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| 1 | Effect of moxa-burning heat stimulating Liangmen(ST 21) and Zusanli(ST 36) on proliferation and apoptosis signaling proteins in rats with stress-induced gastric ulcer显示文摘OBJECTIVE: To observe the effect of moxa-burning heat stimulating acupoints of Liangmen(ST 21)and Zusanli(ST 36) on the proliferation and apoptosis signaling proteins in rats with stress-induced gastric ulcer.METHODS: Forty rats were randomly divided into four groups: negative control(NC), ulcer control(UC), acupoints of stomach meridian(ASM), and acupoints control(AC). The acute gastric ulcer model was established by bound and water immersion.Rats in NC and UC groups didn't receive any moxa-burning heat stimulating treatment, while rats in ASM and AC groups were treated with buringmoxa heat stimulating the acupoints of Liangmen(ST 21) and Zusanli(ST 36) and their controlled points, respectively. Rats in all groups were sacrificed after 12 consecutive days treatment. The ulcer index was evaluated by using Guth's method.The expression of tumor necrosis factor-alpha(TNF-α), apoptotic protease activating facter-1(Apaf-1), Caspase-3, p21 activated kinase 1(PAK1),extracellular regulated protein kinases 2(ERK2),phosphorylated ERK2(p ERK2), phosphoinositide3-kinase(PI3K) and RAC-alpha serine/threonine-protein kinase(Akt) in gastric mucosa was detected by enzyme linked immunosorbent assay(ELISA).RESULTS: Compared with UC group, the ulcer index of ASM and AC groups decreased, and the injured gastric mucosa was improved, the expression of TNF-α, Apaf-1 and Caspase-3 in gastric mucosa was significantly reduced(P < 0.05), while the ex-pression of PAK1, ERK2, p ERK2, PI3 K and Akt in gastric mucosa was significantly increased(P < 0.05).And ASM showed better effect than AC group(P <0.05).CONCLUSION: Moxa-burning Heat stimulating of Liangmen(ST 21) and Zusanli(ST 36) could promote the recovery of gastric mucosal lesion probably by inhibiting cell apoptosis and promoting cell proliferation in stress-induced gastric ulcer. | Peng Li Wang Yadong Chang Xiaorong Wu Huangan Liu Mi Ma Fuqiang Wang Hong Chen Jiaolong Wang Chao Quan Renfu Yang Zongbao | 2016 | Journal of Traditional Chinese Medicine2016，36，3： | 9 |
| 2 | Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution显示文摘The speed of high-resolution optical imaging has been a rate-limiting factor for meso-scale mapping of brain structures and functional circuits,which is of fundamental importance for neuroscience research.Here,we describe a new microscopy method of Volumetric Imaging with Synchronized on-the-fly-scan and Readout(VISo R)for high-throughput,high-quality brain mapping.Combining synchronized scanning beam illumination and oblique imaging over cleared tissue sections in smooth motion,the VISo R system effectively eliminates motion blur to obtain undistorted images.By continuously imaging moving samples without stopping,the system achieves high-speed 3D image acquisition of an entire mouse brain within1.5 hours,at a resolution capable of visualizing synaptic spines.A pipeline is developed for sample preparation,imaging,3D image reconstruction and quantification.Our approach is compatible with immunofluorescence methods,enabling flexible cell-type specific brain mapping and is readily scalable for large biological samples such as primate brains.Using this system,we examined behaviorally relevant whole-brain neuronal activation in 16 c-Fos-sh EGFP mice under resting or forced swimming conditions.Our results indicate the involvement of multiple subcortical areas in stress response.Intriguingly,neuronal activation in these areas exhibits striking individual variability among different animals,suggesting the necessity of sufficient cohort size for such studies. | Hao Wang Qingyuan Zhu Lufeng Ding Yan Shen Chao-Yu Yang Fang Xu Chang Shu Yujie Guo Zhiwei Xiong Qinghong Shan Fan Jia Peng Su Qian-Ru Yang Bing Li Yuxiao Cheng Xiaobin He Xi Chen Feng Wu Jiang-Ning Zhou Fuqiang Xu Hua Han Pak-Ming Lau Guo-Qiang Bi | 2019 | National Science Review2019，6，5： | 7 |
