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| 1 | Tumor necrosis factor-a: a key contributor to intervertebral disc degeneration显示文摘Intervertebral 圆盘(IVD ) 退化(国际直拨长途电话) 是导致腰骶部疼痛(LBP ) 的最普通的原因,它是一高度流行,昂贵,并且削弱世界范围的状况。为国际直拨长途电话的当前的治疗被限制对待症状并且不指向 pathophysiology。肿瘤坏死因素 --(TNF-) 通过它的受体 TNFR1 和 TNFR2 是大多数有势力支持 inflammatory cytokines 和信号之一。TNF- 高度在退化 IVD 纸巾被表示,并且它深深地涉及圆盘退化的多重病理学的过程,包括矩阵破坏,煽动性的回答, apoptosis, autophagy,和房间增长。重要地, anti-TNF- 治疗为减轻圆盘退化并且减轻 LBP 显示出诺言。在这考察,跟随对 TNF- 信号 transduction 的简短描述,我们主要在国际直拨长途电话集中于表达式模式和 TNF- 的角色,并且总结关于它象磁盘退化和联系 LBP 的一条有希望的生物治疗学的途径的抑制的新兴的进步。更好的理解将帮助开发新奇 TNF -- 为退化圆盘疾病的集中的治疗学的干预。 | Cheng Wang Xiaohua Yu Yiguo Yan Wei Yang Shujun Zhang Yongxiao Xiang Jian Zhang Wenjun Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，1： | 26 |
| 2 | Secretory/releasing proteome-based identification of plasma biomarkers in HBV-associated hepatocellular carcinoma显示文摘For successful therapy, hepatocellular carcinoma (HCC) must be detected at an early stage. Herein, we used a proteomic approach to analyze the secretory/releasing proteome of HCC tissues to identify plasma biomarkers. Serum-free conditioned media (CM) were collected from primary cultures of cancerous tissues and surrounding noncancerous tissues. Proteomic analysis of the CM proteins permitted the identification of 1365 proteins. The enriched molecular functions and biological processes of the CM proteins, such as hydrolase activity and catabolic processes, were consistent with the liver being the most important metabolic organ. Moreover, 19% of the proteins were characterized as extracellular or membrane-bound. For validation, secretory proteins involved in transforming growth factor-β signaling pathways were validated in plasma samples. Alphafetoprotein (AFP), metalloproteinase (MMP)1, osteopontin (OPN), and pregnancy-specific beta-1-glycoprotein (PSG)9 were significantly increased in HCC patients. The overall performance of MMP1 and OPN in the diagnosis of HCC remained greater than that of AFP. In addition, this study represents the first report of MMP1 as a biomarker with a higher sensitivity and specificity than AFP. Thus, this study provides a valuable resource of the HCC secretome with the potential to investigate serological biomarkers. MMP1 and OPN could be used as novel biomarkers for the early detection of HCC and to improve the sensitivity of biomarkers compared with AFP. | YANG Lei RONG WeiQi XIAO Ting ZHANG Ying XU Bin LIU Yu WANG LiMing WU Fan QI Jun ZHAO XiuYing WANG HongXia HAN NaiJun GUO SuPing WU JianXiong GAO YanNing CHENG ShuJun | 2013 | Science China(Life Sciences)2013，56，7： | 9 |
| 3 | Characterization of Distinct T Cell Receptor Repertoires in Tumor and Distant Non-tumor Tissues from Lung Cancer Patients显示文摘T cells and T cell receptors(TCRs)play pivotal roles in adaptive immune responses against tumors.The development of next-generation sequencing technologies has enabled the analysis of the TCRb repertoire usage.Given the scarce investigations on the TCR repertoire in lung cancer tissues,in this study,we analyzed TCRb repertoires in lung cancer tissues and the matched distant non-tumor lung tissues(normal lung tissues)from 15 lung cancer patients.Based on our results,the general distribution of T cell clones was similar between cancer tissues and normal lung tissues;however,the proportion of highly expanded clones was significantly higher in normal lung tissues than in cancer tissues(0.021%±0.002%vs.0.016%±0.001%,P=0.0054,Wilcoxon signed rank test).In addition,a significantly higher TCR diversity was observed in cancer tissues than in normal lung tissues(431.37±305.96 vs.166.20±101.58,P=0.0075,Mann-Whitney U test).Moreover,younger patients had a significantly higher TCR diversity than older patients(640.7±295.3 vs.291.8±233.6,P=0.036,Mann-Whitney U test),and the higher TCR diversity in tumors was significantly associated with worse cancer outcomes.Thus,we provided a comprehensive comparison of the TCR repertoires between cancer tissues and matched normal lung tissues and demonstrated the presence of distinct T cell immune microenvironments in lung cancer patients. | Xiang Wang Botao Zhang Yikun Yang Jiawei Zhu Shujun Cheng Yousheng Mao Lin Feng Ting Xiao | 2019 | Genomics, Proteomics & Bioinformatics2019，17，3： | 5 |
