|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study显示文摘 | Hui-Jia Lin Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Jia-Hua Pan Xiao-Mei Tong Qiu-Ping Li Jian-Guo Zhou Bing Yi Ling Liu Yun-Bing Chen Qiu-Fen Wei Hui-Qing Wu Mei Li Cui-Qing Li Xi-Rong Gao Shi-Wen Xia Wen-Bin Li Chao-Ying Ya Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Wen Li Dong-Mei Chen Hong-Ru Lu Xiao-Hong Liu Hong Liu Zhen-Lang Lin Li Liu Jia-Jun Zhu Hong Xiong Shao-Jie Yue Si-Qi Zhuang | 2015 | Chinese Medical Journal2015，，20： | 49 |
| 2 | Pollution characteristics of organic and elemental carbon in PM_(2.5) in Xiamen,China显示文摘Xiamen,located on the southeastern coastal line of China,is undergoing rapid urbanization and industrialization,so its air quality has a trend of degradation.However,studies on level,temporal and spatial changes of fine particles (PM 2.5) and their carbonaceous fractions are scarce.In this article,abundance,sources,seasonal and spatial variations,distribution of organic carbon (OC) and elemental carbon (EC) in PM 2.5,were studied at suburban,urban and industrial sites in Xiamen during four season-representative months in 2009-2010.PM 2.5 samples were collected with middle volume sampler and were analyzed for OC and EC with thermal optical transmittance (TOT) method.Results showed that the annual average PM 2.5 concentrations were 63.88-74.80 μg/m 3 at three sites.While OC and EC concentrations were in the range of 15.81-19.73 μg/m 3 and 2.74-3.49 μg/m 3,respectively,and clearly presented the summerminima and winter maxima in this study.The carbonaceous aerosol accounted for 42.8%-47.3% of the mass of PM 2.5.The annual average of secondary organic carbon (SOC) concentrations in Xiamen were 9.23-11.36 μg/m 3,accounting for approximately 56% of OC.Strong correlations between OC and EC was found in spring (R 2=0.50) and autumn (R 2=0.73),suggesting that there were similar emission and transport processes for carbonaceous aerosols in these two seasons,while weak correlations were found in summer (R 2=0.33) and winter (R 2=0.41).The OC/EC ratios in PM 2.5 varied from 2.1 to 8.7 with an annual average of 5.7,indicating that vehicle exhaust,coal smoke and biomass burning were main source apportionments of carbonaceous fractions in Xiamen. | Fuwang Zhang Jinping Zhao Jinsheng Chen Ya Xu Lingling Xu | 2011 | Journal of Environmental Sciences2011，23，8： | 27 |
| 3 | Effect of HCV NS_3 protein on P53 protein expression in hepatocarcinogenesis显示文摘NTRODUCTIONHepatocelularcarcinoma(HCC)isoneofthemostcommonhumancancersintheworld.Recently,theHCVinfectionwasfoundtobeanetiolo... | FENG De Yun, CHEN Rui Xue, PENG Yong, ZHENG Hui and YAN Ya Hui | 1999 | World Journal of Gastroenterology1999，5，1： | 25 |
| 4 | The pharmacology, toxicology and therapeutic potential of anthraquinone derivative emodin显示文摘Emodin(1, 3, 8-trihydroxy-6-methylanthraquinone) is a derived anthraquinone compound extracted from roots and barks of pharmaceutical plants, including Rheum palmatum, Aloe vera, Giant knotweed, Polygonum multiflorum and Polygonum cuspidatum. The review aims to provide a scientific summary of emodin in pharmacological activities and toxicity in order to identify the therapeutic potential for its use in human specific organs as a new medicine. Based on the fundamental properties, such as anticancer, anti-inflammatory, antioxidant, antibacterial, antivirs, anti-diabetes, immunosuppressive and osteogenesis promotion, emodin is expected to become an effective preventive and therapeutic drug of cancer, myocardial infarction, atherosclerosis, diabetes, acute pancreatitis, asthma, periodontitis, fatty livers and neurodegenerative diseases. This article intends to provide a novel insight for further development of emodin, hoping to reveal the potential of emodin and necessity of further studies in this field. | CUI Ya CHEN Liu-Jing HUANG Tu YING Jian-Qiong LI Juan | 2020 | Chinese Journal of Natural Medicines2020，18，6： | 23 |
