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| 1 | Backup roll contour of a SmartCrown tandem cold rolling mill显示文摘SmartCrown was a new system developed by VAI for improving the strip profile and flatness control first applied in 1700 mm tandem cold rolling mills at Wuhan Iron & Steel(Group)Corporation(WISCO).After tracing and testing,the application of the conventional crown backup roll matching the SmartCrown work roll of the production mill led to heavy and nonuniform wear,and the edge spalling of the backup roll often occurred.A 3-dimension finite element model of roll stacks was established,which was used to analyze the above-mentioned problems,and it was found that the main reason was the highly nonuniform contact pressure distribution between the work roll and the backup roll.A new FSR(flexible shape backup roll)was developed and applied in 1700 mm tandem cold rolling mills.A lot of good actual effects of FSR,such as evident improvement in profile and flatness of strips, non-occurring edge spalling,wear uniform,and remarkable decrease in roll consumption were validated by long-term industrial ap- plications. | Guanghui Yang Jianguo Cao Jie Zhang Shenghui Jia Renwei Tan | 2008 | Journal of University of Science and Technology Beijing2008，15，3： | 3 |
| 2 | Exploration and functionalization of M1-macrophage extracellular vesicles for effective accumulation in glioblastoma and strong synergistic therapeutic effects显示文摘Glioblastoma multiforme(GBM)is a highly aggressive brain tumor with an extremely low survival rate.New and effective approaches for treatment are therefore urgently needed.Here,we successfully developed M1-like macrophage-derived extracellular vesicles(M1EVs)that overcome multiple challenges via guidance from two macrophage-related observations in clinical specimens from GBM patients:enrichment of M2 macrophages in GBM;and origination of a majority of infiltrating macrophage from peripheral blood.To maximize the synergistic effect,we further functionalized the membranes of M1EVs with two hydrophobic agents(the chemical excitation source CPPO(C)and the photosensitizer Ce6(C))and loaded the hydrophilic hypoxiaactivated prodrug AQ4N(A)into the inner core of the M1EVs.After intravenous injection,the inherent nature of M1-derived extracellular vesicles CCA-M1EVs allowed for blood-brain barrier penetration,and modulated the immunosuppressive tumor microenvironment via M2-to-M1 polarization,which increased hydrogen peroxide(H_(2)O_(2))levels.Furthermore,the reaction between H_(2)O_(2) and CPPO produced chemical energy,which could be used for Ce6 activation to generate large amounts of reactive oxygen species to achieve chemiexcited photodynamic therapy(CDT).As this reaction consumed oxygen,the aggravation of tumor hypoxia also led to the conversion of non-toxic AQ4N into toxic AQ4 for chemotherapy.Therefore,CCA-M1EVs achieved synergistic immunomodulation,CDT,and hypoxia-activated chemotherapy in GBM to exert a potent therapeutic effect.Finally,we demonstrated the excellent effect of CCA-M1EVs against GBM in cell-derived xenograft and patient-derived xenograft models,underscoring the strong potential of our highly flexible M1EVs system to support multi-modal therapies for difficult-to-treat GBM. | Xiaojun Wang Hui Ding Zongyang Li Yaonan Peng Hui Tan Changlong Wang Guodong Huang Weiping Li Guanghui Ma Wei Wei | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 3 |
