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| 1 | Molecular cloning and functional analysis of the FLOWERING LOCUS T(FT) homolog Gh FT1 from Gossypium hirsutum显示文摘FLOWERING LOCUS T(FT) encodes a member of the phosphatidylethanolamine-binding protein(PEBP) family that functions as the mobile floral signal, playing an important role in regulating the floral transition in angiosperms. We isolated an FT-homolog(Gh FT1) from Gossypium hirsutum L. cultivar,Xinluzao 33 Gh FT1 was predominantly expressed in stamens and sepals, and had a relatively higher expression level during the initiation stage of fiber development. Gh FT1 m RNA displayed diurnal oscillations in both long-day and short-day condition,suggesting that the expression of this gene may be under the control of the circadian clock. Subcellular analysis revealed that Gh FT1 protein located in the cytoplasm and nucleus. Ectopic expression of Gh FT1 in transgenic arabidopsis plants resulted in early flowering compared with wild-type plants. In addition,ectopic expression of Gh FT1 in arabidopsis ft-10 mutants partially rescued the extremely late flowering phenotype. Finally, several Researchflowering related genes functioning downstream of At FT were highly upregulated in the 35S::Gh FT1 transgenic arabidopsis plants. In summary, Gh FT1 is an FT-homologous gene in cotton that regulates flower transition similar to its orthologs in other plant species and thus it may be a candidate target for promoting early maturation in cotton breeding. | Danli Guo Chao Li Rui Dong Xiaobo Li Xiangwen Xiao Xianzhong Huang | 2015 | Journal of Integrative Plant Biology2015，57，6： | 14 |
| 2 | Variations in leaf carbon isotope composition along an arid and semi-arid grassland transect in northern China显示文摘Aims We aimed to quantify the variation of leafδ^(13)C along an arid and semi-arid grassland transect in northern China.We also evaluated the effects of environmental factors(i.e.precipitation,temperature and altitude)on the spatial variation of leafδ^(13)C in northern grasslands and Tibetan Plateau,China.Method We sampled leaves of plant species belonging to three herb genera(Stipa spp.,Leymus spp.and Cleistogenes spp.)and three shrub genera(Caragana spp.,Reaumuria spp.and Nitraria spp.)for carbon isotope analysis from 50 locations along a 3200-km arid and semiarid grassland transect in northern China.Leafδ^(13)C data in Tibetan Plateau and northern grasslands in China were also compiled from studies in literature.Important Findings Along the transect,leafδ^(13)C for C_(3)plants ranged from−28.0‰to−23.3‰,and from−16.3‰to−13.8‰for C_(4)plant Cleistogenes spp..The change in leafδ^(13)C ranged from−0.26‰to−3.51‰with every 100 mm increase of annual precipitation,and leafδ^(13)C of shrubs(Nitraria spp.,Reaumuria spp.and Caragana spp.)responded more markedly to climatic factors(precipitation and temperature)than that of herbs(Stipa spp.,Leymus spp.and Cleistogenes spp.),indicating higher sensitivity of shrubδ^(13)C to climatic changes.The most important factor regulating spatial variations of leafδ^(13)C in Tibetan Plateau was altitude,while it was precipitation in northern grasslands.Our results suggested that shrubs are more adapted to increasing drought in arid and semi-arid grassland.Controls of environmental factors on leafδ^(13)C depended on the most limiting factors in arid grassland(precipitation)and Tibetan grasslands(atmospheric CO_(2)concentration). | Chao Wang Dongwei Liu Wentao Luo Yunting Fang Xiaobo Wang Xiaotao Lü Yong Jiang Xingguo Han Edith Bai | 2016 | Journal of Plant Ecology2016，9，5： | 3 |