| 5 | Pneumoconiosis: current status and future prospects显示文摘Pneumoconiosis refers to a spectrum of pulmonary diseases caused by inhalation of mineral dust,usually as the result of certain occupations.The main pathological features include chronic pulmonary inflammation and progressive pulmonary fibrosis,which can eventually lead to death caused by respiratory and/or heart failure.Pneumoconiosis is widespread globally,seriously threatening global public health.Its high incidence and mortality lie in improper occupational protection,and in the lack of early diagnostic methods and effective treatments.This article reviews the epidemiology,safeguard procedures,diagnosis,and treatment of pneumoconiosis,and summarizes recent research advances and future research prospects. | Xian-Mei Qi Ya Luo Mei-Yue Song Ying Liu Ting Shu Ying Liu Jun-Ling Pang Jing Wang Chen Wang | 2021 | Chinese Medical Journal2021，，8： | 22 |
| 6 | Transcription analysis of peloric mutants of Phalaenopsis orchids derived from tissue culture显示文摘Tissue culture has been widely used for mass propagation of Phalaenopsis. However, somaclonal variation occurred during micropropagation process posed a severe problem by affecting product quality. In this study, wild type and peloric flower buds of Phalaenopsis hybrids derived from flower stalk nodal culture were used for cDNA-RAPD and cDNA suppression subtractive hybridization analyses in order to study their genetic difference in terms of expressed sequence tags. A total of 209 ESTs from normal flower buds and 230 from mutants were sequenced. These ESTs sequences can be grouped into several functional categories involved in different cellular processes including metabolism, signal transduction, transcription, cell growth and division, protein synthesis, and protein localization, and into a subcat- egory of proteins with unknown function. Cymbidium mosaic virus transcript was surprisingly found expressed fre- quently in the peloric mutant of P. Little Mary. Real-time RT-PCR analysis on selected ESTs showed that in mutant flower buds, a bZIP transcription factor (TGA1a-like protein) was down-regulated, while up-regulated genes include auxin-regulated protein kinase, cyclophilin, and TCP-like genes. A retroelement clone was also preferentially expressed in the peloric mutant flowers. On the other hand, ESTs involved in DNA methylation, chromatin remodeling and post- transcriptional regulation, such as DNA methyltransferase, histone acetyltransferase, ERECTA, and DEAD/DEAH RNA helicase, were enriched in normal flower buds than the mutants. The enriched transcripts in the wild type indicate the down regulation of these transcripts in the mutants, and vice versa. The potential roles of the analyzed transcripts in the development of Phalaenopsis flowers are discussed. | Ya Huei CHEN Yi Jung TSAI Jian Zhi HUANG Fure Chyi CHEN | 2005 | Cell Research2005，15，8： | 21 |
| 7 | Effects of Short-Term Forest Bathing on Human Health in a Broad-Leaved Evergreen Forest in Zhejiang Province,China显示文摘Objective To investigate the effects of short-term forest bathing on human health.Methods Twenty healthy male university students participated as subjects and were randomly divided into two groups of 10.One group was sent on a two-night trip to a broad-leaved evergreen forest,and the other was sent to a city area.Serum cytokine levels reflecting inflammatory and stress response,indicators reflecting oxidative stress,the distribution of leukocyte subsets,and plasma endothelin-1 (ET-1) concentrations were measured before and after the experiment to evaluate the positive health effects of forest environments.A profile of mood states (POMS) evaluation was used to assess changes in mood states.Results No significant differences in the baseline values of the indicators were observed between the two groups before the experiment.Subjects exposed to the forest environment showed reduced oxidative stress and pro-inflammatory level,as evidenced by decreased malondialdehyde,interleukin-6,and tumor necrosis factor α levels compared with the urban group.Serum cortisol