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| 1 | Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells显示文摘Recent progress in chimeric antigen receptor-modified T-cell(CAR-T cell) technology in cancer therapy is extremely promising, especially in the treatment of patients with B-cell acute lymphoblastic leukemia. In contrast, due to the hostile immunosuppressive microenvironment of a solid tumor, CAR T-cell accessibility and survival continue to pose a considerable challenge, which leads to their limited therapeutic efficacy. In this study, we constructed two anti-MUC1 CAR-T cell lines. One set of CAR-T cells contained SM3 single chain variable fragment(sc Fv) sequence specifically targeting the MUC1 antigen and co-expressing interleukin(IL) 12(named SM3-CAR). The other CAR-T cell line carried the SM3 sc Fv sequence modified to improve its binding to MUC1 antigen(named p SM3-CAR) but did not co-express IL-12. When those two types of CAR-T cells were injected intratumorally into two independent metastatic lesions of the same MUC1+ seminal vesicle cancer patient as part of an interventional treatment strategy, the initial results indicated no side-effects of the MUC1 targeting CAR-T cell approach, and patient serum cytokines responses were positive. Further evaluation showed that p SM3-CAR effectively caused tumor necrosis, providing new options for improved CAR-T therapy in solid tumors. | Fengtao You Licui Jiang Bozhen Zhang Qiang Lu Qiao Zhou Xiaoyang Liao Hong Wu Kaiqi Du Youcai Zhu Huimin Meng Zhishu Gong Yunhui Zong Lei Huang Man Lu Jirong Tang Yafen Li Xiaochen Zhai Xiangling Wang Sisi Ye Dan Chen Lei Yuan Lin Qi Lin Yang | 2016 | Science China(Life Sciences)2016，59，4： | 16 |
| 2 | A finite element model for static and dynamical analysis of thin -walled beams with asymmetric cross-sections 显示文摘 | Yuren Hu Xianding Jin Bozhen Chen | 1996 | Computers & Structures1996，61，5： | 1 |
| 3 | CASPT2 Investiga- tion of Ethane Dissociation and Methyl Recombination Using Canonical Variational Transition State Theory 显示文摘 | Li Hua Chen Bozhen Huang Mingbao | 2008 | Int J Chem Kinet2008，40，4： | 1 |
| 4 | A finite element model for static and dynamic analysis of thin-walled beams with asymmetric cross-sections 显示文摘 | HU Yuren JIN Xianding CHEN Bozhen | 1996 | Computers&Structures1996，61，5： | 1 |
| 5 | Effect of allantoin on the stabilization efficiency of Ca-Zn thermal stabilizers for poly(vinyl chloride)显示文摘 | Xu Xiaopeng Chen Si Wu Bozhen | 2015 | J Therm Anal Calorim2015，119，1： | 1 |
| 6 | A finite element model for static and dynamic analysis of thin-walled beams with asymmetric cross-sections显示文摘 | Hu Yuren Jin Xianding Chen Bozhen | 1996 | Computers & Structures1996，61，5： | 1 |
| 7 | Torsional Stiffness Matrix of A Thin-Walled Beam and its Application to Beams Under Combined Loading显示文摘 | Chen Bozhen Hu Yuren | 1988 | Computers & Structures1988，28，3： | 1 |
| 8 | A Finite Element Model for Static and Dynamic Analysis of Thin-Walled Beams With Asymmetric Cross-Sections显示文摘 | Hu Yuren Jin Xianding Bozhen Chen | 1996 | Computers & Structures1996，61，5： | 1 |
| 9 | CASPT2 Investigation of Ethane Dissociation and Methyl Recombination Using Canonical Variational Transition State Theory显示文摘 | Li Hua Chen Bozhen Huang Mingbo | 2008 | Int J Chem Kinet2008，40，4： | 1 |
| 10 | A finite element model for static and dynamical analysis of thin-walled beams with asymmetric crosssections显示文摘 | Yuren Hu Xianding Jin Bozhen Chen | 1996 | Computers & Structures1996，61，5： | 1 |
| 11 | Fatigue Behaviour of Tubular Joints Made of China-Made Platform Steel显示文摘In China, a nationwide research program on fatigue behaviour of tubular joints made of China-made platform steel was carried out from 1983 to 1990, which was set by the Tubular Joint Research Committee for Offshore Structures (TJCOS) of China. This paper gives an outline of the basic properties of the China-made platform steel and fatigue test of tubular joints, including test specimens, test particulars and test results. A p-S-N curve based on the test results was established which reveals that the fatigue strength of tubular joints is fairly good. The thickness effect and effect of corrosion on fatigue strength in sea water are briefly discussed. | Wang Gnanghai and Chen Bozhen Senior Research Engineer, China Ship Scientific Research Center (CSSRC), Wuxi Professor, Shanghai Jiao Tong University, Shanghai | 1992 | China Ocean Engineering1992，7，1： | 1 |
| 12 | Parametric Analysis and Experimental Study on Local Flexibility of TY-Type Tubular Joints显示文摘Loal flexibility of tubular joints has important effect on the static and dynamic behaviour of offshore platforms, therefore, the determination of it becomes an important research subject in the field of offshore engineering. In this paper, the local flexibility of TY-type tubular joints, which are widely used in offshore platforms, is calculated by using semi- analytical method. Based on the calculated results, parametric formulae for evaluating element in the local joint flexibility matrix of TY- type tubular joints are derived by regression. A test on PVC models of TY-type tubular joints to measure the local joint flexibility is also reported. A comparison of the results calculated from the parametric formulae presented in this paper with those measured from the model test shows that the parametric formulae are reliable. It is recommended that these formulae be used in the global structural analysis of offshore platforms. | XuHantao Chen Bozhen HuYuren Pan Hao Department of Naval Architecture and Ocean Engineering, Shanghai Jiao Tong University (SJTU), Shanghai 200030 Professor, Department of Naval Architecture and Ocean Engineering, Shanghai Jiao Tong University (SJTU), Shanghai 200030 | 1996 | China Ocean Engineering1996，11，1： | 0 |
| 13 | STRESS ANALYSIS OF RING STIFFENED TUBULAR JOINTS FOR OFFSHORE STRUCTURES——REVIEW OF STUDIES IN CHINA显示文摘In China, the stress analysis of tubular joints for offshore structures was started at the end of 1970’s . In addition to simple joints, the ring stiffened tubular joint have been analyzed recently. In this paper, the author reviews the research work of stress analysis of ring stiffened joints, including brief introduction to the methods used, stress concentration behaviour, effects of ring stiffeners’ number, location, dimension, type and stress distribution of ring stiffeners. Emperical formulae for predicting SCF of ring stiffened joints are also presented. | Chen, Bozhen | 1990 | China Ocean Engineering1990，5，1： | 0 |
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