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| 1 | PMN-MDSCs modulated by CCL20 from cancer cells promoted breast cancer cell stemness through CXCL2-CXCR2 pathway显示文摘Our previous studies have showed that C-C motif chemokine ligand 20(CCL20)advanced tumor progression and enhanced the chemoresistance of cancer cells by positively regulating breast cancer stem cell(BCSC)self-renewal.However,it is unclear whether CCL20 affects breast cancer progression by remodeling the tumor microenvironment(TME).Here,we observed that polymorphonuclear myeloid-derived suppressor cells(PMN-MDSCs)were remarkably enriched in TME of CCL20-overexpressing cancer cell orthotopic allograft tumors.Mechanistically,CCL20 activated the differentiation of granulocyte-monocyte progenitors(GMPs)via its receptor C-C motif chemokine receptor 6(CCR6)leading to the PMN-MDSC expansion.PMN-MDSCs from CCL20-overexpressing cell orthotopic allograft tumors(CCL20-modulated PMN-MDSCs)secreted amounts of C-X-C motif chemokine ligand 2(CXCL2)and increased ALDH+BCSCs via activating CXCR2/NOTCH1/HEY1 signaling pathway.Furthermore,C-X-C motif chemokine receptor 2(CXCR2)antagonist SB225002 enhanced the docetaxel(DTX)effects on tumor growth by decreasing BCSCs in CCL20high-expressing tumors.These findings elucidated how CCL20 modulated the TME to promote cancer development,indicating a new therapeutic strategy by interfering with the interaction between PMN-MDSCs and BCSCs in breast cancer,especially in CCL20high-expressing breast cancer. | Rui Zhang Mengxue Dong Juchuanli Tu Fengkai Li Qiaodan Deng Jiahui Xu Xueyan He Jiajun Ding Jie Xia Dandan Sheng Zhaoxia Chang Wei Ma Haonan Dong Yi Zhang Lixing Zhang Lu Zhang Suling Liu | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 2 |
| 2 | Structure-design and theoretical-calculation for ultrasmall Co_(3)O_(4) anchored into ionic liquid modified graphene as anode of flexible lithium-ion batteries显示文摘Cobalt oxide(Co_(3)O_(4))is currently suitable in energy storage applications because of its high capacity based on the conversion reaction mechanism.However,unmodified Co_(3)O_(4)suffers from distinctly inferior rate capability and poor cycling stability.On the basis of the aforementioned considerations and density functional theory(DFT)simulations,the three-dimensional hierarchical porous structure(HPS)ultrasmall Co_(3)O_(4)anchored into ionic liquid(IL)modified graphene oxide(GO)has been successfully prepared(ultrasmall/Co_(3)O_(4)-GA-IL).The ultrasmall/Co_(3)O_(4)-GA-IL consists of Co_(3)O_(4)co-assembled with IL modified GO to generate the HPS which can facilitate ion transfer channels through reduction of the electron and ion transportation path and transmission impedance.In addition,N-doping graphene can enhance the inherent electrical conductivity of Co_(3)O_(4),which is proved by the DFT calculations.By virtue of the novel superstructure,the ultrasmall/Co_(3)O_(4)-GA-IL electrode demonstrates a high reversible capacity of 1,304 mAh·g^(−1),an enhanced high-rate capability(715 mAh·g^(−1)at 5 C),and a capacity retention of 98.4%even after 500 cycles at 5 C rate,which corresponds to 0.0003%capacity loss per cycle.Pouch cells based on the cathode are further fabricated and demonstrate excellent mechanical and electrochemical properties under bent and folded state,highlighting the practical application of our deliberately designed electrode in wearable electronics. | Longda Cong Shichao Zhang Hengyao Zhu Weixin Chen Xueyan Huang Yalan Xing Jun Xia Puheng Yang Xia Lu | 2022 | Nano Research2022，15，3： | 1 |
| 3 | Concentrations and fluxes of dissolved uranium in the Yellow River estuary: seasonal variation and anthropogenic (Water-Sediment Regulation Scheme) impact显示文摘 | Sui Juanjuan Yu Zhigang Xu Bochao Dong Wenhua Xia Dong Jiang Xueyan | 2014 | Journal of Environmental Radioactivity2014，，： | 1 |
| 4 | Study on Image Deformation Simulationbased on ARM Linux and OpenGL ES 显示文摘 | Hu Xueyan Xia Zhonglin | 2011 | Intelligence Science andInformation Engineering2011，8，： | 1 |