levels were also lower than in the urban group.Notably,the concentration of plasma ET-1 was much lower in subjects exposed to the forest environment.The POMS evaluation showed that after exposure to the forest environment,subjects had lower scores in the negative subscales,and the score for vigor was increased.Conclusion Forest bathing is beneficial to human health,perhaps through preventive effects related to several pathological factors. | MAO Gen Xiang LAN Xiao Guang CAO Yong Bao CHEN Zhuo Mei HE Zhi Huat LV Yuan Dong WANG Ya Zhen HU Xi Lian WANG Guo Fu YAN Jing | 2012 | Biomedical and Environmental Sciences2012，25，3： | 20 |
| 8 | The Role of Fibrocyte in the Pathogenesis of Silicosis显示文摘Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells.Fibrocytes can differentiate into myofibroblast.Therefore,the present study was designed to investigate whether | LI Juan YAO Wu HOU Jian Yong ZHANG Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao YU Xing Hao ZHANG Jian Hui QU Ya Qian HAO Chang Fu | 2018 | Biomedical and Environmental Sciences2018，31，4： | 20 |
| 9 | Detection of hepatitis C virus NS5 protein and genome in Chinese carcinoma of the extrahepatic bile duct and its significance显示文摘AIM To investigate the hepatitis C virus(HCV)infection in the tissues of carcinoma ofextrahepatic bile duct and study theircorrelation.METHODS HCV NS5 protein and HCV RNA weredetected by labeled streptavidin biotin(LSAB)method and in situ reverse transcriptionpolymerase chain reaction(IS-RT-PCR)insections of 51 cases of carcinoma ofextrahepatic bile duct and 34 cases of controlgroup(without malignant biliary disease).RESULTS In 51 cases of carcinoma ofextrahepatic bile duct,HCV NS5 protein wasdetected in 14(27.5%),which was clearlystained in the cytoplasm of cancer cell but not inthe nucleus or cell membrane.HCV RNA wasdetected in 18(35.4%),which was located inthe nucleus of cancer cell in 12 cases and in thecytoplasm in 6 cases.HCV NS5 protein and RNAcoexistence was found in 2 cases.In 34 cases ofcontrol group,HCV RNA was detected in 2(5.9%).HCV NS5 protein and RNA positive cellswere found either scattered or in clusters.CONCLUSION The prevalence of hepatitis C viral infection in the tissues of carcinoma ofextrahepatic bile duct was significantly higherthan in control group(X^2=9.808,P=0.002).The findings suggest a correlation between HCVinfection and carcinoma of extrahepatic bileduct,which is different from the traditionalviewpoint.HCV infection might be involved inthe development of carcinoma of extrahepaticbile duct. | Ming Yi Chen Zhi Qiang Huang Le Zhen Chen Ya Bing Gao Rui Yun Peng De Wen Wang | 2000 | World Journal of Gastroenterology2000，6，6： | 19 |
| 10 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 11 | Expression of calreticulin is associated with infiltration of T-cells in stage ⅢB colon cancer显示文摘AIM: To investigate the correlation between expression of calreticulin and infiltration of lymphocytes in stage ⅢB colon cancer. METHODS: Sixty-eight pathologically-confirmed speci-mens were obtained from stage ⅢB (T3N1M0) colon cancer patients who underwent radical resection between January 1999 and May 2002 at the Cancer Center of Sun Yat-Sen University, Guangzhou, China. Immuno-histochemical analysis was performed to show infiltration of lymphocytes and expression of calreticulin in colon cancer. Association between calreticulin expression, infiltration of lymphocytes, and 5-year survival rate of patients was assessed. RESULTS: The expression level of calreticulin was lower in cancer nest than in its adjacent normal epithelium since 61.8% (42/68) of the samples were stained with calreticulin in colon cancer. The expression of calreticulin in colon cancer was associated with the infi ltration of CD45RO+ cells rather than with that of CD3+ cells. In addition, the stronger expression of calreticulin and the higher infiltration of CD3+ and CD45RO+ cells in colon cancer were associated with the higher 5-year survival rate of patients. CONCLUSION: Expression of