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| 1 | A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30显示文摘Mitochondrial 熔化是为正常 mitochondrial 功能和 mitochondrial DNA 继承混合并且统一 mitochondrial 分隔空间的一个高度协调的过程。Dysregulated mitochondrial 熔化原因 mitochondrial 破碎,反常 mitochondrial 生理学和继承,并且有原因地与很多 neuronal 疾病被连接了。这里,我们识别了 potently 导致了 mitochondrial 熔化在在 Mfn1 或 Mfn2 是缺乏的房间恢复 mitochondrial 网络和氧化呼吸的 diterpenoid 衍生物 15-oxospiramilactone (S3 ) 。线粒体局部性的 deubiquitinase USP30 是 S3 的一个目标。由 S3 的 USP30 的抑制导致 Mfn1/2 的 non-degradative ubiquitination 的增加,它提高 Mfn1 和 Mfn2 活动并且支持 mitochondrial 熔化。通过 USP30 的一个禁止者的使用,因此,我们的学习揭开在支持 mitochondrial 的 Mfns 的 non-degradative ubiquitination 的异乎寻常的功能熔化。 | Wen Yue Ziheng Chen HaiYang Li Chen Yan Ming Chen Du Feng Chaojun Yan Hao Wu Lei Du Yueying Wang Jinhua Liu Xiaohu Huang Laixin Xia Lei Liu Xiaohui Wang Haijing Jin Jun Wang Zhiyin Song Xiaojiang Hao Quan Chen | 2014 | Cell Research2014，24，4： | 18 |
| 2 | A Superaerophobic Bimetallic Selenides Heterostructure for Efficient Industrial-Level Oxygen Evolution at Ultra-High Current Densities显示文摘Cost-effective and stable electrocatalysts with ultra-high current densities for electrochemical oxygen evolution reaction(OER)are critical to the energy crisis and environmental pollution.Herein,we report a superaerophobic three dimensional(3D)heterostructured nanowrinkles of bimetallic selenides consisting of crystalline NiSe2 and NiFe2Se4 grown on NiFe alloy(NiSe2/NiFe2Se4@NiFe)prepared by a thermal selenization procedure.In this unique 3D heterostructure,numerous nanowrinkles of NiSe2/NiFe2Se4 hybrid with a thickness of ~100 nm are grown on NiFe alloy in a uniform manner.Profiting by the large active surface area and high electronic conductivity,the superaerophobic NiSe2/NiFe2Se4@NiFe heterostructure exhibits excellent electrocatalytic activity and durability towards OER in alkaline media,outputting the low potentials of 1.53 and 1.54 V to achieve ultra-high current densities of 500 and 1000 mA cm^−2,respectively,which is among the most active Ni/Fe-based selenides,and even superior to the benchmark Ir/C catalyst.The in-situ derived FeOOH and NiOOH species from NiSe2/NiFe2Se4@NiFe are deemed to be efficient active sites for OER. | Jiaxin Yuan Xiaodi Cheng Hanqing Wang Chaojun Lei Sameer Pardiwala Bin Yang Zhongjian Li Qinghua Zhang Lecheng Lei Shaobin Wang Yang Hou | 2020 | Nano-Micro Letters2020，12，8： | 4 |
| 3 | Analysis of genetic alterations identifies the frequent mutation of GNAS in colorectal laterally spreading tumors显示文摘Dear Editor,Colorectal cancer(CRC)is among the most commonly diagnosed cancer and the leading cause of cancer-related death worldwide[1].Most CRCs develop from adenomas.Laterally spreading tumors(LSTs)are non-polypoid superficial colorectal neoplasms(CRNs)that are larger than 1 cm and typically extend laterally along the luminal wall.Based on surface morphology,it can be classified into a granular or nongranular type.The pathological morphology of LST manifests only as adenoma or with cancer.Recent studies have characterized 45-79%of LSTs as high-grade intraepithelial neoplasia(HGIN)or submucosal invasion;and the risk of submucosal invasion increases with lesion size[2].Hence,LST is considered a precancerous CRC lesion.Patients with LSTs are usually asymptomatic and diagnosis typically occurs during physical examinations or screening colonoscopy. | Lei Pan Junsheng Chen Chaojun Zhu Lu Han Aimin Li Side Liu | 2020 | Cancer Communications2020，40，11： | 3 |
| 4 | Scientific challenges of research on natural hazards and disaster risk显示文摘As a discipline,the science of natural hazards and disaster risk aims to explain the spatial-temporal pattern,process and mechanism,emergency response and risk mitigation of natural hazards,which requires a multidisci-plinary and interdisciplinary approach.With the support of Natural Science Finance of China(NSFC)and Chinese Academy of Sciences(CAS),in-depth research and systematic analysis on natural hazards and disaster risk were conducted.In this paper,the state of the art in research on natural hazards is summarized from seven aspects:formation process,mechanism and dynamic of natural hazards,disaster risk assessment,forecast,monitoring and early warning,disaster mitigation,emergency treatment and rescue,risk management and post-disaster re-construction.The trends within the natural hazards and disaster risk as a discipline were identified,along with existing shortcomings and significant gaps that need to be addressed.This paper highlighted:1)the scientific challenges including the frontier scientific issues and technological gaps on natural hazards and disaster risk dis-cipline from 2025 to 2035 in China,and 2)the proposal to develop a systemic and holistic natural hazards and disaster risk discipline. | Peng Cui Jianbing Peng Peijun Shi Huiming Tang Chaojun Ouyang Qiang Zou Lianyou Liu Changdong Li Yu Lei | 2021 | Geography and Sustainability2021，2，3： | 3 |
