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| 1 | Physiological effects of weightlessness: countermeasure system development for a long-term Chinese manned spaceflight显示文摘The Chinese space station will be built around 2020. As a national space laboratory, it will offer unique opportunities for studying the physiological effects of weightlessness and the efficacy of the countermeasures against such effects. In this paper, we described the development of countermeasure systems in the Chinese space program. To emphasize the need of the Chinese space program to implement its own program for developing countermeasures, we reviewed the literature on the negative physiological effects of weightlessness, the challenges of completing missions, the development of countermeasure devices, the establishment of countermeasure programs, and the efficacy of the countermeasure techniques in American and Russian manned spaceflights. In addition, a brief overview was provided on the Chinese research and development on countermeasures to discuss the current status and goals of the development of countermeasures against physiological problems associated with weightlessness. | Linjie Wang Zhili Li Cheng Tan Shujuan Liu Jianfeng Zhang Siyang He Peng Zou Weibo Liu Yinghui Li | 2019 | Frontiers of Medicine2019，13，2： | 9 |
| 2 | IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling显示文摘Interleukin-17 (IL-17 或 IL-17A ) 生产是 TH17 房间的一个特点,贡献多重自体免疫、煽动性的疾病的致病的 CD4+ T 淋巴细胞的一个新唯一的系。IL-17 受体(IL-17R 或 IL-17RA ) 为 IL-17 生物活动是必要的。新兴的数据建议 heteromeric 或 homomeric 受体建筑群的形成为 IL-17 发信号被要求。这里,我们证明孤儿受体 IL-17RD (Sef,类似的表示到 FGF 基因或 IL-17RLM ) 被联系并且有 IL-17R 的 colocalized。重要地, IL-17RD 调停 IL-17 发信号,用一个酶记者评估了由 24p3 的本国的倡导者开车, IL-17 目标基因。另外,主导否定地缺乏细胞内部的领域的 IL-17RD 异种压制 IL-17R-mediated IL-17 发信号。而且,象 IL-17R 一样的 IL-17RD 与 TRAF6 被联系,一个 IL-17R 下游的分子。这些结果显示 IL-17RD 是表明建筑群的 IL-17 受体的部分,因此为通过 heteromeric 或 homomeric 受体建筑群发信号的 IL-17 提供新奇证据。 | Zhili Rong Anan Wang Zhiyong Li Yongming Ren Long Cheng Yinghua Li Yinyin Wang Fangli Ren Xiaoning Zhang Jim Hu Zhijie Chang | 2009 | Cell Research2009，19，2： | 6 |
| 3 | Steganalysis of Low Embedding Rates LSB Speech Based on Histogram Moments in Frequency Domain显示文摘As wavelet packet transform is able to focus on minute change of signals, this study proposes an analytic approach of low embedding steganograpy based on high order Histogram moments in frequency domain(HMFD), which provides a key solution to the feature selection and extraction of HMFD. The detection results are tested with the LSB matching steganograpy of different embedding rates in speech signals, respectively, it is proved that the detection performance with HMFD applied is greater than that of histogram statistical moments.HMFD by Wavelet packet decomposition(WPD) can effectively detect low embedding rates Least significant bit(LSB) speech steganography, its accuracy can be 60.8%while the embedding rate is only 3%. | YANG Wanxia TANG Shanyu LI Miaoqi CHENG Yongfeng ZHOU Zhili | 2017 | Chinese Journal of Electronics2017，26，6： | 3 |
| 4 | Truncated glycoprotein E of varicella-zoster virus is an ideal immunogen for Escherichia coli-based vaccine design显示文摘Varicella-zoster virus(VZV)is a highly infectious agent responsible for both varicella and herpes zoster disease.Despite high efficacy,there remain safety and accessibility concerns with the licensed vaccines.Here,we sought to produce a VZV g E immunogen using an E.coli expression system.We found that the soluble expression and yield of g E protein could be enhanced via C-terminal truncations to the protein,thereby facilitating a robust and scalable purification process for the purpose of vaccine manufacturing.The lead truncated g E(aa 31–358),hereafter referred to as tg E,was a homogenous monomer in solution and showed excellent antigenicity.Finally,we assessed and compared the immunogenicity of tg E with commercial v Oka LAV and Shingrix vaccine.We found that aluminum-adjuvanted tg E was immunogenic as compared with v Oka LAV.When adjuvanted with AS01B,a two-dose immunization of tg E showed comparable or better potency in antibody responses and cell-mediated immunity with those of the Shingrix vaccine at the same dosage,especially in terms of the proportion of IFN-γ-expressing CD4^(+)T cells.In conclusion,this method of E.coli-mediate tg E expression offers a cost-effective and scalable strategy to generate an ideal VZV g E immunogen for the development of both varicella and zoster vaccines. | Tingting Chen Jie Sun Sibo Zhang Tingting Li Liqin Liu Wenhui Xue Lizhi Zhou Siting Liang Zhili Yu Qingbing Zheng Hai Yu Tong Cheng Jun Zhang Ying Gu Shaowei Li Ningshao Xia | 2023 | Science China(Life Sciences)2023，66，4： | 1 |
