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| 1 | TRICHOMEAND ARTEMISININ REGULATOR 1 Is Required for Trichome Development and Artemisinin Biosynthesis in Artemisia annua显示文摘毛状体,许多植物种类的表面上的小伸出,能生产并且存储各种各样的第二等的新陈代谢的产品。Artemisinin,最著名并且为疟疾的有势力药,被综合,存储,并且由 Artemisia annua 毛状体藏匿了。然而,糟糕在 A.annua 遗体调整 artemisinin 的生合成和毛状体的发展的分子的基础理解。这里,我们报导那一个 AP2 抄写因素,毛状体和 ARTEMISININ 管理者 1 (TAR1 ) ,在在 A.annua 调整毛状体的发展和 artemisinin 的生合成起关键作用。TAR1,编码特殊位于原子核的蛋白质,主要在年轻叶子,花芽,和一些毛状体被表示。在 TAR1-RNAi 线,毛状体的形态学和表皮的蜡的作文被改变,并且 artemisinin 内容戏剧性地被减少它能被 TAR1 oeverexpression 显著地增加。当 TAR1 是 silenced 或 overexpressed 时,涉及 artemisinin 生合成的几关键基因的表示层次被改变。由 electrophoretic 活动性移动,酵母一个混血儿和短暂转变 -glucuronidase 试金,我们证明广告和 CYP71AV1,在 artemisinin 的生合成小径的二关键基因,是可能的 TAR1 的直接目标。一起拿,我们的结果显示 TAR1 是在 A.annua 调整毛状体开发和 artemisinin 生合成的分子的网络的一个关键部件。 | Hexin Tan Ling Xiao Shouhong Gao Qing Li Junfeng Chen Ying Xiao Qian Ji Ruibing Chen Wansheng Chen Lei Zhang | 2015 | Molecular Plant2015，8，9： | 37 |
| 2 | MicroRNAs in pathogenesis of breast cancer:Implications in diagnosis and treatment显示文摘MicroR NAs(miR NAs) are small non-coding RNAs generated by a two-step complex process and are post transcriptional negative regulators of their target m RNAs. Dysregulation of many of these miR NAs has been associated with tumorigenesis in various cancers including breast cancer. Aberrantly high expression of specific mi RNAs in breast cancer cells is demonstrated to be linked with inhibition of tumor suppressor genes and promote tumorigenesis. They are classified as oncogenic miR NAs. However, the tumor suppressor miR NAs are downregulated in breast cancer cells, since their major targets are oncogenic m RNAs. Understanding mechanism of action of specific miR NAs in breast cancer cells can be utilized to develop newer anti-cancer therapies. Recently, newer techniques are also developed to detect abundance of specific miR NA in the blood plasma samples and can be used in early diagnosis or prognosis in breast cancer. In this review article, we have discussed several mi RNAs dysregulated in breast cancer and their therapeutic potential. | Nirav R Shah Hexin Chen | 2014 | World Journal of Clinical Oncology2014，5，2： | 8 |
| 3 | Key Recovery Against 3DES in CPU Smart Card Based on Improved Correlation Power Analysis显示文摘The security of CPU smart cards,which are widely used throughout China,is currently being threatened by side-channel analysis.Typical countermeasures to side-channel analysis involve adding noise and filtering the power consumption signal.In this paper,we integrate appropriate preprocessing methods with an improved attack strategy to generate a key recovery solution to the shortcomings of these countermeasures.Our proposed attack strategy improves the attack result by combining information leaked from two adjacent clock cycles.Using our laboratory-based power analysis system,we verified the proposed key recovery solution by performing a successful correlation power analysis on a Triple Data Encryption Standard(3DES)hardware module in a real-life 32-bit CPU smart card.All 112 key bits of the 3DES were recovered with about 80 000 power traces. | Yanting Ren Liji Wu Hexin Li Xiangyu Li Xiangmin Zhang An Wang Hongyi Chen | 2016 | Tsinghua Science and Technology2016，21，2： | 3 |
| 4 | Mouse RING finger protein Rnf133 is a testis-specific endoplasmic reticulum-associated E3 ubiquitin ligase显示文摘 | Hong Nian Wei Zhang Hexin Shi Qingzhen Zhao Qi Xie Shangying Liao Yan Zhang Zhuqiang Zhang Chen Wang Chunsheng Han | 2008 | Cell Research2008，18，7： | 2 |
| 5 | An Improved Method of Detecting Edge Direction for Spatial Error Concealment显示文摘 | Yan Zhao Hexin Chen Shigang Wang Moncef Gabbouj | 2012 | Journal of Multimedia2012，，3： | 1 |
| 6 | Hydrogen storage properties and thermal stability of a- morphous Mg70 (RE25 Ni75 )30 alloys 显示文摘 | Chen Hexin Wang Zhongmin Zhou Huaiying | 2013 | J Alloys Compd2013，563，： | 1 |
| 7 | Stereo matching based on adaptive support-Weight approach in RGB vector space 显示文摘 | Yingnan Geng Yan Zhao Hexin Chen | 2002 | Applied Opcics2002，51，16： | 1 |
| 8 | Kruppel - like factor 4 ( KLF4 ) is required for maintenance of breast cancer stem cells and for cell migration and invasion显示文摘 | Fang Yu Juan Li Hexin Chen | 2011 | Oncogene2011，30，18： | 1 |
| 9 | Algo-rithm of aerial films recognition based on moment invari-ant显示文摘 | LI Yingchun CHEN Hexin YANG Jianbo | 2002 | Journal of Jilin University( Information Science E-dition)2002，20，3： | 1 |
| 10 | Distribution and location of immunoreactive atrial natriuretic peptides in cochlearstria vascularis of guinea pig显示文摘 | Chen Hexin Wang Jinling Liu Qianchu | 1994 | Chinese Medical Journal1994，107，： | 1 |