| 5 | Bimetallic Oxyhydroxide as a High-Performance Water Oxidation Electrocatalyst under Industry-Relevant Conditions显示文摘Developing high-performing oxygen evolution reaction(OER)electrocatalysts under high-current operation conditions is critical for future commercial applications of alkaline water electrolysis for clean energy generation.Herein,we prepared a three-dimensional(3D)bimetallic oxyhydroxide hybrid grown on a Ni foam(NiFeOOH/NF)prepared by immersing Ni foam(NF)into Fe(NO_(3))_(3) solution.In this unique 3D structure,the NiFeOOH/NF hybrid was composed of crystalline Ni(OH)_(2) and amorphous FeOOH evenly grown on the NF surface.As a bimetallic oxyhydroxide electrocatalyst,the NiFeOOH/NF hybrid exhibited excellent catalytic activity,surpassing not only the other reported Ni–Fe based electrocatalysts,but also the commercial Ir/C catalyst.In situ electrochemical Raman spectroscopy demonstrated the active FeOOH and NiOOH phases involved in the OER process.Profiting from the synergy of Fe and Ni catalytic sites,the NiFeOOH/NF hybrid delivered an outstanding OER performance under challenging industrial conditions in a 10.0 mol·L^(-1) KOH electrolyte at 80℃,requiring potentials as small as 1.47 and 1.51 V to achieve the super-high catalytic current densities of 100 and 500mA∙cm^(-2),respectively. | Jiaxin Yuan Xiaodi Cheng Chaojun Lei Bin Yang Zhongjian Li Kun Luo K.H.Koko Lam Lecheng Lei Yang Hou Kostya Ken Ostrikov | 2021 | Engineering2021，7，9： | 1 |
| 6 | Co_(1-x)S embedded in porous carbon derived from metal organic framework as a highly efficient electrocatalyst for oxygen evolution reaction显示文摘Developing active, robust, and cost-efficient electrocatalysts is critical for oxygen evolution reaction(OER). Here, a novel composite catalyst of Co_(1-x)S embedded in porous dodecahedron carbon hybrid was synthesized by a two-step conversion protocol of a cobalt-based metal-organic framework(ZIF-67). The porous dodecahedron Co_(1-x)S@C composite catalyst was prepared by direct oxidation of ZIF-67 followed by sulfurization reaction. The Co_(1-x)S@C composite exhibit superior OER performance, including a low overpotential of 260 mV for 10 mA/cm2, a small Tafel slope of ~85 mV/dec, outstanding stability over 80 h and almost 100% Faradaic efficiency. The various material characterizations indicate that the excellent activity and strong stability of Co_(1-x)S@C might be attributed to good conductivity of Co_(1-x)S, mesoporous nanostructure, and synergistic effect of Co_(1-x)S encapsulated within porous carbon. This work provides a novel strategy for designing and synthesizing advanced composite | Denghong He Xiaolin Wu Wei Liu Chaojun Lei Chunlin Yu Guokui Zheng Junjie Pan Lecheng Lei Xingwang Zhang | 2019 | Chinese Chemical Letters2019，30，1： | 1 |
| 7 | CuS/RGO hybrid by one-pot hydrothermal method for efficient electrochemical sensing of hydrogen peroxide显示文摘In this study,a non-enzymatic hydrogen peroxide sensor was successfully fabricated on the basis of copper sulfide nanoparticles/reduced graphene oxide(CuS/RGO) electrocatalyst.Using thiourea as reducing agent and sulfur donor,CuS/RGO hybrid was synthesized through a facile one-pot hydrothermal method,where the reduction of GO and deposition of CuS nanoparticles on RGO occur simultaneously.The results confirmed that the CuS/RGO hybrid helps to prevent the aggregation of CuS nanoparticles.Electrochemical investigation showed that the as-prepared hydrogen peroxide sensor exhibited a low detection limit of 0.18μmol/L(S/N = 3),a good reproducibility(relative standard deviation(RSD) of4.21%),a wide linear range(from 3 to 1215 μmol/L) with a sensitivity of 216.9 μA L/mmol/cm^2 under the optimal conditions.Moreover,the as-prepared sensor also showed excellent selectivity and stability for hydrogen peroxide detection.The excellent performance of CuS/RGO hybrid,especially the lower detection limit than certain enzymes and noble metal nanomaterials ever reported,makes it a promising candidate for non-enzymatic H_2O_2 sensors. | Wei Liu Chaojun Lei Hongxiu Zhang Xiaolin Wu Qing Jia Denghong He Bin Yang Zhongjian Li Yang Hou Lecheng Lei Xingwang Zhang | 2017 | Chinese Chemical Letters2017，28，6： | 1 |