| 5 | Research on tracked vehicles HMT test-bed mensure and control system显示文摘 | Cheng Guangwei Zhou Zhili Deng Chunan | 2007 | Journal of Wuhan University of Technology (Transportation Science & Engineering)2007，8，4： | 1 |
| 6 | Die Theorie des Monismus im sportliehen Training 显示文摘 | Mao Peng Yan Zheng Cheng Zhili | 2011 | Leistungssport2011，1，： | 1 |
| 7 | New strategies for the repair of spinal cord injury显示文摘Spinal cord injury(SCI)leads to several neurologic damages to patients with sensory and motor function loss.Although some inspiring results were reported in animal,even in non-human primate models,the clinical translation of these research achievements barely move forward for the SCI patients.This review mainly focused on the pathogenesis of the primary and secondary injury,the clinical therapies and the new technologies in spinal cord injury.Moreover,the key scientific issues on this field were discussed in the review.Finally,some suggestions were proposed for the scientific and clinical researches. | Zhourui Wu Ziru Zhao Yan Yu Xiao Hu Wei Xu Zhili Zeng Yi Eve Sun Liming Cheng | 2014 | Chinese Science Bulletin2014，59，31： | 1 |
| 8 | Solving the last mile problem: ensure the success of public bicycle system in Beijing显示文摘 | Liu Zhili Xu Dongjia Wen Cheng | 2012 | Procedia-Social and Behavioral Science2012，43，： | 1 |
| 9 | Solving the last mileproblem: ensure the success of public bicycle system inBeijing显示文摘 | Zhili Liu Xudong Jia Wen Cheng | 2012 | Transportation Research Part A2012，43，： | 1 |
| 10 | Aberrant elevation of FTO levels promotes liver steatosis by decreasing the m^(6)A methylation and increasing the stability of SREBF1 and ChREBP mRNAs显示文摘Previous studies have indicated an association of fat mass and obesity-associated(FTO)with nonalcoholic fatty liver disease(NAFLD),the most common chronic liver disease worldwide.This study aimed to decipher the complex role of FTO in hepatic lipid metabolism.We found that a decrease in N^(6)-methyladenosine(m^(6)A)RNA methylation in the liver of mice fed with a high-fat diet(HFD)was accompanied by an increase in FTO expression.Overexpression of FTO in the liver promoted triglyceride accumulation by upregulating the expression of lipogenic genes.Mechanistical studies revealed that FTO could stabilize the mRNAs of sterol regulatory element binding transcription factor 1(SREBF1)and carbohydrate responsive element binding protein(ChREBP),two master lipogenic transcription factors,by demethylating m^(6)A sites.Knockdown ofeither SREBF1 or ChREBP attenuated the lipogenic effect of FTO,suggesting that they are bona fide effectors for FTO in regulating lipogenesis.Insulin could stimulate FTO transcription through a mechanism involving the action of intranuclear insulin receptor beta,while knockdown of FTO abrogated the lipogenic effect of insulin.Inhibition ofFTo by entacapone decreased the expression of SREBF1,ChREBP,and downstream lipogenic genes,ameliorating liver steatosis in HFD-fed mice.Thus,our study established a critical role of FTO in both the insulin-regulated hepatic lipogenesis and the pathogenesis of NAFLD and provided a potential strategyfor treating NAFLD. | Zhili Tang Chao Sun Ying Yan Zhoumin Niu Yuying Li Xi Xu Jing Zhang Yuting Wu Yan Li Li Wang Cheng Hu Zhuoyang Li Jingjing Jiang Hao Ying | 2022 | Journal of Molecular Cell Biology2022，14，9： | 1 |
