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| 1 | Ligand-triggered de-repression of Arabidopsis heterotrimeric G proteins coupled to immune receptor kinases显示文摘 | Xiangxiu Liang Miaomiao Ma ,Zhaoyang Zhou Jinlong Wang Xinru Yang Shaofei Rao Guozhi Bi Lin Li Xiaojuan Zhang Jijie Chai She Chen Jian-Min Zhou | 2018 | Cell Research2018，28，5： | 13 |
| 2 | Structural and temporal dynamics analysis on drug-eluting stents: History, research hotspots and emerging trends显示文摘Purpose:This review aims to explore the history,research hotspots,and emerging trends of drug-eluting stents(DES)in the last two decades from the perspective of structural and temporal dynamics.Methods:Publications on DES were retrieved from WoSCC.The bibliometric tools including CiteSpace and HistCite were used to identify the historical features,the evolution of active topics,and emerging trends on the DES field.Results:In the last 20 years,the field of DES is still in the hot phase and there is a wide range of extensive scientific collaborations.In addition,active topics emerge in different periods,as evidenced by a total of 41 disciplines,511 keywords,and 1377 papers with citation bursts.Keyword clustering anchored five emerging research subfields,namely#0 dual antiplatelet therapy,#3 drug-coated balloon,#4 bifurcation,5#rotational atherectomy,and 6#quantitative flow ratio.The keyword alluvial map shows that the most persistent research concepts in this field are thrombosis,restenosis,etc.,and the emerging keywords are paclitaxel eluting balloon,coated balloon,drug-eluting balloon,etc.There are 7 recent research subfields anchored by reference clustering,namely#2 dual antiplatelet therapy,#4 drug-coated balloon,#5 peripheral artery disease,#8 fractional flow reserve,#10 bioresorbable vascular scaffold,#13 intravascular ultrasound,#14 biodegradable polymer.Conclusion:The findings based on the bibliometric studies provide the current status and trends in DES research and may help researchers to identify hot topics and explore new research directions in this field. | Lili Tan Xiangxiu Wang Kungshan Yuan Tieying Yin Ruolin Du Li Shen Zhirong Zhu Suhua Yu Haijun Zhang Guixue Wang | 2023 | Bioactive Materials2023，，5： | 2 |
| 3 | Targeting cellular senescence prevents glucocorticoid-induced bone loss through modulation of the DPP4-GLP-1 axis显示文摘Dear Editor,Glucocorticoids(GCs)often cause detrimental side effects,including osteoporosis and osteonecrosis,with no specific drugs available to circumvent these problems.1 Cellular senescence plays an essential role in bone loss,2,3 where senescent cells release various factors,termed senescence-associated secretory phenotype(SASP),which influences neighboring cells and disrupts normal tissues.2 Glucocorticoids can induce senescence in bone cells in young mice;2 however,the effects of GCs on senescence and SASP during bone metabolism in adult mice are unclear. | Tiantian Wang Lin Yang Zejun Liang Lin Wang Feijing Su Xiangxiu Wang Xuanhe You Chengqi He | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
| 4 | High efficiency synthesis of octavinylsilsesquioxanes and its high performance hybrids based on bismaleimide‐triazine resin显示文摘 | Jiang‐tao Hu Aijuan Gu Zhijun Jiang Guozheng Liang Dongxian Zhuo Li Yuan Beijing Zhang Xiangxiu Chen | 2011 | Polym Adv Technol2011，，8： | 1 |
| 5 | Flame retarding cyanate ester resin with low curing temperature, high thermal resistance, outstanding dielectric property, and low water absorption for high frequency and high speed printed circuit broads显示文摘 | Chen Xiangxiu Liang Guozheng Gu Aijuan | 2015 | Industrial & Engineering Chemistry Research2015，，6： | 1 |
| 6 | New glass fibre/bismaleimide composites with significantly improved flameretardancy,higher mechanical strength and lower dielectric loss显示文摘 | Chen Xiangxiu Yuan Li Zhang Zhiyong | 2014 | Composites Part B:Engineering2014，71，96： | 1 |
| 7 | Research trends and hotspot topics of exosomes based on citespace bibliometric analysis显示文摘Exosomes are membrane vesicles that exist in pathological or normal cells and are considered to be specifically secreted,contain complex RNAs and proteins,participate in intercellular communication functions,and have functions in organismal immune response,antigen presentation,cell migration,cell differentiation,and tumor invasion.In recent years,with the explosion of the development of minimally invasive diagnostics,the research of exosomes has been rapidly developed,and the number of articles published in this field has increased dramatically,and many articles summarize the published papers in a review-type analysis.In this paper,we use bibliometric analysis combined with theoretical analysis and pathfinding network scaling to visualize data and objectively count the development process,current research,and development trend of the corresponding field by analyzing the literature of the specified field.This paper presents the data visualization by analyzing the literature of the specified field to objectively count the development process,current research and development trend of the corresponding field.This paper presents a retrospective analysis and review of the articles on exosomes in the last 20 years(2001–2021)based on the bibliometric analysis method of CiteSpace software,while presenting the problems of current research and discussing the challenges encountered in the future,hoping to provide new ideas for the development of research in this field. | Qianting Zhang Xiangxiu Wang Lili Tan Yuanfang Hou Daoxi Lei Yin Huang Bin He Guixue Wang | 2022 | Medicine in Novel Technology and Devices2022，，4： | 0 |
