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| 1 | Long-term trend and abrupt events of the Holocene Asian monsoon inferred from a stalagmiteδ^(18)O record from Shennongjia in Central China显示文摘A high-resolution oxygen-isotope record from a thorium-uranium-dated stalagmite from Shanbao Cave at Shennongjia reflects variations in the amount of monsoon precipitation for the period from 11.5 to 2.1 ka (1 ka = 1000 cal aBP). Between 11.5 and 9.3 ka, a sharp decrease in δ18O indicates a rapid increase in monsoon precipitation. An interval of generally high monsoon precipitation is observed between 9.3 and 4.4 ka. An arid period has prevailed between 4.4 and 2.1 ka. The long-term trend of Shanbao record appears to follow summer insolation at 33°N latitude. An abrupt decrease in monsoon precipitation around 4.3 ka is synchronous with the collapse of Neolithic culture in central China. This abrupt change could have resulted from the amplifi- cation of the gradually decreased summer insolation by the positive vegetation-atmosphere-aerosol feed- back. The weakened Asian monsoon events were in concert with decreased Greenland temperature dur- ing the early Holocene, centered at 8.2, 8.6, 9.3, 10.2 and 11.0 ka. This correlation suggests that changes in low-latitude monsoon are connected with climate change in high-latitude polar region. | SHAO Xiaohua WANG Yongjin CHENG Hai KONG Xinggong WU Jiangying EDWARDS R. Lawrence | 2006 | Chinese Science Bulletin2006，51，2： | 64 |
| 2 | A study on relationship of nitric oxide,oxidation,peroxidation,lipoperoxidation with chronic cholecystitis显示文摘AIM To study relationship of injury induced bynitric oxide,oxidation,peroxidation,lipoperoxidation with chronic cholecystitis.METHODS The values of plasma nitric oxide(P-NO),plasma vitamin C(P-VC),plasma vitamin E(P-VE),plasma β-carotene(P-β-CAR),plasmalipoperoxides(P-LPO),erythrocyte superoxidedismutase(E-SOD),erythrocyte catalase(E-CAT),erythrocyte glutathione peroxidase(E-GSH-Px)activities and erythrocyte lipoperoxides(E-LPO)level in 77 patients with chronic cholecystitisand 80 healthy control subjects were determined,differences of the above average values betweenthe patient group and the control group anddifferences of the average values betweenpreoperative and postoperative patients wereanalyzed and compared,linear regression andcorrelation of the disease course with the abovedetermination values as well as the stepwiseregression and correlation of the course with thevalues were analyzed.RESULTS Compared with the control group,theaverage values of P-NO,P-LPO,E-LPO weresignificantly increased(P<0.01),and of P-VC, P-VE,P-β-CAR,E-SOD,E-CAT and E-GSH-Pxdecreased(P<0.01)in the patient group.Theanalysis of the linear regression and correlationshowed that with prolonging of the course,thevalues of P-NO,P-LPO and E-LPO in the patientswere gradually ascended and the values of P-VC,P-VE,P-β-CAR,E-SOD,E-CAT and E-GSH-Pxdescended(P<0.01).The analysis of thestepwise regression and correlation indicated thatthe correlation of the course with P-NO,P-VE andP-β-CAR values was the closest.Compared withthe preoperative patients,the average values of P-NO,P-LPO and E-LPO were significantlydecreased(P<0.01)and the average values of P-VC,E-SOD,E-CAT and E-GSH-Px in postoperativepatients increased(P<0.01)in postoperativepatients.But there was no significant difference inthe average values of P-VE,P-β-CAR preoperativeand postoperative patients.CONCLUSION Chronic cholecystitis could inducethe increase of nitric oxide,oxidation,peroxidation and lipoperoxidation. | Jun Fu Zhou Dong Cai You Gen Zhu Jin Lu Yang Cheng Hong Peng Yang Hai Yu | 2000 | World Journal of Gastroenterology2000，6，4： | 36 |
