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| 1 | Long-term inorganic plus organic fertilization increases yield and yield stability of winter wheat显示文摘An understanding of wheat yield and yield stability response to fertilization is important for sustainable wheat production. A 36-year long-term fertilization experiment was employed to evaluate the yield and yield stability of winter wheat. Five fertilization regimes were compared,including(1) CK, no fertilizer;(2) NPK, inorganic fertilizer only;(3) O, organic fertilizer only;(4)NPKO, 50% of NPK plus 50% of O, and(5) HNPKO, 80% of NPK plus 80% of O. The greatest yield increase was recorded in HNPKO, followed by NPKO, with O producing the lowest mean yield increase. Over the 36 years, the rate of wheat yield increase in fertilized plots ranged from95.31 kg ha-1 year-1 in the HNPKO to 138.65 kg ha-1 year-1 in the O. Yield stability analysis using the additive main effects and multiplicative interactions(AMMI) method assigned 62.3%, 26.3%,and 11.4% of sums of squares to fertilization effect, environmental effect, and fertilization ×environment interaction effect, respectively. The combination of inorganic and organic fertilization(NPKO and HNPKO) appeared to produce more stable yields than O or NPK, with lower coefficients of variation and AMMI stability value. However, wheat grown with O seemed to be the most susceptible to climate change and the least productive among the fertilized plots.Significant correlations of grain yield with soil properties and with mean air temperature were observed. These findings suggest that inorganic + organic fertilizer can increase wheat yield and its stability by improvement in soil fertility and reduction in variability to climate change. | Huan Chen Aixing Deng Weijian Zhang Wei Li Yuqiang Qiao Taiming Yang Chengyan Zheng Chengfu Cao Fu Chen | 2018 | The Crop Journal2018，6，6： | 5 |
| 2 | Serum proteomic analysis revealed diagnostic value of hemoglobin for nonalcoholic fatty liver disease显示文摘 | Chaohui Yu Chengfu Xu Lei Xu Jiekai Yu Min Miao Youming Li | 2011 | Journal of Hepatology2011，，1： | 3 |
| 3 | Synthesis of AgGa1-xInxSe2 Polycrystalline Materials显示文摘AgGa1-xInxSe2 polycrystals were synthesized by the method of mechanical oscillation and temperature oscillation. X-ray diffraction spectra of polycrystal powder are conformable with the JCPDS cards. Lattice constants a and c calculated from the XRD were found to obey Vegard's law. The melting point of AgGa0.8In0.2Se2 obtained by means of differential scanning calorimetry (DSC) is 796.53 ℃. The DSC curve also show that there are no other transformation points below the melting point. The results indicate that polycrystalline materials synthesized by the method mentioned above are high-quality and can be used to grow single crystals by the vertical Bridgman technology. | Liu Juan Zhao Beijun Zhu Shifu Huang Yi Zhang Jianjun Zhu Weilin Xu Chengfu Chen Baojun Li Ming He Zhiyu | 2006 | Journal of Rare Earths2006，24，z1： | 2 |
| 4 | Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology:Implications for Alzheimer's disease therapy显示文摘Alzheimer's disease(AD),characterized by the accumulation of protein aggregates including phosphorylated Tau aggregates,is the most common neurodegenerative disorder with limited therapeutic agents.Autophagy plays a critical role in the degradation of phosphorylated Tau aggregates,and transcription factor EB(TFEB)is a master regulator of autophagy and lysosomal biogenesis.Thus,small-molecule autophagy enhancers targeting TFEB hold promise for AD therapy.Here,we found that celastrol,an active ingredient isolated from the root extracts of Tripterygium wilfordii(Lei Gong Teng in Chinese)enhanced TFEB-mediated autophagy and lysosomal biogenesis in vitro and in mouse brains.Importantly,celastrol reduced phosphorylated Tau aggregates and attenuated memory dysfunction and cognitive