| 5 | A Simple and High Quality Method for Isolation and Extraction of Total RNA of Pholiota adipose显示文摘Analyzing functional values of RNA using RNA-seq technology is a hot spot of researches. In order to study the medicinal value of Pholiota adipose from the transcriptome level,it is necessary to extract and isolate RNA samples of high purity and high quality P. adipose. In this study,liquid nitrogen grinding Trizol one-step method was used to extract the total RNA of P. adipose. Quality test and statistical comparative analysis were carried out for RNA extract of liquid nitrogen grinding treated and untreated P. adipose. The results showed that the concentration of RNA in the samples treated with liquid nitrogen was much higher than that of the samples without grinding treatment. The OD260/280 of both was about 2,indicating that the purity of RNA was very high. Besides,the ratio of fluorescence intensity of 25 S and 18 S subunit strips of three replicate samples was 1. 8,1. 9,and 1. 9,close to 2,indicating RNA integrity is good. RIN test results of Agilent 2100 were 9. 1,8. 7,and 9. 3,higher than the standard value 6. 8,further proving the integrity. In sum,liquid nitrogen grinding Trizol one-step method is a very simple and efficient method for extracting high quality total RNA of P. adipose. | Zhimin WEI Shunguo LI Meng LIU Xueyan XIA Yu ZHAO Hanzhang ZHOU Chengang GUO | 2018 | Asian Agricultural Research2018，10，1： | 1 |
| 6 | Characteristics of Cheuopodium quinoa and Development Recommendations显示文摘Cheuopodium quinoa is annual Chenopodiaceae Cheuopodium herbaceous dicotyledon. It originated in the Andes in South America and has a planting history of more than 5000 years. Due to its unique characteristics,Cheuopodium quinoa has received wide attention in recent years. This paper elaborated the biological characteristics,nutritional value,utilization approach and economic benefits of Cheuopodium quinoa,introduced main problems in the development of Cheuopodium quinoa industry,and finally came up with recommendations for the development Cheuopodium quinoa industry in China. | Zhimin WEI Hanzhang ZHOU Xueyan XIA Fei LIU Meng LIU Yu ZHAO Shunguo LI Wei LU | 2017 | Asian Agricultural Research2017，9，11： | 1 |
| 7 | Discussion on the construction technology of waterproofing roadbed on road and bridge construction显示文摘At present,with the policy support of the state in the coordinated development of the region,the modernization of the city is vigorously promoted and the level of the national urbanization is promoted rapidly and continuously.As a project of urban infrastructure construction,road and bridge plays a vital role in the construction of the whole urban road network system.Throughout the construction process of every subsystem of road and bridge,the main influence on the later period of road and bridge is waterproof pavement.The level of construction of waterproof subgrade is closely related to the construction quality and construction level of the entire project.The two are coordinated and mutually unified,and how to further improve the waterproof road surface construction technology,construction technology and construction quality,has become a major research topic for each road and bridge construction company[1].From the technical point of view,the paper actively excavates potential security hidden dangers and threats hidden in the construction of road and bridge,and makes a comprehensive analysis of some of the most prominent problems,and explores an effective way to effectively solve the problem. | Dezhi Xia Jun Zeng Yiteng Zhao Yan Shen Xueyan Guo | 2018 | Smart Construction Research2018，2，1： | 0 |