| 3 | 南京葫芦洞石笋δ^(13)C对冰期气候的复杂响应与诊断显示文摘文中重建了南京葫芦洞内距今75~10ka期间7支石笋δ13C的时间变化序列,δ13C曲线在重叠时段均具有一致性波动形式.在最后一个冰期/间冰期旋回,δ13C值变化幅度达6‰,反映了C3/C4植被类型变化对δ13C的主控作用.然而,在末次冰期格陵兰冰心记录的DO暖事件时(千年尺度),δ13C与指示降水变化的δ18O呈反相关,主要反映了快速渗水条件下洞穴岩溶水对土壤CO2溶解量的降低.据同期生长石笋δ13C和δ18O对比分析,石笋碳同位素动力分馏程度与生长速率有关.进一步研究发现,本区末次冰消期植被类型变化滞后于降水变化约700年. | 孔兴功 汪永进 吴江滢 Cheng Hai L R Edwards Wang Xianfeng | 2005 | 中国科学(D辑)2005，35，11： | 24 |
| 4 | 广西崇左江州木榄山智人洞古人类遗址及其地质时代显示文摘关于现代智人起源的争论一直是国际古人类学研究的前沿与热点.最近,在广西崇左木榄山智人洞发现了具有现代人解剖特征初始状态的人类下颌骨化石及大量与之共生的哺乳动物化石.木榄山智人洞哺乳动物群以江南象与初现的亚洲象及巨獏等组合为其特征,截然不同于华南早更新世的巨猿动物群和中更新世的大熊猫-剑齿象动物群,是典型亚洲象动物群的早期代表.依动物群性质、地层对比及铀系年代测定木榄山化石智人和伴生的哺乳动物群的时代为距今约11万年的晚更新世早期.该动物群主要由热带-亚热带型动物组成,但木榄山动物群中森林型动物种类单调,草地类型的动物相当多,这表明当时的气候可能比以前干燥.木榄山智人的发现对研究现代人起源及其环境背景具有非常重要的意义. | 金昌柱 潘文石 张颖奇 蔡演军 徐钦琦 唐治路 王頠 王元 刘金毅 秦大公 R.Lawrence Edwards CHENG Hai | 2009 | 科学通报2009，54，19： | 23 |
| 5 | Circulating MicroRNA-145 is Associated with Acute Myocardial Infarction and Heart Failure显示文摘 | Ming Zhang Yun-Jiu Cheng Jaskanwal DS Sara Li-Juan Liu Li-Ping Liu Xin Zhao Hai Gao | 2017 | Chinese Medical Journal2017，，1： | 23 |
| 6 | Modern stalagmite oxygen isotopic composition and its implications of climatic change from a high-elevation cave in the eastern Qinghai-Tibet Plateau over the past 50 years显示文摘An oxygen isotope record of a stalagmite from Huanglong Cave in the eastern Qinghai-Tibet Plateau dated with 230Th and 210Pb methods provides variations of the Asian monsoon with an average resolu-tion of 1 year over the past 50 years. This study shows that the δ18O of dripwater in the cave represents the annual mean δ18O of local meteoric precipitation and the stalagmites were deposited in isotopic equilibrium. A comparison of the stalagmite δ18O record with instrumentally meteorological data indi-cates that shifts of the δ18O are largely controlled by the amount effect of meteoric precipitation con-veyed through the southwest monsoon(the Indian monsoon) and less affected by temperature. Therefore,the variations of δ18O record reflect the changes in monsoon precipitation on inter-annual time scales under the influence of the southwest monsoon. Like many other stalagmite δ18O records in the Asian monsoon regions,the δ18O record of the stalagmite from Huanglong Cave also reveals a gradually enriched trend during the past 50 years,i.e. relatively enriched in 18O. This trend may indicate the decline of the Asian monsoon intensity which is consistent with the decrease of monsoon indices. The weakening of the modern Asian monsoon well matched with the temperature changes in strato-sphere,which may illustrate that the weakening of the monsoon mainly results from the lowering of solar radiation. | YANG XunLin ZHANG PingZhong CHEN FaHu HUH Chih-an LI HongChun CHENG Hai Kathleen R. JOHNSON LIU JingHua AN ChunLei | 2007 | Chinese Science Bulletin2007，52，9： | 20 |
| 7 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 8 | Chinese stalagmite paleoclimate researches: A review and perspective显示文摘Stalagmite is one kind of secondary carbonates formed in limestone caves(speleothem). After cave water droplets containing Ca2+and HCO3 drip onto floor, carbonate in the water might become supersaturated due to CO2 degassing under certain conditions, resulting in the formation of stalagmite in a process year after year. Stalagmite is one of important geological archives for paleoclimate research. The advantages include wide spatial distribution, suitable for U-Th and U-Pb dating, enriched in climate proxies, continuity, long time span, comparability and lower sampling cost etc. These factors have propelled stalagmite paleoclimate research to the forefront of global paleoclimatology with an irreplaceable role. The stalagmite paleoclimate study started in the western countries, mainly in Europe and America in 1960 s–1970 s, while the