| 3 | Ambient air pollution and low temperature associated with case fatality of COVID-19: A nationwide retrospective cohort study in China显示文摘The evidence for the effects of environmental factors on COVID-19 case fatality remains controversial,and it is crucial to understand the role of preventable environmental factors in driving COVID-19 fatality.We thus conducted a nationwide cohort study to estimate the effects of environmental factors(temperature,particulate matter[PM2.5,PM10],sulfur dioxide[SO2],nitrogen dioxide[NO2],and ozone[O3])on COVID-19 case fatality.A total of 71,808 confirmed COVID-19 cases were identified and followed up for their vital status through April 25,2020.Exposures to ambient air pollution and temperature were estimated by linking the city-and county-level monitoring data to the residential community of each participant.For each participant,two windows were defined:the period from symptom onset to diagnosis(exposure window I)and the period from diagnosis date to date of death/recovery or end of the study period(exposure window II).Cox proportional hazards models were used to estimate the associations between these environmental factors and COVID-19 case fatality.COVID-19 case fatality increased in association with environmental factors for the two exposure windows.For example,each 10 mg/m^(3) increase in PM2.5,PM10,O3,and NO2 in window I was associated with a hazard ratio of 1.11(95%CI 1.09,1.13),1.10(95%CI 1.08,1.13),1.09(95 CI 1.03,1.14),and 1.27(95%CI 1.19,1.35)for COVID-19 fatality,respectively.A significant effect was also observed for low temperature,with a hazard ratio of 1.03(95%CI 1.01,1.04)for COVID-19 case fatality per 1C decrease.Subgroup analysis indicated that these effects were stronger in the elderly,as well as in those with mild symptoms and living in Wuhan or Hubei.Overall,the sensitivity analyses also yielded consistent estimates.Short-term exposure to ambient air pollution and low temperature during the illness would play a nonnegligible part in causing case fatality due to COVID-19.Reduced exposures to high concentrations of PM2.5,PM10,O3,SO2,and NO2 and low temperature would help improve the prognosis and reduce public health burden. | Fei Tian Xiaobo Liu Qingchen Chao Zhengmin(Min)Qian Siqi Zhang Li Qi Yanlin Niu Lauren DArnold Shiyu Zhang Huan Li Hualiang Lin Qiyong Liu | 2021 | The Innovation2021，2，3： | 2 |
| 4 | Tow-and three-dimensional oil spill model for coastal waters 显示文摘 | Chao Xiaobo Shankar N Jothi Hin Fatt Cheong | 2001 | Ocean Engineering2001，28，6： | 1 |
| 5 | Genome-wide signatures of the geographic expansion and breeding of soybean显示文摘Soybean is a leguminous crop that provides oil and protein. Exploring the genomic signatures of soybean evolution is crucial for breeding varieties with improved adaptability to environmental extremes. We analyzed the genome sequences of 2,214 soybeans and proposed a soybean evolutionary route, i.e., the expansion of annual wild soybean(Glycine soja Sieb. & Zucc.) from southern China and its domestication in central China, followed by the expansion and local breeding selection of its landraces(G. max(L.) Merr.). We observed that the genetic introgression in soybean landraces was mostly derived from sympatric rather than allopatric wild populations during the geographic expansion. Soybean expansion and breeding were accompanied by the positive selection of flowering time genes, including GmSPA3c. Our study sheds light on the evolutionary history of soybean and provides valuable genetic resources for its future breeding. | Ying-Hui Li Chao Qin Li Wang Chengzhi Jiao Huilong Hong Yu Tian Yanfei Li Guangnan Xing Jun Wang Yongzhe Gu Xingpeng Gao Delin Li Hongyu Li Zhangxiong Liu Xin Jing Beibei Feng Tao Zhao Rongxia Guan Yong Guo Jun Liu Zhe Yan Lijuan Zhang Tianli Ge Xiangkong Li Xiaobo Wang Hongmei Qiu Wanhai Zhang Xiaoyan Luan Yingpeng Han Dezhi Han Ruzhen Chang Yalong Guo Jochen C.Reif Scott A.Jackson Bin Liu Shilin Tian Li-juan Qiu | 2023 | Science China(Life Sciences)2023，66，2： | 1 |
| 6 | Detection of Dim Maneuvering Target Ased on Randomized Hough Transform显示文摘 | Chao Gao Xiaobo Deng Changhai Shi | 2012 | Procedia Engineering2012，，： | 1 |
| 7 | Recovering relationships between documentation and source code based on the characteristics of software engineering 显示文摘 | Wang Xiaobo Lai Guanhui Liu Chao | 2009 | Electronic Notes in Theoretical Computer Science2009，243，： | 1 |