| 4 | Post-surgical resection prognostic value of combined OPN, MMP7, and PSG9 plasma biomarkers in hepatocellular carcinoma显示文摘Biomarkers for hepatocellular carcinoma (HCC) following curative resection are not currently sufficient for prognostic indication of overall survival (OS) and disease-free survival (DFS). The aim of this study was to investigate the prognostic performance of osteopontin (OPN), matrix metalloproteinase 7 (MMP7), and pregnancy specific glycoprotein 9 (PSG9) in patients with HCC. A total of 179 prospective patients with HCC provided plasma before hepatectomy. Plasma OPN, MMP7, and PSG9 levels were determined by enzyme-linked immunosorbent assay. Correlations between plasma levels, clinical parameters, and outcomes (OS and DFS) were overall analyzed. High OPN (≥149.97 ng/mL), MMP7 (≥2.28 ng/mL), and PSG9 (≥45.59 ng/mL) were prognostic indicators of reduced OS (P<0.001, P<0.001, and P=0.007, respectively). Plasma PSG9 protein level was an independent factor in predicting OS (P=0.008) and DFS (P=0.038). Plasma OPN+MMP7+PSG9 elevation in combination was a prognostic factor for OS (P<0.001). OPN was demonstrated to be a risk factor-associated OS in stage I patients with HCC and patients with low α-fetoprotein levels (<20 ng/mL). These findings suggested that OPN, MMP7, PSG9 and their combined panels may be useful for aiding in tumor recurrence and mortality risk prediction of patients with HCC, particularly in the early stage of HCC carcinogenesis. | Weiqi Rong Yang Zhang Lei Yang Lin Feng Baojun Wei Fan Wu Liming Wang Yanning Gao Shujun Cheng Jianxiong Wu Ting Xiao | 2019 | Frontiers of Medicine2019，13，2： | 5 |
| 5 | Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein as a serum biomarker and implicates potential therapeutic targets显示文摘Macrolide and corticosteroid resistance has been reported in patients with Mycoplasma pneumoniae(MP)pneumonia(MPP).MP clearance is difficult to achieve through antibiotic treatment in sensitive patients with severe MPP(SMPP).SMPP in children might progress to airway remodeling and even bronchiolitis/bronchitis obliterans.Therefore,identifying serum biomarkers that indicate MPP progression and exploring new targeted drugs for SMPP treatment require urgency.In this study,serum samples were collected from patients with general MPP(GMPP)and SMPP to conduct proteomics profiling.The Fc fragment of the IgG-binding protein(FCGBP)was identified as the most promising indicator of SMPP.Biological enrichment analysis indicated uncontrolled inflammation in SMPP.ELISA results proved that the FCGBP level in patients with SMPP was substantially higher than that in patients with GMPP.Furthermore,the FCGBP levels showed a decreasing trend in patients with GMPP but the opposite trend in patients with SMPP during disease progression.Connectivity map analyses identified 25 possible targeted drugs for SMPP treatment.Among them,a mechanistic target of rapamycin kinase(mTOR)inhibitor,which is a macrolide compound and a cell proliferation inhibitor,was the most promising candidate for targeting SMPP.To our knowledge,this study was the first proteomics-based characterization of patients with SMPP and GMPP. | Jinrong Liu Rongfang Shen Lin Feng Shujun Cheng Jun Chen Ting Xiao Shunying Zhao | 2022 | Frontiers of Medicine2022，16，3： | 3 |
| 6 | PSG9 promotes angiogenesis by stimulating VEGFA production and is associated with poor prognosis in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is a common malignant solid tumor characterized by rich vascularization. Pregnancy-specific glycoprotein 9(PSG9) is a member of the carcinoembryonic antigen(CEA)/PSG family and is produced at high levels during pregnancy. We previously identified PSG9 as an HCC-related protein. However, the expression of PSG9 and its regulation during HCC carcinogenesis remain poorly explored. In the present study, we first found that the levels of PSG9 protein were significantly increased in the plasma of HCC patients. PSG9 overexpression also increased the proliferation ability of an HCC cell line. High expression of PSG9 was associated with angiogenesis by accelerating VEGFA expression. In addition, Cox's proportional hazards model analysis revealed that the plasma level of PSG9 was an independent prognostic factor for overall survival. We propose that PSG9 is a novel indicator of prognosis in patients with HCC and could serve as a novel therapeutic target for HCC. Furthermore,our results indicate that PSG9 protein may facilitate the development of HCC by fostering angiogenesis via promoting VEGFA production in cancer cells. | Weiqi Rong Lei Yang Liyuan Yin Yanning Gao Ting Xiao Shujun Cheng | 2017 | Science China(Life Sciences)2017，60，5： | 3 |
