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| 1 | mi R-122 negatively correlates with liver fibrosis as detected by histology and FibroScan显示文摘AIM: To investigate whether expression of selected mi RNAs obtained from fibrotic liver biopsies correlate with fibrosis stage.METHODS: Altogether, 52 patients were enrolled in the study representing various etiologic backgrounds of fibrosis: 24 cases with chronic hepatitis infections(types B, C), 19 with autoimmune liver diseases(autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, overlapping syndrome cases), and 9 of mixed etiology(alcoholic and nonalcoholic steatosis, cryptogenic cases). Severity of fibrosis was determined by both histologic staging using the METAVIR scoring system and noninvasive transient elastography. Following RNAisolation, expression levels of mi R-21, mi R-122, mi R-214, mi R-221, mi R-222, and mi R-224 were determined using Taq Man Micro RNA Assays applying mi R-140 as the reference. Selection of mi RNAs was based on their characteristic up- or downregulation observed in hepatocellular carcinoma. Relative expression of mi RNAs was correlated with fibrosis stage and liver stiffness(LS) value measured by transient elastography, as well as with serum alanine aminotransferase(ALT) level.RESULTS: The expression of individual mi RNAs showed deregulated patterns in stages F1-F4 as compared with stage F0, but only the reduced level of mi R-122 in stage F4 was statistically significant(P < 0.04). When analyzing mi RNA expression in relation to fibrosis, levels of mi R-122 and mi R-221 showed negative correlations with fibrosis stage, and mi R-122 was found to correlate negatively and mi R-224 positively with LS values(all P < 0.05). ALT levels displayed a positive correlation with mi R-21(P < 0.04). Negative correlations were observed in the fibrosis samples of mixed etiology between mi R-122 and fibrosis stage and LS values(P < 0.05), and in the samples of chronic viral hepatitis, between mi R-221 and fibrosis stage(P < 0.01), whereas mi R-21 showed positive correlation with ALT values in the samples of autoimmune liver diseases(P < 0.03). The results also revealed a strong correlation between fibrosis stage and LS values(P < 0.01) when etiology of fibrosis was not taken into account.CONCLUSION: Reduced expression of mi R-122 in advanced fibrosis and its correlation with fibrosis stage and LS values seem to be characteristic of hepatic fibrosis of various etiologies. | Tünde Halász Gábor Horváth Gabriella Pár Klára Werling András Kiss Zsuzsa Schaff Gábor Lendvai | 2015 | World Journal of Gastroenterology2015，21，25： | 11 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | Newly discovered coronavirus as the primary cause of severe acute respiratory synd rome 显示文摘 | Kuiken T Fouchier RA Schutten M Rimmelzwaan GF van Amerongen G van Riel D | 2003 | Lance t2003，362，： | 1 |
| 4 | Calpeptin-dependent dephosphorylation of brain mitochondrial calcium/cAMP response element binding protein(CREB)显示文摘 | Schuh RA Kristian T Fiskum G | 2005 | J Neurochem2005，92，2： | 1 |
| 5 | Surface ex- pression patterns of negative regulatory molecules identify determinants of virus-specific CD8 T-cell exhaustion in HIV infection 显示文摘 | Yamamoto T Price DA Casazza JP Ferrari G Nason M Chattopadhyay PK Roederer M Gostick E Katsikis PD Douek DC Haubrich R Petrovas C Koup RA | 2011 | Blood2011，117，18： | 1 |
| 6 | Liver stem cells:a potential source of hepatocytes for the treatment of human liver disease显示文摘 | Faris RA Konkin T Halpert G | 2002 | Artif Organs2002，25，： | 1 |
| 7 | Liver stem cells :a potential source of hepatocytes for the treatment of human liver disease 显示文摘 | Faris RA Konkin T Halpert G | 2001 | Artif Organs2001，25，7： | 1 |
| 8 | Arabidopsis ECERIFERUM9 involvement in cuticle formation and maintenance of plant water status显示文摘 | Lue S Zhao H Des Marais DL Parsons EP Wen X Xu X Bangarusamy DK Wang G Rowland O Juenger T Bressan RA Jenks MA | | 0，，： | 1 |
| 9 | Homocysteinylation of low-den-sity lipoproteins(LDL)from subjects with type 1 diabetes:effect onoxidative damage of human endothelial cells显示文摘 | Ferretti G Bacchetti T Rabini RA | 2006 | Diabet Med2006，23，7： | 1 |
| 10 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 11 | Quantitative magnetic resonance imaging in temporal lobe epilepsy: relationship to neuropathology and neuropsychological function显示文摘 | Lencz T McCarthy G Bronen RA | 1992 | Ann Neurol1992，31，6： | 1 |
| 12 | Jumps in Cross- Sectional Rank and Expected Returns: A Mixture Model显示文摘 | GONAZLEZ RIVE RA G LEE T H MISHRA S | 2008 | Journal of Ap- plied Econometrics2008，23，5： | 1 |
| 13 | Integrin ανβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels 显示文摘 | Brooks PC Montgomery AM Rosenfeld M Reisfeld RA Hu T Klier G | 1994 | Cell1994，79，7： | 1 |
| 14 | Low-dose levalbuterol in children with asthma:safety and efficacy in comparison with placebo and racemic albuterol显示文摘 | Milgrom H Skoner D P Bensch G Kim K T Claus R Baumgartner RA for the evalbuterol Pediatric Study Group | 2001 | Allergy Clin Immunol2001，108，： | 1 |
| 15 | Liver stem cells:A potential source of hepatocytes for the treatment of human liver disease 显示文摘 | Faris RA Konkin T Helpert G | 2001 | Artif Organs2001，25，7： | 1 |
| 16 | A prospective study of risk-adapted therapy for large cell non-Hodgkin's lymphoma with VACOP-B followed by high-dose CBV and autologous progenitor cell transplantation for high-risk patients in remission 显示文摘 | Stahel RA Jost LM Kroner T Dommann Scherrer C Maurer R Glanzmann C Jacky E Pichert G Pestalozzi B Marincek B Sauter C Honegger H | 1999 | Br J Haematol1999，104，4： | 1 |
| 17 | Particle-size,size distribution and dislocations in nanocrystalline tungsten-carbide显示文摘 | Ungára T Borbélya A Goren-Muginstein G R | 1999 | Nanostructured Materials1999，11，1： | 1 |
| 18 | Additional effects of taurine on the benefits of BCAA intake for the delayed-onset muscle显示文摘 | Ra S G Miyazaki T Ishikura K | 2013 | Advances in Experimental Medicine and Biology2013，776，： | 1 |
| 19 | Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels显示文摘 | Brooks PC Montgomery AM Rosenfeld M Reisfeld RA Hu T Klier G Cheresh DA | 1994 | Cell1994，79，7： | 1 |
| 20 | Introducing mothur: open- source, platform-independent, community-supported software for describing and comparing microbial communities显示文摘 | Schloss P D Westcott S L Ryabin T Hall J R Hartmarm M Hollister E B Lesniewski RA Oakley B B Parks D H Robinson C J Sahl J W Stres B ThaUinger G G Van Horn D J Weber C F | 2009 | Applied and Environmental Microbiology2009，75，23： | 1 |
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