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| 1 | MicroRNA-21 in the pathogenesis of acute kidney injury显示文摘Acute kidney injury(AKI),associated with significant mor-bidity and mortality,is widely known to involve epithelial apoptosis,excessive inflammation,and fibrosis in re-sponse to ischemia or reperfusion injury,which results in either chronic pathological changes or death.Therefore,it is imperative that investigations are conducted in order to fi nd effective,early diagnoses,and therapeutic targets needed to help prevent and treat AKI.However,the mech-anisms modulating the pathogenesis of AKI still remain largely undetermined.MicroRNAs(miRNAs),small non-coding RNA molecules,play an important role in several fundamental biological and pathological processes by a post transcriptional regulatory function of gene expres-sion.MicroRNA-21(miR-21)is a recently identifi ed,typi-cal miRNA that is functional as a regulator known to be involved in apoptosis as well as inflammatory and fi brotic signaling pathways in AKI.As a result,miR-21 is now considered a novel biomarker when diagnosing and treat-ing AKI.This article reviews the correlative literature and research progress regarding the roles of miR-21 in AKI. | Ya-Feng Li Ying Jing Jielu Hao Nathan C Frankfort Xiaoshuang Zhou Bing Shen Xinyan Liu Lihua Wang Rongshan Li | 2013 | Protein & Cell2013，4，11： | 18 |
| 2 | miR-181b functions as an oncomiR in colorectal cancer by targeting PDCDZ显示文摘 | Yanqing Liu Uzair-ur-Rehman Yu Guo Hongwei Liang Rongjie Cheng Fei Yang Yeting Hong Chihao Zhao Minghui Liu Mengchao Yu Xinyan Zhou Kai Yin Jiangning Chen Junfeng Zhang Chen-Yu Zhang Feng Zhi Xi Chen | 2016 | Protein & Cell2016，7，10： | 14 |
| 3 | A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis显示文摘 | Shuying Shen Xiaocan Guo Huan Yan Yi Lu Xinyan Ji Li Li Tingbo Liang Dawang Zhou Xin-Hua Feng Jonathan C Zhao Jindan Yu Xing-Guo Gong Lei Zhang Bin Zhao | 2015 | Cell Research2015，25，9： | 10 |
| 4 | Trust Access Authentication in Vehicular Network Based on Blockchain显示文摘Data sharing and privacy securing present extensive opportunities and challenges in vehicular network.This paper introducestrust access authentication scheme’as a mechanism to achieve real-time monitoring and promote collaborative sharing for vehicles.Blockchain,which can provide secure authentication and protected privacy,is a crucial technology.However,traditional cloud computing performs poorly in supplying low-latency and fast-response services for moving vehicles.In this situation,edge computing enabled Blockchain network appeals to be a promising method,where moving vehicles can access storage or computing resource and get authenticated from Blockchain edge nodes directly.In this paper,a hierarchical architecture is proposed consist of vehicular network layer,Blockchain edge layer and Blockchain network layer.Through a authentication mechanism adopting digital signature algorithm,it achieves trusted authentication and ensures valid verification.Moreover,a caching scheme based on many-to-many matching is proposed to minimize average delivery delay of vehicles.Simulation results prove that the proposed caching scheme has a better performance than existing schemes based on central-ized model or edge caching strategy in terms of hit ratio and average delay. | Shaoyong Guo Xing Hu Ziqiang Zhou Xinyan Wang Feng Qi Lifang Gao | 2019 | China Communications2019，16，6： | 10 |
| 5 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 6 | Efficacy of Shenzhuo formula on diabetic kidney disease:a retrospective study显示文摘OBJECTIVE:To observe the efficacy of a traditional Chinese medicine,Shenzhuo formula,on patients with diabetic kidney disease(DKD).METHODS:Eighty-eight outpatients with DKD were enrolled.Changes in estimated glomerular filtration rate(eGFR),creatinine clearance,serum creatinine,blood-urea-nitrogen,albuminuria,glycosylated hemoglobin(Hb_(A1C)),blood pressure,and lipid profile were measured and analyzed before and after intervention with Shenzhuo formula for 1,3,6,9,12,and 18 months.RESULTS:Compared with the baseline amounts,serum creatinine decreased,and eGFR and creatinine clearance increased,significantly after intervention for 1,3,6,9,12,and 18 months(all