| 7 | Elevated expression of lung development-related protein HSP9O0 indicates poor prognosis in non-small cell lung cancer through affecting the cell cycle and apoptosis显示文摘Dear Editor,Oncogenesis was considered to be similar to the early embryonic development process in a variety of ways.1 Using normal development samples as research models will help us understand tumors and identify potential biomarkers.Heat-shock protein 90 beta(HSP90P,HSP90AB1)is one of the major isoforms of HSP90 and is involved in embryonic development,signal transduction,and cellular adaptability. | Xiang Wang Yaru Wang Lin Feng Minghui Wang Kaitai Zhang Yousheng Mao Ting Xiao Shujun Cheng | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 2 |
| 8 | Four-protein model for predicting prognostic risk of lung cancer显示文摘Patients with lung cancer at the same stage may have markedly different overall outcome and a lack of specific biomarker to predict lung cancer outcome.Heat-shock protein 90β(HSP90β)is overexpressed in various tumor cells.In this study,the ELISA results of HSP90βcombined with CEA,CA125,and CYFRA21-1 were used to construct a recursive partitioning decision tree model to establish a four-protein diagnostic model and predict the survival of patients with lung cancer.Survival analysis showed that the recursive partitioning decision tree could distinguish the prognosis between high-and low-risk groups.Results suggested that the joint detection of HSP90β,CEA,CA125,and CYFRA21-1 in the peripheral blood of patients with lung cancer is plausible for early diagnosis and prognosis prediction of lung cancer. | Xiang Wang Minghui Wang Lin Feng Jie Song Xin Dong Ting Xiao Shujun Cheng | 2022 | Frontiers of Medicine2022，16，4： | 2 |
| 9 | Large electrostrain in Bi_(1/2)Na_(1/2)TiO_(3)-based relaxor ferroelectrics:A case study of Bi_(1/2)Na_(1/2)TiO3-Bi_(1/2)K_(1/2)TiO_(3)-Bi(Ni_(2/3)Nb_(1/3))O_(3) ceramics显示文摘(1-x)(0.8Bi_(1/2)Na_(1/2)TiO3-0.2Bi_(1/2)K_(1/2)TiO3)-xBi(Ni_(2/3)Nb_(1/3))O3(BNKT-xBNN)solid solution ceramics were fabricated by high temperature solid-state reaction method.All the compositions possess relaxor ferroelectric features,among which the ergodic BNKT-0.02BNN exhibits large repeatable electrostrain value Suni¼0.51%at electric field of 65 kV/cm,with high piezoelectric stain coefficient d33*of 890 pm/V at 45 kV/cm,while the non-ergodic compositions present unrepeatable large strain response.Based on the electric field-composition phase diagram,the repeatability of strain response in ergodic compositions can be attributed to the reversible electric-field-induced phase transition.In addition,the effects of BNN contents on the macroscopic strain properties are explored by analyzing the existing states of the polar regions with corresponding thermal evolutions and electric-field-induced phase transitions.This research is expected to guide the design of lead free relaxor ferroelectric materials with desired electrostrain properties. | Guangzhi Dong Huiqing Fan Laijun Liu Pengrong Ren Zhenxiang Cheng Shujun Zhang | 2021 | Journal of Materiomics2021，7，3： | 2 |