| 11 | Assessment of carbon sink potential and methane reduction scenarios of marine macroalgae(Gracilaria)cultivation显示文摘Marine macroalgae cultivation is an important part of the effort to address climate change through carbon sinks.Gracilaria,especially Gracilaria lemaneiformis and Gracilaria lichenoides are the major macroalgae cultivated in China.This study proposes a method to assess the net carbon sink of marine macroalgae(Gracilaria)cultivation.First,the net carbon sink of Gracilaria cultivation in China is calculated based on the yield of annual cultivated Gracilaria recorded in China Fishery Statistical Yearbook from 2011 to 2020.Next,we predict the net carbon sink trend of Gracilaria cultivation from 2021 to 2030 using the autoregressive integrated moving average model(ARIMA).Finally,the potential carbon sink increase and methane reduction related to Gracilaria cultivation in China is explored through a scenario analysis.We find that the net carbon sink of Gracilaria cultivation in China was about 32.1-92.4 kilotons per year from 2011 to 2020,and shows a great annual growth trend.Moreover,the predicted net carbon sink of Gracilaria cultivation would increase to 77.8-191.4 kilotons per year from 2021 to2030,thereby could contribute considerably in the achievement of China's carbon peak goal.Under a scenario of producing ruminant green feed with additional Gracilaria cultivation,each ton of macroalgae is predicted to reduce carbon emission(i.e.,methane)by 0.33-0.68 tons.Thus,marine macroalgae cultivation might form a synergistic chain of'carbon sink increase-water purification-economy-methane reduction'.This study proposes a synergistic new model that operates through marine macroalgae cultivation,economic aquaculture,and green feed production. | Yifan XU Huanping LIU Yufeng YANG Hongtao SHEN Ruimin ZHANG Cheng WANG Zhijian HUANG Jianguo HE Zhili HE Qingyun YAN | 2023 | Science China Earth Sciences2023，66，5： | 0 |
| 12 | Environmental selection and evolutionary process jointly shape genomic and functional profiles of mangrove rhizosphere microbiomes显示文摘Mangrove reforestation with introduced species has been an important strategy to restore mangrove ecosystem functioning.However,how such activities affect microbially driven methane(CH4),nitrogen(N),and sulfur(S)cycling of rhizosphere microbiomes remains unclear.To understand the effect of environmental selection and the evolutionary process on microbially driven biogeochemical cycles in native and introduced mangrove rhizospheres,we analyzed key genomic and functional profiles of rhizosphere microbiomes from native and introduced mangrove species by metagenome sequencing technologies.Compared with the native mangrove(Kandelia obovata,KO),the introduced mangrove(Sonneratia apetala,SA)rhizosphere microbiome had significantly(p<0.05)higher average genome size(AGS)(5.8 vs.5.5 Mb),average 16S ribosomal RNA gene copy number(3.5 vs.3.1),relative abundances of mobile genetic elements,and functional diversity in terms of the Shannon index(7.88 vs.7.84)but lower functional potentials involved in CH4 cycling(e.g.,mcrABCDG and pmoABC),N2 fixation(nifHDK),and inorganic S cycling(dsrAB,dsrC,dsrMKJOP,soxB,sqr,and fccAB).Similar results were also observed from the recovered Proteobacterial metagenome-assembled genomes with a higher AGS and distinct functions in the introduced mangrove rhizosphere.Additionally,salinity and ammonium were identified as the main environmental drivers of functional profiles of mangrove rhizosphere microbiomes through deterministic processes.This study advances our understanding of microbially mediated biogeochemical cycling of CH_(4),N,and S in the mangrove rhizosphere and provides novel insights into the influence of environmental selection and evolutionary processes on ecosystem functions,which has important implications for future mangrove reforestation. | Xiaoli Yu Qichao Tu Jihua Liu Yisheng Peng Cheng Wang Fanshu Xiao Yingli Lian Xueqin Yang Ruiwen Hu Huang Yu Lu Qian Daoming Wu Ziying He Longfei Shu Qiang He Yun Tian Faming Wang Shanquan Wang Bo Wu Zhijian Huang Jianguo He Qingyun Yan Zhili He | 2023 | mLife2023，2，3： | 0 |
| 13 | Growth of Aligned Carbon Nanotubes on Large Scale by Methane Decomposition with Deactivation Inhibitor显示文摘在 Mo/MgO 催化剂上由甲烷分解在碳 nanotubes (CNT ) 的生长上在化学蒸汽免职(CVD ) 期间包含铁或镍的添加剂的效果被调查。Ferrocene 和镍硝酸盐作为释放禁止者被介绍由在原处蒸发在 CVD 期间。精确在原处控制了这些禁止者的介绍增加了催化剂的表面更新,因此阻止了催化剂释放。用这个方法,与平行中央毛孔排列了多围的 CNT 能在大规模上被生产。 | Hao Yu Zhili Li Cheng Zhang Feng Peng Hongjuan Wang | 2007 | Journal of Natural Gas Chemistry2007，16，4： | 0 |