| 3 | Combination therapy for scalp angiosarcoma using bevacizumab and chemotherapy: a case report and review of literature显示文摘Bevacizumab, an angiogenesis inhibitor, is a recombined humanized monoclonal antibody against vascular endothelial growth factor and a promising therapeutic option for angiosarcoma management. This is a case report and review of the literature using bevacizumab and combination chemotherapy for angiosarcoma. The understanding of the effectiveness of combined therapy of bevacizumab and chemotherapy agents is still limited. The benefits of bevacizumab treatment for angiosarcoma will need to be weighed against the risks of venous thromboembolism in this population. | Ping Yang Qi Zhu Fuqiang Jiang | 2013 | Chinese Journal of Cancer Research2013，25，3： | 7 |
| 4 | Preparation of Potato Whole Flour and Its Effects on Quality of Flour Products: A Review显示文摘When harvested the potato has a high moisture content, this could make its transportation and storage difficult. To help solve the transportation difficulties, potato is made into whole flour by many food processing companies. Potato whole flour has high nutritional value and may be regarded as beneficial to human health and fitness. In addition to the direct use of potato whole flour,it can also be used as added ingredients into other food products. This study summarizes and analyzes the processing technology of potato whole flour and its application in noodle products. | CUI Lingling TIAN Yange TIAN Shuangqi WANG Yanbo GAO Fuqiang | 2018 | Grain & Oil Science and Technology2018，1，3： | 7 |
| 5 | Triglycerides and ratio of triglycerides to high-density lipoprotein cholesterol are better than liver enzymes to identify insulin resistance in urban middle-aged and older non-obese Chinese without diabetes显示文摘 | Sun Yu Li Wenjuan Hou Xinguo Wang Chuan Li Chengqiao Zhang Xiuping Yang Weifang Ma Zeqiang Wang Weiqing Ning Guang Zheng Huizhen Ma Aixia Song Jun Lin Peng Liang Kai Liu Fuqiang Gong Lei Wang Meijian Xiao Juan Yan Fei Yang Junpeng Wang Lingshu Tian Meng Liu Jidong Zhao Ruxing Zhu Ping Chen Li | 2014 | Chinese Medical Journal2014，，10： | 7 |
| 6 | Epidemiological serosurvey of Hepatitis B in China—Declining HBV prevalence due to Hepatitis B vaccination显示文摘 | Xiaofeng Liang Shengli Bi Weizhong Yang Longde Wang Gang Cui Fuqiang Cui Yong Zhang Jianhua Liu Xiaohong Gong Yuansheng Chen Fuzhen Wang Hui Zheng Feng Wang Jing Guo Zhiyuan Jia Jingchen Ma Huaqing Wang Huiming Luo Li Li Shuigao Jin Stephen C. Hadler Yu W | 2009 | Vaccine2009，，47： | 7 |
| 7 | Spatial distribution and sources of soil heavy metals in the outskirts of Yixing City,Jiangsu Province,China显示文摘City outskirts serve as the concentration centers for the pollutants discharged from various sources such as industry,agriculture and transportation.With the acceleration of industrialization and urbanization,the eco-environment of the city outskirts has become a hot spot of public concern.An analysis was conducted in this paper on the soil in the outskirts of Yixing City using frequency distribution functions.The heavy metal sources in this region had been divided into two components,i.e.natural background component and strong human disturbance component.The corresponding interpretation of the distribution pattern and features of heavy metal elements was presented by spatial analysis.The results showed that the strong human disturbance components of Hg,Pb,and Cu accounted for 36.9%, 26.7%,and 23.3%in their contents respectively,which indicated directly the serious effect of human activities on heavy metal contents.Hg and Pb,because of the human disturbance,showed the greatest spatial variability,and human activities intensified the heterogeneity of the spatial distribution.The anisotropic analysis showed the higher organisation of Hg and Zn in the direction of urban-rural transition,which indicated their spatial characteristics with urban-rural transition.Pb displayed distinctive structure in the vertical direction of urban-rural transition,which was largely controlled by highway distribution.Cu content in paddy fields was significantly higher than those of other land-use-types,and the agricultural non-point source pollution played an important role in the distribution pattern of Cu. | ShaoHua Wu ShengLu Zhou DeZhi Yang FuQiang Liao HongFu Zhang Kui Ren | 2008 | Chinese Science Bulletin2008，53，S1： | 7 |
