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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Dusty cloud radiative forcing derived from satellite data for middle latitude regions of East Asia显示文摘尘封的云在东亚的中间的纬度区域上的放射的强迫被使用估计 2 年(7 月 2002-June 日 2004 ) 并置的云和地球的绚烂的精力系统(谷神星) 的数据从水编辑 1B SSF (单个扫描仪脚印) 的扫描仪和中等分辨率成像分光辐射函数(MODIS ) 。尘封的云在灰尘暴风雨环境被定义为云或灰尘污染了云。为面对灰尘成长的云,在空气(TOA ) 的顶强迫的即时短波(SW ) 关于 -275.7 W/m 2 为阴郁灰尘(货到付款) 区域。在没有灰尘开发云(CLD ) 区域的云产出最否定的短波(SW ) forcint (是大约 12.8% 的 -311.0 W/m 2), 比那些强壮在货到付款区域。为长波浪(LW ) 放射的强迫,没有灰尘云(CLD ) 在是 20% 的 102.8 W/m 2, 附近不到从货到付款区域强迫的 LW。为 CLD 区域的放射的强迫关于是 42.1% 的 -208.2W/m2, 的即时 TOA 网比货到付款区域的价值大。在云下面的灰尘喷雾器的存在显著地减少云的冷却效果。 | HUANG Jianping WANG Yujie WANG Tianhe YI Yuhong | 2006 | Progress in Natural Science:Materials International2006，16，10： | 20 |
| 3 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 4 | An Overview of Mineral Dust Modeling over East Asia显示文摘East Asian dust(EAD) exerts considerable impacts on the energy balance and climate/climate change of the earth system through its influence on solar and terrestrial radiation, cloud properties, and precipitation efficiency. Providing an accurate description of the life cycle and climate effects of EAD is therefore critical to better understanding of climate change and socioeconomic development in East Asia and even worldwide. Dust modeling has undergone substantial development since the late 1990 s, associated with improved understanding of the role of EAD in the earth system. Here, we review the achievements and progress made in recent decades in terms of dust modeling research,including dust emissions, long-range transport, radiative forcing(RF), and climate effects of dust particles over East Asia. Numerous efforts in dust/EAD modeling have been directed towards furnishing more sophisticated physical and chemical processes into the models on higher spatial resolutions. Meanwhile, more systematic observations and more advanced retrieval methods for instruments that address EAD related science issues have made it possible to evaluate model results and quantify the role of EAD in the earth system, and to further reduce the uncertainties in EAD simulations. Though much progress has been made, large discrepancies and knowledge gaps still exist among EAD simulations. The deficiencies and limitations that pertain to the performance of the EAD simulations referred to in the present study are also discussed. | Siyu CHEN Jianping HUANG Yun QIAN Chun ZHAO Litai KANG Ben YANG Yong WANG Yuzhi LIU Tiangang YUAN Tianhe WANG Xiaojun MA Guolong ZHANG | 2017 | Journal of Meteorological Research2017，31，4： | 7 |
| 5 | Secure Two-Party Distance Computation Protocol Based on Privacy Homomorphism and Scalar Product in Wireless Sensor Networks显示文摘Numerous privacy-preserving issues have emerged along with the fast development of the Internet of Things. In addressing privacy protection problems in Wireless Sensor Networks(WSN), secure multi-party computation is considered vital, where obtaining the Euclidian distance between two nodes with no disclosure of either side's secrets has become the focus of location-privacy-related applications. This paper proposes a novel Privacy-Preserving Scalar Product Protocol(PPSPP) for wireless sensor networks. Based on PPSPP, we then propose a Homomorphic-Encryption-based Euclidean Distance Protocol(HEEDP) without third parties. This protocol can achieve secure distance computation between two sensor nodes. Correctness proofs of PPSPP and HEEDP are provided, followed by security validation and analysis. Performance evaluations via comparisons among similar protocols demonstrate that HEEDP is superior; it is most efficient in terms of both communication and computation on a wide range of data types, especially in wireless sensor networks. | Haiping Huang Tianhe Gong Ping Chen Reza Malekian Tao Chen | 2016 | Tsinghua Science and Technology2016，21，4： | 5 |
| 6 | Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants显示文摘Dear Editor,The spread of the SARS-CoV-2 variants,especially the global variants of concern(VOCs),could seriously dampen our efforts to tackle the COVID-19 pandemic.The SARS-CoV-2 spike protein recognizes the host angiotensin-converting enzyme 2(ACE2)via its receptor-binding domain(RBD)to mediate viral entry into the cells.Several notorious mutations have been identified in the spike RBD of the VOCs.For example,B.1.1.7(Alpha),B.1.351(Beta),and P.1(Gamma)all contain the N501Y mutation,which increases the binding affinity for human ACE2 and confers higher infectivity in mice. | Shuo Du Pulan Liu Zhiying Zhang Tianhe Xiao Ayijiang Yasimayi Weijin Huang Youchun Wang Yunlong Cao Xiaoliang Sunney Xie Junyu Xiao | 2021 | Cell Research2021，31，10： | 3 |
