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| 1 | Microstructure evolution of AZ91 alloy processed by a combination method of equal channel angular pressing and rolling显示文摘In the present work,AZ91 alloy was successfully processed by equal channel angular pressing(ECAP)for up to 16 passes and rolling(R)for multiple passes with a total reduction of 75%in addition to a combination method with ECAP plus rolling(ECAP+R).The effects of various processes(ECAP,R and ECAP+R)on microstructure evolution were analyzed and the influence of ECAP process on the rolling performance was examined.The result shows that ECAP contributed to a homogenous grain structure and formed a texture with higher Schmidt factors that was easy for rolling.A plate with smoother surface and reduced edge cracks was observed in the ECAP+R process than in the single R process.Although the microstructure of the alloy was similar after ECAP+R and R process,the sample of ECAP+R was more refined and had stronger second phase precipitation than the sample of R,which resulted in better rolling characteristics,along with the external surfaces. | Qiong Xu Aibin Ma Yuhua Li Jiapeng Sun Yuchun Yuan Jinghua Jiang Chaoying Ni | 2020 | Journal of Magnesium and Alloys2020，8，1： | 10 |
| 2 | Preliminary analysis of spatiotemporal pattern of global land surface water显示文摘Land surface water(LSW) is one of the most important resources for human survival and development, and it is also a main component of global water recycling. A full understanding of the spatial distribution of land surface water and a continuous measuring of its dynamics can support to diagnose the global ecosystem and environment. Based on the Global Land 30-water 2000 and Global Land 30-water 2010 products, this research analyzed the spatial distribution pattern and temporal fluctuation of land surface water under scale-levels of global, latitude and longitude, continents, and climate zones. The Global Land 30-water products were corrected the temporal inconsistency of original remotely sensed data using MODIS time-series data, and then calculated the indices such as water area, water ration and coefficient of spatial variation for further analysis. Results show that total water area of land surface is about 3.68 million km2(2010), and occupies 2.73% of land area. The spatial distribution of land surface water is extremely uneven and is gathered mainly in mid- to high-latitude area of the Northern Hemisphere and tropic area. The comparison of water ratio between 2000 and 2010 indicates the overall fluctuation is small but spatially differentiated. The Global Land 30-water products and the statistics provided the fundamental information for analyzing the spatial distribution pattern and temporal fluctuation of land surface water and diagnosing the global ecosystem and environment. | CAO Xin CHEN Jun CHEN LiJun LIAO AnPing SUN FangDi LI Yang LI Lei LIN ZhongHui PANG ZhiGuo CHEN Jin HE ChaoYing PENG Shu | 2014 | Science China Earth Sciences2014，57，10： | 8 |
| 3 | Capecitabine maintenance therapy for XT chemotherapy-sensitive patients with metastatic triple-negative breast cancer显示文摘Objective: To investigate the efficacy and safety of capecitabine maintenance therapy(MT) after initial capecitabine plus docetaxel(XT) chemotherapy in patients with metastatic triple-negative breast cancer(m TNBC).Methods: Fifty-five m TNBC patients treated with XT chemotherapy between May 2007 and June 2013 were retrospectively analyzed. When initial disease control was achieved by the combination chemotherapy, capecitabine was continued for 32 patients(MT), while 23 patients remained without any treatment(nonMT). We compared progression-free survival(PFS) and safety of both groups.Results: The median PFS of 55 patients was 8.1 months, overall median PFS time of 32 patients in the capecitabine MT group and 23 in the non-MT group was 10.1 vs. 6.7 months(P=0.032), respectively. When compared PFS time of maintenance treatment, single-agent capecitabine prolonged PFS by 7.1 months, for