Maekawa Makoto Kadokura Ryota Sueki Kazuki Komase Hiroko Shindo Takako Ohmori Asuka Kanayama Kuniaki Shindo Fumitake Amemiya Yasuhiro Nakayama Takatoshi Kitamura Tomoyoshi Uetake Taisuke Inoue Minoru Sakamoto Shunichi Okada Nobuyuki Enom | 2012 | Hepatology International2012，，1： | 1 |
| 2 | Lysophosphatidic receptor, LPA 3 , is positively and negatively regulated by progesterone and estrogen in the mouse uterus显示文摘 | Kotaro Hama Junken Aoki Koji Bandoh Asuka Inoue Tomoko Endo Tomokazu Amano Hiroshi Suzuki Hiroyuki Arai | 2006 | Life Sciences2006，，18： | 1 |
| 3 | Analysis of viral amino acids sequences and the IL28B SNP influencing the development of hepatocellular carcinoma in chronic hepatitis C显示文摘 | Mika Miura Shinya Maekawa Makoto Kadokura Ryota Sueki Kazuki Komase Hiroko Shindo Takako Ohmori Asuka Kanayama Kuniaki Shindo Fumitake Amemiya Yasuhiro Nakayama Takatoshi Kitamura Tomoyoshi Uetake Taisuke Inoue Minoru Sakamoto Shunichi Okada Nobuyuki Enom | 2012 | Hepatology International2012，，1： | 1 |
| 4 | The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice显示文摘 | Fukuhara Shigetomo Simmons Szandor Kawamura Shunsuke Inoue Asuka Orba Yasuko Tokudome Takeshi Sunden Yuji Arai Yuri Moriwaki Kazumasa Ishida Junji Uemura Akiyoshi Kiyonari Hiroshi Abe Takaya Fukamizu Akiyoshi Hirashima Masanori Sawa Hirofu | 2012 | EN2012，，： | 1 |
| 5 | Identification of oleic acid as an endogenous ligand of GPR3显示文摘Although GPR3 plays pivotal roles in both the nervous system and metabolic processes,such as cold-induced thermogenesis,its endogenous ligand remains elusive.Here,by combining structural approach(including cryo-electron microscopy),mass spectrometry analysis,and functional studies,we identify oleic acid(OA)as an endogenous ligand of GPR3.Our study reveals a hydrophobic tunnel within GPR3 that connects the extracellular side of the receptor to the middle of plasma membrane,enabling fatty acids to readily engage the receptor.Functional studies demonstrate that OA triggers downstream Gs signaling,whereas lysophospholipids fail to activate the receptor.Moreover,our research reveals that cold stimulation induces the secretion of OA in mice,subsequently activating Gs/cAMP/PKA signaling in brown adipose tissue.Notably,brown adipose tissues from Gpr3 knockout mice do not respond to OA during cold stimulation,reinforcing the significance of GPR3 in this process.Finally,we propose a“born to be activated and cold to enhance”model for GPR3 activation.Our study provides a starting framework for the understanding of GPR3 signaling in cold-stimulated thermogenesis. | Yangjie Xiong Zhenmei Xu Xinzhi Li Yuqin Wang Jing Zhao Na Wang Yaning Duan Ruixue Xia Zhengbin Han Yu Qian Jiale Liang Anqi Zhang Changyou Guo Asuka Inoue Yu Xia Zheng Chen Yuanzheng He | 2024 | Cell Research2024，34，3： | 0 |
| 6 | Structural and functional characterization of the endogenous agonist for orphan receptor GPR3显示文摘Dear Editor,GPR3 is a class A orphan G protein-coupled receptor(GPCR)exhibiting broad expression across various brain regions including the hypothalamus,hippocampus,and cortex,as well as in peripheral tissues such as liver and ovary.1,2 Previous studies have highlighted the critical roles of GPR3 in regulating a diversity of physiological functions,including neurite outgrowth/neuronal survival,neuropathic pain,and oocyte maturation. | Geng Chen Nico Staffen Zhangsong Wu Xinyu Xu Jinheng Pan Asuka Inoue Tingyi Shi Peter Gmeiner Yang Du Jun Xu | 2024 | Cell Research2024，34，3： | 0 |
