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| 1 | Surface characterization of steel/steel contact lubricated by PA06 with novel black phosphorus nanocomposites显示文摘In the present work,two types of novel nano additives,titanium sulfonate ligand/black phosphorus(TiLi/BP)and titanium dioxide/black phosphorus(TiCVBP)nanocomposites,were prepared.The tribological behavior of the steel/steel friction pairs lubricated by polyalphaolefins type 6(PA06)containing the nanocomposites under boundary lubrication was studied.The worn surfaces were analyzed using modem surface techniques.The experimental results show that the rubbed surfaces became smooth and showed little wear with the addition of the nanocomposites.TiO_(2)/BP nanocomposites can significantly improve the lubricity of BP nanosheets under high contact stress.The synergistic roles of the load-bearing abilities and rolling effect of TiO_(2) nanoparticles,the slip induced by the BP with its layered structure,and the establishment of a tribofilm on the sliding interface are the basis of the tribological mechanisms. | Zhiheng LUO Jingyuan YU Yufu XU He XI Gang CHENG Lulu YAO Ruhong SONG Karl D DEARN | 2021 | Friction2021，9，4： | 2 |
| 2 | Loss-of-function of sox3 causes follicle development retardation and reduces fecundity in zebrafish显示文摘Folliculogenesis is essential for production of female gametes in vertebrates.However,the molecular mechanisms underlying follicle development,particularly apoptosis regulation in ovary,remain elusive.Here,we gen erated sox3 knockout zebrafish lines using CRISPR/Cas9.sox3 knockout led to follicle development retardation and a reduced fecundity in females.Comparative analysis of transcriptome between sox3^-/-and wild-type ovaries revealed that Sox3 was invoIved in pathways of ovarian steroidogenesis and apoptosis.Knockout of sox3 promoted follicle apoptosis and obvious apoptosis signals were detected in somatic cells of stages III and IV follicles of sox3^-/-ovaries.Moreover,Sox3 can bind to and activate the promoter of cyp19a1a.Up-regulation of Cyp19a1a expression promoted 17β-estradiol synthesis,which inhibited apoptosis in follicle development.Thus,Sox3 functions as a regulator of Cyp19a1a expression,via 17β-E2 linking apoptosis suppression,which is implicated in improving female fecundity. | Qiang Hong Cong Li Ruhong Ying Heming Lin Jingqiu Li Yu Zhao Hanhua Cheng Rongjia Zhou | 2019 | Protein & Cell2019，10，5： | 1 |
| 3 | GRK2 mediated degradation of SAV1 initiates hyperplasia of fibroblast-like synoviocytes in rheumatoid arthritis显示文摘Hyperplasia and migration of fibroblast-like synoviocytes(FLSs)are the key drivers in the pathogenesis of rheumatoid arthritis(RA)and joint destruction.Abundant Yes-associated protein(YAP),which is a powerful transcription co-activator for proliferative genes,was observed in the nucleus of inflammatory FLSs with unknown upstream mechanisms.Using Gene Expression Omnibus database analysis,it was found that Salvador homolog-1(SAV1),the pivotal negative regulator of the Hippo-YAP pathway,was slightly downregulated in RA synovium.However,SAV1 protein expression is extremely reduced.Subsequently,it was revealed that SAV1 is phosphorylated,ubiquitinated,and degraded by interacting with an important serine-threonine kinase,G protein-coupled receptor(GPCR)kinase 2(GRK2),which was predominately upregulated by GPCR activation induced by ligands such as prostaglandin E2(PGE2)in RA.This process further contributes to the decreased phosphorylation,nuclear translocation,and transcriptional potency of YAP,and leads to aberrant FLSs proliferation.Genetic depletion of GRK2 or inhibition of GRK2 by paroxetine rescued SAV1 expression and restored YAP phosphorylation and finally inhibited RA FLSs proliferation and migration.Similarly,paroxetine treatment effectively reduced the abnormal proliferation of FLSs in a rat model of collagen-induced arthritis which was accompanied by a significant improvement in clinical manifestations.Collectively,these results elucidate the significance of GRK2 regulation of Hippo-YAP signaling in FLSs proliferation and migration and the potential application of GRK2 inhibition in the treatment of FLSs-driven joint destruction in RA. | Paipai Guo Ji Jiang Rui Chu Feng He Mingli Ge Ruhong Fang Qiuyun Guan Huijuan Cheng Chunru Jiang Tiantian Su Zhenduo Zhu Hao Liu Wei Wei Shihao Zhang Qingtong Wang | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
| 4 | Haplotype variation and KASP markers for SiPSY1-A key gene controlling yellow kernel pigmentation in foxtail millet显示文摘Carotenoid biosynthesis and accumulation are important in determining nutritional and commercial value of crop products.Yellow pigmentation of mature kernels caused by carotenoids is considered a vital quality trait in foxtail millet,an ancient and widely cultivated cereal crop across the world.Genomic regions associated with yellow pigment content(YPC),lutein and zeaxanthin in foxtail millet grains were identified by genome-wide association analysis(GWAS),and SiPSY1(Phytoene synthase 1 which regulates formation of the 40-carbon backbone of carotenoids)was confirmed as the main contributor to all three components by knockout and overexpression analysis.SiPSY1 was expressed in seedlings,leaves,panicles,and mature seeds,and was subcellularly localized to chloroplasts.Transcription of SiPSY1 in 15 DAP immature grains was responsible for YPC in mature seeds.Selection of SiPSY1 combined with increased YPC in mature grains during domestication of foxtail millet was confirmed.Haplotype analysis suggested that expression level of SiPSY1 could be a selection target for future breeding programs,and a KASP marker was developed for selection of favorable SiPSY1 alleles in breeding.The results of this work will benefit nutritional and commercial improvement of foxtail millet varieties,as well as other cereal crops. | Rongjun Zuo Yanyan Zhang Yanbing Yang Chunfang Wang Hui Zhi Linlin Zhang Sha Tang Yanan Guan Shunguo Li Ruhong Cheng Zhonglin Shang Guanqing Jia Xianmin Diao | 2023 | The Crop Journal2023，11，6： | 0 |
| 5 | Primary Research on Screening of Herbicides in Summer Sowing Broomcorn Millet Field显示文摘[Objective] The paper was to select the suitable herbicides for summer sowing broomcorn millet and reduce labor costs. [Method] More than 20 kinds of herbicides commonly used in fields had been preliminarily screened,and six kinds of herbicides were selected for further field herbicidal effect experiment. [Result] The herbicidal effects of 2,4-D butylate,MCPA-Na,tribenuron,2,4-D isooctyl ester and monosulfuron plus propazine against Pharbitis nil(Linn.) Choisy,Amaranth mangostanus L. and Portulaca oleracea L. were greater than 70%,and the weed control effect on fresh weight by leaf and stem spray of tribenuron and MCPA-Na were greater than 96% after herbicide application for 20 d. [Conclusion] The study provides the guidance for production of broomcorn millet. | Xiang Jinying Cheng Ruhong Zhang Ye Shi Zhigang Zhang Ting Xia Xueyan | 2013 | Plant Diseases and Pests2013，4，3： | 0 |
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