P < 0.05).Mean eGFR increased by 2.11 mL/min per 1.73 m7 y after18-month treatment.Urinary protein at 24 h decreased significantly after 1,3,9,and 12 months(P < 0.05).Hb_(A1C) decreased significantly(P < 0.05) after 3,6,9,12,and 18 months,and systolic blood pressure decreased significantly(P < 0.05) after 1,3,and 6 months.Total cholesterol decreased significantly(P < 0.05) after 1,3,6,and 18 months.Triglyceride and low-density lipoprotein-cholesterol decreased significantly(P < 0.05) after 1 and 3 months.CONCLUSION:Shenzhuo formula can improve eGFR and possibly slow DKD progression.Shenzhuo formula can also lower Hb_(A1C),lipid levels and blood pressure. | Tian Jiaxing Zhao Linhua Zhou Qiang Liu Wenke Chen Xinyan Lian Fengmei Tong Xiaolin | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 8 |
| 7 | Balancing flexural strength and porosity in DLP-3D printing Al_(2)O_(3)cores for hollow turbine blades显示文摘High porosity and high strength are usually mutually exclusive in the preparation of ceramic materials.However,high porosity and flexural strength are required for the preparation of complex ceramic cores for hollow turbine blades.In this study,Al_(2)O_(3)cores with high porosity and high flexural strength were successfully prepared using digital light processing(DLP)3 D printing technology.The influence of sintering temperature on the microstructure,pore evolution,and flexural strength of the cores were investigated.With an increase in the sintering temperature,the porosity of the ceramic cores first increased and then decreased,reaching a maximum value of 35%at 1400℃.The flexural strength increased with the increase in sintering temperature,but at 1400℃the incremental enhancement of flexural strength was greatest.Combined with the core service requirements and core performance,this study selected 1400℃(open porosity of 35.1%and flexural strength of 20.3 MPa)as the optimal sintering temperature for the DLP-3 D printed Al_(2)O_(3)core. | Qiaolei Li Xiaolong An Jingjing Liang Yongsheng Liu Kehui Hu Zhigang Lu Xinyan Yue Jinguo Li Yizhou Zhou Xiaofeng Sun | 2022 | Journal of Materials Science & Technology2022，，9： | 4 |
| 8 | Boosting the kinetics of PF_(6)^(-) into graphitic layers for the optimal cathode of dual-ion batteries:The rehearsal of pre-intercalating Li^(+)显示文摘Large anions exhibit slow diffusion kinetics in graphite cathode of dual-ion batteries(DIBs);particularly at high current density,it suffers severely from the largely-reduced interlayer utilization of graphite cathode,which as a bottleneck limits the fast charge application of DIBs.To maximize interlayer utilization and achieve faster anion diffusion kinetics,a fast and uncrowded anion transport channel must be established.Herein,Li^(+)was pre-intercalated into the graphite paper(GP)cathode to increase the interlayer spacing,and then hosted for the PF_(6)^(-)anion storage.Combined with theoretical calculation,it shows that the local interlayer spacing enlargement and the residual Li^(+)reduce the anion intercalation energy and diffusion barrier,leading to better rate stability.The obtained GP with Li^(+)pre-intercalation(GP-Li)electrode exhibits a discharge capacity of 23.1 m Ah g^(-1) at a high current of 1300 m A g^(-1).This work provides a facile method to efficiently improve the interlayer utilization of graphite cathode at large currents. | He Yang Tingting Qin Xinyan Zhou Yu Feng Zizhun Wang Xin Ge Nailin Yue Dabing Li Wei Zhang Weitao Zheng | 2022 | Journal of Energy Chemistry2022，31，8： | 2 |
| 9 | Detection and analysis of DNA recapture through a solid-state nanopore显示文摘Motion control of a single molecule through a solid-state nanopore offers a new perspective on detecting and analyzing single biomolecules.Repeat recapture of a single DNA molecule reveals the dynamics in DNA translocation through a nanopore and may significantly increase the signal-to-noise ratio for DNA base distinguishing.However,the transient current at the moment of voltage reversal prevents the observation of instantly recaptured molecules and invalidates the continuous DNA ping-pong control.We performed and analyzed the DNA translocation and recapture experiment in a silicon nitride solid-state nanopore.Numerical calculation