| 8 | High thermoelectric performance at room temperature of n-type Mg_(3)Bi_(2)-based materials by Se doping显示文摘Bi_(2)Te_(3) based alloys have been the most widely used thermoelectric material at low temperature for many decades.Here we report Se doped n-type Mg_(3)Bi_(2) based materials with a thermoelectric figure-of-merit ZT of 0.82 at 300 K and a peak ZT of 1.24 at 498 K,which is comparable to the n-type Bi_(2)Te_(3) and Te doped Mg_(3)Bi_(1.4)Sb_(0.6).The improved thermoelectric performance is benefited from the high carrier concentration and mobility as well as the thermal conductivity reduction.The reduced resistivity increased the power factor at all measured temperatures,leading to a higher engineering ZT(ZTeng)and engineering power factor(PFeng)for n-type Mg_(3)Bi_(2).The n-type Mg_(3)Bi_(1.4)Sb_(0.6) materials are promising for thermoelectric power generation and cooling applications near room temperature. | Xiaobo Mo Jiansong Liao Guocai Yuan Sha Zhu Xiaobo Lei Lihong Huang Qinyong Zhang Chao Wang Zhifeng Ren | 2022 | Journal of Magnesium and Alloys2022，10，4： | 1 |
| 9 | Nu- merical Simulation of Sediment-associated Water Quality Processes for a Mississippi Delta Lake显示文摘 | Chao Xiaobo Jia Yafei Shields Jr F D | 2009 | Ecohydrology2009，2，3： | 1 |
| 10 | N + plasma-assisted wafer bonding between silicon and chemical vapor deposition oxide at low temperature显示文摘 | Xiaobo Ma Weili Liu Chao Chen Jiayi Xu Zhitang Song Chenglu Lin | 2009 | Materials Science in Semiconductor Processing2009，，4： | 1 |
| 11 | Dissolved organic carbon fractionation in wet deposition and its potential impact on radiative forcing in the central Tibetan Plateau显示文摘As an important component of carbonaceous matters,dissolved organic carbon(DOC)can absorb and scatter the solar radiation at ultraviolet and blue wavelengths.The wet deposition process has great impact on the con-centration and light absorption ability of precipitation DOC,affecting the climatic effect caused by DOC in the atmosphere.In this study,light absorption and fluorescence characteristics of precipitation DOC was investigated in the central Tibetan Plateau(TP).The results showed that the mean DOC concentration and mass absorption cross-section measured at 365 nm(MAC_(365)) in Tanggula(TGL)station were 0.59±0.42 mg/L and 0.37±0.19 m^(2)/g,respectively,while both values showed much higher volatilities than those of aerosols.DOC concentrations had significant negative correlation with the precipitation amount,while MAC_(365) values increase with the precipitation amount in TGL station.Therefore,DOC with high light-absorbing ability was preferred to be retained in the atmosphere during wet deposition.In this study,precipitation DOC contained three fluorescent components(one humic-like component and two tyrosine-like components)mainly from local biomass burning sources.DOC concentration showed a negative relationship with MAC_(365) value in TGL station.The wet deposition of DOC with low light-absorbing ability can reduce the strong negative radiative forcing caused by secondary organic aerosol due to high proportion of DOC in secondary organic carbon.Similar phenomenon was also found in Nam Co,Lulang and Everest stations of previous study,which may have a potential impact on radiative forcing in the atmosphere of TP. | ZhaoFu Hu ChaoLiu Li ShiChang Kang XiaoFei Li Chao Zhang Fangping Yan XiaoBo He PengFei Chen | 2023 | Research in Cold and Arid Regions2023，15，4： | 0 |
| 12 | VPS35 Protects Against TMEM230-mutation-induced Progressive Locomotor Deficits in Drosophila显示文摘The discovery of genes related to Parkinson's disease(PD)provides an imporant basis for the progress of research into PD,helps to clarify is mechanism,and provides many new opportunities to find therapeutic targelts[1.2].The article by Deng and colleagues in 2016 found a new autosomal dominant PD(ADPD)gene,transmembrane protein 230(TMEM230).Four PD-linked mutations were identifed in PD patients:Y92C,RI4IL.184Wexr*5(replacing the stop codon with six amino-acids.WHPPHS,in the C-terminus in North American patients),and 184PGext*5(replacing the stop codon with proline and glycine,thus adding seven amino acids,PGHPPHS,to the C-lerminus in Chinese families with PD)[3].Subsequenly,studies have suggested thal TMEM230 variants are related to PD pathogenesis in viro[4-6]. | Chao Ma Xiaobo Wang Wanli W.Smith Zhaohui Liu | 2022 | Neuroscience Bulletin2022，38，6： | 0 |