| 8 | Detection and characterization of diverse alpha-and betacoronaviruses from bats in China显示文摘Bats have been implicated as important reservoir hosts of alpha- and betacoronaviruses. In this study, diverse coronaviruses(CoVs) were detected in 50 of 951(positive rate 5.3%) intestinal specimens of eight bat species collected in four provinces and the Tibet Autonomous Region of China by pan-coronavirus RT-PCR screening. Based on 400-nt RNA-dependent RNA polymerase(Rd RP) sequence analysis, eight belonged to genus Alphacoronavirus and 42 to Betacoronavirus.Among the 50 positive specimens, thirteen gave rise to CoV full-length Rd RP gene amplification for further sequence comparison, of which three divergent sequences(two from a unreported province) were subjected to full genome sequencing. Two complete genomes of betacoronaviruses(JTMC15 and JPDB144) and one nearly-complete genome of alphacoronavirus(JTAC2) were sequenced and their genomic organization predicted. The present study has identified additional numbers of genetically diverse bat-borne coronaviruses with a wide distribution in China. Two new species of bat CoV, identified through sequence comparison and phylogenetic analysis, are proposed. | Lin Xu Fuqiang Zhang Weihong Yang Tinglei Jiang Guanjun Lu Biao He Xingyu Li Tingsong Hu Gang Chen Yun Feng Yuzhen Zhang Quanshui Fan Jiang Feng Hailin Zhang Changchun Tu | 2016 | Virologica Sinica2016，31，1： | 6 |
| 9 | Resolvin-D1 inhibits interleukin-8 and hydrogen peroxide production induced by cigarette smoke extract in 16HBE cells via attenuating NF-κB activation显示文摘 | Dong Jiajia Zhang Mingke Liao Zenglin Wu Wei Wang Tao Chen Lei Yang Ting Guo Lingli Xu Dan Wen Fuqiang | 2014 | Chinese Medical Journal2014，，3： | 6 |
| 10 | To explore the curative effect of CT-guided Iodine-125 radioactive seed implantation in the treatment of stage Ⅳprimary hepatocellular carcinoma显示文摘Objectives: To explore the clinical efficacy and survival of CT-guided Iodine-125 radioactive seed implantation in the treatment of stage Ⅳ primary hepatocellular carcinoma.Methods: A retrospective study of 62 patients with primary hepatocellular carcinoma in our hospital from January2017 to December 2018 [60 males, 2 females, age(52.76 ± 10.82) years old], All patients were implanted with Iodine-125 radioactive seeds under CT guidance, followed up regularly after operation to observe the clinical efficacy, including comparison of changes in cancer size before and after treatment, tumor marker AFP, and improvement in complications such as abdominal pain and ascites. Follow-up 3–36 months to assess patient survival.Results: Among the 62 patients, 3 months after Iodine-125 radioactive seed implantation, 5 cases(8.1%) had complete remission of cancer, 33 cases(53.2%) had partial remission, 12 cases(19.4%) had stable lesions, and 12 cases(19.4%) had disease progression. The effective rate was 61.3%. The tumor volume(31.44 ± 14.51 cm3) was significantly smaller than before(50.96 ± 30.13 cm3)(t=5.303, p < 0.05). The tumor marker AFP(69.28 ±50.99) ug/L of 3 months after implantation was significantly lower than that before treatment(90.63 ± 68.58)ug/L(t=3.702, P < 0.05). The average survival time of Iodine-125 seed implantation for stageⅣhepatocellular carcinoma is 11.47 ± 0.85 months, and the median survival time is 9 months. The survival time of the group with better pathological differentiation(grade Ⅰ+ⅡⅠ) was significantly better than that of the group with poor differentiation(grade Ⅲ+Ⅳ)(x2=6.869 p < 0.05). Among the 38 patients with different degrees of abdominal pain,22 patients improved better than before;15 of 28 patients with different degrees of ascites were better than before. All patients had no serious complications related to treatment.Conclusions: Iodine-125 radioactive seed implantation therapy can safely and effectively treat hepatocellular carcinoma, and relieve the clinical symptoms of abdominal pain and ascites. | Fuqiang Zhang Lin Zheng Deyu Li Hui Yang | 2021 | Journal of Interventional Medicine2021，4，2： | 4 |