| 8 | Particle Size-Controlled Oxygen Reduction and Evolution Reaction Nanocatalysts Regulate Ru(bpy)_(3)^(2+)’s Dual-potential Electrochemiluminescence for Sandwich Immunoassay显示文摘Multiple signal strategies remarkably improve the accuracy and efficiency of electrochemiluminescence(ECL)immunoassays,but the lack of potential-resolved luminophore pairs and chemical cross talk hinders their development.In this study,we synthesized a series of gold nanoparticles(AuNPs)/reduced graphene oxide(Au/rGO)composites as adjustable oxygen reduction reaction and oxygen evolution reaction catalysts to promote and modulate tris(2,2′-bipyridine)ruthenium(II)(Ru(bpy)_(3)^(2+))’s multisignal luminescence.With the increase in the diameter of AuNPs(3 to 30 nm),their ability to promote Ru(bpy)_(3)^(2+)’s anodic ECL was first impaired and then strengthened,and cathodic ECL was first enhanced and then weakened.Au/rGOs with medium-small and medium-large AuNP diameters remarkably increased Ru(bpy)_(3)^(2+)’s cathodic and anodic luminescence,respectively.Notably,the stimulation effects of Au/rGOs were superior to those of most existing Ru(bpy)_(3)^(2+)co-reactants.Moreover,we proposed a novel ratiometric immunosensor construction strategy using Ru(bpy)_(3)^(2+)’s luminescence promoter rather than luminophores as tags of antibodies to achieve signal resolution.This method avoids signal cross talk between luminophores and their respective co-reactants,which achieved a good linear range of 10−7 to 10−1 ng/ml and a limit of detection of 0.33 fg/ml for detecting carcinoembryonic antigen.This study addresses the previous scarcity of the macromolecular co-reactants of Ru(bpy)_(3)^(2+),broadening its application in biomaterial detection.Furthermore,the systematic clarification of the detailed mechanisms for converting the potential-resolved luminescence of Ru(bpy)_(3)^(2+)could facilitate an in-depth understanding of the ECL process and should inspire new designs of Ru(bpy)_(3)^(2+)luminescence enhancers or applications of Au/rGOs to other luminophores.This work removes some impediments to the development of multisignal ECL biodetection systems and provides vitality into their widespread applications. | Shijun Wang Shu Zhu Ziqi Kang Xiangxiu Wang Zixin Deng Kun Hu Jianjun Hu Xiancheng Liu Guixue Wang Guangchao Zang Yuchan Zhang | 2023 | Research2023，，4： | 0 |
| 9 | Regulation of plant responses to biotic and abiotic stress by receptor-like cytoplasmic kinases显示文摘As sessile organisms,plants have to cope with environmental change and numerous biotic and abiotic stress.Upon perceiving environmental cues and stress signals using different types of receptors,plant cells initiate immediate and complicated signaling to regulate cellular processes and respond to stress.Receptor-like cytoplasmic kinases(RLCKs)transduce signals from receptors to cellular components and play roles in diverse biological processes.Recent studies have revealed the hubbing roles of RLCKs in plant responses to biotic stress.Emerging evidence indicates the important regulatory roles of RLCKs in plant responses to abiotic stress,growth,and development.As a pivot of cellular signaling,the activity and stability of RLCKs are dynamically and tightly controlled.Here,we summarize the current understanding of how RLCKs regulate plant responses to biotic and abiotic stress. | Xiangxiu Liang Jie Zhang | 2022 | Stress Biology2022，2，1： | 0 |
| 10 | A pair of G-type lectin receptor-like kinases modulates nlp20-mediated immune responses by coupling to the RLP23 receptor complex显示文摘Plant cells recognize microbial patterns with the plasma-membrane-localized pattern-recognition receptors consisting mainly of receptor kinases(RKs) and receptor-like proteins(RLPs). RKs, such as bacterial flagellin receptor FLS2, and their downstream signaling components have been studied extensively. However, newly discovered regulatory components of RLP-mediated immune signaling, such as the nlp20 receptor RLP23, await identification. Unlike RKs, RLPs lack a cytoplasmic kinase domain, instead recruiting the receptor-like kinases(RLKs) BAK1 and SOBIR1. SOBIR1 specifically works as an adapter for RLP-mediated immunity. To identify new regulators of RLP-mediated signaling, we looked for SOBIR1-binding proteins(SBPs) in Arabidopsis thaliana using protein immunoprecipitation and mass spectrometry,identifying two G-type lectin RLKs, SBP1 and SBP2, that