| 8 | Novel systemic lupus erythematosus autoantigens identified by human protein microarray technology显示文摘 | Wei Huang Chaojun Hu Haipan Zeng Ping Li Lei Guo Xiaofeng Zeng Guozhen Liu Fengchun Zhang Yongzhe Li Lin Wu | 2012 | Biochemical and Biophysical Research Communications2012，，2： | 1 |
| 9 | Study on the mechanical properties of outwash deposits with random structure method显示文摘Outwash deposit is one of the major threats to the safety and stability of railway transit engineering in the Sichuan–Tibet area.In this paper,different samples of outwash deposits were prepared based on the random structure method,and a series of large-scale direct shear tests were carried out under different normal stresses.The influence of stone content and the spatial distribution of stone blocks on the physical and mechanical properties of outwash deposits were studied.The results show that with the increase of stone content,the shear stress-displacement curve changs from strain softening to strain hardening.The shear zone is larger,and its shape is more tortuous due to the movement and rotation of stone blocks.The internal frictional angle increases linearly while the cohesion diseases with the increase of stone content.The main influence of the spatial distribution of stone blocks on the mechanical properties of outwash deposits is the peak stress.The shear zone is mainly determined by the distribution of the stone blocks near the shear zone. | Chaojun Jia Qiang Zhang Mingfeng Lei Jun Yu Rubin Wang Jingyan Liu | 2021 | Transportation Safety and Environment2021，3，3： | 0 |
| 10 | Coal and gas outburst prediction model based on principal component analysis and improved support vector machine显示文摘In order to predict the coal outburst risk quickly and accurately,a PCA-FA-SVM based coal and gas outburst risk prediction model was designed.Principal component analysis(PCA)was used to pre-process the original data samples,extract the principal components of the samples,use firefly algorithm(FA)to improve the support vector machine model,and compare and analyze the prediction results of PCA-FA-SVM model with BP model,FA-SVM model,FA-BP model and SVM model.Accuracy rate,recall rate,Macro-F1 and model prediction time were used as evaluation indexes.The results show that:Principal component analysis improves the prediction efficiency and accuracy of FA-SVM model.The accuracy rate of PCA-FA-SVM model predicting coal and gas outburst risk is 0.962,recall rate is 0.955,Macro-F1 is 0.957,and model prediction time is 0.312s.Compared with other models,The comprehensive performance of PCA-FA-SVM model is better. | Chaojun Fan Xinfeng Lai Haiou Wen Lei Yang | 2023 | Geohazard Mechanics2023，1，4： | 0 |
| 11 | Practice Research on Standardization of Undergraduate Graduation Design of Tunnel and Underground Engineering显示文摘Graduation project(thesis)is an important practice part in undergraduate education,which forms an organic whole with theoretical teaching link,and it is the continuation,deepening and examination of the theoretical teaching part.This paper focuses on the constitution that the lack of quality standards for undergraduate graduation design,resulting in different depth and breadth standards;the graduation design materials are scattered and lack of standardization,which leads to the lack of systematic reference materials for students,taking the tunnel and underground engineering major as an example,this paper carries out the practice research on the standardization of the graduation design of tunnel and underground engineering through investigation and combining the teaching resources accumulated in the past decades.Through the study of practice,the content of undergraduate graduation design of tunnel and underground engineering is standardized,the breadth and depth of graduation design is defined,and the“Guide for undergraduate graduation design of tunnel and underground engineering”is organized and compiled,which can provide reference for the standardization and guidance of undergraduate graduation design of tunnel and underground engineering. | Mingfeng Lei Weidong Wang Chenghua Shi Chaojun Jia Chenjie Gong | 2022 | Journal of Educational Theory and Management2022，6，1： | 0 |