| 8 | Study on Quinoa Characteristics in Central and Southern Hebei显示文摘Quinoa is rich in nutrients and has high economic value,which attracts people's attention.Given that the quinoa has not yet been planted in the low-altitude Central and Southern Hebei plain,we used the quinoa seeds from five different habitats in China to conduct a planting test under different date of seeding in the low-altitude Central and Southern Hebei plain,and obtained the comprehensive data about the phenophase and agronomic traits of quinoa in this region.The test results showed that the grain quinoa should not be planted in Central and Southern Hebei plain,the limiting factors were identified,and a new way for local development of vegetable quinoa was found. | Zhimin WEI Hanzhang ZHOU Fei LIU Meng LIU Yu ZHAO Xueyan XIA Shunguo LI Wei LU | 2017 | Asian Agricultural Research2017，9，12： | 0 |
| 9 | Effects of fatty acid chain length and degree of unsaturation on the surface activities of monoacyl trehaloses显示文摘The surface properties of monoacyl trehaloses with different acyl chains were investigated at 30℃,40℃,50℃,and 60℃.Monoacyl trehaloses were enzymatically synthesized and purified with silica gel column chromatography and semi-preparative high-performance liquid chromatography(HPLC),and the purity of products was identified by mass spectrometry(MS)and nuclear magnetic resonance(NMR).The surface tension of monoacyl trehalose in pure water was measured using Doüy ring method at different temperatures.The critical micelle concentrations(CMC),surface tension at the CMC,γCMC,and residual area per molecule,a,were estimated from the curves.The CMC value of unsaturated monoacyl trehalose was affected by both the degree of unsaturation and the acyl chain length,and the effect of chain length on the CMC value was much stronger than that of the unsaturation degree.However,there was no significant dependency of theγCMC value and a values on the chain length or the unsaturated degree. | Yue-E SUN Wenshui XIA Xueyan TANG Zhiyong HE Jie CHEN | 2009 | Frontiers of Chemical Science and Engineering2009，3，4： | 0 |
| 10 | Effects of Seeding Rate, Water and Fertilizer Coupling on Grass Yield of Forage Millet ( Setaria itlica) in Hebei显示文摘The paper was to study the effects of seeding rate,water and fertilizer (N,P,K) coupling on grass yield of forage millet Jigu No.18 (Setaria itlica).A quadratic regression orthogonal rotation combination with five factors was designed in pot experiment.The mathematical model between hay yield of forage millet (Y) and soil moisture content (x_1),N fertilizer (x_2),P fertilizer (x_3),K fertilizer (x_4) and seeding rate (x_5) was established to simulate optimization.The results showed that moisture content,seeding rate,P fertilizer and K fertilizer had important effects on hay yield.Soil moisture content had the biggest impact on yield,followed by seeding rate,P and K fertilizer.The coupling effects of various factors successively were moisture content/seeding rate > K fertilizer/seeding rate > N/P fertilizer > soil moisture/N fertilizer > soil moisture/P fertilizer.Moreover,the mathematical model,Y=20 543.756-565.570x_1- 39.942x_2- 23.102x_3- 38.470x_4- 151.877x_5+ 1.052x_1x_2+ 1.604x_1x_3+ 12.953x_1x_5- 0.173x_2x_3+ 0.737x_4x_5- 2.292x^2_5,was established.The optimum soil moisture and seeding rate were determined as 10% and15 kg/hm^2,respectively.In this scheme,the hay yield was 14 037.151 0 kg/hm^2 and the economic benefit was 13 887.15 yuan/hm^2; the income was increased by 23.68% (3 288.98 yuan/hm^2) compared to the optimal combination in the test.The results provided a theoretical basis and technical support for forage millet production in Hebei Province. | Zhou Hanzhang Liu Huan Zhou Xinjian Wei Zhimin Yuan Shuhong Hou Shenglin Xia Xueyan | 2016 | Animal Husbandry and Feed Science2016，8，5： | 0 |
