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| 1 | Lake eutrophication and its ecosystem response显示文摘China is a country with many lakes,about one-third of which are freshwater mainly distributed in the middle and lower reaches of the Yangtze River.Currently most of the lakes are mesotrophic or eutrophic.Lake eutrophication has become one of the major ecological and environmental problems faced by lakes in China and can lead to a series of abnormal ecosystem responses,including extinction of submerged plants,frequent occurrence of cyanobacterial blooms,increased microbial biomass and productivity,decreased biodiversity,accelerated cycles,and a change in the efficient use of nutrients.With development of eutrophication,the whole lake ecosystem suffers decreased biodiversity,simplification of biotic community structure,instability of the ecosystem,and ultimately the clear-water,macrophyte-dominated ecosystem gradually shifts to a turbid-water,algae-dominated ecosystem.This ecosystem succession mechanism is speculated to be caused by different nutrient utilization efficiencies of macrophytes and phytoplankton.The ultimate ecosystem succession trend of seriously eutrophic lakes is that a phytoplankton-dominated autotrophic lake shifts to a heterotrophic lake dominated by micro-organisms,protozoans. | QIN BoQiang GAO Guang ZHU GuangWei ZHANG YunLin SONG YuZhi TANG XiangMing XU Hai DENG JianMing | 2013 | Chinese Science Bulletin2013，58，9： | 63 |
| 2 | Identification and genetic mapping of four novel genes that regulate leaf development in Arabidopsis显示文摘Molecular and genetic characterizations of mutants have led to a better understanding of many developmental processes in the model system Arabidopsis thaliana. However, the leaf development that is specific to plants has been little studied. With the aim of contributing to the genetic dissection of leaf development, we have performed a large-scare screening for mutants with abnormal leaves. Among a great number of leaf mutants we have generated by T-DNA and transposon tagging and ethylmethae sulfonate (EMS) mutagenesis, four independent mutant lines have been identified and studied genetically. Phenotypes of these mutant lines represent the defects of four novel nuclear genes designated LL1 (LOTUS LEAF 1), LL2 (LOTUS LEAF 2), URO (UPRIGHT ROSETTE), and EIL (ENVIRONT CONDITION INDUCED LESION). The phenotypic analysis indicates that these genes play important roles during leaf development. FOr the further genetic analysis of these genes and the map-based cloning of LL1 and LL2, we have mapped these genes to chromosome regions with an efficient and rapid mapping method. | SUN YUE WEI ZHANG FENG LING LI YING LI GUO TIAN LEI LIU HAI HUANG | 2000 | Cell Research2000，10，4： | 53 |
| 3 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 4 | Why Lake Taihu continues to be plagued with cyanobacterial blooms through 10 years(2007–2017) efforts显示文摘With the expansion of urban, industry, and agriculture after World War II, eutrophication firstly emerged as a major water quality threat in small water bodies [1]. As the increasing magnitudes and scales of nutrient pollution and habitat alteration, many of the world's large lakes exhibit symptoms of eutrophication, e.g., toxic cyanobacterial blooms, deoxygenation, and habitat loss. | Boqiang Qin Hans W.Paerl Justin D.Brookes Jianguo Liu Erik Jeppesen Guangwei Zhu Yunlin Zhang Hai Xu Kun Shi Jianming Deng | 2019 | Science Bulletin2019，64，6： | 50 |
| 5 | Buyang Huanwu decoction increases angiopoietin-1 expression and promotes angiogenesis and functional outcome after focal cerebral ischemia显示文摘 | Jian SHEN Yu ZHU Hai YU Zuo-xu FAN Feng XIAO Pan WU Qi-hui ZHANG Xiao-xing XIONG Jian-wei PAN Ren-ya ZHAN | 2014 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2014，15，3： | 36 |
