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| 1 | Re-Os isotopes and PGE geochemistry of black shales and intercalated Ni-Mo polymetallic sulfide bed from the Lower Cambrian Niutitang Formation, South China显示文摘The Lower Cambrian Niutitang Formation consists of a thick black shale sequence with a regionally distributed conformable Ni Mo polymetallic sulfide horizon and a chert bed at its basal strata on theYangtze Platform, South China. In this paper, we discuss all available data on Re Os isotopes and Platinum Group Element (PGE) distribution pattern of the Ni Mo polymetallic sulfide ore and its host rocks (black shales, cherts, and phosphorites) from Guizhou and Hunan provinces. Our results show that the black shales and the Ni Mo sulfide ore have a high initial 187 Os/ 188 Os ratio of 0.78~0.86, indicating that the Early Cambrian ocean across the Yangtze Platform had a highly radiogenic Os value. This ratio is slightly lower than but still similar to present day seawater, possibly as a result of high continental weathering at that time. The Ni Mo sulfide ore yields a Re Os isochron of 537±10 Ma (MSWD=11.9), possibly representing the depositional age of the Niutitang Formation. The chondrite normalized PGE pattern, Pt anomaly (Pt/Pt *), Pt/Pd, Ir/Pd, Au/Ir and Re/Mo ratios of the Ni Mo sulfide ore and its host rocks from South China indicate a varying source contribution of the PGE and other metals for different rocks. It is suggested that the cherts and Ni Mo sulfide ore may have a significant proportion of PGE and probably other metals deriving from submarine hydrothermal fluids with a mantle signature. | JIANG Shaoyong*, YANG Jinghong, LING Hongfei, FENG Hongzhen, CHEN Yongquan and CHEN Jianhua(State Key Laboratory for Mineral Deposits Research, Department of Earth Sciences, Nanjing University, Nanjing 210093, China) | 2003 | Progress in Natural Science:Materials International2003，13，10： | 78 |
| 2 | Temporal and spatial variation of annual mean air temperature in arid and semiarid region in northwest China over a recent 46 year period显示文摘We analyzed the 1961-2006 mean surface air temperature data of 138 stations in China's northwest arid and semi-arid areas(CNASA),to measure climate change in terms of annual mean air temperature changes.We used methods of linear regression analysis,multinomial fitting,Empirical Or-thogonal Function(EOF),Rotated Empirical Orthogonal Function(REOF),Mann-Kendall,Glide T-examination,wavelet analysis and power spectrum analysis.The results show that(1) the warming rate of the annual mean air temperature in CNASA was 0.35oC/10a during the 1961-2006 study period.Some places in the west part of Xinjiang and east part of the Qinghai plateau,which is impacted by the terrain of leeward slope,exhibit smaller increasing trends.However,the majority of region has shown distinct warming in line with general global warming;(2) The standard deviation of the annual mean temperature distribution is non-uniform.The south Xinjiang and east Qinghai-south Gansu areas show relatively small standard deviations,but the inter-annual variation in annual mean air temperature in the greater part of the region is high;(3) Inner Mongolia,Shaanxi,Gansu,Ningxia and Tarim Basin are the areas where the temperature changes are most sensitive to the environment.The degree of uniformity in annual mean air temperature increase is higher in the arid and semi-arid area.From the early 1970s,the trend in tempera-ture changed from a decrease to an increase,and there was a marked increase in mean temperature in 1986.After that mean temperature went through a period of rapid increase.The entire area's 10 hottest years all occurred in or since the 1990s,and 90% of various sub-districts' hottest years also occurred after 1990.The process of temperature change appears to have a roughly 5-year and a 10-year cycle;(4) An-nual mean air temperature variation has regional differences.In Inner Mongolia-Xinjiang and Shaanxi-Gansu-Ningxia-Qinghai areas,the temperature variation in their northern areas was very different from that in their southern areas;(5) Using the REOF method we divided the region into 4 sub-regions:the Northern region,the Plateau region,the Southern Xinjiang region and the Eastern region.The region's annual mean air temperature transition has regional differences.The Plateau and Southern Xinjiang re-gions got warmer steadily without any obvious acceleration in the rate of warming.The Northern region's warming started about 5-years earlier than that of the low latitude Eastern region.The 'Startup region' of the Qinghai-Tibet Plateau,appears to undergo temperature changes 3 to 10 years earlier than the other regions,and exhibits inter-decadal variations 1 to 2 years ahead of the other regions. | Chen, ShaoYong Shi, YuanYuan Guo, YuZhen Zheng, YanXiang | 2010 | Journal of Arid Land2010，2，2： | 24 |