relevant research in China was progressively developed in the 1980 s–1990 s after the Reform and Opening up. Although there was a huge gap between the overall research level in China and western countries, a solid research foundation, as well as a number of talent teams were established during the period. In the 21 st century, starting from the publication of stalagmite records from Hulu Cave in Nanjing in 2001, the stalagmite paleoclimate research in China has ushered in a flourishing development and a real leap on the basis of international cooperation, resulting in significant international impacts. The landmark achievements, including establishment of the world’s longest(640000 years) East Asian monsoon stalagmite record, as well as the longest Indian monsoon(280000 years),South American monsoon(250000 years), North American westerly climate(330000 years), Central Asian westerly climate(135000 years), and northwestern China westerly climate(500000 years), have laid a milestone in the paleoclimate study in these climate domains. Importantly, these stalagmite records have revealed the relationship of Asian monsoon variations with solar insolation climate change in polar regions, and the South American monsoon changes on orbital-suborbital timescales, which have provided new geological observations for the development of orbital-suborbital climate theory;elaborated coupling and differentiation relationships between the Asian monsoon and the westerly climate;reconstructed the history of Asian monsoon changes in the Holocene in detail, and thus the hydrological and climate variances behind Chinese and Indian civilizationcultural evolutions. Furthermore, a large number of high-resolution stalagmite records over the past 2000 years have been reconstructed, which are important for understanding short-term climate variability and magnitude, events, cycles, and thus the future climate projection. The achievements have also involved the improvements of a number of important techniques, such as U-Th dating method, the establishments of various hydroclimatic proxies, as well as the contributions to the reconstruction of the atmosphere14C variation history over the past ~54000 years. On the perspective of the future, the Chinese stalagmite community should continue to develop key techniques, further clarify the hydroclimatic significance of stalagmite proxies, impel the integration of related disciplines, and concentrate on key scientific issues in global climate change and major social demands. | Hai CHENG Haiwei ZHANG Jingyao ZHAO Hanying LI Youfeng NING Gayatri KATHAYAT | 2019 | Science China Earth Sciences2019，62，10： | 17 |
| 9 | Great flood in the middle-lower Yellow River reaches at 4000 a BP inferred from accurately-dated stalagmite records显示文摘Recently,Wu et al.[1]suggested an earthquake-induced landslide dam outburst flood on the eastern Tibetan Plateau at 1920BCE(3870 a BP,BP denotes year before 1950 CE)caused the Great Flood in the middle-lower Yellow River reaches,and resulted in the founding of Xia Dynasty at 3850 a BP.This age is$150–300younger than the previously estimated age of the Xia Dynasty[2].While the geological evidence of the outburst flood。 | Liangcheng Tan Chuan-Chou Shen Yanjun Cai Hai Cheng R.Lawrence Edwards | 2018 | Science Bulletin2018，63，4： | 16 |
| 10 | 倒数第三次冰消期亚洲季风气候可能的类Younger Dryas事件显示文摘对湖北省神农架两个高海拔洞穴(天鹅洞:海拔1600m;永兴洞:海拔1400m)石笋实测了7个U-Th年龄、560个氧同位素以及年纹层厚度变化序列.天鹅洞石笋十年际分辨率δ18O曲线十分类似于江苏南京和贵州荔波石笋记录的波令暖期和新仙女木事件基本特征,表明本区石笋δ18O反映了区域性亚洲季风经向环流及其降水变化特征.相距天鹅洞约70km的永兴洞石笋高分辨率(平均30a左右)δ18O时间序列揭示了倒数第三次冰消期亚洲季风突变过程.基于3个U-Th年龄和连续5000a左右生长纹层计数结果,在245±5kaBP左右冰消期识别出一个千年级冷事件.这一事件持续时间为1371±59a,并在74±4a内快速向间冰期(MIS7e)突变,δ18O的变幅达2.30‰,相当于冰期/间冰期振幅的1/2强.这些事件特征类似于亚洲季风区石笋δ18O记录的新仙女木事件,说明新仙女木事件不是末次冰消期的一次偶然事件,很可能是第四纪冰盖、大尺度海洋/大气环流耦合作用的产物. | 陈仕涛 汪永进 孔兴功 刘殿兵 Cheng Hai L. R. Edwards | 2006 | 中国科学(D辑)2006，36，5： | 14 |