| 14 | The expression characteristics and biological significance of bFGF,EGF,TGF-β isoforms and their receptors in skins from fetus and adult显示文摘Objective:To observe the localization and expression characteristics of alpha-smooth muscle actin (AS-MA),basic fibroblast growth factor (bFGF),epidermal growth factor (EGF),transforming growth factor-β(TGF-β) isoforms,and their receptors in fetal and adult skins in order to explore their potential biological significance.Methods;The expression and the distribution of ASMA,bFGF,EGF,TGF-βisoforms,and their receptors were de-tected with immunohistochemistry and histopathology methods in 36 skin specimens.... | Chen Wei Fu Xiaobing Sun Xiaoqing Sun Tongzhu Zhao Zhili Sheng Zhiyong Wound Healing Unit,Department of Basic Research,Burn Institute,304th Hospital,51 Fu Cheng Road,Beijing 100037 | 2002 | 感染.炎症.修复2002，3，4： | 0 |
| 15 | Evaluation of different primers of the 18S rRNA gene to profile amoeba communities in environmental samples显示文摘Amoeboid protists,an assemblage of organisms belonging to different phylogenetic lineages,have drawn increasing attention due to their crucial ecological roles in various environments and their potential health risks.Currently,18S rRNA gene sequencing is widely applied for the detection of amoebae.However,it is not clear which is the best primer pair for 18S rRNA gene amplification in amoebae.This study compared the four most commonly used primer pairs for revealing the diversity,composition,core species,and community assembly processes of amoebae in water and sediments.We found that the choice of primers artificially influences the detection of community composition of amoebae.We also found that short-read fragments may lead to mismatches in taxonomy and were not suitable for phylogenetic analyses.In contrast,full-length primers could detect the highest number of amoeba lineages and annotate 80%of reads belonging to amoebae to known species.However,full-length primers did not detect as many amoeba species as V4 primers.Moreover,we showed that beta diversity and community assembly determination were largely unaffected by primer choice,but different primers could influence our interpretations of the ecological process underlying stochasticity and determinism.This study indicates that full-length read sequencing and V4 region Illumina sequencing are suitable for profiling amoeba diversity in the environment. | Xiafei Zheng Zhili He Cheng Wang Qingyun Yan Longfei Shu | 2022 | Water Biology and Security2022，1，3： | 0 |
| 16 | An Outbreak of Dengue Virus Type 1--Jiangxi Province,China,2019显示文摘What is known about this topic?Dengue fever is an acute febrile illness caused by four types of dengue virus(DENV 1–4),and is a mosquitoborne infectious disease.The incidence of dengue has increased dramatically around the world in recent decades.An estimated of 3.9 billion people in 128 countries are at risk of infection with dengue viruses,70%of whom are in Asia.In 2017,the first local infections of dengue virus(DENV-2)in Jiangxi Province was reported in Zhanggong District,Ganzhou City.What is added by this report?From August to September 2019,the first dengue outbreak happened in Xin’gan County,where 81 local dengue fever cases were reported,35 were laboratoryconfirmed cases,and 46 were clinically-diagnosed cases;all cases were dengue virus type 1.The DENV-virus strains isolated from the cases of Xin’gan County were close to the strains isolated in Singapore(MF033254|25657|Singapore|2016)and Henan(MK905537|He nan201903|China:Henan Province|2019).What are the implications for public health practice?The outbreak might have been caused by imported cases or covert infections.The outbreak in Xin’gan County indicated that more proactive countermeasures should be taken during the dengue epidemic period such as intensifying surveillance for dengue cases,virus serotype,and Aedes vector density and strengthening cooperation with customs and tourism departments.Moreover,the outbreak should prompt training in medical institutions and improved ability for doctor’s to diagnose dengue fever,which is very important for early detection of dengue cases and taking preventive measures. | Fuqiang Yang Guanghui Xia Zhili Zeng Zhongjian Li Huijian Cheng Daping Che Jun Zong Jianxiong Li Tian Gong Guihua Liu Weidong Zhou Bihai Wei Xiaobo Liu Jiandong Li Sheng Ding | 2020 | China CDC weekly2020，2，35： | 0 |
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