of molecular motion clearly shows the recapture dynamics with different delay times.The prohibited time when the data acquisition system is saturated by the transient current is derived by equivalent circuit analysis and finite element simulation.The COMSOL simulation reveals that the membrane capacitance plays an important role in determining the electric field distribution during the charging process.As a result of the transient charging process,a non-constant driving force pulls the DNA back to nanopores faster than theoretically predicted.The observed long time constant in the transient current trace is explained by the dielectric absorption of the membrane capacitor. | Ying Hu Zhi Zhou Xinyan Shan Xinghua Lu | 2014 | Chinese Science Bulletin2014，59，35： | 2 |
| 10 | Precoder Design and Impulsive Noise Mitigation Scheme for Industrial Wireless Communications显示文摘In industrial wireless scenarios,the impulsive noise(IN)incurred by machine running or operation causes a serious influence on the powerlimited industrial wireless communications.It is challenging to ensure efficient and reliable transmission with quality of service(QoS)guarantee for machinetype communication devices(MTCDs).Considering the IN in the industrial process,this paper establishes the multiuser multiple-input single-output(MU-MISO)orthogonal frequency division multiplexing(OFDM)system model,which combines transmitter and receiver design.Two precoding schemes are designed to improve communication effectiveness at the transmitter.More specifically,the precoder design scheme which combines semi-definite relaxation(SDR)with difference-of-two-convex-function(D.C.)iterative algorithm,is developed by utilizing the Dinkelbach method to improve the system effectiveness.To decrease the computational complexity,we devise the quadratic-based fractional programming(QFP)algorithm,which decouples the variables by using a quadratic transform method.On this basis,the IN mitigation scheme is studied to reduce the system error rate(SER)at the receiver.With the goal of improving the reliability of industrial wireless communications,we propose a hybrid nonlinear IN mitigation(HNINM)scheme and then derive its closed-form expression of SER.The simulation results show that the proposed QFP algorithm achieves superior performance while the HNINM scheme decreases the SER of industrial wireless communications. | Yanjing Sun Xinyan Li Jiasi Zhou Ruirui Chen BowenWang Yanfen Wang | 2021 | China Communications2021，18，4： | 1 |
| 11 | Molecular genetic analysis of phosphomannomutase genes in Triticum monococcum显示文摘In higher plants, phosphomannomutase(PMM) is essential for synthesizing the antioxidant ascorbic acid through the Smirnoff–Wheeler pathway. Previously, we characterized six PMM genes(Ta PMM-A1, A2, B1, B2, D1 and D2) in common wheat(Triticum aestivum, AABBDD).Here, we report a molecular genetic analysis of PMM genes in Triticum monococcum(AmAm), a diploid wheat species whose Amgenome is closely related to the A genome of common wheat. Two distinct PMM genes, Tm PMM-1 and Tm PMM-2, were found in T. monococcum. The coding region of Tm PMM-1 was intact and highly conserved. In contrast, two main Tm PMM-2 alleles were identified, with Tm PMM-2a possessing an intact coding sequence and Tm PMM-2b being a pseudogene. The transcript level of Tm PMM-2a was much higher than that of Tm PMM-2b, and a bacterially expressed Tm PMM-2a recombinant protein displayed relatively high PMM activity. In general, the total transcript level of PMM was substantially higher in accessions carrying Tm PMM-1 and Tm PMM-2a than those harboring Tm PMM-1 and Tm PMM-2b. However, total PMM protein and activity levels did not differ drastically between the two genotypes. This work provides new information on PMM genes in T. monococcum and expands our understanding on Triticeae PMM genes, which may aid further functional and applied studies of PMM in crop plants. | Chunmei Yu Xinyan Liu Qian Zhang Xinyu He Wan Huai Baohua Wang Yunying Cao Rong Zhou | 2015 | The Crop Journal2015，3，1： | 1 |
| 12 | The molecular basis of effect of llpid lowering drugs on the growth factors after de-endothellulization显示文摘 | ZHOU Yi LIIJ Xinyan SHE Mingpeng | 2001 | CMJ2001，114，： | 1 |