| 11 | The Homo sapiens Cave hominin site of Mulan Mountain,Jiangzhou District,Chongzuo,Guangxi with emphasis on its age显示文摘One of the most hotly debated and frontal issues in paleoanthropology focuses on the origins of modern humans. Recently, an incomplete hominin mandible with a distinctly weaker mental protuberance than modern human and a great variety of coexisting fossil mammals were unearthed from the Homo sapiens Cave of Mulan Mountain, Chongzuo, Guangxi. The mammalian fauna from the Homo sapiens Cave characterized by the combination of Elephas kiangnanensis, first occurring Elephas maixmus, and Megatapirus augustus, and strikingly different from the Early Pleistocene Gigantopithecus fauna and the Middle Pleistocene Ailuropoda-Stogodon fauna of South China could be regarded as an early representive of the typical Asian elephant fauna. Faunal analysis, biostratigraphic correlation, and, most importantly, U-series dating all consistently support an estimate of ca. 110 ka for the age of the fossil Homo sapiens and coexisting mammalian fauna, that is, the early Late Pleistocene. The fauna is mainly made up of tropical-subtropical elements, but grassland elements have a much greater variety than forest elements, which probably indicates a drier climate at that time. This discovery of early Homo sapiens at the Mulan Mountain will play a significant role in the study of the origin and its environmental background of modern humans. | JIN ChangZhu PAN WenShi ZHANG YingQi CAI YanJun XU QinQi TANG ZhiLu WANG Wei WANG Yuan LIU JinYi QIN DaGong R. Lawrence Edwards CHENG Hai | 2009 | Chinese Science Bulletin2009，54，21： | 13 |
| 12 | Asian summer monsoon precipitation recorded by stalagmite oxygen isotopic composition in the western Loess Plateau during AD1875―2003 and its linkage with ocean-atmosphere system显示文摘Based on 5 high-precision 230Th dates and 103 stable oxygen isotope ratios (δ18O) obtained from the top 16 mm of a stalagmite collected from Wanxiang Cave,Wudu,Gansu,variation of monsoonal precipita-tion in the modern Asian Monsoon (AM) marginal zone over the past 100 years was reconstructed. Comparison of the speleothem δ18O record with instrumental precipitation data at Wudu in the past 50 years indicates a high parallelism between the two curves,suggesting that the speleothem δ18O is a good proxy for the AM strength and associated precipitation,controlled by 'amount effect' of the pre-cipitation. Variation of the monsoonal precipitation during the past 100 years can be divided into three stages,increasing from AD 1875 to 1900,then decreasing from AD 1901 to 1946,and increasing again thereafter. This variation is quite similar to that of the Drought/Flooding index archived from Chinese historical documents. This speleothem-derived AM record shows a close association with the Pacific Decadal Oscillation (PDO) between AD 1875 and 1977,with higher monsoonal precipitation corre-sponding to cold PDO phase and vice versa at decadal timescale. The monsoonal precipitation varia-tion is out of phase with the PDO after AD 1977,probably resulting from the decadal climate jump in the north Pacific occurring at around AD 1976/77. These results demonstrate a strong linkage between the AM and associated precipitation and the Pacific Ocean via ocean/atmosphere interaction. This rela-tionship will aid to forecast future hydrological cycle for the AM monsoon region,and to improve forecasting potential of climatic model with observation data from cave. | LIU JingHua ZHANG PingZhong CHENG Hai CHEN FaHu YANG XunLin ZHANG DeZhong ZHOU Jing JIA JiHong AN ChunLei SANG WenCui Kathleen R. JOHNSON | 2008 | Chinese Science Bulletin2008，53，13： | 13 |