| 3 | Effects of overlying water aeration on phosphorus fractions and alkaline phosphatase activity in surface sediment显示文摘Microbial activity may influence phosphorus (P) deposit and release at the water sediment interface.The properties of DO (dissolved oxygen),pH,P fractions (TP,Ca-P,Fe-P,OP,IP),and APA (alkaline phosphatase activity) at the water sediment interface were measured to investigate microbial activity variations in surface sediment under conditions of two-month intermittent aeration in overlying water.Results showed that DO and TP of overlying water increased rapidly in the first week and then decreased gradually after 15 day of intermittent aeration.Microorganism metabolism in surface sediment increased pH and decreased DO and TP in the overlying water.After two-month intermittent aeration,APA and OP from surface sediment (0-2 cm) were both significantly higher than those from bottom sediment (6-8 cm) (p < 0.05),and surface sediment Fe-P was transferred to OP during the course of microorganism reproduction on the surface sediment.These results suggest that microbial activity and microorganism biomass from the surface sediment were higher than those from bottom sediment after two-month intermittent aeration in the overlying water. | Jianjun Chen Shaoyong Lu Yikun Zhao Wei Wang Minsheng Huang | 2011 | Journal of Environmental Sciences2011，23，2： | 20 |
| 4 | Pb-Pb isotope dating of black shales from the Lower Cambrian Niutitang Formation, Guizhou Province, South China显示文摘The Lower Cambrian black shales of the Niutitang Formation and their lateral equivalents occur widely on the Yangtze Platform, South China. In this study, we examine two sections of the Niutitang Formation in Guizhou Province. We employ a stepwise acid leaching technique to obtain Pb isotope compositions of the black shales. At the Zhongnan section, the black shales display large Pb isotope variations, with 206 Pb/ 204 Pb of 20.5396~33.5709, and 207 Pb/ 204 Pb of 15.8407~16.5782. In contrast, Pb isotope data show a relatively limited range in 206 Pb/ 204 Pb (18.2797~18.5972) and 207 Pb/ 204 Pb (15.6813~15.7159) at the Zhijin section. Data for all acid leached black shale samples from the two sections yield a Pb Pb isochron age of 531±24 Ma. This age may represent the sedimentary age of the black shales. The initial Pb isotope composition of the black shales falls near the upper crust evolution curve in a Zartman Pb Pb evolution diagram. Hence, it is likely that the Pb in the black shales may have been derived from an upper continental crustal source. | CHEN Yongquan, JIANG Shaoyong*, LING Hongfei, FENG Hongzhen, YANG Jinghong and CHEN Jianhua (State Key Laboratory for Mineral Deposits Research, Department of Earth Sciences, Nanjing University, Nanjing 210093, China) | 2003 | Progress in Natural Science:Materials International2003，13，10： | 19 |
| 5 | Geochemistry of pore waters from HQ-1PC of the Qiongdongnan Basin, northern South China Sea, and its implications for gas hydrate exploration显示文摘The Qiongdongnan Basin is one of the target areas for marine gas hydrate exploration in the northern margin of the South China Sea. In this study, major anion (e.g., SO42 , Cl, Br, I), cation (e.g., Ca, Mg, K, Na), and trace element (e.g., Sr, Ba) con- centrations of pore water samples collected from site HQ-1PC in the Qiongdongnan Basin were analyzed. These geochemical data suggest that the process of AOM (Anaerobic Oxidation of Methane) is dominant in sulfate-reduction zone in this site due to high upwelling iodine flux and strong microbial activities. The iodine-rich fluids, which may carry methane for the gas hydrate formation, pass through the gas hydrate stability zone, mix with brine released during gas hydrate formation, and cause the geochemical anomalies observed at site HQ-1PC. The pore water geochemical characteristics and anomalies in the Qiongdongnan Basin are quite similar to those found in other gas hydrate locations in the Shenhu area in the northern South China Sea, and a genetic link is suggested with the possibility of gas hydrate occurrence in the study area. | YANG Tao JIANG ShaoYong GE Lu YANG JingHong WU NengYou ZHANG GuangXue LIU Jian CHEN DaoHua | 2013 | Science China Earth Sciences2013，56，4： | 14 |