| 6 | Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells显示文摘Spermatogonial 干细胞(SSC ) 能在移植以后生产众多的男配偶子进接受者睾丸,介绍为基因治疗和修改基因的动物的连续生产的一条珍贵途径。然而, SSC 的成功的基因操作被限制了,部分由于复杂性和当前可得到的基因编辑技术的低效率。这里,我们证明有效基因修正能用 CRISPR-Cas9 系统被介绍进 SSC。我们使用了 CRISPR-Cas9 系统变异在 SCC 的 EGFP transgene 或内长的 Crygc 基因。变异的 SSC 在移植以后经历了精子发生进不肥沃的老鼠睾丸的生精的小管。圆 spermatids 被产生并且在进成熟卵母细胞的注射以后,支持了显示相应变异的显型的异质接合的后代的生产。而且,在 Crygc 的一个引起疾病的变化(在 SSC 先存在的 Crygc −/−) 能乐意地到加入的 CRISPR-Cas9-induced nonhomologous 结束(NHEJ ) 或指导相同的修理(HDR ) 被修理,导致没有是的离开目标修正的证据带改正的基因的 SSC 线由整个染色体的定序出现。用从这些线产生的圆 spermatids 的授精在 100% 的效率与改正的显型产生了后代。我们的结果表明有效基因由 CRISPR-Cas9 系统在老鼠 SSC 编辑,并且提供在 SSC 经由基因修正治好基因疾病的原则的证明。 | Yuxuan Wu Hai Zhou Xiaoying Fan Ying Zhang Man Zhang Yinghua Wang Zhenfei Xie Meizhu Bai Qi Yin Dan Liang Wei Tang Jiaoyang Liao Chikai Zhou Wujuan Liu Ping Zhu Hongshan Guo Hong Pan Chunlian Wu Huijuan Shi Ligang Wu Fuchou Tang Jinsong Li | 2015 | Cell Research2015，25，1： | 37 |
| 7 | Strategies of minimally invasive treatment for intrahepatic and extrahepatic bile duct stones显示文摘 | Zongming Zhang Zhuo Liu Limin Liu Mengmeng Song Chong Zhang Hongwei Yu Baijiang Wan Mingwen Zhu Zixu Liu Hai Deng Haiming Yuan Haiyan Yang Wenping Wei Yue Zhao | 2017 | Frontiers of Medicine2017，11，4： | 37 |
| 8 | L_(1/2) regularization显示文摘In this paper we propose an L1 /2 regularizer which has a nonconvex penalty.The L 1/2 regularizer is shown to have many promising properties such as unbiasedness, sparsity and oracle properties.A reweighed iterative algorithm is proposed so that the solution of the L 1/2 regularizer can be solved through transforming it into the solution of a series of L 1 regularizers.The solution of the L 1/2 regularizer is more sparse than that of the L 1 regularizer, while solving the L 1/2 regularizer is much simpler than solving the L 0 regularizer.The experiments show that the L 1/2 regularizer is very useful and efficient, and can be taken as a representative of the Lp(0 < p < 1) regularizer. | XU ZongBen ZHANG Hai WANG Yao CHANG XiangYu LIANG Yong | 2010 | Science China(Information Sciences)2010，53，6： | 32 |
| 9 | Representative of L1/2 Regularization among Lq (0 〈 q ≤ 1) Regularizations: an Experimental Study Based on Phase Diagram显示文摘 | XU Zong-Ben GUO Hai-Liang WANG Yao ZHANG Hai | 2012 | 自动化学报2012，38，7： | 34 |
| 10 | Diver CE versus Guardwire Plus for thrombectomy in patients with inferior myocardial infarction:a trial of aspiration of thrombus during primary angioplasty for inferior myocardial infarction显示文摘背景不同可行、安全的 thrombectomy 和远侧的保护设备用 Diver CE 设备在临床的 practice.The 效率和附属物 thrombectomy 的安全被使用了( Invatec ,意大利 )对 Guardwire 正设备( Medtronic ,美国)在经皮的冠的干预(一种总线标准)与尖锐劣等的 ST-segment-elevation 心肌的梗塞( STEMI )在病人被作比较不到 12 个小时以前,在心肌的梗塞( TIMI )的 thrombolysis 流动分级 0~1 ,并且总计吸藏第二等的结束点被让结束心脏舒张的体积( LVEDV )室,左室喷射部分( LVEF )和包括死亡的主要不利心脏的事件(权标),心肌的梗塞,在 122 个病人的 30 days.Results A 总数的目标容器 revascularization 和击同等地被划分成 Diver CE 组和 Guardwire 正组,它到年龄是可比较的(( 60 ?????????汣灯摩杯敲????朠潲灵?潃据畬楳湯??湡獵? | YAN Hong-bing WANG Jian LI Nan ZHU Xiao-ling GAO Hai AI Hui LI Xiang YE Ming CHI Yun-peng ZHANG Hong | 2007 | Chinese Medical Journal2007，，7： | 29 |
| 11 | An atomic force microscopy study of coal nanopore structure显示文摘Coal nanopore structure is an important factor in understanding the storage and migration of absorbed gas in coal. A new method for studying coal nanopore structures is proposed. This idea is based on the nano-level resolution of atomic force microscopy, which can be employed to observe the structural features of coal nanopores clearly, conduct quantitative three-dimensional measurements and obtain structural parameters. Analysis results show that coal nanopores are mainly metamorphic pores