| 13 | Genetic lineage tracing identifies cardiac mesenchymal-to-adipose transition in an arrhythmogenic cardiomyopathy model显示文摘Arrhythmogenic cardiomyopathy(ACM)is one of the most common inherited cardiomyopathies,characterized by progressive fibrofatty replacement in the myocardium.However,the cellular origin of cardiac adipocytes in ACM remains largely unknown.Unraveling the cellular source of cardiac adipocytes in ACM would elucidate the underlying pathological process and provide a potential target for therapy.Herein,we generated an ACM mouse model by inactivating desmosomal gene desmoplakin in cardiomyocytes;and examined the adipogenic fates of several cell types in the disease model.The results showed that SOX9^(+),PDGFRa^(+),and PDGFRb^(+)mesenchymal cells,but not cardiomyocytes or smooth muscle cells,contribute to the intramyocardial adipocytes in the ACM model.Mechanistically,Bmp4 was highly expressed in the ACM mouse heart and functionally promoted cardiac mesenchymal-to-adipose transition in vitro. | Xinyan Huang Lei Yan Jufeng Meng Nanbo Liu Shuoji Zhu Zhen Jiang Shan Kou Teng Feng Chao-Po Lin Bin Zhou Juan Tang Ping Zhu Hui Zhang | 2023 | Science China(Life Sciences)2023，66，1： | 1 |
| 14 | Whole-brain patterns of the presynaptic inputs and axonal projections of BDNF neurons in the paraventricular nucleus显示文摘Brain-derived neurotrophic factor (BDNF) plays a crucial role in human obesity. Yet, the neural circuitry supporting the BDNF-mediated control of energy homeostasis remains largely undefined. To map key regions that might provide inputs to or receive inputs from the paraventricular nucleus (PVN) BDNF neurons, a key type of cells in regulating feeding and thermogenesis, we used rabies virus-based transsynaptic labeling and adeno-associated virus based anterograde tracing techniques to reveal their whole-brain distributions. We found that dozens of brain regions provide dense inputs to or receive dense inputs from PVN BDNF neurons, including several known weight control regions and several novel regions that might be functionally important for the BDNF-mediated regulation of energy homeostasis.Interestingly, several regions show very dense reciprocal connections with PVN BDNF neurons, including the lateral septum, the preoptic area, the ventromedial hypothalamic nucleus, the paraventricular thalamic nucleus, the zona incerta, the lateral parabrachial nucleus, the subiculum, the raphe magnus nucleus, and the raphe pallidus nucleus. These strong anatomical connections might be indicative of important functional connections. Therefore, we provide an outline of potential neural circuitry mediated by PVN BDNF neurons, which might be helpful to resolve the complex obesity network. | Fang Luo Yuling Mu Cuicui Gao Yan Xiao Qian Zhou Yiqing Yang Xinyan Ni Wei L.Shen Jiajun Yang | 2019 | Journal of Genetics and Genomics2019，46，1： | 1 |
| 15 | The epidemic status and genetic diversity of 14 highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) isolates from China in 2009显示文摘 | Zhi Zhou Jianqiang Ni Zhen Cao Xue Han Yingju Xia Zhanchao Zi Kun Ning Qi Liu Lin Cai Peng Qiu Xiaoyu Deng Dongmei Hu Qian Zhang Yunfeng Fan Jiajun Wu Lilin Wang Miaojie Zhang Xiuling Yu Xinyan Zhai Kegong Tian | 2011 | Veterinary Microbiology2011，，3： | 1 |
| 16 | Holocene loess and its deposition dynamics in the upper reaches of the Huaihe River显示文摘灰尘来源和搬运系统是在 loess-palaeosol 累积的进程的二个不可缺少的方面。黄土高原的灰尘主要来自西北的内陆 gobi 和沙漠,这被证明了,由东亚季风系统和 westerlies 搬运了。然而,几乎关于灰尘来源和 Huaihe 河的上面的活动范围的免职动力学没有小研究。在现在的学习,我们在 Huaihe 河的上面的活动范围与高分辨率调查了并且收集 YPC 节。按年代先后的框架被标明日期的光学地刺激的光(OSL ) 重建并且与出版黄土时间系列相关。由磁性的危险性( MS )和在 YPC 侧面, XJN 侧面(西方的黄土高原)和 JYC 侧面(南部的黄土高原)之中的黄土土壤侧面的谷物尺寸( GS )的比较,我们发现在 Huaihe 河和黄土高原的上面的活动范围之间的类似的气候变化和 pedogenic 过程,两个都在最后期间经历了干燥的极端和最弱的成土作用冰川,列在后面由一过渡事件从寒冷干燥对温暖潮湿的 mid-Holocene 和增加上次冰川但是在 Huaihe 河的上面的活动范围的黄土土壤侧面序列的 MS 是比在黄土高原的那些低得多的,并且 GS 是比在黄土高原的那些粗糙得多的。为这三侧面的 GS 的比较表明有不同灰尘来源,它属于不同风神的搬运系统。在 Huaihe 河的上面的活动范围的黄土是吹的风近的来源的免职,当更粗糙的灰尘主要来自松开的冲积存款时冲积并且黄河的 proluvial 扇子。Huaihe 河里的灰尘的让步并且带的动力学是东北风在冬季占优势半年。 | HE Zhong HUANG Chunchang ZHENG Hongbo ZHOU Jie PANG Jiangli LI Xinyan WANG Lijun | 2011 | Journal of Geographical Sciences2011，21，3： | 1 |