| 6 | High precision in-situ Pb isotopic analysis of sulfide minerals by femtosecond laser ablation multi-collector inductively coupled plasma mass spectrometry显示文摘An in-situ microanalysis of Pb isotopic compositions in sulfide minerals is carried out by using femtosecond laser-ablation multi-collector inductively coupled plasma mass spectrometry(fs LA-MC-ICP-MS).High-temperature-activated carbon was used to filter Hg contained in the carrier gas,which reduced the Hg background signal by 48%and also lowered the detection limit of the analysis.Fractionation and mass discrimination effects existing in the ICP-MS analytical processes were corrected using an internal reference Tl in conjunction with an external reference NIST SRM 610.The proposed method was used to analyze the Pb isotopic compositions of chalcopyrite,pyrite,and sphalerite from the Dulong Sn-Zn-In polymetallic ore district.The results showed that in this ore district,the sulfide minerals and different grains of the same sulfide mineral show a large variation in Pb content up to 1000-fold.The studied pyrites show relatively higher Pb contents and homogeneous Pb isotopic compositions,whereas the sphalerites have low Pb contents but most variable Pb isotopic compositions.It is suggested that the large variation of Pb isotopic composition may reflect a late hydrothermal superimposition on the primary sulfide formation.In addition,radiogenic Pb accumulated by radioactive decay of trace amounts of U over time in the host minerals may also be one of the causes for the large variation range of Pb content and Pb isotopic composition of those low-Pb sphalerites.Chalcopyrite and sphalerite grains with Pb content greater than 10 ppm presented a consistent Pb isotopic distribution,whereas all the sulfide grains with Pb content greater than 100 ppm had consistent Pb isotopic composition within 2s measurement uncertainties.The in-situ analysis of Pb isotopic composition agreed well with the results obtained by conventional chemical methods within2s measurement uncertainties,indicating that the data obtained by fs LA-MC-ICP-MS are reliable.Additionally,this study indicates that the Pb isotopic composition could truthfully record the source of ore-forming minerals only for sulfide minerals with high Pb content.On the contrary,the Pb isotopic composition of low-Pb sulfide minerals may be affected by trace amounts of U in the host minerals that may lead to a highly radiogenic Pb isotope ratio.Alternatively,it is also possible that late fluid metasomatic overprinting may alter the Pb isotopic compositions. | YUAN HongLin YIN Cong LIU Xu CHEN KaiYun BAO ZhiAn ZONG ChunLei DAI MenNing LAI ShaoCong WANG Rong JIANG ShaoYong | 2015 | Science China Earth Sciences2015，58，10： | 14 |
| 7 | Effects of different forms of yeast Saccharomyces cerevisiae on growth performance,intestinal development,and systemic immunity in early-weaned piglets显示文摘The present study was conducted to determine effects of different forms of yeast(Saccharomyces cerevisiae,strain Y200007) on the growth performance,intestinal development,and systemic immunity in early-weaned piglets.A total of 96 piglets(14-d old,initial average body weight of 4.5 kg) were assigned to 4 dietary treatments:(1) basal diet without yeast(Control);(2) basal diet supplemented with 3.00 g/kg live yeast(LY);(3) basal diet supplemented with 2.66 g/kg heat-killed whole yeast(HKY);and(4) basal diet supplemented with 3.00 g/kg superfine yeast powders(SFY).Diets and water were provided ad libitum to the piglets during 3-week experiment.Growth performance of piglets was measured weekly.Samples of blood and small intestine were collected at days 7 and 21 of experiment.Dietary supplementation with LY and SFY improved G:F of piglets at days 1-21 of the experiment(P<0.05) compared to Control group.Serum concentrations of growth hormone(GH),triiodothyronine(T_3),tetraiodothyronine(T_4),and insulin growth factor 1(IGF-1) in piglets at day 21 of the experiment were higher when fed diets supplemented with LY and SFY than those