and intermolecular pores. The metamorphic pores are commonly rounded and elliptical, increasing quantitatively with the coalification degree. The forms of intermolecular pores change markedly. The average pore size of low-rank coal is bigger than high-rank coal, and the number of intermolecular pores decreases as the coal rank increases. Section analysis effectively characterizes the coal pore microstructure, bearing analysis is a vital approach to measure microporosity, and grain analysis can be employed to study the pore size distribution. Atomic force microscopy is a tool for the in-depth research of coal pore microstructure and the coal-bed methane adsorption mechanism. | YAO SuPing JIAO Kun ZHANG Ke HU WenXuan DING Hai LI MiaoChun PEI WenMing | 2011 | Chinese Science Bulletin2011，56，25： | 30 |
| 12 | Outbreak of Dengue Fever in Central China,2013显示文摘In 2013,the first dengue fever(DF) outbreak in central China was reported in the central of Henan province,northern temperate regions,although they have been sequentially recorded in Southern China.106 suspected DF cases were reported and 73 patients were confirmed dengue virus type 3(DEN-3) infections.62/392(15.8%) local health persons showed DEN antibodies positive.To this day Henan is the northernmost province in China which has been reported about outbreak of DF and what is important is that it warns us the endemic range of DF has been expanded geographically in China. | HUANG Xue Yong MA Hong Xia WANG Hai Feng DU Yan Hua SU Jia LI Xing Le TANG Xiao Yan MA Hong Peng ZU Bing Can ZHANG Qiao Hong CHEN Hao Min XU Bian Li | 2014 | Biomedical and Environmental Sciences2014，27，11： | 30 |
| 13 | Shenfu Injection(参附注射液) Inhibits Inflammation in Patients with Acute Myocardial Infarction Complicated by Cardiac Shock显示文摘Objectives: To investigate the effect of Shenfu Injection(参附注射液, SFI) on inflammatory factors in patients with acute myocardial infarction complicated by cardiogenic shock(CS) treated with and intra-aortic balloon pump(IABP). Methods: This study enrolled 60 patients with ST-segment elevation myocardial infarction(STEMI) complicated by CS. Patients underwent IABP and emergency percutaneous coronary intervention(PCI) were randomly divided into two groups by random number table with 30 cases in each group, one given SFI treatment(100 m L/24 h), one not. The two groups were then compared in a clinical setting for left ventricular function, biochemical indicators and Inflammatory factors, including C-reactive proteins(CRP), interleukin-1(IL-1) and tumor necrosis factor alpha(TNF-α). Major adverse cardiac and cerebrovascular events(MACCE) events were compared between patients of the two groups both in-hospital and in follow-ups. Results: The IABP support treatment times of patients in the IABP+SFI group were significantly shorter than the IABP group(52.87±28.84 vs. 87.45±87.31, P=0.047). In the patients of the IABP+SFI group, the CRP peak appeared in 24 h after PCI operation. The CRP peak in the patients of the IABP+SFI group was significantly lower than that in the IABP group(31.27±3.93 vs. 34.62±3.47, P=0.001). The increases in range of TNF-α in the patients of the IABP+SFI group were significantly lower than those of the IABP group(182.29±22.79 vs. 195.54±12.02, P=0.007). The increases in range of IL-1 in the patients of the IABP+SFI group were significantly lower than those of the IABP group(214.98±29.22 vs. 228.60±7.03, P=0.019). The amplitude elevated TNF-α 72 h after admission was an independent risk factor of in-hospital MACCE events(OR 0.973, 95% CI 0.890–0.987, P=0.014) in patients with STEMI and CS. Conclusion: Patients with STEMI complicated by CS treated by IABP and SFI had a reduced inflammatory reaction, a reduced dependence of CS on IABP and shortened the course of disease. | JIN Yan-yan GAO Hai ZHANG Xin-yong AI Hui ZHU Xiao-lin WANG Jing | 2017 | Chinese Journal of Integrative Medicine2017，23，3： | 27 |