| 13 | Activation of Pancreatic Acinar FXR Protects against Pancreatitis via Osginl-Mediated Restoration of Efficient Autophagy显示文摘Pancreatitis is the leading cause of hospitalization in gastroenterology,and no medications are available for treating this disease in current clinical practice.FxR plays an anti-inflammatory role in diverse inflammatory diseases,while its function in pancreatitis remains unknown.In this study,we initially observed a marked increase of nuclear FXR in pancreatic tissues of human patients ithpancratis eleting theFXRinpancreati acinar cels FXRicnara/a)ledto moreseverepancreatitis in mousemodels of caerulein-induced acute and chronic pancreatitis,while the FXR agonist GW4064 significantly attenuated pancreatitis in caerulein or arginine-induced acute pancreatitis and caerulein-induced chronic pancreatitis.FXR deletion impaired the viability and stress responses of pancreatic exocrine organoids(PEOs)in vitro.Utilizing RNA-seq and ChIP-seq of PEOs,we identified Osginl as a direct target of FxR in the exocrine pancreas,which was also increasingly expressed in human pancreatitis tissues compared to normal pancreatic tissues.Pancreatic knockdown of Osgin1 by AAV-pan abolished the therapeutic effects of FXR activation on pancreatitis,whereas pancreatic overexpression of Osginl effectively alleviated caerulein-induced pancreatitis.Mechanistically,we found that the FXR-OSGINl axis stimulated autophagic flux in the pancreatic tissues and cell lines,which was considered as the intrinsic mechanisms through which FXR-OSGINI protecting against pancreatitis.Our results highlight the protective role of the FXR-OSGIN1 axis in pancreatitis and provided a new target for the treatment of this disease. | Yufan Zheng Wenrui Sun Zhengyang Wang Jiaying Liu Cong Shan Chenxi He Borui Li Xiao Hu Wenjia Zhu Liyan Liu Fei Lan Changtao Jiang Chao Zhao Xiaobo Li Ning Sun | 2023 | Research2023，，1： | 0 |
| 14 | Pressure-tuning domain-wall chirality in noncentrosymmetric magnetic Weyl semimetal CeAlGe显示文摘Topological magnetic Weyl semimetals have been proposed to host controllable chiral domain walls which bear a great prospect in device applications. To exploit them in applications, it is important to have a proper way to tune and manipulate these domain walls. One possible means is through magnetoelastic coupling. The involvement of rare earth in the lately proposed RAl X(R =rare earth, X = Si and Ge) family magnetic Weyl semimetals may provide such a platform. Here we present the transport and thermodynamic properties of Ce Al Ge under hydrostatic pressure. We find that pressure enhances the antiferromagnetic exchange in Ce Al Ge but essentially retains its magnetic structure. A large topological Hall effect with a pronounced loop shape is observed within the magnetically ordered state, and it splits into two regions under pressure. Such an unusual electromagnetic response is inferred to be a consequence of chiral magnetic domain walls. The unprecedented concomitance of its evolution under pressure and the reentrance of antiferromagnetic order strongly suggest the capability of switching on/off this electromagnetic response in noncentrosymmetric magnetic Weyl semimetals via magnetoelastic coupling. | Xiaobo He Yuke Li Hai Zeng Zengwei Zhu Shiyong Tan Yongjun Zhang Chao Cao Yongkang Luo | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，3： | 0 |
| 15 | Evolution of TWIN SISTER of FT(TSF) Genes in Brassicaceae显示文摘FT and its homolog, TWIN SISTER OF FT(TSF), act redundantly as integrators in flora transition pathways in Arabidopsis thaliana. The evolution of these key fl wering regulatory genes during Brassicaceae speciation has not been well studied; therefore, we investigated their evolution in 13 sequenced Brassicaceae species. While the phylogenetic analysis indicated that FT gene evolution has followed two independent lineagespecifi routes, TSF evolution does not appear to have been completely consistent within the Brassicaceae lineage I and lineage II division. The two TSF copies in the Thellungiella genus were divided into A and B