physically interacted with SOBIR1.SBP1 and SBP2 showed high sequence similarity,were tandemly repeated on chromosome 4, and also interacted with both RLP23 and BAK1. sbp1 sbp2 double mutants obtained via CRISPR-Cas9 gene editing showed severely impaired nlp20-induced reactive oxygen species burst, mitogenactivated protein kinase(MAPK) activation, and defense gene expression, but normal flg22-induced immune responses. We showed that SBP1 regulated nlp20-induced immunity in a kinase activityindependent manner. Furthermore, the nlp20-induced the RLP23–BAK1 interaction, although not the flg22-induced FLS2–BAK1 interaction, was significantly reduced in sbp1 sbp2. This study identified SBPs as new regulatory components in RLP23 receptor complex that may specifically modulate RLP23-mediated immunity by positively regulating the interaction between the RLP23 receptor and the BAK1 co-receptor. | Yazhou Bao Yixin Li Qin Chang Rubin Chen Weijie Wang Qian Zhang Shuxian Chen Guangyuan Xu Xiaodan Wang Fuhao Cui Daolong Dou Xiangxiu Liang | 2023 | Journal of Integrative Plant Biology2023，65，5： | 0 |
| 11 | CPR5 positively regulates pattern-triggered immunity via a mediator protein显示文摘Plant cells possess a two-layered immune system consisting of pattern-triggered immunity(PTI)and effector-triggered immunity(ETI), mediated by cell surface pattern-recognition receptors and intracellular nucleotide-binding leucine-rich repeat receptors(NLRs), respectively. The CONSTITUTIVE EXPRESSION OF PR GENES 5(CPR5) nuclear pore complex protein negatively regulates ETI, including ETI-associated hypersensitive response. Here, we show that CPR5 is essential for the activation of various PTI responses in Arabidopsis, such as resistance to the non-adapted bacterium Pseudomonas syringae pv. tomato DC3000 hrc C-. In a forward-genetic screen for suppressors of cpr5, we identified the mediator protein MED4. Mutation of MED4 in cpr5 greatly restored the defective PTI of cpr5. Our findings reveal that CPR5 plays opposite roles in regulating PTI and ETI, and genetically regulates PTI via MED4. | Miaomiao Ma Meng Li Rongfang Zhou Jian-Bin Yu Ying Wu Xiaojuan Zhang Jinlong Wang Jian-Min Zhou Xiangxiu Liang | 2023 | Journal of Integrative Plant Biology2023，65，7： | 0 |
| 12 | Recent advances of mechanosensitive genes in vascular endothelial cells for the formation and treatment of atherosclerosis显示文摘Atherosclerotic cardiovascular disease and its complications are a high-incidence disease worldwide.Numerous studies have shown that blood flow shear has a huge impact on the function of vascular endothelial cells,and it plays an important role in gene regulation of pro-inflammatory,pro-thrombotic,pro-oxidative stress,and cell permeability.Many impor-tant endothelial cell mechanosensitive genes have been discovered,including KLK10,CCN gene family,NRP2,YAP,TAZ,HIF-1α,NF-kB,FOS,JUN,TFEB,KLF2/KLF4,NRF2,and ID1.Some of them have been intensively studied,whereas the relevant regulatory mechanism of other genes remains unclear.Focusing on these mechanosensitive genes will provide new strategies for therapeutic intervention in atherosclerotic vascular disease.Thus,this article reviews the mechanosensitive genes affecting vascular endothelial cells,including classical pathways and some newly screened genes,and summarizes the latest research progress on their roles in the pathogenesis of atherosclerosis to reveal effective therapeutic targets of drugs and provide new insights foranti-atherosclerosis. | Shuyu Li Zichen Xu Yi Wang Lizhao Chen Xiangxiu Wang Yanghao Zhou Daoxi Lei Guangchao Zang Guixue Wang | 2024 | Genes & Diseases2024，11，3： | 0 |
| 13 | The secret of fertilization in flowering plants unveiled显示文摘As recapitulated in the famous Chinese fairy tale Journey to the West,the Buddhist monk Xuanzang of the Tang Dynasty(Tangseng)took a heroic journey in a quest for India Buddhist sacred scriptures.The long and dangerous journey was made possible only with the help of the powerful Monkey King,who had been pinned down under a mountain by the Buddha as a punishment for his prior misdemeanor.The Buddha had to secure the | Xiangxiu Liang Jian-Min Zhou | 2018 | Science Bulletin2018，63，7： | 0 |
| 14 | Transmission Electron Microscopy Investigation of the Ar^+ Ion Irradiation Effect in Semiconductor GaAs显示文摘Room temperature irradiation effect of GaAs compound semiconductor by 100 keV Ar^+ ions hasbeen systematically studied by means of transmission electron microscopy. The dose dependence of the Arcion lrradlatlon and room temperature annealing errects have been Investigated. The experimental results sho’vthat the structure of GaAs transforms from perrect crystalline through weakly snd severely damaged crystalline to amorphous states with the increase of the irradiation dose and the damaged states are changed during room temperature annealing. | Yang Xiangxiu Wang Renhui Yan Heping Zhang Ze | 1998 | Wuhan University Journal of Natural Sciences1998，3，1： | 0 |
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