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| 1 | A Convolution-Based System for Malicious URLs Detection显示文摘Since the web service is essential in daily lives,cyber security becomes more and more important in this digital world.Malicious Uniform Resource Locator(URL)is a common and serious threat to cybersecurity.It hosts unsolicited content and lure unsuspecting users to become victim of scams,such as theft of private information,monetary loss,and malware installation.Thus,it is imperative to detect such threats.However,traditional approaches for malicious URLs detection that based on the blacklists are easy to be bypassed and lack the ability to detect newly generated malicious URLs.In this paper,we propose a novel malicious URL detection method based on deep learning model to protect against web attacks.Specifically,we firstly use auto-encoder to represent URLs.Then,the represented URLs will be input into a proposed composite neural network for detection.In order to evaluate the proposed system,we made extensive experiments on HTTP CSIC2010 dataset and a dataset we collected,and the experimental results show the effectiveness of the proposed approach. | Chaochao Luo Shen Su Yanbin Sun Qingji Tan Meng Han Zhihong Tian | 2020 | Computers, Materials & Continua2020，，1： | 1 |
| 2 | AAZ2 induces mitochondrial-dependent apoptosis by targeting PDK1 in gastric cancer显示文摘Drastic surges in intracellular reactive oxygen species(ROS)induce cell apoptosis,while most chemotherapy drugs lead to the accumulation of ROS.Here,we constructed an organic compound,arsenical N-(4-(1,3,2-dithiarsinan-2-yl)phenyl)acrylamide(AAZ2),which could prompt the ROS to trigger mitochondrial-dependent apoptosis in gastric cancer(GC).Mechanistically,by targeting pyruvate dehydrogenase kinase 1(PDK1),AAZ2 caused metabolism alteration and the imbalance of redox homeostasis,followed by the inhibition of phosphoinositide-3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)pathway and leading to the activation of B-cell lymphoma 2(Bcl2)/Bcl2-associated X(Bax)/caspase-9(Cas9)/Cas3 cascades.Importantly,our in vivo data demonstrated that AAZ2 could inhibit the growth of GC xenograft.Overall,our data suggested that AAZ2 could contribute to metabolic abnormalities,leading to mitochondrial-dependent apoptosis by targeting PDK1 in GC. | Yi LI Wenyan SHE Xiaoran XU Yixin LIU Xinyu WANG Sheng TIAN Shiyi LI Miao WANG Chaochao YU Pan LIU Tianhe HUANG Yongchang WEI | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，3： | 0 |
| 3 | Lignin-based electrospun nanofiber membrane decorated with photo-Fenton Ag@MIF-100(Fe) heterojunctions for complex wastewater remediation显示文摘Membrane technology for wastewater remediation has aroused wide interest owing to its unique properties and potential applications.However,it remains challenging to explore green,efficient and robust membrane material and technique for complex wastewater treatment.Herein,we proposed using a simple electrospinning and in situ seeding method to fabricate a lignin-based electrospun nanofiber membrane(LENM)decorated with photo-Fenton Ag@MIL-100(Fe)heterojunctions for efficient separation of oil/water emulsions and degradation of organic dye.Thanks to the embedded lignin in LENM,an ultrahigh MIL-100(Fe)loading(53 wt%)with good wettability and high porosity was obtained.As a result,the hybrid Ag@MIL-100(Fe)/LENM exhibited excellent oil/water emulsions separation efficiency(more than 97%)without a compromise of water flux.Moreover,the hybrid membrane showed an excellent dye removal with degradation of 99%methylene blue within 30 min under illumination,which is attributed to a synergy of dye adsorption/enrichment and photo-Fenton catalytic degradation from Ag@MIL-100(Fe).Therefore,the lignin-based photo-Fenton hybrid membrane can lay the foundation for the preparation and application of green,sustainable and versatile membrane materials and technologies for efficient complex wastewater remediation. | Guodong Tian Chao Duan Bingxu Zhou Chaochao Tian Qiang Wang Jiachuan Chen | 2023 | Frontiers of Chemical Science and Engineering2023，17，7： | 0 |
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