calreticulin is associated with infiltration of T-cells, which implies that a low expression level of molecular marker may represent a new mechanism underlying immune escape in colon cancer. | Rui-Qing Peng, Ya Ding, Xing Zhang, Yi-Xin Zeng, Xiao- Shi Zhang, State Key Laboratory of Oncology in South China, Biotherapy Center, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Ying-Bo Chen, Zhi-Wei Zhou, State Key Laboratory of Oncology in South China, Department of Gastric and Pancreatic Oncology, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Rong Zhang, State Key Laboratory of Oncology in South China, Department of Endoscopy, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Xing-Juan Yu, Yi-Xin Zeng, State Key Laboratory of Oncology in South China, Department of Experimental Research, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China | 2010 | World Journal of Gastroenterology2010，16，19： | 16 |
| 12 | Hippocampal gene expression in a rat model of depression after electroacupuncture at the Baihui and Yintang acupoints显示文摘Preliminary basic research and clinical findings have demonstrated that electroacupuncture therapy exhibits positive effects in ameliorating depression.However,most studies of the underlying mechanism are at the single gene level;there are few reports regarding the mechanism at the whole-genome level.Using a rat genomic gene-chip,we profiled hippocampal gene expression changes in rats after electroacupuncture therapy.Electroacupuncture therapy alleviated depression-related manifestations in the model rats.Using gene-chip analysis,we demonstrated that electroacupuncture at Baihui(DU20)and Yintang(EX-HN3)regulates the expression of 21genes.Real-time PCR showed that the genes Vgf,Igf2,Tmp32,Loc500373,Hif1a,Folr1,Nmb,and Rtn were upregulated or downregulated in depression and that their expression tended to normalize after electroacupuncture therapy.These results indicate that electroacupuncture at Baihui and Yintang modulates depression by regulating the expression of particular genes. | Dongmei Duan Xiuyan Yang2 Institute of Health Maintenance Beijing University of Chinese Medicine Ya Tu Liping Chen | 2014 | Neural Regeneration Research2014，9，1： | 16 |
| 13 | Physiological mechanisms of resistance to cold stress associated with 10 elite apple rootstocks显示文摘A study was conducted in attempting to identify the cold-resistant apple rootstocks and to establish a comprehensive evaluation system. In this study, 10 elite apple dwarfing rootstocks(GM256, JM7, M26, M7, SC1, SH1, SH38, SH6, M9, and T337) were employed for the experiment and the following parameters were investigated under different low temperature stress conditions(0, –15, –20, –25, –30, and –35°C): the changes of the relative electrical conductivity(REC), anthocyanin content, protein content, soluble sugar content, soluble starch content, proline content, malondialdehyde(MDA) content, superoxide dismutase(SOD) activity, and peroxidase(POD) activity of the dormant branches. The inflection temperature that could represent the plant tissue semi-lethal temperature(LT_(50)) was obtained by the measurements of REC. The LT_(50) was used to evaluate eight other indices. The results showed that there was no significant correlation between LT_(50) and POD activity as well as between the soluble sugar, protein and proline contents at 0 and –15°C. Soluble starch content at 0 and –15°C and anthocyanin content at –15–(–30)°C were significantly but negatively correlated to the LT50 and the MDA content at 0–(–20)°C was significantly positively correlated to the LT_(50). Statistical analysis based on principal component analysis and LT50 showed that cold resistant apple rootstocks in the decreasing order from high to low as GM256, SH6, SH38, SH1, SC1, M26, M7, JM7, T337, and M9. | WANG Yan-xiu HU Ya CHEN Bai-hong ZHU Yan-fang Mohammed Mujitaba Dawuda Sofkova Svetla | 2018 | Journal of Integrative Agriculture2018，17，4： | 15 |