| 3 | Polyhexamethylene biguanide chemically modified cotton with desirable hemostatic,inflammation-reducing,intrinsic antibacterial property for infected wound healing显示文摘Medical cotton dressing is cheap and widely used in diversified fields,but in the application of promoting wound healing,the continuous research of multifunctional medical cotton dressing is still of great significance.Here,we developed a fresh type of antibacterial cotton dressing through a succinct strategy based on chemically anchoring polyhexamethylene biguanide(PHMB).Intriguingly,after PHMB modification,the cotton dressing exhibited outstanding antibacterial performance which could maintain>99.99%antibacterial rate after several treatments,including washing 50 times,repeated use 10 times,UV irradiation for 7 days,cationic dyes dying,and conditioned under 90℃water bath for 2 h.In addition,the water contact angle of cotton dressing increased dramatically from 0°to 111°,which could facilitate bacterial adhesion,thus further enhance the antibacterial efficiency,and easily remove the bacterial debris.Apart from that,the developed cotton dressing showed good cytocompatibility,promoted blood clotting and expression of platelets,and promoted the wound healing process in the infection intervened skin wound model.Taken together,this antibacterial cotton dressing with desirable blood clotting,sustained protection against bacterial infection and bacterial removal features shows the potential to be a candidate for infected skin wound healing. | Chuan Guo Jie Zhang Xiaojun Feng Zhenggui Du Yuanzhang Jiang Yidong Shi Guanghui Yang Lin Tan | 2022 | Chinese Chemical Letters2022，33，6： | 2 |
| 4 | Flesh quality of hybrid grouper(Epinephelus fuscoguttatus♀×Epinephelus lanceolatus♂)fed with hydrolyzed porcine mucosasupplemented low fishmeal diet显示文摘Iso-nitrogenous and iso-lipidic diets containing 0%,3%,6%,9%,and 12%hydrolyzed porcine mucosa(namely,HPM0,HPM3,HPM6,HPM9,and HPM12)were prepared to evaluate their effects on the growth performance,muscle nutrition composition,texture property,and gene expression related to muscle growth of hybrid groupers(Epinephelus fuscoguttatus\Epinephelus lanceolatus_).Groupers were fed to apparent satiation at 08:00 and 16:00 every day for a total of 56 days.It was found that the weight gain percentage in the HPM0,HPM3,and HPM6 groups did not differ(P>0.05).The cooking loss and drip loss of the dorsal muscle in the HPM3 group were lower than those in the HPM6 and HPM9 groups(P<0.05).The hardness and chewiness of the dorsal muscle in the HPM3 group were higher than those in the HPM0,HPM9,and HPM12 groups(P<0.05).The gumminess in the HPM3 group was higher than that in the HPM9 and HPM12 groups(P<0.05).The total essential amino acid content of the dorsal muscle in the HPM12 group was higher than that in the HPM0 group(P<0.05).The contents of total n-3 polyunsaturated fatty acid and total n-3 highly unsaturated fatty acid,as well as the ratio of n-3/n-6 polyunsaturated fatty acid in the dorsal muscle was higher in the HPM0 group than in all other groups(P<0.05).The relative expressions of gene myogenic factor 5,myocyte enhancer factor 2c,myocyte enhancer factor 2a,myosin heavy chain,transforming growth factor-beta 1(TGF-b1),and follistatin(FST)were the highest in the dorsal muscle of the HPM3 group.The results indicated that the growth performance of hybrid grouper fed a diet with 6%HPM and 27%fish meal was as good as that of the HPM0 group.When fish ingested a diet containing 3%HPM,the expression of genes TGF-β1 and FST involved in muscle growth were upregulated,and then the muscle quality related to hardness and chewiness were improved.An appropriate amount of HPM could be better used in grouper feed. | Xuanyi Yang Xinyan Zhi Ziling Song Guanghui Wang Xumin Zhao Shuyan Chi Beiping Tan | 2022 | Animal Nutrition2022，，1： | 2 |
