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您的检索式：作者名="Chaomei Liao"
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| 1 | Prediction of the anti-inflammatory mechanisms of curcumin by module-based protein interaction network analysis显示文摘Curcumin,the medically active component from Curcuma longa(Turmeric),is widely used to treat inflammatory diseases.Protein interaction network(PIN) analysis was used to predict its mechanisms of molecular action.Targets of curcumin were obtained based on ChE MBL and STITCH databases.Protein–protein interactions(PPIs) were extracted from the String database.The PIN of curcumin was constructed by Cytoscape and the function modules identified by gene ontology(GO) enrichment analysis based on molecular complex detection(MCODE).A PIN of curcumin with 482 nodes and 1688 interactions was constructed,which has scale-free,small world and modular properties.Based on analysis of these function modules,the mechanism of curcumin is proposed.Two modules were found to be intimately associated with inflammation.With function modules analysis,the anti-inflammatory effects of curcumin were related to SMAD,ERG and mediation by the TLR family.TLR9 may be a potential target of curcumin to treat inflammation. | Yanxiong Gan Shichao Zheng Jan P.A.Baak Silei Zhao Yongfeng Zheng Nini Luo Wan Liao Chaomei Fu | 2015 | Acta Pharmaceutica Sinica B2015，5，6： | 5 |
| 2 | Effects of Genetic Variation in the 20th Intron of Sansui Duck ATP2A2 Gene on Eggshell Quality显示文摘In order to explore the influence of the polymorphism in the 20intron region of the Sansui duck ATP2A2 gene on the eggshell quality,this study used Primer Premier 5 software to design and synthesize a pair of primers in the 20 intron region,two-way direct sequencing and sequence alignment to mine SNPs Sites,SPSS 18.0 software was used to analyze the relationship between SNP sites and eggshell quality of Sansui duck.Three SNP sites were found in the 20 intron region of the ATP2A2 gene:g.40874 T>C,g.40920 G>A and g.40990 T=C,all of which were moderately polymorphic,at the site g.40874 T>C and g.40920 G>A both deviated significantly from Hardy-Weinberg equilibrium(P>0.05),position g.40990 T=C accords with Hardy-Weinberg equilibrium(P<0.05),and position g.40874 T>C There is a strong linkage disequilibrium between g.40990 T=C;a total of 4 haplotypes and 9 double types were detected at 3 SNP loci;the results of association analysis showed that g.40874 T>C mutation had a significant effect on eggshell strength and eggshell weight.The eggshell strength of CC genotype was significantly higher than that of TC and TT genotypes(P<0.05),the eggshell weight of CC genotype was significantly higher than that of TC genotype(P<0.05),and 40990 T=C mutation had a significant effect on eggshell strength.The eggshell strength of TC genotype was significantly higher than that of the TT genotype(P<0.05).In summary,the g.40874 T>C and g.40990 T=C found in the 20th intron region of the Sansui duck ATP2A2 gene may be the marker sites that affect the quality of the eggshell. | Junhan Mei Yiyu Zhang Minfang You Chaomei Liao Guanghui Tan Jiezhang Li | 2021 | Journal of Zoological Research2021，3，2： | 0 |
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