| 14 | Reponses and sensitivities of maize phenology to climate change from 1981 to 2009 in Henan Province, China显示文摘与全球温暖,响应气候变化的庄稼 phenological 移动成为了一个热研究话题。基于长期的观察 agro 气象学的 phenological 数据(1981-2009 ) 和气象学的数据,我们时间、空间的分析的份量上变在玉米物候学和他们的敏感给因素用气候趋势改变的气候调音率和敏感分析方法。结果显示播种朋友显著地被耽搁,延期趋势率是 9.0 d ?????????????????? ┴吗?? | LIU Yujie QIN Ya GE Quansheng DAI Junhu CHEN Qiaomin | 2017 | Journal of Geographical Sciences2017，27，9： | 14 |
| 15 | Evaluating the Nutritional Status of Oncology Patients and Its Association with Quality of Life显示文摘Objective The primary aim of the study was to compare two nutritional status evaluation tools: the Patient-Generated Subjective Global Assessment(PG-SGA) and Nutritional Risk Screening(NRS-2002). Using the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30(EORTC QLQ-C30), the second aim was to provide constructive advice regarding the quality of life of patients with malignancy. Methods This study enrolled 312 oncology patients and assessed their nutritional status and quality of life using the PG-SGA, NRS-2002, and EORTC QLQ-C30. Results The data indicate that 6% of the cancer patients were well nourished. The SGA-A had a higher sensitivity(93.73%) but a poorer specificity(2.30%) than the NRS-2002(69.30% and 25.00%, respectively) after comparison with albumin. There was a low negative correlation and a high similarity between the PG-SGA and NRS-2002 for evaluating nutritional status, and there was a significant difference in the median PG-SGA scores for each of the SGA classifications(P < 0.001). The SGA-C group showed the highest PG-SGA scores and lowest body mass index. The majority of the target population received 2 points for each item in our 11-item questionnaire from the EORTC QLQ-C30. Conclusion The data indicate that the PG-SGA is more useful and suitable for evaluating nutritional status than the NRS-2002. Additionally, early nutrition monitoring can prevent malnutrition and improve the quality of life of cancer patients. | ZHANG Ya Hui XIE Fang Yi CHEN Ya Wen WANG Hai Xia TIAN Wen Xia SUN Wen Guang WU Jing | 2018 | Biomedical and Environmental Sciences2018，31，9： | 14 |
| 16 | Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1显示文摘Ferroptosis is a form of regulated cell death, characterized by excessive membrane lipid peroxidation in an iron-and ROS-dependent manner. Celastrol, a natural bioactive triterpenoid extracted from Tripterygium wilfordii, shows effective anti-fibrotic and anti-inflammatory activities in multiple hepatic diseases. However, the exact molecular mechanisms of action and the direct protein targets of celastrol in the treatment of liver fibrosis remain largely elusive. Here, we discover that celastrol exerts anti-fibrotic effects via promoting the production of reactive oxygen species(ROS) and inducing ferroptosis in activated hepatic stellate cells(HSCs). By using activity-based protein profiling(ABPP) in combination with bio-orthogonal click chemistry reaction and cellular thermal shift assay(CETSA), we show that celastrol directly binds to peroxiredoxins(PRDXs), including PRDX1, PRDX2, PRDX4 and PRDX6,through the active cysteine sites, and inhibits their anti-oxidant activities. Celastrol also targets to heme oxygenase 1(HO-1) and upregulates its expression in activated-HSCs. Knockdown of PRDX1, PRDX2,PRDX4, PRDX6 or HO-1 in HSCs, to varying extent, elevated cellular ROS levels and induced ferroptosis. Taken together, our findings reveal the direct protein targets and molecular mechanisms via which celastrol ameliorates hepatic fibrosis, thus supporting the further development of celastrol as a promising therapeutic agent for liver fibrosis. | Piao Luo Dandan Liu Qian Zhang Fan Yang Yin-Kwan Wong Fei Xia Junzhe Zhang Jiayun Chen Ya Tian Chuanbin Yang Lingyun Dai Han-Ming Shen Jigang Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 14 |