| 5 | Backup roll contour of a SmartCrown tandem cold rolling mill 显示文摘 | Yang Guanghui Cao Jianguo Zhang Jie Jia Shenghui Tan Renwei | 2008 | Journal of University of Science and Technology Beijing: Mineral Metallurgy Materials2008，15，3： | 1 |
| 6 | Prediction of buried calcite dissolution in the Ordovician carbonate reservoir of the Tahe Oilfield, NW china: Evidence from formation water显示文摘 | Zhuang Ruan Bingsong Yu Lidong Wang Yinglu Pan Guanghui Tan | 2013 | Chemie der Erde - Geochemistry - Interdisciplinary Journal for Chemical Problems of the Geosciences and Geoecology2013，，4： | 1 |
| 7 | Unusual resolution of N-( 3, 5-dinitrobenzoyl)-α-amino acids on a chiral stationary phase based on( + )-( 18- crown-6)-2,3,11,12-tetrarboxylic acid 显示文摘 | Myung Ho Hyun Guanghui Tan Jin Ying Xue | 2005 | Journal of Chromatography A2005，1097，： | 1 |
| 8 | Extended application of a chiral stationary phase based on ( + ) - (18-crown-6) -2,3,11,12-tetrarboxylic acid to the resolution of N-( substituted benzoyl)-a-amino acid amides 显示文摘 | Guanghui Tan Jin Ying Xuc Myung Ho Hyun | 2006 | Journal of Separation Science2006，29，10： | 1 |
| 9 | Experi- mental study on two-phase flow instability of natural circulation under rolling motion condition显示文摘 | TAN Sichao SU Guanghui GAO Puzhen | 2009 | An- nals of Nuclear Energy2009，36，1： | 1 |
| 10 | Experimental Study on Two-Phase Flow Instability of Natural Circulation under Rolling Motion Condition 显示文摘 | Tan Sichao SU Guanghui Gao Puzhen | 2009 | Annals of Nuclear Energy2009，36，1： | 1 |
| 11 | AdhesiveFailure of Grooved Tool in Milling of 3Cr-lMo-1/ 4V Steel显示文摘 | Tan Guangyu Liu Guangj un Li Guanghui | 2011 | International Journal of Materials Product Technology2011，42，34： | 1 |
| 12 | Experi- mental Study on Adhesive Wear of Milling Insert with Complex Groove显示文摘 | Tan Guangyu Liu Guangjun Li Guanghui | 2009 | International Journal of Advanced Manufacturing Technology2009，44，78： | 1 |
| 13 | Experimental andtheoretical study on single-phase natural circula-tion flow and heat transfer under rolling motioncondition 显示文摘 | TAN Sichao SU Guanghui | 2009 | Applied Thermal Engineering2009，29，1415： | 1 |
| 14 | Experimental and theoretical study on single-phase natural circulation flow 显示文摘 | TAN Sichao SU Guanghui GAO Puzhen | 2009 | Applied Thermal Engineering2009，29，： | 1 |
| 15 | Liquid chromatographic resolution of aryl-amino ketones on stationary phase based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid显示文摘 | Hyun Myung Ho Tan Guanghui Cho goon Jae | 2004 | Journal of Liquid Chromatography & Related Technologies2004，27，11： | 1 |
| 16 | Ex- perimental and theoretical study on single-phase natural circulation flow and heat transfer under rolling motion condition显示文摘 | TAN Sichao SU Guanghui GAO Puzhen | 2009 | Applied Thermal Engineering2009，29，： | 1 |
| 17 | Production and characterization of acidophilic xylanolytic enzymes from Penicillium oxalicum GZ-2显示文摘 | Hanpeng Liao Chunmiao Xu Shiyong Tan Zhong Wei Ning Ling Guanghui Yu Waseem Raza Ruifu Zhang Qirong Shen Yangchun Xu | 2012 | Bioresource Technology2012，，： | 1 |
| 18 | Experimental study on two-phase flow instability of natural circulation under rolling motion condition显示文摘 | TAN Sichao SU Guanghui GAO Puzhen | | 0，，01： | 1 |
| 19 | Some inequalities for the minimum eigenvalue of the Hadamard product of an M-matrix and its inverse显示文摘 | CHENG GUANGHUI TAN Q1N WANG ZHUANDE | 2013 | Journal of Inequalities and Applications2013，65，1： | 1 |
| 20 | Experimental and theoretical study on single-phase natural circulation flow and heat transfer under rolling motion condition显示文摘 | TAN Sichao SU Guanghui GAO Puzhen | | 0，，14： | 1 |
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