| 11 | Study on the Influence of Sowing Rate,Water and Fertilizer Coupling on Water Use Efficiency of Fodder Millet显示文摘To study the influence of sowing rate,water and fertilizer( N,P and K) coupling on water use efficiency of fodder millet grown in autumn fallow field,taking ' Jigu 18' as the tested material,a orthogonal rotation combination with five factors was designed in pot experiment. Results showed that both water and phosphate fertilizer had important impacts on water use efficiency,in which water had the maximum impact,followed by phosphate fertilizer,and nitrogen fertilizer,potassium fertilizer and sowing rate all had no obvious impact. Significant item of sowing rate,water and fertilizer coupling had the below sequence: potassium fertilizer + sowing rate > nitrogen fertilizer + phosphate fertilizer > water + phosphate fertilizer > water + sowing rate > water + potassium fertilizer,and other items had no obvious impact. Mathematical model was established: y = 44. 26- 1. 311x1- 2. 298x2- 3. 682x3- 6. 401x4- 34. 540x5+ 0. 273x1x3+ 0. 118x1x4+ 0. 843x1x5- 1. 948x2x3+ 6. 631x4x5. The optimal scheme taking economic benefit as the examining index was cleared,that is,soil water content maintained 10%,and sowing rate of fodder millet was 15 kg / hm2. By the scheme,water use efficiency was 26. 24 g / kg,and hay yield was13980. 90 kg / hm2,with economic benefit of 13830. 90 yuan/hm2,which was 3063. 73 yuan/hm2 more than the optimized combination with the highest hay yield,with increase magnitude of 22. 15%,and was 6215. 15 yuan / hm2 more than the optimized combination with the highest water use efficiency,with increase magnitude of 44. 94%. The research could provide theoretic basis and technical support for production practice of fodder millet grown in autumn fallow field. | Hanzhang ZHOU Huan LIU Xinjian ZHOU Zhimin WEI Shuhong YUAN Shenglin HOU Xueyan XIA | 2016 | Asian Agricultural Research2016，8，10： | 0 |
| 12 | Discussion on the construction technology of waterproofing roadbed on road and bridge construction显示文摘At present, with the policy support of the state in the coordinated development of the region, the modernization of the city is vigorously promoted and the level of the national urbanization is promoted rapidly and continuously. As a project of urban infrastructure construction, road and bridge plays a vital role in the construction of the whole urban road network system. Throughout the construction process of every subsystem of road and bridge, the main influence on the later period of road and bridge is waterproof pavement. The level of construction of waterproof subgrade is closely related to the construction quality and construction level of the entire project. The two are coordinated and mutually unified, and how to further improve the waterproof road surface construction technology, construction technology and construction quality, has become a major research topic for each road and bridge construction company[1]. From the technical point of view, the paper actively excavates potential security hidden dangers and threats hidden in the construction of road and bridge, and makes a comprehensive analysis of some of the most prominent problems, and explores an effective way to effectively solve the problem. | Dezhi Xia Jun Zeng Yiteng Zhao Yan Shen Xueyan Guo | 2018 | Smart Construction Research2018，2，2： | 0 |
| 13 | Primary Research on Screening of Herbicides in Summer Sowing Broomcorn Millet Field显示文摘[Objective] The paper was to select the suitable herbicides for summer sowing broomcorn millet and reduce labor costs. [Method] More than 20 kinds of herbicides commonly used in fields had been preliminarily screened,and six kinds of herbicides were selected for further field herbicidal effect experiment. [Result] The herbicidal effects of 2,4-D butylate,MCPA-Na,tribenuron,2,4-D isooctyl ester and monosulfuron plus propazine against Pharbitis nil(Linn.) Choisy,Amaranth mangostanus L. and Portulaca oleracea L. were greater than 70%,and the weed control effect on fresh weight by leaf and stem spray of tribenuron and MCPA-Na were greater than 96% after herbicide application for 20 d. [Conclusion] The study provides the guidance for production of broomcorn millet. | Xiang Jinying Cheng Ruhong Zhang Ye Shi Zhigang Zhang Ting Xia Xueyan | 2013 | Plant Diseases and Pests2013，4，3： | 0 |