non-MT patients, the PFS without any treatment was 3.1 months, and this between-group difference was statistically significant(P=0.003). Adverse events, including of hematologic toxicity, gastrointestinal toxicities, hand-foot syndrome and abnormal liver function were not significantly different between two groups.Conclusions: After initial disease control was achieved with the XT combination chemotherapy, capecitabine MT can significantly prolong PFS time with a favorable safety profile in m TNBC patients. | Xu Liang Lijun Di Guohong Song Ying Yan Chaoying Wang Hanfang Jiang Huiping Li | 2014 | Chinese Journal of Cancer Research2014，26，5： | 8 |
| 4 | Blunted nitric oxide regulation in Tibetans under high-altitude hypoxia显示文摘Nitric oxide(NO) is an important molecule for vasomotor tone, and elevated NO signaling was previously hypothesized as a unique and adaptive physiological change in highland Tibetans. However, there has been lack of NO data from Tibetans living at low altitude and lowlander immigrants living at high altitude, which is crucial to test this hypothesis. Here, through cross-altitude(1990–5018 m) and cross-population(Tibetans and Han Chinese) analyses of serum NO metabolites(NOx) of 2086 individuals, we demonstrate that although Tibetans have a higher serum NOx level compared to lowlanders, Han Chinese immigrants living at high altitude show an even higher level than Tibetans. Consequently, our data contradict the previous proposal of increased NO signaling as the unique adaptive strategy in Tibetans.Instead, Tibetans have a relatively lower circulating NOx level at high altitude. This observation is further supported by data from the hypoxic experiments using human umbilical vein endothelial cells and gene knockout mice. No difference is detected between Tibetans and Han Chinese for endothelial nitric oxide synthase(e NOS), the key enzyme for circulating NO synthesis, suggesting that e NOS itself is unlikely to be the cause. We show that other NO synthesis-related genes(e.g. GCH1) carry Tibetan-enriched mutations significantly associated with the level of circulating NOx in Tibetans. Furthermore, gene network analysis revealed that the downregulation and upregulation of NOx is possibly achieved through distinct pathways.Collectively, our findings provide novel insights into the physiological and genetic mechanisms of the evolutionary adaptation of Tibetans to high-altitude hypoxia. | Yaoxi He Xuebin Qi Ouzhuluobu Shiming Liu Jun Li Hui Zhang Baimakangzhuo Caijuan Bai Wangshan Zheng Yongbo Guo Duojizhuoma Baimayangji Dejiquzong Bianba Gonggalanzi Yongyue Pan Qula Kangmin Cirenyangji Wei Guo Yangla Yi Peng Xiaoming Zhang Kun Xiang Zhaohui Yang Liangbang Wang Gengdeng Yanfeng Zhang Tianyi Wu Bing Su Chaoying Cui | 2018 | National Science Review2018，5，4： | 7 |
| 5 | Research on an Mg–Zn alloy as a degradable biomaterial显示文摘 | Shaoxiang Zhang Xiaonong Zhang Changli Zhao Jianan Li Yang Song Chaoying Xie Hairong Tao Yan Zhang Yaohua He Yao Jiang Yujun Bian | 2009 | Acta Biomaterialia2009，，2： | 5 |
| 6 | De novo assembly of a Tibetan genome and identification of novel structural variants associated with high-altitude adaptation显示文摘Structural variants(SVs) may play important roles in human adaptation to extreme environments such as high altitude but have been under-investigated. Here, combining long-read sequencing with multiple scaffolding techniques, we assembled a high-quality Tibetan genome(ZF1), with a contig N50 length of 24.57 mega-base pairs(Mb) and a scaffold N50 length of 58.80 Mb. The ZF1 assembly filled 80 remaining N-gaps(0.25 Mb in total length) in the reference human genome(GRCh38). Markedly, we detected17 900 SVs, among which the ZF1-specific SVs are enriched in GTPase activity that is required for activation of the hypoxic pathway. Further population analysis uncovered a 163-bp intronic deletion in the MKL1 gene showing large divergence between highland Tibetans and lowland Han Chinese. This deletion is significantly associated with lower systolic