deficits in P301S Tau and 3xTg mice,two commonly used AD animal models.Mechanistical studies suggest that TFEB-mediated autophagy-lysosomal pathway is responsible for phosphorylated Tau degradation in response to celastrol.Overall,our findings indicate that Celastrol is a novel TFEB activator that promotes the degradation of phosphorylated Tau aggregates and improves memory in AD animal models.Therefore,Celastrol shows potential as a novel agent for the treatment and/or prevention of AD and other tauopathies. | Chuanbin Yang Chengfu Su Ashok Iyaswamy Senthil Kumar Krishnamoorthi Zhou Zhu Sichang Yang Benjamin Chunkit Tong Jia Liu Sravan G.Sreenivasmurthy Xinjie Guan Yuxuan Kan Aston Jiaxi Wu Alexis Shiying Huang Jieqiong Tan Kingho Cheung Juxian Song Min Li | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 2 |
| 5 | Characteristics of the turbidite fan in the Wenchang Formation of the Enping Sag, Pearl River Mouth Basin, China and its hydrocarbon significance显示文摘A turbidite fan in the Eocene upper Wenchang Formation in the Enping Sag, Pearl River Mouth Basin (PRMB) has been studied using seismic, logging and borehole data. The fan is characterized by parallel progradation on the dip seismic profile and is mound-shaped or lenticular-shaped on the strike seismic profile. The study of the core and logging data from well EP17-3-1, which is located in the front side of the turbidite fan, shows that this fan is a set of normal grading sand beds, interbedded within thick dark grey mudstones of semi-deep to deep lake deposits in the Wenchang Formation. The fan is interpreted as a sand/mud-rich turbidite fan that has an area of over 140 km2 and a maximum thickness of over 340 m. Combined with a study of the regional geological background and previous provenance analysis of the Eocene Wenchang Formation, the main potential provenances for the turbidite fan are considered to be the Panyu low-uplift and northern fault terrace zone. The Enping Sag is considered to be a half graben-like basin whose north side is faulted and whose south side is overlapped. Basement subsidence in the Eocene was mainly controlled by boundary faults which dip relatively steeply on the north side, causing the subsidence center of the Enping Sag in this stage to be close to the north boundary faults. Sustained faults developed in the Enping Sag during the Eocene caused an increase of the relative height difference between the north and the south uplift zone in the Enping Sag. Affected by the second episode of the Zhuqiong movement (39-36 Ma) in late Eocene, sediments which had accumulated on the Panyu low-uplift zone were triggered and moved toward the subsidence center of the Enping Sag and formed the turbidite fan. The second episode of the Zhuqiong movement is the most important triggering factor for the formation of the turbidite fan in the Wenchang Formation. Seismic attribute characterization shows that the low frequency energy is enhanced and high frequency energy is weakened when seismic waves propagate through the oil-bearing zone in this fan. Amplitude versus offset (AVO) anomalies are observed in the seismic data and abnormally high pressure is encountered. The turbidite fan in the Wenchang Formation has provided important information for sedimentary evolution in deep layers of the Enping Sag and pointed to a new direction for the hydrocarbon exploration in the study area. | Chen Guojun Li Chao Du Guichao Zhang Gongcheng Lü Chengfu Wang Qi | 2013 | Petroleum Science2013，10，3： | 1 |
| 6 | 2 - 42 Development of High-accuracy Detector for Measuring K显示文摘 | Lei Fuan Qin Zhi Song Haihong Dong Chengfu Li Songlin Ding Huajie Tian Wei Zhao Liang Fan Fangli Bai Jing Wu Xiaolei Guo Junsheng | 2010 | IMP & HIRFL Annual Report2010，，1： | 1 |
| 7 | 2 - 43 Determining Threshold Value of High-accuracy Detector for Measuring 40K显示文摘 | Lei Fuan Qin Zhi Song Haihong Dong Chengfu Li Songlin Ding Huajie Tian Wei Zhao Liang Fan Fangli Bai Jing Wu Xiaolei Guo Junsheng | 2010 | IMP & HIRFL Annual Report2010，，1： | 1 |