groups in the phylogenetic analysis. Examination of conserved non-coding sequences and conserved domains within a 5 kb region upstream of the TSF start codon revealed the same group division inferred by the phylogenetic analysis. In addition, TSF genes retained syntenic relationships among genes in the same group, but not between group A and group B.The two copies of the TSF gene in the Thellungiella species were syntenic to the TSF genes in group A and group B, respectively. We also identifie TSF-A gene residues in the syntenic region of group B species, but no TSF-B residues could be found in the group A syntenic region. Therefore,we inferred that the TSF genes in lineage II species experienced a duplication event after diversificatio from lineage I. Following their split from Thellungiella, Brassica species lost the ancestral TSF gene and retained the duplicated copy. | HU Yunyan LIU Bo SUN Chao LIU Jing WANG Xiaobo CHENG Feng LIANG Jianli WANG Xiaowu WU Jian | 2016 | Horticultural Plant Journal2016，2，1： | 0 |
| 16 | Compressive Behaviour and Failure Mechanisms of GFRP Composite at High Strain Rates显示文摘Experimental investigations into the compressive behavior of glass fiber reinforced polymer(GFRP)composite at high strain rates were carried out using a split Hopkinson pressure bar(SHPB)setup.The GFRP laminates were made from E-glass fibers and epoxy resins by vacuum assisted compression molding machine.The results of the compressive tests indicated that the mechanical behavior of the GFRP composite depends highly on the strain rate.The compressive peak stress,toughness and Young's modulus of the GFRP composite increased with the increase of strain rate,while the strain level at the initial stages of damage was shortened with the increase of strain rate.In addition,the dynamic deformation behavior and failure process of the specimens were observed directly by using a high-speed camera.Following the experiments,the fracture morphologies and damage modes were examined by scanning electron microscopy(SEM)to explore the possible failure mechanisms of the specimens.The results showed that multiple failure mechanisms appeared,such as matrix crack,fiber-matrix debonding,fiber failure and shear fracture. | Dejun Yin Jian Zheng Chao Xiong Junhui Yin Huiyong Deng Xiaobo Su | 2019 | Journal of Beijing Institute of Technology2019，28，1： | 0 |
| 17 | Electrical property enhancement and lattice thermal conductivity reduction of n-type Mg_(3)Sb_(1.5)Bi_(0.5)-based Zintl compound by In&Se co-doping显示文摘Mg_(3)Sb_(1.5)Bi_(0.5)-based Zintl compounds have attracted extensive attention as potential thermoelectric materials due to their earth-abundant elements.However,pure and intrinsic Mg_(3)Sb_(1.5)Bi_(0.5)manifests a poor thermoelectric performance because of its low electrical conductivity of about 3×10^(2)S/m at room temperature.In this work,In and Se co-doping was carried out to optimize the thermoelectric perfor-mance of n-type Mg_(3)Sb_(1.5)Bi_(0.5)-based material.The experimental results revealed that the carrier con-centration and mobility of Mg_(3)Sb_(1.5)Bi_(0.5)significantly increased after In and Se co-doping,leading to an improvement of power factor.Simultaneously,lattice thermal conductivity was significantly reduced due to the large mass difference between In and Mg.A maximum zT of 1.64 at 723 K was obtained for the Mg_(3.17)In_(0.03)Sb_(1.5)Bi_(0.49)Se_(0.01)sample.And an average zT value of about 1.1 between 300 and 723 K was achieved,which insures its possible application at medium temperature range as a non-toxic and low-cost TE material. | Tong Liu Jiansong Liao Hang Liu Runyu Wang Guocai Yuan Jing Jiang Yi Niu Xiaobo Lei Lihong Huang Chao Wang Qinyong Zhang | 2023 | Journal of Materiomics2023，9，3： | 0 |