| 7 | Validation of the Japan Coma Scale for the prediction of mortality in children:analysis of a nationwide trauma database显示文摘Objective The Japan Coma Scale(JCS)is widely used in clinical practice to evaluate levels of consciousness in Japan.There have been several studies on the usefulness of JCS in adults.However,its usefulness in evaluating children has not been reported.Therefore,this study aimed to assess the usefulness of the JCS for the prediction of mortality in children.Methods This is a multicenter cohort study which used data from a national trauma registry(Japan Trauma Data Bank).This study included patients under 16 years of age who were treated between 2004 and 2015.The primary outcome measure was in-hospital mortality.Two models were used to examine each item of the Glasgow Coma Scale(GCS)and the JCS.Model A included the discrete levels of each index.In model B,data regarding age,sex,vital signs on arrival to hospital,the Injury Severity Score,and blunt trauma were added to each index.The effectivity of the JCS score was then evaluated using the area under the curve(AUC)for discrimination,a calibration plot,and the Hosmer-Lemeshow test for calibration.Results A total of 9045 patients were identified.The AUCs of the GCS and JCS were 0.929(95%confidence interval(CI)0.904 to 0.954)and 0.930(95%CI 0.906 to 0.954)in model A and 0.975(95%CI 0.963 to 0.987)and 0.974(95%CI 0.963 to 0.985)in model B,respectively.The results of the Hosmer-Lemeshow test were 0.00(p=1.00)and 0.00(p=1.00)in model A and 4.14(p=0.84)and 8.55(p=0.38)in model B for the GCS and JCS,respectively.Conclusions We demonstrated that the JCS is as valid as the GCS for predicting mortality.The findings of this study indicate that the JCS is a useful and relevant tool for pediatric trauma care and future research. | Yuki Enomoto Yusuke Tsutsumi Asuka Tsuchiya Takahiro Kido Koji Ishigami Masahito Togo Susumu Yasuda Yoshiaki Inoue | 2022 | World Journal of Pediatric Surgery2022，5，2： | 0 |
| 8 | Chemogenetic activation of G12 signaling enhances adipose tissue browning显示文摘Dear Editor,Beige adipocytes,which increase energy expenditure by dissipating energy as heat,have gained attention as a therapeutic target for combating obesity.1 Adipocytes express many types of G-protein-coupled receptors(GPCRs),each of which has a unique preference for the Gs,Gi,Gq,and G12 subfamilies.While the function of Gs-coupledβ-adrenergic receptors in beige adipocyte induction is well established,2 little is known about the function of G12-coupled GPCRs beyond its suppressive roles in white adipocyte maturation.3 In this study,we generated transgenic mice conditionally expressing a G12-coupled designer GPCR using a Cre-loxP system and investigated the potential effects of G12 signaling on adipocyte biology. | Yuki Ono Ryo Ito Kaito Arai Gurdeep Singh Tsuyoshi Saitoh Robert BRussell Francesco Raimondi Junken Aoki Juro Sakai Asuka Inoue | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 9 | Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity显示文摘Dear Editor,Omega(w)-3 fatty acids are known to have multiple beneficial effects on health,including anti-inflammation,enhancement of glucose uptake and promotion of brain development.'The effects of w-3 fatty acids are mainly mediated by free fatty acid receptor 4(FFAR4,also known as GPR120),a member of G protein-coupled receptor(GPCR)superfamily.FFAR4 plays crucial roles in main-taining metabolic homeostasis via regulating adipogenesis,insulin sensitivity and inflammation,and is a highly valuable target for treating metabolic diseases such as diabetes.Other FFARs include FFAR1(GPR40)which responds to long-chain FFAs(>12 carbons),and FFAR2(GPR43)and FFAR3(GPR41)that respond to short-chain FFAs(<6 carbons).FFAR4 responds to long-chain FFAs,and a common feature of FFAR4 ligands is the existence of multiple cis double-bonds on the acyl chain of the fatty acids,such as a-linolenic acid(18:3,aLa),stearidonic acid(18:4),eicosapentaenoic acid(20:5,EPA)and docosahexaenoic acid(22:6,DHA).'FFAR4 primarily couples to Gg pathway,but also has been reported to signal through Gs and G. | Han Yin Asuka Inoue Zhengxiong Ma Xinyan Zhu Ruixue Xia Zhenmei Xu Na Wang Yaning Duan Anqi Zhang Changyou Guo Yuanzheng He | 2023 | Cell Research2023，33，8： | 0 |
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