| 14 | Circulating MicroRNA-145 is Associated with Acute Myocardial Infarction and Heart Failure显示文摘 | Ming Zhang Yun-Jiu Cheng Jaskanwal DS Sara Li-Juan Liu Li-Ping Liu Xin Zhao Hai Gao | 2017 | Chinese Medical Journal2017，，1： | 23 |
| 15 | Climate and litter C/N ratio constrain soil organic carbon accumulation显示文摘Soil organic carbon(SOC) plays critical roles in stabilizing atmospheric CO2 concentration, but the mechanistic controls on the amount and distribution of SOC on global scales are not well understood. In turn, this has hampered the ability to model global C budgets and to find measures to mitigate climate change. Here, based on the data from a large field survey campaign with 2600 plots across China’s forest ecosystems and a global collection of published data from forested land, we find that a low litter carbon-to-nitrogen ratio(C/N) and high wetness index(P/PET, precipitation-to-potentialevapotranspiration ratio) are the two factors that promote SOC accumulation, with only minor contributions of litter quantity and soil texture. The field survey data demonstrated that high plant diversity decreased litter C/N and thus indirectly promoted SOC accumulation by increasing the litter quality. We conclude that any changes in plant-community composition, plant-species richness and environmental factors that can reduce the litter C/N ratio, or climatic changes that increase wetness index, may promote SOC accumulation. The study provides a guideline for modeling the carbon cycle of various ecosystem scales and formulates the principle for land-based actions for mitigating the rising atmospheric CO2 concentration. | Guoyi Zhou Shan Xu Philippe Ciais Stefano Manzoni Jingyun Fang Guirui Yu Xuli Tang Ping Zhou Wantong Wang Junhua Yan Gengxu Wang Keping Ma Shenggong Li Sheng Du Shijie Han Youxin Ma Deqiang Zhang Juxiu Liu Shizhong Liu Guowei Chu Qianmei Zhang Yuelin Li Wenjuan Huang Hai Ren Xiankai Lu Xiuzhi Chen | 2019 | National Science Review2019，6，4： | 21 |
| 16 | Modern stalagmite oxygen isotopic composition and its implications of climatic change from a high-elevation cave in the eastern Qinghai-Tibet Plateau over the past 50 years显示文摘An oxygen isotope record of a stalagmite from Huanglong Cave in the eastern Qinghai-Tibet Plateau dated with 230Th and 210Pb methods provides variations of the Asian monsoon with an average resolu-tion of 1 year over the past 50 years. This study shows that the δ18O of dripwater in the cave represents the annual mean δ18O of local meteoric precipitation and the stalagmites were deposited in isotopic equilibrium. A comparison of the stalagmite δ18O record with instrumentally meteorological data indi-cates that shifts of the δ18O are largely controlled by the amount effect of meteoric precipitation con-veyed through the southwest monsoon(the Indian monsoon) and less affected by temperature. Therefore,the variations of δ18O record reflect the changes in monsoon precipitation on inter-annual time scales under the influence of the southwest monsoon. Like many other stalagmite δ18O records in the Asian monsoon regions,the δ18O record of the stalagmite from Huanglong Cave also reveals a gradually enriched trend during the past 50 years,i.e. relatively enriched in 18O. This trend may indicate the decline of the Asian monsoon intensity which is consistent with the decrease of monsoon indices. The weakening of the modern Asian monsoon well matched with the temperature changes in strato-sphere,which may illustrate that the weakening of the monsoon mainly results from the lowering of solar radiation. | YANG XunLin ZHANG PingZhong CHEN FaHu HUH Chih-an LI HongChun CHENG Hai Kathleen R. JOHNSON LIU JingHua AN ChunLei | 2007 | Chinese Science Bulletin2007，52，9： | 20 |