| 11 | Viral Tools for Neural Circuit Tracing显示文摘Neural circuits provide an anatomical basis for functional networks.Therefore,dissecting the structure of neural circuits is essential to understanding how the brain works.Recombinant neurotropic viruses are important tools for neural circuit tracing with many advantages over non-viral tracers:they allow for anterograde,retrograde,and trans-synaptic delivery of tracers in a cell type-specific,circuit-selective manner.In this review,we summarize the recent developments in the viral tools for neural circuit tracing,discuss the key principles of using viral tools in neuroscience research,and highlight innovations for developing and optimizing viral tools for neural circuit tracing across diverse animal species,including nonhuman primates. | Qing Liu Yang Wu Huadong Wang Fan Jia Fuqiang Xu | 2022 | Neuroscience Bulletin2022，38，12： | 4 |
| 12 | An MID-Based Load Balancing Approach for Topic-Based Pub-Sub Overlay Construction显示文摘A large proportion of Internet of Things (IoT) applications are internally publish/subscribe in nature,and traditional architecture cannot support them efficiently and flexibly.In essence,supporting efficient publish/subscribe systems requires data-oriented naming and efficient multicast.Since deployment of native IP-based multicast has failed,overlay-based multicast has become the practical choice.Since load balancing between heterogeneous nodes is an important issue,designing an optimal load balancing overlay network for publish/subscribe systems is a necessary endeavor.This study focuses on the optimal load balancing overlay design problem for topic-based publish/subscribe systems in a heterogeneous environment (in terms of node processing power,bandwidth,and reachability).The Minimum Idle Degree (MID) model is introduced to capture the heterogeneity of overlay nodes.Based on the MID model,new node load measures are defined that can accommodate heterogeneous server capacities and capture the node load in publish/subscribe systems more accurately than traditional measures.A new optimization problem,Maximum Minimum Idle Degree Topic-Connected Overlay (MMID-TCO),is established.This problem is NP-complete and a constant approximation algorithm does not exist for this problem (unless P=NP).Based on MID metrics,the Maximum Minimum Idle Degree Overlay Design Algorithm (MMID-ODA),which has polynomial time,is introduced.To improve performance,an approach that breaks down the problem into several small-scale problems by exploiting the potential inherent disjoint characteristic in the subscription table is presented.Simulation results show that the proposed algorithm is able to achieve better load balance than Min-Max-ODA in a heterogeneous environment. | Ruisheng Shi Fuqiang Liu Yang Zhang Bo Cheng Junliang Chen | 2011 | Tsinghua Science and Technology2011，16，6： | 4 |
| 13 | Numerical study on the thermal performance of packed-bed latent heat thermal energy storage system with biomimetic alveoli structure capsule显示文摘Bionics provides a positive and beneficial impact on the development of various materials and systems, which has been widely used in energy storage, heat transfer enhancement, and solar thermochemical reactions. In this paper, the idea of heat storage unit with biomimetic alveoli structure is proposed and introduced to increase the heat transfer area and improve the thermal performance of the packed-bed latent heat thermal energy storage(LHTES) system. The effects of heat storage unit structure on temperature distribution, liquid fraction, thermal storage capacity, and