| 17 | New role of microRNA: carcinogenesis and clinical application in cancer显示文摘MicroRNA (miRNA ) 是在长度的 2123 核苷酸的小非编码的 RNA 分子的簇,它在 post-transcriptional 水平控制目标基因的表达式。最近的研究显示了 miRNA 在 carcinogenesis 起一个必要作用,例如影响房间生长,区别, apoptosis,和房间周期。现在,涉及 carcinogenesis 的 miRNA 的多重答应角色正在出现,并且 miRNA 仔细联系到 epithelialmesenchymal 转变(EMT ) 的进程,这被显示出,癌症干细胞(CSC ) 的规定,肿瘤侵略和移植的开发。miRNA 也充当稳定地在浆液表示的 biomarker 并且为各种各样的癌症的分子的目标治疗提供新目标。这评论的目的是在 carcinogenesis 说明 miRNA 的新角色并且在癌症加亮 miRNA 的新前景临床的申请,例如在血清学的诊断和分子目标的治疗学。 | Luqing Zhao Xue Chen Ya Cao | 2011 | Acta Biochimica et Biophysica Sinica2011，43，11： | 13 |
| 18 | Association between Ambient Air Pollution and Outpatient Visits for Acute Bronchitis in a Chinese City显示文摘Objective To investigate the short-term association between outdoor air pollution and outpatient visits for acute bronchitis,which is a rare subject of research in the mainland of China.Methods A time-series analysis was conducted to examine the association of outdoor air pollutants with hospital outpatient visits in Shanghai by using two-year daily data(2010-2011).Results Outdoor air pollution was found to be associated with an increased risk of outpatient visits for acute bronchitis in Shanghai.The effect estimates of air pollutants varied with the lag structures of the concentrations of the pollutants.For lag06,a 10 μg/m3 increase in the concentrations of PM10,SO2,and NO2 corresponded to 0.94%(95% CI:0.83%,1.05%),11.12%(95% CI:10.76%,11.48%),and 4.84%(95% CI:4.49%,5.18%) increases in hospital visits for acute bronchitis,respectively.These associations appeared to be stronger in females(P<0.05).Between-age differences were significant for SO2(P<0.05),and between-season differences were also significant for SO2(P<0.05).Conclusion Our analyses have provided the first evidence that the current air pollution level in China has an effect on acute bronchitis and that the rationale for further limiting air pollution levels in Shanghai should be strengthened. | GUO Li Juan ZHAO Ang CHEN Ren Jie KAN Hai Dong KUANG Xing Ya | 2014 | Biomedical and Environmental Sciences2014，27，11： | 13 |
| 19 | Gene-Gene Interaction of GJB2, SOD2, and CAT on Occupational Noise-induced Hearing Loss in Chinese Han Population显示文摘The effects of genetic factors on the noise-induced hearing loss(NIHL)are still unclear.In the present study,eight single-nucleotide polymorphisms(SNPs)included rs1227049 and rs3802711(CDH23),rs1695(GSTP1),rs137852540(GJB2),rs2289274(PMCA2),rs4880(SOD2),rs7943316,and rs769214 within CAT that might associated with NIHL were further validated | WANG Sheng Li YU Lu Gang LIU Ren Ping ZHU Wan Zhan GAO Wei Min XUE Li Ping JIANG Xu ZHANG Ya Han YI Ding CHEN Dong ZHANG Yong Hong | 2014 | Biomedical and Environmental Sciences2014，27，12： | 12 |
| 20 | Esophageal cancer:Epidemiology,risk factors and screening显示文摘More than 600,000 people are diagnosed with esophageal cancer(EC)every year globally,and the five-year survival rate of EC is less than 20%.Two common histological subtypes of EC,esophageal squamous cell carcinoma(ESCC)and esophageal adenocarcinoma(EAC),have great geographical variations in incidence rates.About half of the world’s EC was diagnosed in China and a majority of which belong to ESCC.Globally,the overall incidence rate of EC is decreasing.In some high-risk Asian regions,such as China,the incidence rate of ESCC has generally declined,potentially due to economic growth and improvement of diet habits.In some European high-income countries and the United States,the decline is mainly attributed to the decrease in smoking and drinking.The risk factors of EC are not well understood,and the importance of environmental and genetic factors in the pathogenesis is also unclear.The incidence and mortality of advanced EC can be reduced through early diagnosis and screening.White light endoscopy is still the gold standard in the current screening technology.This article reviews the epidemiology,risk factors,and screening strategies of EC in recent years to help researchers determine the most effective management strategies to reduce the risk of EC. | Jiang Li Jianguo Xu Yadi Zheng Ya Gao Siyi He He Li Kaiyong Zou Ni Li Jinhui Tian Wanqing Chen Jie He | 2021 | Chinese Journal of Cancer Research2021，33，5： | 12 |
您所在的机构暂未开通此部分的功能，请联系管理员