| 17 | Experimental study on the angle of repose of pulverized coal显示文摘An experimental study on the angle of repose(AoR)of pulverized coal with different particle sizes and different moisture contents(MC)was conducted.Three different measurement methods,free-base piling,fixed-base piling and sliding,were used.The data were analyzed by one-way and two-way analysis of variance.The results showed that the AoRs of pulverized coal with particle sizes smaller than 150 m were in the range of 30-50°.The characterization of the flowability of pulverized coal was some cohesiveness or true cohesiveness.The increase of MC will increase AoR and thus decrease the flowability of the powder.However,the particle size effect is bifurcated.Below a critical size,the decrease of particle size decreases the flowability;while above the critical size,the decrease of particle size increases the flowability.It was found that the value of the critical size strongly depends on the powder density.Moreover,the AoR dependence on particle size could be linked with the Geldart's particle classification.The critical size at the turning point is on the boundary between Group A and Group B in Geldart's classification diagram.Based on the experimental results,there is no significant cross interaction between particle size and MC.The AoRs measured by free-base method and fixed-base method are close,but both remarkably smaller than that measured by the sliding method. | Wei Wang Jiansheng Zhang Shi Yang Hai Zhang Hairui Yang Guangxi Yue | 2010 | Particuology2010，8，5： | 20 |
| 18 | Serum vascular endothelial growth factor is a potential biomarker of metastatic recurrence after curative resection of hepatocellular carcinoma显示文摘INTRODUCTIONHepatocellular carcinoma(HCC)is one of the mostcommon malignancies in China.To date,surgery is stillthe best solution to it.However,metastatic recurrencesafter curative hepatic resections are very common.Tang etal have reported that recurrence rate within 5 years | Qi Niu Zhao You Tang Zeng Chen Ma Lun Xiu Qin Lian Hai Zhang | 2000 | World Journal of Gastroenterology2000，6，4： | 20 |
| 19 | Advances in the reintroduction of rare and endangered wild plant species显示文摘Human disturbance and climate change have increased the risk of extinction for rare and endangered wild plant species.One effective way to conserve these rare and endangered species is through reintroduction.In this review,we summarize the advances in wild plant reintroduction from five perspectives:the establishment of reintroduction biology as an important tool for biodiversity conservation;the importance of genetic diversity in reintroduction;reintroduction under global climate change;recruitment limitation in reintroduction;and reintroduction and ecological restoration.In addition,we consider the future of plant reintroduction strategies. | REN Hai JIAN ShuGuang LIU HongXiao ZHANG QianMei LU HongFang | 2014 | Science China(Life Sciences)2014，57，6： | 20 |
| 20 | The efficacy and safety of weekly 35-mg risedronate dosing regimen for Chinese postmenopausal women with osteoporosis or osteopenia: 1-year data显示文摘目的: 当每周,每天管理了时,口头的 risedronate 在绝经后的骨质疏松症的处理是有效的。在这 1 年,使随机化,双窗帘,我们比较了的 multicenter 学习在有骨质疏松症或 osteopenia 的中国绝经后的女人的处理的每周的 35-mg 和每日的 5-mg risedronate dosing 政体。 | Jie-mei GU Li WANG Hua LIN De-cai CHEN Hai TANG Xiao-lan JIN Wei-bo XIA Yun-qiu HU Wen-zhen FU Jin-wei HE Hao ZHANG Chun WANG Hua YUE Wei-wei HU Yu-juan LIU Zhen-lin ZHANG | 2015 | Acta Pharmacologica Sinica2015，36，7： | 19 |
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