other performance indexes of the conventional model and biomimetic model are analyzed. The numerical results indicate that the biomimetic alveoli structure can improve the thermal response of heat storage unit, increase the specific surface area, and achieve a faster heat storage process of the packed-bed compared with the conventional structure. Among various existing models, the double-cell model has a significant improvement.Compared with the conventional model, the maximum increase of liquid fraction and charging efficiency are 9.8% and 6.4%,respectively. This study can provide references to optimize packed-bed LHTES and improve its thermal performance under practical conditions. | WANG FuQiang DONG Yan LI Yang XU Jie ZHANG GuoLiang | 2021 | Science China(Technological Sciences)2021，64，7： | 4 |
| 14 | Characteristics of evolution of mining-induced stress field in the longwall panel:insights from physical modeling显示文摘The evolution of mining-induced stress field in longwall panel is closely related to the fracture field and the breaking characteristics of strata.Few laboratory experiments have been conducted to investigate the stress field.This study investigated its evolution by constructing a large-scale physical model according to the in situ conditions of the longwall panel.Theoretical analysis was used to reveal the mechanism of stress distribution in the overburden.The modelling results showed that:(1)The major principal stress field is arch-shaped,and the strata overlying both the solid zones and gob constitute a series of coordinated load-bearing structures.The stress increasing zone is like a macro stress arch.High stress is especially concentrated on both shoulders of the arch-shaped structure.The stress concentration of the solid zone in front of the gob is higher than the rear solid zone.(2)The characteristics of the vertical stress field in different regions are significantly different.Stress decreases in the zone above the gob and increases in solid zones on both sides of it.The mechanical analysis show that for a given stratum,the trajectories of principal stress are arch-shaped or inverselyarched,referred to as the‘‘principal stress arch’’,irrespective of its initial breaking or periodic breaking,and determines the fracture morphology.That is,the trajectories of tensile principal stress are inversely arched before the first breaking of the strata,and cause the breaking lines to resemble an inverted funnel.In case of periodic breaking,the breaking line forms an obtuse angle with the advancing direction of the panel.Good agreement was obtained between the results of physical modeling and the theoretical analysis. | Jinfu Lou Fuqiang Gao Jinghe Yang Yanfang Ren Jianzhong Li Xiaoqing Wang Lei Yang | 2021 | International Journal of Coal Science & Technology2021，8，5： | 3 |
| 15 | Prevention and management of wind-blown sand damage along Qinghai-Tibet Railway in Cuonahu Lake area显示文摘This paper analyzes the characteristics of climate,geology and geomorphology,vegetation,and sand dune distribution in the Cuonahu Lake area beside the Qinghai-Tibet Railway.The types and causes of railway blown-sand hazards are discussed,and the effectiveness of various sand-controlling measures is assessed.From the perspective of integrated management,a sand-controlling system that combines several engineering measures,including nylon net sand barriers,concrete sand barriers,movable-board sand barriers,sand interception ditches,gravel/rock cover,film sandbags,and permanent vegetation is most beneficial. | YinHai Yang BenZhen Zhu FuQiang Jiang XiLai Wang Yong Li | 2012 | Research in Cold and Arid Regions2012，4，2： | 3 |
| 16 | Human INO80/YY1 chromatin remodeling complex transcriptionally regulates the BRCA2-and CDKNIA-interacting protein (BCCIP) in cells显示文摘 | Jiaming Su Yi Sui Jian Ding Fuqiang Li Shuang Shen Yang Yang Zeming Lu Fei Wang Lingling Cao Xiaoxia Liu Jingji Jin Yong Cai | 2016 | Protein & Cell2016，7，10： | 3 |