| 17 | AstragalosideⅣplays a role in reducing radiation-induced liver inflammation in mice by inhibiting thioredoxin-interacting protein/nod-like receptor protein 3 signaling pathway显示文摘OBJECTIVE:To investigate the efficacy of Astragaloside IV(AS-IV)on radiation-induced liver inflammation in mice.METHODS:The mice were divided into normal group,dimethyl sulfoxide solvent group,irradiation group(IR),irradiation+AS-IV(20 mg/kg)group(IR+AS-20)and irradiation+AS-IV(40 mg/kg)group(IR+AS-40).One month after intraperitoneal injection of AS-IV,the mice were irradiated with 8Gry Co60γ,the blood was collected for biochemical analysis,and the liver was collected for hematoxylin-eosin staining,immunofluorescence and electron microscopic observation,oxidative stress,and Western blot analysis.RESULTS:The AS-IV treatment significantly ameliorated the pathological morphology of liver and reduced the alanine aminotransferase and aspertate aminotransferase levels in serum induced by radiation;AS-IV treatment also significantly reduced the expression of inflammatory factors tumor necrosis factor alpha and interleukin 6 and antagonized malonaldehyde content and superoxide dismutase activity in liver caused by radiation;in addition,AS-IV treatment can significantly inhibited the positive expression of thioredoxin-interacting protein(TXNIP)and nod-like receptor protein 3(NLRP3)inflammasome in liver tissue after radiation;The expression of TXNIP,NLRP3 inflammasome,apoptosisassociated speck-like protein containing a CARD,cysteinyl aspartate-specific proteinase 1 and interleukin 1beta in the AS-IV prevention group decreased significantly compared to the radiation group.CONCLUSIONS:These findings suggested that Co60γradiation can cause structural and functional damage to the liver,which may be related to the NLRP3 mediated inflammatory pathway;AS-IV may play a protective role by inhibiting the TXNIP/NLRP3 inflammasome signaling pathway in the radiation-induced liver injury model. | DING Yanping DONG Xiaoqing MA Yifan CHEN Lili ZHOU Jie LI Xinyan SHAO Baoping | 2023 | Journal of Traditional Chinese Medicine2023，43，1： | 1 |
| 18 | A comparative study of VMI replenishment policies-Toward rule-based decision making based on Monte Carlo simulations 显示文摘 | Liu Lanjuan Zhou Xinyan | 2009 | International Journal of Services Operations and Informatics2009，4，1： | 1 |
| 19 | Licochalcone A inhibiting proliferation of bladder cancer T24 cells by inducing reactive oxygen species production显示文摘 | Feng Liu Ali Goodarzi Haifeng Wang Joanna Stasiak Jianbo Sun Yu Zhou Jiangtao Jiang Xuan Yuan Hong Zhao Xinyan Yan Xiling Sun Qiusheng Zheng | 2014 | Bio-Medical Materials and Engineering2014，，1： | 1 |
| 20 | Individually-atomic governing d-π*orbital interactions via Cupromoted optimization of Fe-d band centers for high-efficiency zinc-air battery显示文摘It is challenging for precise governing of electronic configuration of the individually-atomic catalysts toward optimal electrocatalysis,as d-band configuration of a metal center determines the adsorption behavior of reactive species to the center in oxygen reduction reaction(ORR).The addition of Cu atom modifies the d-band center position of Fe central atom,thus strengthening the d-π*orbital interactions.Herein,FeCu-NC catalyst in the nitrogen-doped carbon(NC)support containing individual dual-metal CuN4/FeN4 sites was prepared by the surface confinement strategy of zeolitic imidazolate framework(ZIF),treated as a model catalyst.Experimentally and theoretically co-verified dual-metal CuN4/FeN4 sites highly dispersed in the NC support,enable transferring more electrons from FeN4 sites to*OH intermediates,thereby accelerating the desorption process of*OH species.Superior to those commercial Pt/C,Our FeCu-NC catalyst exhibited extraordinary ORR activity(with a E1/2 as high as 0.87 V)and cycling stability in 0.1 M KOH electrolyte,and thereof demonstrated excellent discharge performance in zinc-air batteries.Our construction of dual-atom catalysts(DACs)provides a strategy for atom-by-atom designing high-efficiency catalysts via orbital regulation. | Xinyan Zhou Kexin Song Yu Feng Chao Jiang Zhongjun Chen Zizhun Wang Nailin Yue Xin Ge Wei Zhang Weitao Zheng | 2023 | Nano Research2023，16，4： | 0 |
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