|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 3 | Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) – NCT01514890<!-- Doctopic: VH -->显示文摘 | Christophe Hézode Hélène Fontaine Céline Dorival Dominique Larrey Fabien Zoulim Valérie Canva Victor de Ledinghen Thierry Poynard Didier Samuel Marc Bourlière Jean-Pierre Zarski Jean-Jacques Raabe Laurent Alric Patrick Marcellin Ghassan Riachi Pierre-Henr | 2013 | Journal of Hepatology2013，，： | 2 |
| 4 | Characterization of Hepatitis C Virus Particle Subpopulations Reveals Multiple Usage of the Scavenger Receptor BI for Entry Steps显示文摘 | Viet Loan Dao Thi Christelle Granier Mirjam B. Zeisel Maryse Guérin Jimmy Mancip Ophélia Granio Fran?ois Penin Dimitri Lavillette Ralf Bartenschlager Thomas F. Baumert Fran?ois-Lo?c Cosset Marlène Dreux | 2012 | Journal of Biological Chemistry2012，，37： | 2 |
| 5 | SSJD15011600007878显示文摘 | María A. Mejía-Benítez Amélie Bonnefond Lo?c Yengo Marlène Huyvaert Aurélie Dechaume Jesús Peralta-Romero Miguel Klünder-Klünder Jaime García Mena Julia S. El-Sayed Moustafa Mario Falchi Miguel Cruz Philippe Froguel | 2015 | Diabetologia2015，，2： | 2 |
| 6 | Erythropoietin enhances recovery after cisplatin-induced acute renal failure in the rat显示文摘 | Corinne Bagnisl Hél(c)ne Beaufils Claude Jacquiaud | 2001 | Nephrol Dial Transplant2001，16，： | 1 |
| 7 | The relationship between health related quality of life and disease activity and damage in systemic lupus erythematosus显示文摘 | Wang C Mayo NE Fortin PR | 2001 | J Rheumatol2001，28，3： | 1 |
| 8 | Myxoid malignant histiocy- toma:experience with chemotherapy显示文摘 | Petel SR Plager C Papadopoulos NE | 1995 | Cancer Clin Trials1995，18，： | 1 |
| 9 | Rennet coagulation of skim milk and curd drainage:Effect of pH,casein concentration,ionic strength and heat treatment显示文摘 | Cé1ina D Marie-Hé1ène F Alice P | | 0，，： | 1 |
| 10 | Mycoplasma genitalium compared to chlamydia, gonorrhoea and trichomonas as an aetiol- ogical agent of urethritis in men attending STD clinics显示文摘 | Gaydos C Maldeis NE Hardick A | 2009 | Sex Transm Infect2009，85，6： | 1 |
| 11 | Analysisof mechanism of protection in transgenic plants expressing the potatovirus X coat protein or its antisense RNA显示文摘 | Hemenway C Fang RX Kaniewski J J Chua NH Tumer NE | 1988 | EMBO J1988，7，： | 1 |
| 12 | Differentiation of U-937promonocytic cells by etoposide and ICRF-1993, two antitumour DNA topoisomerase Ⅱ inhibitors with different mechanisms of action显示文摘 | Perez C Vilaboa NE Garcia BL | 1997 | J Cell Science1997，110，： | 1 |
| 13 | Testicular dysgenesis syndrome:possible role of endocrine disrupters显示文摘 | Bay K Asklund C Skakkebaek NE | 2006 | Best Pract Res Clin Endocrinol Metab2006，20，1： | 1 |
| 14 | Simultaneous spectrophotometric determination of amylose and amylopectin in starch from maize kernel by multi-wavelength analysis显示文摘 | Séne M Thévenot C Prioul J L | | 0，，02： | 1 |
| 15 | Up-rugulation of vascular endothelial growth factor-A by active membranetype matrix metalloproteinase through activation of Src-tyrosine kinase 显示文摘 | Sounni NE Roghi C Chabottaux V | 2004 | Biol Chcm2004，279，13： | 1 |
| 16 | Somatic mutation in the p53 gene and prognosis in beast cancer A meta-analysis显示文摘 | Pharoah PD Day NE Caldas C | 1999 | Br J Cancer1999，80，12： | 1 |
| 17 | Mycoplasma genitali- um as a Contributor to the Multiple Etiologies of Cervicitis in Women Attending Sexually Transmitted Disease Clinics显示文摘 | Gaydos C Maldeis NE Hardick A | 2009 | Sex Transm Dis2009，21，： | 1 |
| 18 | Tricuspid valve replacement: an analysis of 25 years of experience at a single center显示文摘 | Michel Carrier Yves Hébert Michel Pellerin Denis Bouchard Louis P Perrault Raymond Cartier Arsène Basmajian Pierre Pagé Nancy C Poirier | 2003 | The Annals of Thoracic Surgery2003，，1： | 1 |
| 19 | Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone显示文摘 | Sanchez C Deberg MA Bel ahcène A | | 0，，02： | 1 |
| 20 | Clinical and laboratory eval- uation of periodically monitored Turkish children with IgG subclass deficiencies显示文摘 | Karaca NE Karadeniz C Aksu G | 2009 | Asian Pac J Allergy Immuuol2009，27，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员