| 14 | PRPF19 promotes tongue cancer growth and chemoradiotherapy resistance显示文摘Pre-mRNA processing factor 19(PRPF19)is a multifaceted protein and participates in DNA damage response and pre-mRNA processing.The role of PRPF19 in cancer is unclear.Here,we report that the expression of PRPF19 in human tongue cancer is associated with unfavorable prognosis.Overexpression of PRPF19 promotes while knockdown of PRPF19 inhibits tongue cancer cell migration,proliferation,and tumor growth.Overexpression of PRPF19 increases the resistance of tongue cancer cells to radiation and cisplatin treatment.Furthermore,PRPF19 regulates the expression of solute carrier family 40 member 1(SLC40A1)and mono-ADP ribosylhydrolase 2(MACROD2),knockdown of SLC40A1 or MACROD2 decreases the sensitivity of tongue cancer cells to radiation and cisplatin treatment.Thus,our results establish a key role of PRPF19 in tongue cancer growth and chemoradiotherapy resistance,targeting PRPF19 would be an effective therapeutic strategy for tongue cancer,especially for those resistant to chemoradiotherapy. | Yihong He Changhao Huang Kaimei Cai Pei Liu Xueyan Chen Yi Xu Zhengnan Ming Qingqing Liu Qiongxuan Xie Xue Xia Yangqing Sun Junli Luo Rui Wei | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 0 |
| 15 | Specific control of BMP signaling and mesenchymal differentiation by cytoplasmic phosphatase PPMIH显示文摘骨头形态基因的蛋白质(BMP ) 属于 TGF-β在结构上的总科联系了调整细胞的功能的一个宽数组的发信号的蛋白质。在 BMP 信号 transduction 的关键步是抄写因素 Smad1 的 BMP 调停受体的 phosphorylation, 5,和 8 (一起 Smad1/5/8 ) ,它在原子核导致导致 BMP 的基因抄写的随后的激活。在这研究,我们把 PPM1H 的鉴定和描述描述为新奇细胞质局部性的 Smad1/5/8-specific 磷酸酶。PPM1H 直接在细胞质通过它的 Smad 有约束力的领域,和 dephosphorylates phospho-Smad1/5/8 (P-Smad1/5/8 ) 与 Smad1/5/8 交往。PPM1H 的宫外的表示稀释 BMP 发信号,而 PPM1H 活动或表示的损失极大地提高 BMP 依赖的基因规定和间充质的区别。在结论,这研究建议 PPM1H 充当一个看门人阻止过多的 BMP 通过 dephosphorylation 和 P-Smad1/5/8 蛋白质的随后的原子排除发信号。 | Tao Shen Chuang Sun Zhengmao Zhang Ningyi Xu Xueyan Duan Xin-Hua Feng Xia Lin | 2014 | Cell Research2014，24，6： | 0 |
| 16 | SiRAP2-12,a Positive Regulatory Factor,Effectively Improves the Waterlogging Tolerance of Foxtail Millet(Setaria italica)显示文摘Foxtail millet(Setaria italica)growth was inhibited because of waterlogging stress,which has caused yield reduc-tion.ERF family plays an important role to plant adversity tolerance.In our study,we obtained 19,819 differential expressed genes(DEGs)between the two treatments based on the RNA-seq sequencing of foxtail millet of water-logging stress.Furthermore,a total of 28 ERF family members were obtained,which have a complete open read-ing frame.We studied the evolution and function of SiERF family and how they affected the waterlogging tolerance.It was found that SiERF1A/B/C(GenBank ID:OR775217,OR775219,OR775218)and SiRAP2-12(GenBank ID:OR775216)have similar functions to the known waterlogging tolerance genes of other plants.Among them,the SiRAP2-12 expression was obviously significantly up-regulated in foxtail millet after 5d water-logging stress.After SiRAP2-12 was silenced,the activity of defense enzymes in millet decreased significantly.In details,superoxide dismutase(SOD),catalase(CAT)and peroxidase(POD),the osmotic regulator proline(Pro),and the activity of the anaerobic respiratory enzyme alcohol dehydrogenase(ADH)content were decreased by 78.61%,29.52%,79.95%,19.41%and 54.77%,respectively.In contrast,the relative electrical conductivity contents(REC),malondialdehyde(MDA),and hydrogen peroxide(H_(2)O_(2))of the foxtail millet subjected to virus-induced gene silencing clearly increased by 1.03-fold,36.09%,and 15.21%,respectively.The content of sodium(Na^(+))in the SiRAP2-12-silenced foxtail millet also increased,but that of potassium(K^(+))decreased.Interestingly,we found that ethylene content was significantly reduced.Further,the SiAOC1 expression,an essential gene for ethylene synthesis,was inhibited in SiRAP2-12-silenced foxtail millet after waterlogging stress.Taken together,we hypothesized that SiRAP2-12 might be a positive regulator of millet tolerance to waterlogging stress. | Xueyan Xia Xiaohong Fu Yu Zhao Jihan Cui Nuoya Xiao Jingxin Wang Yiwei Lu Meihong Huang Cheng Chu Jia Zhang Mengxin Yang Shunguo Li Jianfeng Liu | 2024 | Phyton-International Journal of Experimental Botany2024，93，3： | 0 |
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