| 8 | Evaluation of antioxidant and immune activity of Phellinus ribis glucan in mice显示文摘 | Chengfu Yuan Xiuning Huang Li Cheng Youquan Bu Geli Liu Faping Yi Zhengmei Yang Fangzhou Song | 2008 | Food Chemistry2008，，2： | 1 |
| 9 | Existence of positive solutions of the boutIdary value problem for nonlinear fractional differential equations显示文摘 | Li Chengfu Luo Xiacnan Zhou Yong | 2010 | Comput Math Appl2010，59，3： | 1 |
| 10 | Existence of positive solutions of the boundary value problem for nonlinear fractional differential equations 显示文摘 | Li Chengfu Luo Xiannan Zhou Yong | 2010 | Computers and Mathematics with Applications2010，59，3： | 1 |
| 11 | Evaluation of antioxidant and immune activity of Phellinus ribis glucan in mice显示文摘 | Yuan Chengfu Huang Xiuning Cheng Li | 2009 | Food Chemistry2009，115，2： | 1 |
| 12 | Association of serum uric acid level with non-alcoholic fatty liver disease: A cross-sectional study显示文摘 | Youming Li Chengfu Xu Chaohui Yu Lei Xu Min Miao | 2008 | Journal of Hepatology2008，，5： | 1 |
| 13 | Evaluation of antioxidant and immune activity of Phellinus ribis gluean in mice显示文摘 | YUAN Chengfu HUANG Xiuning CHENG Li | 2009 | Food Chemistry2009，115，： | 1 |
| 14 | Expression and function on embryonic development of lissencephaly-1 genes in zebrafish显示文摘Lissencephaly,严重疾病被大脑畸形性描绘。主要原因的基因 lissencephaly 是 LIS1。LIS1 的变化或删除在大脑开发导致增长和神经原的迁居缺乏。然而,很少在胚胎的开发对它的生物函数被知道。在这篇文章,我们识别了 zebrafish LIS1 基因的表达式模式并且在胚胎的开发调查了它的函数。我们证明 zebrafish 由二 LIS1 基因, LIS1a 和 LIS1b 组成了。生物信息学分析表明 LIS1 基因在蛋白质序列和 genomic 结构两个都在进化被保存。zebrafish LIS1a 和 LIS1b 的表示模式证明两个抄本无所不在地被表示根本胚胎的发展阶段并且在检验的成年纸巾。在蛋白质水平, LIS1 产品主要在由西方的弄污显示出分析的早阶段在大脑织物并且在胚胎存在。整个山的 immunostaining 数据证明 LIS1 蛋白质在整个从 1 房间舞台的胚胎是分布式的到 5 白天授精以后。通过 morpholino antisense oligonucleotides 的 LIS1 蛋白质表示击倒在 zebrafish,包括的大脑畸形性,发行量反常,和身体导致了许多发展缺乏卷屈。一起拿,我们的学习建议 zebrafish LIS1 在胚胎的开发起一个很重要的作用。 | Chengfu Sun Mafei Xu Zhen Xing Zhili Wu Yiping Li Tsaiping Li Mujun Zhao | 2009 | Acta Biochimica et Biophysica Sinica2009，41，8： | 1 |
| 15 | Seismic Recognition and Origin of Miocene Meishan Formation Contourite Deposits in the Southern Qiongdongnan Basin,Northern South China Sea显示文摘Research into the contourite deposits in the Upper Meishan Formation of the southern Qiongdongnan Basin in South China Sea is weak;their characteristics,distribution and original geological conditions are not clear.Using geologic al and geophysical methods including seismic and drilling data,based on seismic reflection characteristics,geometrical configuration description,and wave impedance inversion,two types of contourite deposits are recognized.Contourite deposits have blurred boundaries between each deposit and disordered internal seismic reflections;They are mound-shaped only in transverse section,and banded in the longitudinal direction.TypeⅠcontourite deposits are conical,with mediumhigh amplitude,low-continuity,low-frequency mound-shaped seismic facies,and subparallel-chaotic reflections internally.These deposits are conical with sharp tops,the canal between mounds is V-shaped and deep.The western wing is gentle and the eastern wing is steep,with the slope toe mostly between 10°and 20°,and width height ratio about 1-2.TypeⅡcontourite deposits are flat,exhibiting medium-amplitude,medium-continuity,low-frequency mound-shaped seismic facies,with subparallel weak reflections internally.Their mounds are flat with gently arced tops,with shallow canals between.The slope toe is between 5°and 10°,with a width height ratio of about 2-5.The wave impedance value of these contourite deposits is 4.6 kg/m^(3)×m/s to 6.8 kg/m^(3)×m/s,about 5.8 kg/m^(3)×m/s on average,which is presumed to represent marlycalcareous clastic sediments.The contourite deposits mainly develop beneath the slope break at the margin of the faultcontrolled