| 13 | Effects of Fuzhenghuayu decoction on collagen synthesis of cultured hepatic stellate cells,hepatocytes and fibroblasts in rats显示文摘INTRODUCTIONLiverfibrosisisthecommonpathologicalfeatureofchronicliverdiseases,andiscloselyasociatedwithchangesoflivercelfunct... | LIU Cheng 1, LIU Ping 1, LIU Cheng Hai 1, ZHU Xiu Qing 1 and JI Guang 1 | 1998 | World Journal of Gastroenterology1998，4，6： | 11 |
| 14 | Comment on 'On linking climate to Chinese dynastic change:Spatial and temporal variations of monsoonal rain'显示文摘An article by Zhang et al. questions the interpretation of our oxygen isotope record from Wanxiang Cave and the sediment titanium record from Lake Huguang Maar,and the possible linkage between climate change and Chinese culture. In response,we explain that their approach lacks logical rigor and their major argument is broadly consistent with,rather than contradictory to our original conclusions. We also note that climate-culture relationships similar to those that we observe in China have been observed for other cultures around the world. | CHENG Hai EDWARDS R Lawrence HAUG Gerald H | 2010 | Chinese Science Bulletin2010，55，32： | 10 |
| 15 | Graph Regularized L_p Smooth Non-negative Matrix Factorization for Data Representation显示文摘This paper proposes a Graph regularized Lpsmooth non-negative matrix factorization(GSNMF) method by incorporating graph regularization and L_p smoothing constraint, which considers the intrinsic geometric information of a data set and produces smooth and stable solutions. The main contributions are as follows: first, graph regularization is added into NMF to discover the hidden semantics and simultaneously respect the intrinsic geometric structure information of a data set. Second,the Lpsmoothing constraint is incorporated into NMF to combine the merits of isotropic(L_2-norm) and anisotropic(L_1-norm)diffusion smoothing, and produces a smooth and more accurate solution to the optimization problem. Finally, the update rules and proof of convergence of GSNMF are given. Experiments on several data sets show that the proposed method outperforms related state-of-the-art methods. | Chengcai Leng Hai Zhang Guorong Cai Irene Cheng Anup Basu | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，2： | 9 |
| 16 | The record of paleoclimatic change from stalagmites and the determination of termination II in the south of Guizhou Province, China显示文摘A high-resolution climate record from 163.00 kaBP to 113.80 kaBP has been obtained through TIMS-U series dating and carbon and oxygen isotope analysis of the three large stalagmites from two caves in the south of Guizhou Province, China. The record of the oxygen isotopes from the stalagmites reveals that the undulation characteristics between the cooling event of the glacial period and the warming event of the interglacial period in the research area can compare well to those of ice cores, lake sediments, loess and deep sea sediments on the scale of ten-thousand years or millennium time scale. The climate undulation provided by the record of the stalagmites has a coherence with the global changes and a tele-connection to the paleoclimate changes in the north polar region. Our results suggest that the direct dynamics of paleo-monsoon circulation changes reflected in the record of the stalagmites might be caused by changes of the global ice volume, and in turn related to various factors, including the solar radiation strength at the mid-latitudes in the Northern Hemisphere, the southern extension of the ice-rafted event in the North Atlantic, and changes of the equatorial Pacific sea surface temperature at the low-latitudes. Using δ18O values, we have calculated the temperatures and the results show that