in Control group(P < 0.05).Compared to Control group,contents of serum urea nitrogen of piglets were reduced by the 3 yeast-supplemented diets(P< 0.05).Diets supplemented with LY increased villus height and villus-to-crypt ratio in duodenum and jejunum of piglets(P < 0.05) compared to other two groups at day 7 of the experiment.Feeding diets supplemented with LY and SFY increased(P< 0.05) serum concentrations of IgA,IL-2,and IL-6 levels in piglets compared to Control.The CD4^+/CD8^+ ratio and proliferation of T-lymphocytes in piglets fed diets supplemented with LY were increased compared to that of Control group at day 7 of the experiment(P < 0.05).In conclusion,dietary supplementation with both LY and SFY enhanced feed conversion,small intestinal development,and systemic immunity in early-weaned piglets,with better improvement in feed conversion by dietary supplementation with LY,while dietary supplementation with SFY was more effective in increasing systemic immune functions in early-weaned piglets. | Zongyong Jiang Shaoyong Wei Zhilin Wang Cui Zhu Shenglan Hu Chuntian Zheng Zhuang Chen Youjun Hu Li Wang Xianyong Ma Xuefen Yang | 2016 | Journal of Animal Science and Biotechnology2016，7，1： | 13 |
| 8 | Types and Origin of Dolostones in Tarim Basin, Northwest China: Petrographic and Geochemical Evidence显示文摘In the Tarim Basin of northwestern China hydrocarbon deposits have been discovered in parts of the thick strata of Cambrian dolostones. Based on petrographic study, six types of dolostone have been distinguished: Type-1, pink mud-bearing silty crystalline dolostone (PMSD); Type-2, gypsum- and salt-bearing fine crystalline dolostone (GSFD); Type-3, fine crystalline dolostone with dolomite crystals with cloudy core and clear rim (CCFD); Type-4, deep gray mud-bearing silty crystalline dolostone (GMSD); Type-5, euhedral coarse crystalline dolostone (ECD); and Type-6, xenotopic coarse crystalline dolostone (XCD). Applying petrographic and geochemical methods, the genesis of the dolostones is studied in this paper. Normally, Type-1 dolostone shows U- and Mo-depleted characteristics, reflecting a more oxidized formation environment; High δ18O and the purple color are consistent with formation of Sabkha dolostones on a supratidal flat. Types 2, 3, 4 dolostones show strata formation, similar REE patterns and 87Sr/86Sr ratios with contemporaneous limestones, suggesting a penecontemporaneous origin from seawater. Types 5 and 6 dolostones commonly occur as interbedded rocks, indicating secondary genesis after diagenesis. Type-6 dolostone has the highest order degree (OD) values (average 0.86), the lowest oxygen isotope values and positive Eu anomalies, which are consistent with previously reported hydrothermal dolostones. Differently, Type-5 shows euhedral texture, higher δ18O value, similar REE characteristic and 87Sr/86Sr ratios in comparison with contemporaneous limestones, suggesting that this type might have been dolomitized by down-transferring evaporated seawater during shallow burial stage. Dolostone fluid sources, formation environments and crystallizing dynamics are summarized and possible genetic models for the six types are proposed. | CHEN Yongquan ZHOU Xinyuan JIANG Shaoyong ZHAO Kuidong | 2013 | Acta Geologica Sinica(English Edition)2013，87，2： | 12 |
| 9 | Rare earth elements and carbon isotope geochemistry of the Doushantuo Formation in South China:Implication for middle Ediacaran shallow marine redox conditions显示文摘The middle Ediacaran Shuram excursion, the largest negative δ 13 C carb excursion in Earth history, has been interpreted as indirect evidence for episodic oxidation and remineralization of deep ocean DOC (dissolved organic carbon). It has been hypothesized that such oxidation event may have occurred when anoxic DOC-laden deep water was brought to shallow shelves during oceanic upwelling, which is expected to cause localized anoxia in shallow environments. To test this prediction, we systematically analyzed rare earth elements (REE) and δ 13 C carb of the upper Doushantuo Formation carbonates in the Yangtze Gorges area of South China, which were deposited in an inner shelf environment and record a large negative δ 13 C carb excursion correlated to the Shuram event. The REE data show a significant positive shift in Ce/Ce* values, synchronous with a pronounced negative δ 13 C carb shift. This positive Ce/Ce* shift is interpreted to represent an oceanic anoxia event in shallow shelf environments, which may have been caused by the upwelling or impingement of oxygen-depleted and 12 C-enriched deep water onto shelves. This anoxia event coincides with a sharp decline in the abundance and diversity of Ediacaran acanthomorphic acritarchs, raising the possibility that these two geobiological events may be causally related. | ZHOU ChuanMing JIANG ShaoYong XIAO ShuHai CHEN Zhe YUAN XunLai | 2012 | Chinese Science Bulletin2012，57，16： | 11 |