| 17 | Adsorption performances and mechanisms of the newly synthesized N,N′-di (carboxymethyl) dithiocarbamate chelating resin toward divalent heavy metal ions from aqueous media显示文摘 | XiaoSheng Jing FuQiang Liu Xin Yang PanPan Ling LanJuan Li Chao Long AiMin Li | 2009 | Journal of Hazardous Materials2009，，1： | 2 |
| 18 | Regional Metabolic Patterns of Abnormal Postoperative Behavioral Performance in Aged Mice Assessed by XH-NMR Dynamic Mapping Method显示文摘Abnormal postoperative neurobehavioral performance(APNP)is a common phenomenon in the early postoperative period.The disturbed homeostatic status of metabolites in the brain after anesthesia and surgery might make a significant contribution to APNP.The dynamic changes of metabolites in different brain regions after anesthesia and surgery,as well as their potential association with APNP are still not well understood.Here,we used a battery of behavioral tests to assess the effects of laparotomy under isoflurane anesthesia in aged mice,and investigated the metabolites in 12 different sub-regions of the brain at different time points using proton nuclear magnetic resonance('H-NMR)spectroscopy.The abnormal neurobehavioral performance occurred at 6 h and/or 9 h,and recovered at 24 h after anesthesia/surgery.Compared with the control group,the altered metabolite of the model group at 6 h was aspartate(Asp),and the difference was mainly displayed in the cortex;while significant changes at 9 h occurred predominantly in the cortex and hippocampus,and the corresponding metabolites were Asp and glutamate(Glu).All changes returned to baseline at 24 h.The altered metabolic changes could have occurred as a result of the acute APNP,and the metabolites Asp and Glu in the cortex and hippocampus could provide preliminary evidence for understanding the APNP process. | Taotao Liu Zhengqian Li Jindan He Ning Yang Dengyang Han Yue Li Xuebi Tian Huili Liu Anne Manyande Hongbing Xiang Fuqiang Xu Jie Wang Xiangyang Guo | 2020 | Neuroscience Bulletin2020，36，1： | 2 |
| 19 | Additional acoustic attenuation of coastal turbid water—Measurements compared with predictions using particle size distributions techniques显示文摘把方法基于回响,粘滞 0.2-2.0 kg/m3 的吸收沉积和玻璃祷告混浊的海水被测量。测量结果与用粒子尺寸分布技术的预言结果更一致而不是使用平均粒子半径技术,这被显示出。由预言的比较,用粒子的结果用平均粒子半径技术与那缩放分布技术,差异是 2.3-2.6 dB,这被观察为沉积的 1.0 kg/m3 的每 100 米在试验性的频率的范围以内的混浊的海水。粒子尺寸分布应该在预言被考虑,这被建议粘滞沿海的混浊的水里的吸收。 | WEN Hongtao YANG Yanming LIU Zhenwen NIU Fuqiang | 2011 | Chinese Journal of Acoustics2011，30，3： | 2 |
| 20 | Numerical and experimental investigation on emission performance of a fuel staged combustor显示文摘The low NOx emission technology has become an important feature of advanced aviation engine.A wide range of applications attempt to take advantage of the fact that staged combustion under lean-premixed-prevaporized(LPP)conditions can significantly cut down emission and improve combustion efficiency.This paper proposes a scheme with fuel centrally staged and multi-point injection.The mixing of fuel and air is improved,and the flame temperature is relative low in combustion zone,minimizing the formation of nitrogen oxides(NOx),especially thermal NOx.In terms of the field distribution of equivalence ratio and temperature obtained from Computational Fluid Dynamics(CFD),a chemical reactor network(CRN),including several different ideal reactor,namely perfectly stirred reactor(PSR)and plug flow reactor(PFR),is constructed to simulate the combustion process and predict pollution emission.The influences of the pilot equivalence ratio and percentage of pilot/main fuel on NOx and carbon monoxide(CO)emission were investigated by CRN model.The effects of the pilot fuel and primary fuel on pollution emission were investigated experimentally.Finally,the effects of pilot equivalence ratio and pilot fuel proportion on NOx emission were discussed in detail by comparing predict of CRN and experimental results. | LIU FuQiang ZHANG KaiYu LIU CunXi MU Yong YANG JinHu XU Gang ZHU JunQiang | 2014 | Science China(Technological Sciences)2014，57，10： | 2 |
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