| 11 | Pregnancy Loss in Relation to the Risks of Female-Specific Cancers in a Population-Based Cohort and Mendelian Randomization Study — China, 2004–2017显示文摘Summary What is already known about this topic?Limited evidence exists regarding the relationship between pregnancy loss and female-specific cancers within the Chinese population from prospective cohort studies.What is added by this report?Terminations were associated with a 13%lower risk of endometrial cancer,whereas stillbirths were related to an 18%higher risk of cervical cancer.Rural residents with a history of pregnancy loss experienced a 19%and 38%increased risk of breast and cervical cancers,respectively,compared to their urban counterparts.Moreover,a positive graded relationship between live births and pregnancy loss on cervical cancer was observed.What are the implications for public health practice?This study has significant implications for identifying women at an increased risk for breast and genital cancers and contributes to the development of effective public health strategies for female cancer prevention.Future research on reproductive history,particularly in rural areas,should be given priority in efforts to improve female cancer screening and early detection. | Yongle Zhan Yawen Wang Yimin Qu Lin Zhang Xuan Liu Ruiyi Liu Peng Xue Jiaxu Wang Dongxu Qin Hexin Yue Canqing Yu Jun Lyu Yu Guo Zhengming Chen Yu Jiang Liming Li China Kadoorie Biobank Collaborative Group | 2023 | China CDC weekly2023，5，19： | 0 |
| 12 | A Shot Clustering Based Algorithm for Scene Segmentation显示文摘A scene segmentation method utilizing both visual features and motion features of video is presented in this paper.Not only the visual similarity but also the motion consistency of shots within a scene is considered in clustering shots into scenes.In addition,a method to merge the over-segmented scenes is presented also.And the experimental results show the effectiveness of the proposed algorithms. | Wang Xuejun Wang Shigang Chen Hexin | 2007 | China Communications2007，4，4： | 0 |
| 13 | Cancer resistance to immunotherapy: What is the role of cancer stem cells?显示文摘Immunotherapy is an emerging form of cancer therapy that is associated with promising outcomes.However,most cancer patients either do not respond to immunotherapy or develop resistance to treatment.The resistance to immunotherapy is poorly understood compared to chemotherapy and radiotherapy.Since immunotherapy targets cells within the tumor microenvironment,understanding the behavior and interactions of different cells within that environment is essential to adequately understand both therapy options and therapy resistance.This review focuses on reviewing and analyzing the special features of cancer stem cells(CSCs),which we believe may contribute to cancer resistance to immunotherapy.The mechanisms are classified into three main categories:mechanisms related to surface markers which are differentially expressed on CSCs and help CSCs escape from immune surveillance and immune cells killing;mechanisms related to CSC-released cytokines which can recruit immune cells and tame hostile immune responses;and mechanisms related to CSC metabolites which modulate the activities of infiltrated immune cells in the tumor microenvironment.This review also discusses progress made in targeting CSCs with immunotherapy and the prospect of developing novel cancer therapies. | Gourab Gupta George Merhej Shakthika Saravanan Hexin Chen | 2022 | Cancer Drug Resistance2022，5，4： | 0 |
| 14 | Optimizing health-span:advances in stem cell medicine and longevity research显示文摘Introduction The pursuit of optimal health and longevity is a long-standing human aspiration[1,2].Advances in public health policies and population medicine have significantly extended life expectancy,which has tripled from 20–30 years a century and a half ago.However,this has also led to an increase in age-related diseases.As we age,stem cells,the foundation of every organ and tissue in our body,lose their regenerative capacity,leading to tissue decline and age-related diseases.Environmental conditions and disease treatments can also negatively impact the quality of life and health span[3]. | Yue Zhang Hexin Chen Cibo Huang | 2023 | Medical Review2023，3，4： | 0 |
| 15 | High-contrast and real-time visualization of membrane proteins in live cells with malachite green-based fluorogenic probes显示文摘Imaging dynamics of membrane proteins of live cells in a wash-free and real-time manner has been a challenging task. Herein, we report unprecedented applications of malachite green(MG), an organic dye widely used in pigment industry, as a switchable fluorophore to monitor membrane enzymes or noncatalytic proteins in live cells. Conformationally flexible MG is non-fluorescent in aqueous solution, yet covalent binding with endogenous proteins of cells significantly enhances its fluorescence at 670 nm by restricting flexibility of dye. Integrating a phosphate-caged quinone methide precursor with MG yielded a covalent labeling fluorogenic probe, allowing real-time imaging of membrane alkaline phosphatase(ALP,a model catalytic protein) activity in live cells with over 100-fold enhancement of fluorescence intensity.Moreover, MG is also applicable to image non-catalytic protein by conjugation with protein-specific ligand. A fluorogenic probe consisted of c-RGDf K peptide and MG proved to be compatible with wash-free and real-time visualization of non-catalytic integrin α_(v)β_(3) in live cells with high contrast. | Yefeng Chen Chenghong Xue Jie Wang Minqiu Xu Yuyao Li Yiru Ding Heng Song Weipan Xu Hexin Xie | 2022 | Chinese Chemical Letters2022，33，3： | 0 |
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