| 10 | Benthic macro red alga:A new possible bio-precursor of Jurassic mudstone source rocks in the northern Qaidam Basin,northwestern China显示文摘Whether benthic macroalga can be an important type of bio-precursor of source rocks is a contentious issue in source-rock studies,and has not been well understood.This paper represents a case study of Jurassic mudstone source rocks from the northern Qaidam Basin,northwestern China,in which the benthic macro red algae were recognized for the first time based on combined organic petrological and biomarker works.We found not only cystocarps in the algae,representative of rhodophyta,but also diahopanes,which are diagnostic biomarkers of such algae.Thus,as many reservoired oils in the northern Qaidam Basin contain abundant diahopanes,it may indicate that the red algae have contributed to hydrocarbon accumulation.This was confirmed by integrated geological and geochemical analyses.Hence,this study provides new evidence for macroalga-generated hydrocarbons. | CAO Jian BIAN LiZeng HU Kai LIU YunTian WANG LiQun YANG ShaoYong CHEN Yan PENG XiaoQun | 2009 | Science China Earth Sciences2009，52，5： | 5 |
| 11 | Isotopic compositions of small shelly fossil Anabarites from Lower Cambrian in Yangtze Platform of South China: Implications for palaeocean temperature显示文摘Anabarites belong to small shelly fossils (SSF), which occur widely in the Lower Cambrian strata of Yangtze Platform in South China. They are phosphate shell in composition and represent the earliest stage of the Cambrian bioradiation of Bilateria, the so-called 'Cambrian Explosion'. In this study, we attempted to separate Anabarites fossils from Lower Cambrian dolostones, and we obtained samples of both the fossils (SSF) and the granular phosphates (GP). Isotopic analyses were performed on samples of SSF, GP, and matrix dolostone (DH-23). The results showed that the δ30Si values of the quartz filling in fossils celoms, and the siliceous materials in granular phosphates are -0.6‰ and -0.7‰, which is different from normal sedimentary siliceous rocks from the Lower Cambrian strata (0—0.7‰) as reported by Li et al., but is consistent with the data for siliceous rocks and cherts of submarine hydrothermal origin. It is likely that a later hydrothermal replacement could have taken place in the SSF-bearing sedimentary rocks. The oxygen isotope values of the phosphate of SSF and GP are 16.8‰ and 17.0‰, respectively. These are significantly higher than the Neoproterozoic phosphate ores (10.9‰—13.9‰) as reported by Ling et al., hence, late diagenesis and hydrothermal replacement may not have caused a significant change in the oxygen isotope compositions of the small shelly fossils, and the calculated temperatures (25.4—26.3℃) for palaeo-seawater using a SSF phosphate oxygen isotope thermometer are therefore considered here as the upper limit of seawater temperature in the Early Cambrian ocean of the Yangtze Platform. | Chen Yongquan Jiang Shaoyong Ling Hongfei Yang Jlnghong Wan Defan | 2007 | Progress in Natural Science:Materials International2007，17，10： | 4 |
| 12 | Spatiotemporal distribution characteristics of the fog regions in China显示文摘The spatial distribution and monthly/annual variation of foggy days in China are analyzed based on the monthly mean fog data collected from 604 observational stations for the period 1961–2000. Results show that there are six fog regions in China: the middle reaches of the Yangtze River, coastal areas, Yunnan-Guizhou Plateau, eastern Gansu–Shaanxi region, Huaihe River valley, Tianshan mountainous area and northern Xinjiang. On the whole the interannual variation trend of foggy days is descending, especially an obvious decline after the 1980s. The areas where the foggy days have obvious tendency present a southwest-northeast direction. The rising trend regions alternate with descending trend regions, forming a SE-NW directional wave structure. In general, the number of foggy days in autumn and winter is larger than in spring and summer over most fog regions. The monthly variation curves of foggy days are bimodal in the coastal area of the Yellow Sea and northern Xinjiang, and unimodal in other regions. | WANG Liping CHEN Shaoyong DONG Anxiang SONG Lianchun | 2006 | Journal of Geographical Sciences2006，16，3： | 3 |