pulmonary arterial pressure, one of the key adaptive physiological traits in Tibetans. Moreover, with the use of the high-quality de novo assembly, we observed a much higher rate of genome-wide archaic hominid(Altai Neanderthal and Denisovan) shared non-reference sequences in ZF1(1.32%–1.53%) compared to other East Asian genomes(0.70%–0.98%),reflecting a unique genomic composition of Tibetans. One such archaic hominid shared sequence-a662-bp intronic insertion in the SCUBE2 gene-is enriched and associated with better lung function(the FEV1/FVC ratio) in Tibetans. Collectively, we generated the first high-resolution Tibetan reference genome, and the identified SVs may serve as valuable resources for future evolutionary and medical studies. | Ouzhuluobu Yaoxi He Haiyi Lou Chaoying Cui Lian Deng Yang Gao Wangshan Zheng Yongbo Guo Xiaoji Wang Zhilin Ning Jun Li Bin Li Caijuan Bai Baimakangzhuo Gonggalanzi Dejiquzong Bianba Duojizhuoma Shiming Liu Tianyi Wu Shuhua Xu Xuebin Qi Bing Su | 2020 | National Science Review2020，7，2： | 4 |
| 7 | Adsorption of phenol from aqueous solution by a hierarchical micro-nano porous carbon material显示文摘A hierarchical micro-nano porous carbon material (MNC) was prepared using expanded graphite (EG), sucrose, and phosphoric acid as raw materials, followed by sucrose-phosphoric acid solution impregnation, solidification, carbonization and activation. Nitrogen adsorption and mercury porosimetry show that mixed nanopores and micropores coexist in MNC with a high specific surface area of 1978 m2·g-1 and a total pore volume of 0.99 cm3·g-1. In addition, the MNC is found to consist of EG and activated carbon with the latter deposited on the interior and the exterior surfaces of the EG pores. The thickness of the activated carbon layer is calculated to be about one hundred nanometers and is further confirmed by scanning electron microscope (SEM) and transmission election microscope (TEM). A maximum static phenol adsorption of 241.2 mg·g-1 was obtained by using MNC, slightly higher than that of 220.4 mg·g-1 by using commercial activated carbon (CAC). The phenol adsorption kinetics were investigated and the data fitted well to a pseudo-second-order model. Also, an intra-particle diffusion mechanism was proposed. Furthermore, it is found that the dynamic adsorption capacity of MNC is nearly three times that of CAC. The results suggest that the MNC is a more efficient adsorbent than CAC for the removal of phenol from aqueous solution. | Liu Chengbao Chen Zhigang Ni Chaoying Chen Feng Gu Cheng Cao Yu Wu Zhengying Li Ping | 2012 | Rare Metals2012，31，6： | 4 |
| 8 | La1-xCexMnO3/attapulgite nanocomposites as catalysts for NO reduction with NH3 at low temperature显示文摘 | Xiazhang Li YU Yin Chao Yao Shixiang Zuo Xiaowang Lu Shiping Luo Chaoying Ni | 2016 | Particuology2016，14，3： | 4 |
| 9 | In vitro degradation, hemolysis and MC3T3-E1 cell adhesion of biodegradable Mg–Zn alloy显示文摘 | Shaoxiang Zhang Jianan Li Yang Song Changli Zhao Xiaonong Zhang Chaoying Xie Yan Zhang Hairong Tao Yaohua He Yao Jiang Yujun Bian | 2009 | Materials Science & Engineering C2009，，6： | 2 |
| 10 | Functional evolutionary developmental biology (evo-devo) of morphological novelties in plants显示文摘The origin of morphological and ecological novelties is a long-standing problem in evolutionary biology.Understanding these processes requires investigation from both the development and evolution standpoints,which promotes a new research field called 'evolutionary developmental biology' (evo-devo).The fundamental mechanism for the origin of a novel structure may involve heterotopy,heterochrony,ectopic expression,or loss of an existing regulatory factor.Accordingly,the morphological and ecological traits controlled by the regulatory genes may be gained,lost,or regained during evolution.Floral morphological novelties,for example,include homeotic alterations (related to organ identity),symmetric diversity,and changes in the size and morphology of the floral organs.These gains and losses can potentially arise