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| 1 | The relationship of Imp2 and DR3 genes with susceptibility to type Ⅰ diabetes mellitus in south China Han population显示文摘AIN To study the relationship of Imp2 and DR3genes with type Ⅰ diabetes mellitus.NETHODS Imp2 genotypes and DR3 wereidentified in 68 patients with type Ⅰ diabetesmellitus(Ⅰ-DM)and 71 healthy controls.Then,Ⅰ-DM patients and controls were respectivelyallocated into DR3-positive and DR3-negativegroups.The frequencies of Imp2 and DR3 genein random subjects,and Imp2 genotypes in DR3-matched subjects were compared between Ⅰ-DMpatients and controls.At the same time,Ⅰ-DMpatients were divided into 3 groups based on theonset age of diabetics:group A≤14 years,group B 15-30 years and group C≥31 years.RESULTS The frequency of DR3 in Ⅰ-DMpatients was significantly higher than that incontrols(47% vs 21%,P<0.005),and it wassignificantly higher in group A than that in groupB+C(70% vs 36%,x^2=7.07,P<0.01).Therewas a significant difference among groups withdifferent onset age of diabetics(x^2=8.19,rp=0.33,P<0.05).In random subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(43% vs 61%,P<0.05)and Imp2.R/Hhigher(53% vs 28%,P<0.05)than that incontrols,and there was no significant differenceamong groups with different onset age ofdiabetics.In DR3-positive subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(47% vs 87%,P<0.05)and Imp2-R/H higher(47% vs 13%,P<0.05)than that incontrols.In DR3-negative subjects,thefrequency of Imp2.R/H in Ⅰ-DM patients washigher than that in controls(58% vs 32%,P<0.01),but the frequency of Imp2-R/R and Imp2H/H was not significantly different betweenthese two groups.CONCLUSION DR3 gene may be one of thesusceptible genes of Ⅰ-DM,and significantlyrelated to the onset age of diabetics,and thepersons with DR3 may have an younger onsetage of diabeteS.The Imp2-R/R may be theprotective genotype of Ⅰ-DM,and Imp2-R/H thesusceptible genotype.These were not affectedby DR3 gene.Imp-2 genotypes were not relatedwith the onset age of diabetics. | Ding HL Cheng H Fu ZZ Deng QL Yan L Yan T | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
| 2 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 3 | Astragaloside IV protects against ischemia reperfusion in a murine model of orthotopic liver transplantation显示文摘 | Cheng MX Chen ZZ Cai YL | 2011 | Transplant Proc2011，43，5： | 1 |
| 4 | randomised, double-blind, place- bo-controlled trial显示文摘 | Cheng AL Guan ZZ Chen ZD et ah Efficacy and safety of sor- afenib in patients in the Asia-Pacific region with advanced hepato- cellular carcinoma: a phase III | 2009 | Lancet Oncol2009，10，1： | 1 |
| 5 | Transcriptomic and genomic evolution under constant cold in Antarctic notothenioid fish显示文摘 | Chen ZZ Cheng CHC Zhang JF Cao LX Chen L Zhou LH Jin YD Ye H Deng C Dai ZH Xu QH Hu P Sun SH Shen Y Chen LB | | 0，，： | 1 |
| 6 | Astragaloside IV protects against ischemia reperfusion in a murine model of orthotopic liver transplantation显示文摘 | Cheng MX Chen ZZ Cai YL | 2011 | Transplant Proc2011，43，5： | 1 |
| 7 | Efficacy and safety of sorafenibin patients in the Asia-Pacific region with advanced hepatocellularcarcinoma: a phase m randomized, double-blind, placebo-controlledtrial 显示文摘 | Cheng AL Guan ZZ Chen ZD | 2009 | Lancet Oncology2009，10，： | 1 |
| 8 | Astragaloside IV protects against ischemia reperfusion in a murine model of orthotopic liver transplantation显示文摘 | Cheng MX Chen ZZ Cai YL | 2011 | Transplant Proc2011，43，5： | 1 |
| 9 | Computed tomography morphometric study of gender differences in osteoarthritis proximal tibias显示文摘 | Yang B Yu JK Zheng ZZ Lu ZH Zhang JY Cheng JH | | 0，，： | 1 |
| 10 | Astragaloside IV protectsagainst ischemia reperfusion in a murine model of orthotopic livertransplantation 显示文摘 | Cheng MX Chen ZZ Cai YL | 2011 | TransplantProc2011，43，5： | 1 |
| 11 | Comprehensive profiling of novel microRNA-9 targets and a tumor suppressor role of microRNA-9 via targeting IGF2BP1 in hepatocellular carcinoma显示文摘 | Zhang JB Cheng J Zeng ZZ | 2015 | Oncotarget2015，6，42： | 1 |
| 12 | Farinosones A-C, neurotrophic alkaloidal metabolites from the entomogenous deuteromycete Paecilomyces farinosus 显示文摘 | Cheng YX Li zz Hamburger M | 2004 | J Nat Prod2004，67，： | 1 |
| 13 | Expression of high mobility group box-B1(HMGB-1)and matrix metalloproteinase-9(MMP-9)in non-small cell lung cancer(NSCLC)显示文摘 | Wang JL Wu DW Cheng ZZ | 2014 | Asian Pac J Cancer Prev2014，15，12： | 1 |
| 14 | Efficacy and safety of sor- afenib in patients with advanced hepatocellular carcinoma according to baseline status: subset analyses of the phase III Sorafenib Asia- Pacific trial显示文摘 | Cheng AL Guan ZZ Chen AD | 2012 | Eur J Cancer2012，48，7： | 1 |
| 15 | Hypercholesterolemia is a prerequisite for puromycin inducible damage in mouse kidney显示文摘 | Cheng ZZ Patari A Aalto-Setala K | 2003 | Kidney Int2003，63，1： | 1 |
| 16 | Changed cellular membrane lipid composition and lipid peroxidation of kidney in rats with chronic fluorosis显示文摘 | Guan ZZ Xiao KQ Zeng XY long YG Cheng YH Jiang SF Wang YN | 2000 | Arch Toxicol2000，74，10： | 1 |
| 17 | Adaptive evolution of hepcidin genes in antarctic notothenioid fishes显示文摘 | Xu QH Cheng CHC Hu P Ye H Chen ZZ Cao LX Chen L Shen Y Chen LB | | 0，，： | 1 |
| 18 | Chlorbipram:a novel PDE4 inhibitor with improved safety as a potential antidepressant and cognitive enhancer显示文摘 | Zhang MZ Zhou ZZ Yuan X Cheng YF Bi BT Gong MF | 2013 | Eur J Pharmacol2013，721，13： | 1 |
| 19 | Changed cellular membrane lipid composition and lipid peroxidation of kidney in rats with chronic fluorosis 显示文摘 | Xiao KQ Zeng XY long YG Cheng YH Jiang SF Wang YN | 2000 | Arch Toxicol2000，74，10： | 1 |
| 20 | Neurotrophic alkaloidalmetabolites from the entomogenous deuteromycete Paecilomyces fari-nosus 显示文摘 | Cheng YX Li ZZ Hamburger M | 2004 | Journal of Natural Products2004，，67： | 1 |
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