| 13 | Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators显示文摘The recent discovery of activator compounds binding to an allosteric site on the NAD+-dependent protein lysine deacetylase,sirtuin 6(SIRT6)has attracted interest and presents a pharmaceutical target for aging-related and cancer diseases.However,the mechanism underlying allosteric activation of SIRT6 by the activator MDL-801 remains largely elusive because no major conformational changes are observed upon activator binding.By combining molecular dynamics simulations with biochemical and kinetic analyses of wild-type SIRT6 and its variant M136 A,we show that conformational rotation of 2-methyl-4-fluoro-5-bromo substituent on the right phenyl ring(R-ring)of MDL-801,which uncovers previously unseen hydrophobic interactions,contributes to increased activating deacetylation activity of SIRT6.This hypothesis is further supported by the two newly synthesized MDL-801 derivatives through the removal of the 5-Br atom on the R-ring(MDL-801-D1)or the restraint of the rotation of the R-ring(MDL-801-D2).We further propose that the 5-Br atom serves as an allosteric driver that controls the ligand allosteric efficacy.Our study highlights the effect of allosteric enzyme catalytic activity by activator binding and provides a rational approach for enhancing deacetylation activity. | Shaoyong Lu Yingyi Chen Jiacheng Wei Mingzhu Zhao Duan Ni Xinheng He Jian Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 2 |
| 14 | Connotation analysis, source-reservoir assemblage types and development potential of unconventional hydrocarbons in China显示文摘Through analysis of the connotation of unconventional hydrocarbons,the source-reservoir assemblages of unconventional hydrocarbons are divided into three types,i.e.,source-reservoir neighboring type,source-reservoir integration type,and source-reservoir separation type.The source-reservoir neighboring type resources mainly include tight oil and tight gas with the following formation conditions and characteristics:(1)efficient near-source accumulation close to high-quality source rocks with the pressure difference between source and reservoir as the dynamic force;(2)large-area tight reservoirs with certain porosity,dominated by micro-nanopores of inorganic origin;(3)distributed in depressions and slopes with large hydrocarbon-bearing area and great resource quantity,low abundance and local development of“sweet spots”;(4)weak tectonism.The source-reservoir integration type resources mainly include coalbed methane,shale gas,shale oil and oil shale.The formation conditions and characteristics are:(1)high abundance of organic matter,different types of organic matter and thermal evolution grades leading to formation of different resources types;(2)organic-rich sections are distributed continuously in the reservoiring space which is dominated by nanometer organic pores,interparticle pores and microfissures;(3)hydrocarbons mainly occur in free or adsorbed state,varying much with resource type;(4)the resources are self-conserved,and enriched in depressions and slopes,the conservation conditions are controlled by tectonics,temperature and pressure;(5)the production per well can be enhanced by volume fracturing,which increases the permeability of the reservoirs.The source-reservoir separation type resources are more special,mainly including(1)transformed conventional resources such as oil sand and heavy oil;(2)unsteady resources formed under special conditions of temperature and pressure,among which natural gas hydrate is a representative.These three types of resources in China are different in both development prospect and current situation:(1)the source-reservoir neighboring type is most practical and will develop fast in the next 5 years;(2)the source-reservoir integration type needs continuous exploration and technical breakthrough,and is expected to develop rapidly in the coming decade;(3)in the source-reservoir separation type resources,natural gas hydrates have the greatest development potential,on which technical tests are being conducted. | Jianzhong Li Min Zhen Xiaoming Chen Denghua Li Shaoyong Wang Tao Song | 2016 | Petroleum Research2016，1，2： | 2 |