| 18 | Effect of Enhanced Plasma Density on the Properties of Aluminium Doped Zinc Oxide Thin Films Produced by DC Magnetron Sputtering显示文摘Aluminum doped zinc oxide (AZO) thin films were prepared by DC magnetron sputtering at low substrate temperature. A coaxial solenoid coil was placed near the magnetron target to enhance the plasma density (Ji). The enhanced plasma density improved significantly the bulk resistivity (ρ) and its homogeneity in spatial distribution of AZO films. X-ray diffraction (XRD) analysis revealed that the increased Ji had inuenced the crystallinity, stress relaxation and other material properties. The AZO films deposited in low plasma density (LPD) mode showed marked variation in ρ (ranging from ~6.5×10?2 to 1.9×10-3 ·cm), whereas those deposited in high plasma density (HPD) mode showed a better homogeneity of films resistivity (ranging from ~1.3×10?3 to 3.3×10?3 ?·cm) at di?erent substrate positions. The average visible transmittance in the wavelength range of 500-800 nm was over 80%, irrespective of the deposition conditions. The atomic force microscopy (AFM) surface morphology showed that AZO films deposited in HPD mode were smoother than that in LPD mode. The high plasma density produced by the coaxial solenoid coil improved the electrical property, surface morphology and the homogeneity in spatial distribution of AZO films deposited at low substrate temperature. | Jun Gong Xiaobo Zhang Zhiliang Pei Chao Sun Lishi Wen | 2011 | Journal of Materials Science & Technology2011，27，5： | 0 |
| 19 | Isogenic human pluripotent stem cell disease models reveal ABRA deficiency underlies cTnT mutation-induced familial dilated cardiomyopathy显示文摘Dear Editor,Dilated cardiomyopathy(DCM)is a common form of inherited cardiomyopathy.In the past decades,single mutations in various genes encoding sarcomeric,cytoskeletal,and channel proteins etc.have been found to be associated with DCM(Hershberger et al.,2013;McNally and Mestroni,2017).However,the mechanisms how single mutations in sarcomeric or structural genes lead to the disease remain elusive.An interesting phenomenon often seen in familial cardiomyopathy is that different single mutations on the same gene can cause either DCM or hypertrophic cardiomyopathy(HCM)(Kathiresan and Srivastava,2012),which exhibit almost opposite disease phenotypes.DCM is characterized by thinned myocardium and septum,ventricular chamber dilation,and systolic dysfunction(Jefferies and Towbin,2010;McNally and Mestroni,2017),while HCM exhibits thickened myocardium and septum,reduced ventricular chamber,and diastolic dysfunction(Richard et al.,2003).At the cellular level,HCM cardiomyocytes exhibit concentric hypertrophy characterized by assembly of myofilaments in parallel and widening of the myocytes.In contrast,DCM cardiomyocytes show eccentric hypertrophy,with assembly of the myofilaments in series and myocyte elongation(Kehat and Molkentin,2010). | Bin Li Yongkun Zhan Qianqian Liang Chen Xu Xinyan Zhou Huanhuan Cai Yufan Zheng Yifan Guo Lei Wang Wenqing Qiu Baiping Cui Chao Lu Ruizhe Qian Ping Zhou Haiyan Chen Yun Liu Sifeng Chen Xiaobo Li Ning Sun | 2022 | Protein & Cell2022，13，1： | 0 |
| 20 | Energy Pumping by Surface Collectors on Upconversion Nanoparticles for Extended Transfer and Efficient Self-Evaluable Photodynamic Therapy显示文摘Although upconversion nanoparticle(UCNP)-based luminescence resonance energy transfer(LRET)has attracted intensive attention,its application in sensing strategies for biomacromolecule detection is still limited due to the low energy-transfer efficiency.Here,we develop an energy pumping strategy to enhance the upconversion LRET efficiency of UCNP from 3.6% to 70.3%.Surface collector dye cyanine-3(Cy3)is modified on the UCNP surface to concentrate the scattered emission energy from interior UCNP to particle surface and then further pumped to the surface extended acceptor.Using caspase-3 as a target,its recognition and cleavage of QSY7-labeled peptide co-assembled on UCNP-Cy3 leads to the release of QSY7 to recover Cy3 fluorescence.Owing to the multiple emissions of UCNP,this system can be integrated with another surface collector to enhance reactive oxygen species(ROS)generation for photodynamic therapy(PDT).Caspase-3,as a PDT product,is imaged in situ with an internal standard to self-evaluate the PDT effect. | Xiaobo Zhang Weiwei Chen Xiaoyu Xie Yue Zhang Zhicong Chao Haibo Ma Ying Liu Huangxian Ju | 2022 | CCS Chemistry2022，4，4： | 0 |
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