| 10 | Growth, structure and upconversion mechanisms of Ba_2ErCl_7 crystal显示文摘The methods to grow a novel upconversion crystal Ba2ErCI7 are reported in this note. Ba2ErCI7 material was synthesized with Er2O3, BaCI2-2H2O and NH4CI by using a so-called 'direct synthesis method'. High quality Ba2ErCI7 single crystals with size up to 4 mm×8 mm×15 mm were grown by using the Czochralski and the Bridgman methods. Intense yellow-green luminescence was detected when the crystal was pumped by an 803 laser diode (LD). Transmittance spectrum was measured by using HITACH U-3500 spectrophotometer at room temperature for the first time, in which one can see that the transmittance is high in the range from 350 to 1 600 nm and the cut-off wavelength of the crystal was 230 nm. The upconversion mechanisms were discussed. | HAN Jianru, ZHOU Guangyong, ZHANG Shujun, CHENG Zhenxiang & CHEN HuanchuState Key Laboratory of Crystal Materials, Institute of Crystal Materials of Shandong University, Jinan 250100, China | 2000 | Chinese Science Bulletin2000，45，11： | 2 |
| 11 | A thermoresponsive ehitosan-NIPAAm/vinyl laurate copolymer vector for gene transfection显示文摘 | Sun Shujun Liu Wengguang Cheng Nan | 2005 | Bioconjugate Chemical2005，，16： | 1 |
| 12 | Preparation and thermal properties of form stable paraffin phase change material encapsulation 显示文摘 | Liu Xing Liu Hongyan Wang Shujun Zhang Lu Cheng Hua | 2006 | Energy Conversion and Management2006，47，1516： | 1 |
| 13 | Scavenging effect of extracts of green tea and natural antioxidants on active oxygen radicals显示文摘 | Baolu Zhao Xiaojie Li Rungen He Shujun Cheng Xin Wenjuan | 1989 | Cell Biophysics1989，，2： | 1 |
| 14 | Identificaton of differentially expressed genes in human lung squamous cell carcinoma using suppression subtractive hybridization 显示文摘 | Sun Wenyue Zhang Kaitai Cheng Shujun | 2004 | Cancer Lett2004，83，： | 1 |
| 15 | Research on data load balancing technology of massive storage systems for wearable devices显示文摘Because of the limited memory of the increasing amount of information in current wearable devices,the processing capacity of the servers in the storage system can not keep up with the speed of information growth,resulting in low load balancing,long load balancing time and data processing delay.Therefore,a data load balancing technology is applied to the massive storage systems of wearable devices in this paper.We first analyze the object-oriented load balancing method,and formally describe the dynamic load balancing issues,taking the load balancing as a mapping problem.Then,the task of assigning each data node and the request of the corresponding data node’s actual processing capacity are completed.Different data is allocated to the corresponding data storage node to complete the calculation of the comprehensive weight of the data storage node.According to the load information of each data storage node collected by the scheduler in the storage system,the load weight of the current data storage node is calculated and distributed.The data load balancing of the massive storage system for wearable devices is realized.The experimental results show that the average time of load balancing using this method is 1.75h,which is much lower than the traditional methods.The results show the data load balancing technology of the massive storage system of wearable devices has the advantages of short data load balancing time,high load balancing,strong data processing capability,short processing time and obvious application. | Shujun Liang Jing Cheng Jianwei Zhang | 2022 | Digital Communications and Networks2022，8，2： | 1 |
| 16 | Inhibitor of Growth 4 Induces Growth Suppression and Apoptosis in Glioma U87MG显示文摘 | Li Xiaomei Cai Limin Chen Hui Zhang Qingyuan Zhang Shujun Wang Yanhua Dong Yanyan Cheng Hui Qi Jiping | 2009 | Pathobiology2009，，4： | 1 |
| 17 | Scavenging effect of extracts of green tea and natural antioxidants on active oxygen radicals显示文摘 | Baolu Zhao Xiaojie Li Rungen He Shujun Cheng Xin Wenjuan | 1989 | Cell Biophysics1989，，2： | 1 |
| 18 | Detection of p16 hypermethylation in circulating plasma DNA of non-small cell lung cancer patients显示文摘 | Qian An Yong Liu Yanning Gao Jinfeng Huang Xiaoli Fong Ling Li Dechao Zhang Shujun Cheng | 2002 | Cancer Letters2002，，1： | 1 |
| 19 | Comparison of the Effects of Commercial Nucleation Agents on the Crystallization and Melting Behaviour of Polylaetide 显示文摘 | Gui Zongyan Lu Chong Cheng Shujun | 2013 | Polym Test2013，32，： | 1 |
| 20 | Biomimetic Synthesis of Equisetin and (+)‐Fusarisetin A显示文摘 | Jun Yin Lili Kong Cheng Wang Yingbo Shi Shujun Cai Shuanhu Gao | 2013 | Chem. Eur. J2013，，39： | 1 |
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