| 15 | Mineral Chemistry of Melanite from Calcitic Ijolite, the Oka Carbonatite Complex, Canada: Implications for Multi-Pulse Magma Mixing显示文摘Ti-rich garnet is found within calcitic ijolite from the Oka carbonatite complex in Canada, which is characterized by 58%–73% andradite component(2.12 wt.%–4.18 wt.% TiO_2) and classified as melanite. The garnet displays complex zoning and contains abundant high field strength elements(HFSEs) and rare earth elements(REEs). Three groups(Ⅰ, Ⅱ, Ⅲ) have been identified based on their petrographic nature. Compared to groups Ⅱ and Ⅲ, Group Ⅰ garnet cores contain higher TiO_2, Mg O, HFSE, and REE and lower SiO_2 abundances. The distinct chemical and petrographic signatures of the investigated garnets cannot be attributed to simple closed system crystallization, but they are consistent with the multi-pulse magma mixing. Combined with previously reported U-Pb ages for apatite from the calcitic ijolite, at least three stages of magma evolution and subsequent mixing have been involved in the generation of calcitic ijolite at Oka. The early-formed melt that generated Group I garnet core was later mixed with at least two small-volume, more evolved melts. The intermediate stage melt formed the remaining garnet along with some pyroxene, calcite, nepheline, and apatite at 127±3.6 Ma. The youngest, most evolved melt generated the majority of pyroxene, calcite, nepheline, and apatite within the calcitic ijolite at 115±3.1 Ma. | Wei Chen Weiqi Zhang Antonio Simonetti Shaoyong Jiang | 2016 | Journal of Earth Science2016，27，4： | 2 |
| 16 | Petroleum pollution in surface sediments of Daya Bay, South China, revealed by chemical fingerprinting of aliphatic and alicyclic hydrocarbons 显示文摘 | GAO Xuelu CHEN Shaoyong | 2008 | Estuarine Coastal and Shelf Science2008，80，1： | 1 |
| 17 | Composition and sources of organic matter and its solvent extractable components in surface sediments of a bay under serious anthropogenic influences: Daya Bay, China 显示文摘 | Gao Xuelu Chen Shaoyong Long Aimin | 2008 | Marine Pollution Bulletin2008，56，： | 1 |
| 18 | Geology, geochemistry and ore genesis of the Wenyu gold deposit, Xiaoqinling gold field,Qinling Orogen,Southern Margin of North China Craton显示文摘 | ZHOU Zhenju CHEN Yanjing JIANG Shaoyong | 2014 | Ore Geology Reviews2014，59，1： | 1 |
| 19 | Prevalence, Awareness, Treatment, and Control of Hypertension in China显示文摘 | Dongfeng Gu Kristi Reynolds Xigui Wu Jing Chen Xiufang Duan Paul Muntner Guanyong Huang Robert F. Reynolds Shaoyong Su Paul K. Whelton Jiang He | 2002 | Hypertension: Journal of the American Heart Association2002，，6： | 1 |
| 20 | Targeting RAS phosphorylation in cancer therapy:Mechanisms and modulators显示文摘RAS,a member of the small GTPase family,functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded state.RAS gain-of-function mutations are one of the leading causes in human oncogenesis,accounting for w19%of the global cancer burden.As a well-recognized target in malignancy,RAS has been intensively studied in the past decades.Despite the sustained efforts,many failures occurred in the earlier exploration and resulted in an‘undruggable’feature of RAS proteins.Phosphorylation at several residues has been recently determined as regulators for wild-type and mutated RAS proteins.Therefore,the development of RAS inhibitors directly targeting the RAS mutants or towards upstream regulatory kinases supplies a novel direction for tackling the anti-RAS difficulties.A better understanding of RAS phosphorylation can contribute to future therapeutic strategies.In this review,we comprehensively summarized the current advances in RAS phosphorylation and provided mechanistic insights into the signaling transduction of associated pathways.Importantly,the preclinical and clinical success in developing anti-RAS drugs targeting the upstream kinases and potential directions of harnessing allostery to target RAS phosphorylation sites were also discussed. | Yuran Qiu Yuanhao Wang Zongtao Chai Duan Ni Xinyi Li Jun Pu Jie Chen Jian Zhang Shaoyong Lu Chuan Lv Mingfei Ji | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 1 |
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