| 12 | Research and Practice of Online Teaching Methods in Universities in the Context of COVID-19显示文摘In order to effectively prevent the spread of novel coronavirus pneumonia and ensure the orderly development of teaching tasks,colleges and universities have launched online teaching activities.As a new teaching method,how to reasonably carry out teaching design,teaching organization and ensure teaching quality has become a new problem in front of educators.Taking the“Subway”course as an example,this paper summarizes and introduces the online teaching methods and personal experience under the epidemic situation from the aspects of the overall framework design,specific implementation scheme,effect investigation and reflection of the online teaching mode based on MOOC platform,so as to enrich the experience of online teaching activities in colleges and universities during the epidemic period. | Mingfeng Lei Chenghua Shi Weidong Wang Chenjie Gong Chaojun Jia | 2022 | Journal of Educational Theory and Management2022，6，1： | 0 |
| 13 | Reasonable start time of carbon dioxide injection in enhanced coalbed methane recovery involving thermal-hydraulic-mechanical couplings显示文摘Injection of gas (CO_(2)) into coal seams is an effective method to benefit from both CO_(2) geological storage and coalbed methane recovery. Based on the dual pore structure of coal mass, and the Weibull distribution of fracture permeability, a menmal-hydraulic-mechanical (THM) coupling mathematical model is proposed involving the non-isothermal adsorption of binary gases, dynamic gas diffusion between matrix and fractures, multiphase seepage, coal deformation, heat conduction and heat convection. This mathematical model is applied to study the process of CO_(2)-enhanced coalbed methane recovery (CO_(2)-ECBM). Results show that the CH4 content of CO_(2)-ECBM in coal seam decreases significantly when compared with that of regular drainage, and decreases rapidly in the early stage but slowly in the later stage. Coal seam permeability evolution is triggered by changes in gas adsorption/desorption, temperature and effective stress. For regular drainage, the early permeability shows a decreasing trend dominated by the increase of effective stress, while the later permeability shows an increasing trend dominated by the CH4 desorption caused shrinkage of coal matrix. For CO_(2)-ECBM, the permeability in coal seam generally shows a downward trend due to both matrix swelling induced by gas adsorption and thermal expansion, particularly near injection well. There appears an increased and delayed peak production rate of CH4. The CH4 production rate of CO_(2)-ECBM is always higher than that of regular drainage. The CH4 cumulative production and CO_(2) cumulative storage linearly increase with time, and the CH4 cumulative production of CO_(2)-ECBM increased by 39.2% in the duration of 5000 d compared with regular drainage. Reasonable CO_(2) injection starting time can overcome the issue of early CO_(2) breakthrough and ineffective increase of CH4 production. In the studied case, the optimal injection starting time is 2500 d. Compared with the simultaneous CH4 extraction and CO_(2) injection, the CH4 cumulative production of optimal time has increased by 30.1%. The research provides a reference for determining the reasonable CO_(2) injection time under similar conditions. | Chaojun FAN Lei YANG Bin XIAO Lijun ZHOU Haiou WEN Hao SUN | 2023 | Frontiers of Earth Science2023，17，3： | 0 |
| 14 | High performance n^+p-Si/Ti/NiS_xO_y photocathode for photoelectrochemical hydrogen evolution in alkaline solution显示文摘Silicon, as a promising semiconductor for fabricating photocathode toward photoelectrochemical hydrogen evolution reaction(PEC-HER), should be improved in light harvesting ability and catalytic kinetics to obtain high PEC performance. Herein, a novel amorphous Nickel Oxysulfide(NiS_xO_y) film is effectively integrated with a Ti protected n^+p-Si micropyramid photocathode by the electrodeposition method. The fabricated n^+p-Si/Ti/Ni SxOyphotocathode exhibits excellent PEC-HER performance with an onset potential of 0.5 V(at J =-0.1 mA/cm^2), a photocurrent density of-26 mA/cm^2 at 0 V vs. RHE, and long term stability of six hours in alkaline solution(pH ≈ 14). The synergy of unique n^+p-Si micropyramid architectures(omnidirectional broadband light harvesting ability), novel amorphous NiS_xO_y catalyst(high HER electrocatalytic activity and good optical transparency) results in the high performance of n^+pSi/Ti/Ni S_xO_y. This work offers a novel strategy for effectively integrating electrocatalysts with semiconductor to design efficient photoelectrode toward PEC water splitting. | Qing Jia Chunlin Yu Wei Liu Guokui Zheng Chaojun Lei Lecheng Lei Xingwang Zhang | 2019 | Journal of Energy Chemistry2019，28，3： | 0 |
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