through modification of the existing regulatory networks.Here,we review current knowledge concerning the origin of novel floral structures,such as 'evolutionary homeotic mutated flowers',floral symmetry in various plant species,and inflated calyx syndrome (ICS) within Solanaceae.Functional evo-devo of the morphological novelties is a central theme of plant evolutionary biology.In addition,the discussion is extended to consider agronomic or domestication-related traits,including the type,size,and morphology of fruits (berries),within Solanaceae. | Jisi ZHANG Ying TIAN Li WANG Chaoying HE | 2010 | Journal of Systematics and Evolution2010，48，2： | 2 |
| 11 | Comparison of Mastoscopic and Conventional Axillary Lymph Node Dissection in Breast Cancer: Long-term Results From a Randomized, Multicenter Trial显示文摘 | Chengyu Luo Wenbin Guo Jie Yang Qiuru Sun Wei Wei Suhua Wu Shubing Fang Qingliang Zeng Zhensheng Zhao Fanjie Meng Xuandong Huang Xianlan Zhang Ruihua Li Xiufeng Ma Chaoying Luo Yun Yang | 2012 | Mayo Clinic Proceedings2012，，12： | 1 |
| 12 | Structure and crystallization behavior of Nylon 66/muhi-walled carbon nanotube nanocomposites at low carbon nanotube contents 显示文摘 | LI Lingyu LI C Y NI Chaoying | 2007 | Polymer2007，48，12： | 1 |
| 13 | Structure and crystallization behavior of Nylon 66/multi-walled carbon nanotube nanocomposites at low carbon nanotube contents显示文摘 | Li Lingyu Li Christopher Ni Chaoying | 2007 | Polymer2007，48，12： | 1 |
| 14 | Structure and crystallization behavior of Nylon 66/multi-walled carbon nanotube nanocomposites at low carbon nanotube contents显示文摘 | Lingyu Li Christopher Y. Li Chaoying Ni Lixia Rong Benjamin Hsiao | 2007 | Polymer2007，，12： | 1 |
| 15 | Prognostic signicance of vascularendothelial growth factor,basicbroblast growth factor,and angiogenin inpatients with resectable hepatocellular carcinoma after surgery显示文摘 | ChaoY Li CP Chau GY | 2003 | Ann SurgOncol2003，10，4： | 1 |
| 16 | Raman characterization of aligned cadon nanotubes produced by thermal decomposition of hedrocarbon vapor显示文摘 | HAO ZHANG CHAOYING WANG | 1997 | Appl Phys Lett1997，70，20： | 1 |
| 17 | Oriented polycrystalline mesoporous CeO 2 with enhanced pore integrity显示文摘 | Chaoying Ni Xiazhang Li Zhigang Chen Hui-Yin Harry Li Xinqiao Jia Ismat Shah John Q. Xiao | 2008 | Microporous and Mesoporous Materials2008，，3： | 1 |
| 18 | Pharmacogenetic assessment of clinical outcome in patients with metastatic breast cancer treated with docetaxel plus capecitabine显示文摘 | Ningning Dong Jing Yu Chaoying Wang Xiaohui Zheng Zheng Wang Lijun Di Guohong Song Budong Zhu Li Che Jun Jia Hanfang Jiang Xinna Zhou Xiaoli Wang Jun Ren | 2012 | Journal of Cancer Research and Clinical Oncology2012，，7： | 1 |
| 19 | One-step fabrication of two-dimensional hierarchical Mn_(2)O_(3)@graphene composite as high-performance anode materials for lithium ion batteries显示文摘Two-dimensional(2 D) hierarchical Mn_(2)O_(3)@graphene composite is synthesized by a one-step solid-phase reaction. The nanosheets of Mn_(2)O_(3) are vertically grown on few-layered graphene, constructing a unique2 D hierarchical structure. As an anode material for lithium-ion batteries(LIBs), this hierarchical composite displays excellent electrochemical performances, showing an extraordinary reversible discharge capacity of 2125.9 mA hg^(–1). Moreover, a record high reversible capacity of 1746.8 mA hg^(–1) is maintained after 100 cycles at a current density of 100 mA g^(–1), which retains 82.2 % of the initial capacity. Such an outstanding performance could be attributed to its novel structure and the synergistic effects between the Mn_(2)O_(3) and graphene. | Zhou Zhou Chaoying Ding Wenchao Peng Yang Li Fengbao Zhang Xiaobin Fan | 2021 | Journal of Materials Science & Technology2021，，21： | 1 |
| 20 | Structure and Crys- tallization Behavior of Nylon 66/Multi-Walled Carbon Nano- tube Nanocomposites at Low Carbon Nanotube Contents 显示文摘 | Li Lingyu Li C Y Ni Chaoying | 2007 | Polymer2007，48，12： | 1 |
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