the temperature difference between the penultimate glacial period (with an average temperature of 8.1℃, and a minimum temperature range from 0.65℃ to -1.43℃ at stage 6 ) and the last interglacial period (with an average temperature of 18.24℃ at sub-stage 5e ) was about 10℃. This temperature difference from the record of the stalagmites corresponds in general to the record temperature variation (about 10℃) of measured ice cores. The climate records from the three stalagmites in the two caves have shown that the circulation strength of the Asian summer monsoon and the winter monsoon in the penultimate glacial period and the last interglacial period had a clear change. With the TIMS-U series method, termination II of the penultimate glacial period has been precisely dated at an age of (129.28±1.10) kaBP for the three stalagmites in the south of Guizhou Province, China. This borderline age represents the beginning of the last interglacial period or the boundary between the Middle Pleistocene and the Late Pleistocene, and corresponds to the beginning age of the last interglacial period shown by the ice cores and in the SPECMAP curve of the marine oxygen isotopes. The chronology determination of termination II is not only of stratigraphic and chronological significance, but also lays an important foundation for discussing the short time scales of climate oscillation and rapidly changing events of paleoclimate in the circulation region of the East Asian monsoon. | ZHANG Meiliang, YUAN Daoxian1, LIN Yushi, CHENG Hai, QIN Jiaming &ZHANG HuilingKarst Dynamics Laboratory, Institute of Karst Geology, Chinese Academy of Geological Sciences, Guilin 541004, China Geography Department, Minnesota University, MN 55455, USA Correspondence should be addressed to Zhang Meiliang | 2004 | Science China Earth Sciences2004，47，1： | 9 |
| 17 | Abrupt climate change of EastAsian Monsoon at 130 kaBP inferred from a high resolu-tion stalagmite δ^(18)O record显示文摘230Th ages and oxygen isotope data of a stalagmite from Shanbao Cave in Hubei Province characterize thEast Asian Monsoon precipitation from 133 to127 ka. Thdecadal-scale high-resolution δ18O record reveals a detailedtransitional process from the Penultimate Glaciation to thLast Interglaciation. As established with 230Th dates, the agof the Termination II is determined to be 129.5±1.0 kaBPwhich supports the Northern Hemisphere insolation as thtriggers for the ice-age cycles. In our δ18O record, the glacialinterglacial fluctuation reaches about 4‰, almost the samlevel as in other Asian Monsoon cave stalagmite δ18O recordThe transition of the glacial/interglacial period in our recordcan be recognized as four stepwise stages, among which, arapid rise of monsoon precipitation follows the stage o“Termination II pause”. The rapid rise is synchronous withthe abrupt change of global methane concentration, whichreflects that an increase in both Asian Monsoon precipitationand tropical wetland plays an important role in the globaclimate changes. | JIANG Xiuyang WANG Yongjin KONG Xinggong WU Jiangying SHAO Xiaohua XIA Zhifeng CHENG Hai | 2005 | Chinese Science Bulletin2005，50，23： | 9 |
| 18 | Over-expression of LPTS-Lin hepatocellular carcinoma cell line SMMC-7721 induces crisis显示文摘AIM: To evaluate the function of the longer transcripts LPTS-Lin hepatocellular carcinoma cell line SMMC-7721.METHODS: SMMC-7721 cells were transfected with LPTSL expression construct and stably transfected cells were selected by G418. Multiple single clones formed and were checked for their phenotype. In the study of the effect on telomerase activity of LPTS-Lin vitro, GST-LPTS-L fusion protein was expressed in E.coli and purified by glutathioneagarose column. Telomeric repeat amplification protocol (TRAP) assays were performed to study the influence of telomerase activity in SMMC-7721 cells.RESULTS: Over-expression of LPTS-L induced SMMC-7721 cells into crisis. LPTS-L could inhibit the telomerase activity in SMMC-7721 cellsin vitro.CONCLUSION: LPTS-L is a potent telomeraseinhibitor. Over-expression of LPTS-L can induce hepatoma cells into crisis due to the reduction of telomerase activity. | Cheng Liao Mu-Jun Zhao Jing Zhao Di Jia Hai Song Zai-Ping Li,State Key Laboratory of Molecular Biology,Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China | 2002 | World Journal of Gastroenterology2002，8，6： | 9 |
| 19 | Synthesis and characterization of quaternized poly(phthalazinone ether sulfone ketone)for anion-exchange membrane显示文摘(phthalazinone 醚 sulfone 酉同类)(CMPPESK ) Chloromethylated poly 被准备从(phthalazinone 醚 sulfone 酉同类)(PPESK ) poly 与更低的毒性把 chloromethyl 辛基醚(CMOE ) 用作 chloromethylated 总督。CMPPESK 是可溶的在 N-methyl-2-pyrrolidone (NMP ) , N, N-dimethylacetamide (DMAc ) 和氯仿。(phthalazinone 醚 sulfone 酉同类)(QAPPESK ) Quaternized 被 quaternization poly 从 CMPPESK 准备。QAPPESK 有优秀溶剂抵抗,它在硫磺的酸(98%) 仅仅是部分可溶的并且在 N 肿, N-dimethylformamide (DMF ) 。用 QAPPESK 阴离子交换膜的钒氧化还原作用流动电池(V-RFB ) 最好有 88.3% 全面精力效率的性能。 | Xi Gao Jian Chun Yan Hua Min Zhang Shou Hai Zhang Cheng Liu Ping Zhao | 2007 | Chinese Chemical Letters2007，18，10： | 9 |
| 20 | Mechanism of exogenous nucleic acids and their precursors improving the repair of intestinal epithelium after 7-irradiation in mice显示文摘AIM To clone expressed genes associated withrepair of irradiation-damaged mice intestinalgland cells treated by small intestinal RNA,andto explore the molecular mechanism ofexogenous nucleic acids improving repair ofintestinal crypt.METHODS The animal mode of test group andcontrol group was established,forty-five micebeing irradiated by γ ray were treated with smallintestinal RNA as test group,forty mice beingirradiated by γ ray were treated withphysiological saline as control group,five micewithout irradiation were used as normal control,their jejunal specimens were collectedrespectively at 6h,12h,24h,4d and 8d afterirradiation.Then by using LD-PCR based onsubtractive hybridization,these gene fragmentsdifferentially expressed between test group andcontrol group were obtained,and then werecloned into T vectors as well as beingsequenced.Obtained sequences were screenedagainst.GeneBank,if being new sequences,they were submitted to GeneBank.RESULTS Ninety clones were associated withrepair of irradiation-damaged intestinal glandcells treated by intestinal RNA.These clonesfrom test group of 6h,12h,24h,4d and 8dwere respectively 18,22,25,13,12.By screening against GeneBank,18 of which werenew sequences,the others were dramaticallysimilar to the known sequences,mainly similarto hsp,Nmi,Dutt1,alkaline phosphatase,homeobox,anti-CEA ScFv antibody,arginine/serine kinase and BMP-4,repA.Eighteen genefragments were new sequences,their acceptnumbers in GeneBank were respectivelyAF240164-AF240181.CONCLUSION Ninety clones were obtained tobe associated with repair of irradiation-damagedmice intestinal gland cells treated by smallintestinal RNA,which may be related toabnormal expression of genes and matchedproteins of hsp,Nmi,Duttl,Na,K-ATPase,alkalineph-osphatase,glkA,single strandedreplicative centromeric gene as well as 18 newsequences. | Da Xiang Cui~1 Guei Ying Zeng~2 Feng Wang~1 Jun Rong Xu~1 Dong Qing Ren~2 Yan Hai Guo~1 Fu Rong Tian~2 Xiao Jun Yan~1 Yu Hou~1 Cheng Zhi Su~1 1 Institute of Genetic Diagnosis of the Fourth Military Medical University,Xi’an 710032,China 2 Department of Irradiation Medicine of the Fourth Military Medical University,Xi’an 710032,China | 2000 | World Journal of Gastroenterology2000，6，5： | 8 |
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