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| 1 | Ligand-triggered de-repression of Arabidopsis heterotrimeric G proteins coupled to immune receptor kinases显示文摘 | Xiangxiu Liang Miaomiao Ma ,Zhaoyang Zhou Jinlong Wang Xinru Yang Shaofei Rao Guozhi Bi Lin Li Xiaojuan Zhang Jijie Chai She Chen Jian-Min Zhou | 2018 | Cell Research2018，28，5： | 13 |
| 2 | High efficiency synthesis of octavinylsilsesquioxanes and its high performance hybrids based on bismaleimide‐triazine resin显示文摘 | Jiang‐tao Hu Aijuan Gu Zhijun Jiang Guozheng Liang Dongxian Zhuo Li Yuan Beijing Zhang Xiangxiu Chen | 2011 | Polym Adv Technol2011，，8： | 1 |
| 3 | Flame retarding cyanate ester resin with low curing temperature, high thermal resistance, outstanding dielectric property, and low water absorption for high frequency and high speed printed circuit broads显示文摘 | Chen Xiangxiu Liang Guozheng Gu Aijuan | 2015 | Industrial & Engineering Chemistry Research2015，，6： | 1 |
| 4 | New glass fibre/bismaleimide composites with significantly improved flameretardancy,higher mechanical strength and lower dielectric loss显示文摘 | Chen Xiangxiu Yuan Li Zhang Zhiyong | 2014 | Composites Part B:Engineering2014，71，96： | 1 |
| 5 | A pair of G-type lectin receptor-like kinases modulates nlp20-mediated immune responses by coupling to the RLP23 receptor complex显示文摘Plant cells recognize microbial patterns with the plasma-membrane-localized pattern-recognition receptors consisting mainly of receptor kinases(RKs) and receptor-like proteins(RLPs). RKs, such as bacterial flagellin receptor FLS2, and their downstream signaling components have been studied extensively. However, newly discovered regulatory components of RLP-mediated immune signaling, such as the nlp20 receptor RLP23, await identification. Unlike RKs, RLPs lack a cytoplasmic kinase domain, instead recruiting the receptor-like kinases(RLKs) BAK1 and SOBIR1. SOBIR1 specifically works as an adapter for RLP-mediated immunity. To identify new regulators of RLP-mediated signaling, we looked for SOBIR1-binding proteins(SBPs) in Arabidopsis thaliana using protein immunoprecipitation and mass spectrometry,identifying two G-type lectin RLKs, SBP1 and SBP2, that physically interacted with SOBIR1.SBP1 and SBP2 showed high sequence similarity,were tandemly repeated on chromosome 4, and also interacted with both RLP23 and BAK1. sbp1 sbp2 double mutants obtained via CRISPR-Cas9 gene editing showed severely impaired nlp20-induced reactive oxygen species burst, mitogenactivated protein kinase(MAPK) activation, and defense gene expression, but normal flg22-induced immune responses. We showed that SBP1 regulated nlp20-induced immunity in a kinase activityindependent manner. Furthermore, the nlp20-induced the RLP23–BAK1 interaction, although not the flg22-induced FLS2–BAK1 interaction, was significantly reduced in sbp1 sbp2. This study identified SBPs as new regulatory components in RLP23 receptor complex that may specifically modulate RLP23-mediated immunity by positively regulating the interaction between the RLP23 receptor and the BAK1 co-receptor. | Yazhou Bao Yixin Li Qin Chang Rubin Chen Weijie Wang Qian Zhang Shuxian Chen Guangyuan Xu Xiaodan Wang Fuhao Cui Daolong Dou Xiangxiu Liang | 2023 | Journal of Integrative Plant Biology2023，65，5： | 0 |
| 6 | Recent advances of mechanosensitive genes in vascular endothelial cells for the formation and treatment of atherosclerosis显示文摘Atherosclerotic cardiovascular disease and its complications are a high-incidence disease worldwide.Numerous studies have shown that blood flow shear has a huge impact on the function of vascular endothelial cells,and it plays an important role in gene regulation of pro-inflammatory,pro-thrombotic,pro-oxidative stress,and cell permeability.Many impor-tant endothelial cell mechanosensitive genes have been discovered,including KLK10,CCN gene family,NRP2,YAP,TAZ,HIF-1α,NF-kB,FOS,JUN,TFEB,KLF2/KLF4,NRF2,and ID1.Some of them have been intensively studied,whereas the relevant regulatory mechanism of other genes remains unclear.Focusing on these mechanosensitive genes will provide new strategies for therapeutic intervention in atherosclerotic vascular disease.Thus,this article reviews the mechanosensitive genes affecting vascular endothelial cells,including classical pathways and some newly screened genes,and summarizes the latest research progress on their roles in the pathogenesis of atherosclerosis to reveal effective therapeutic targets of drugs and provide new insights foranti-atherosclerosis. | Shuyu Li Zichen Xu Yi Wang Lizhao Chen Xiangxiu Wang Yanghao Zhou Daoxi Lei Guangchao Zang Guixue Wang | 2024 | Genes & Diseases2024，11，3： | 0 |
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