| 7 | Rattan Cultivation for Edible Shoot Production in Guangzhou,Southern China显示文摘Field studies were conducted in the Jiuwantan Forest Farm,Huadu District of Guangzhou City from June 2004 to March 2006 to evaluate the effects of planting spacings(0.5 m × 0.5 m,0.5 m × 1.0 m and 1.0 m × 1.0 m) and different fertilizers(bio-fermented manure,NPK compound fertilizer and NPK mixed fertilizer) on the growth of Daemonorops margaritae grown under irrigation and full-light conditions for edible shoots production.The effects of application of different fertilizers on the mean height,length of stems and number of leaves of 30-month old seedlings were not statistically significant,but the planting spacings were(P < 0.05).The two trial plantations became harvestable 18 months after planting when about one-third of seedlings produced new shoots.Results obtained from a sample harvest 20 months after planting showed that the average number of new shoots(suckers) per plant was 1.8,the average lengths of stems and edible shoots(palm hearts) were 45.3 cm and 18.8 cm,respectively.The average fresh weights of defoliated stems and edible shoots were 182.2 g and 14.9 g,respectively.These results suggest that the productivity in the first harvest is rather low. | HUANG Shi’neng1 JIANG Zehui2 ZHAO Xia1 XIAN Guangyong1 1.Research Institute of Tropical Forestry,Chinese Academy of Forestry,No.682 Guangshan Yilu,Tianhe District,Guangzhou 510520,P.R.China 2.International Centre for Bamboo and Rattan(ICBR),No.8 Futong Dongdajie,Wangjing,Chaoyang District,Beijing 100102,P.R.China | 2010 | Chinese Forestry Science and Technology2010，9，3： | 2 |
| 8 | Investigation of molecular aggregation mechanism of glipizide/cyclodextrin complexation by combined experimental and molecular modeling approaches显示文摘Cyclodextrin complexation is a wise strategy to enhance aqueous solubility of waterinsoluble drugs.However,the aggregation mechanism of drug-cyclodextrin complexes is still unclear.This research aimed to investigate the molecular aggregation mechanism of glipizide/cyclodextrin complexation by the combination of experimental and modeling methods.Binding free energies between glipizide and cyclodextrins from modeling calculations were higher than those by the phase solubility diagram method.Both experimental and modeling results showed that methylated-β-cyclodextrin exhibited the best solubilizing capability to glipizide.Size-measurement results confirmed the aggregation between glipizide and all four cyclodextrins in high concentrations.Glipizide/γ-cyclodextrin and glipizide/β-cyclodextrin complexes showed stronger aggregation trend than HP-β-cyclodextrin and methylated-β-cyclodextrin.The substituted groups in the rim of HP-β-cyclodextrin and methylated-β-cyclodextrin lead to weak aggregation.This research provided us a clear molecular mechanism of glipizide/cyclodextrin complexation and aggregation.This research will also benefit the formulation development of cyclodextrin solubilization. | Tianhe Huang Qianqian Zhao Yan Su Defang Ouyang | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，6： | 2 |
| 9 | Comparison of CERES surface radiation fluxes with surface observations over Loess Plateau显示文摘 | Hongru Yan Jianping Huang Patrick Minnis Tianhe Wang Jianrong Bi | 2011 | Remote Sensing of Environment2011，，6： | 1 |
| 10 | AAZ2 induces mitochondrial-dependent apoptosis by targeting PDK1 in gastric cancer显示文摘Drastic surges in intracellular reactive oxygen species(ROS)induce cell apoptosis,while most chemotherapy drugs lead to the accumulation of ROS.Here,we constructed an organic compound,arsenical N-(4-(1,3,2-dithiarsinan-2-yl)phenyl)acrylamide(AAZ2),which could prompt the ROS to trigger mitochondrial-dependent apoptosis in gastric cancer(GC).Mechanistically,by targeting pyruvate dehydrogenase kinase 1(PDK1),AAZ2 caused metabolism alteration and the imbalance of redox homeostasis,followed by the inhibition of phosphoinositide-3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)pathway and leading to the activation of B-cell lymphoma 2(Bcl2)/Bcl2-associated X(Bax)/caspase-9(Cas9)/Cas3 cascades.Importantly,our in vivo data demonstrated that AAZ2 could inhibit the growth of GC xenograft.Overall,our data suggested that AAZ2 could contribute to metabolic abnormalities,leading to mitochondrial-dependent apoptosis by targeting PDK1 in GC. | Yi LI Wenyan SHE Xiaoran XU Yixin LIU Xinyu WANG Sheng TIAN Shiyi LI Miao WANG Chaochao YU Pan LIU Tianhe HUANG Yongchang WEI | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，3： | 0 |
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