platform in the Southern Uplift zone of the basin.In plane view,they are distributed approaching a west-to-east direction,and in section,lie in low-lying areas near the faults at fault-controlled terraces of the Southern Uplift zone,with a paleo-current direction nearly west-to-east.The paleotectonic setting of the gentle monoclinic platform was favorable for the development of such contourite deposits.The intensification of the Mid-Miocene deepest bottom current gave rise to the contourite-forming currents around the Southern Uplift zone in the northern South China Sea,which flow from Hainan Island to the Xisha Trough in a nearly west-to-east direction leading to the contourite deposits developing in the late MidMiocene transgressive environment,with multiple slow sea-level fall cycles. | FENG Yangwei REN Yan LYU Chengfu ZHANG Peng CHEN Ying JIN Li | 2021 | Acta Geologica Sinica(English Edition)2021，95，1： | 1 |
| 16 | Evaluation of antioxidant and immune activity of Phellinus ribis glucan in mice显示文摘 | YUAN CHENGFU HUANG XIUNING CHENG LI | 2009 | Food Chemistry2009，，115： | 1 |
| 17 | Graphs with chromatic polynominal ∑ι≤m0(^ιm0-ι) (λ)ι显示文摘 | Chengfu Ye Nianzu Li | 2002 | Discrete Math2002，259，： | 1 |
| 18 | Municipal Road Quality Control and Testing显示文摘As the infrastructure project in the city,municipal road is the quality of urban transportation service,which determines the city image and government image.Therefore,the relevant units and personnel must strengthen the efforts of municipal road quality control,management of municipal road test in order to ensure the quality of municipal roads can satisfy the stability and bearing requirements. | Jian Li Peng Liu Chengfu Yan Jinhui Huo Qiang Liu | 2018 | Smart Construction Research2018，2，4： | 0 |
| 19 | 'Third eye' of colonoscopists: a preclinical comparative study of artificial intelligence-assisted polyp detection显示文摘To the Editor: In China, colorectal cancer (CRC) ranks third in cancer incidence and fifth in cancer-related deaths.[1] Most CRCs arise from adenomatous polyps. Colonoscopy can detect and remove polyps early to prevent CRC. However, the polyp miss rate in conventional colonoscopy may be more than 40%.[2] New endoscopic devices for detecting polyps have made some progress over the past few decades,[3] but are still operator-dependent and require additional costs. Therefore, artificial intelligence (AI)-assisted polyp detection systems have emerged in recent years. This study aimed to evaluate the effectiveness of our newly developed AI-assisted polyp detection system for colonoscopy in a preclinical manner. | Xinjue He Lei Xu Chengfu Xu Jie Zhang Meng Li Weihong Wang Xiaoyun Ding Youming Li Xuequn Zhang | 2022 | Chinese Medical Journal2022，135，22： | 0 |
| 20 | LncRNA KCNQ1OT1:Molecular mechanisms and pathogenic roles in human diseases显示文摘Long non-coding RNAs(lncRNAs)exhibit a length more than 200 nucleotides and they are characterized by non-coding RNAs(ncRNA)not encoded into proteins.Over the past few years,the role and development of lncRNAs have aroused the rising attention of researchers.To be specific,KCNQ1OT1,the KCNQ1 opposite strand/antisense transcript 1,is clearly classified as a regulatory ncRNA.KCNQ1OT1 is capable of interacting with miRNAs,RNAs and proteins,thereby affecting gene expression and various cell functions(e.g.,cell proliferation,migration,epithelialemesenchymal transition(EMT),apoptosis,viability,autophagy and inflammation).KCNQ1OT1 is dysregulated in a wide range of human diseases(e.g.,cardiovascular disease,cancer,diabetes,osteoarthritis,osteoporosis and cataract),and it is speculated to act as a therapeutic target for treating various human diseases.On the whole,this review aims to explore the biological functions,underlying mechanisms and pathogenic roles of KCNQ1OT1 in human diseases. | Fangqi Xia Yaqi Wang Mengzhen Xue Leiqi Zhu Dengke Jia Yue Shi Yan Gao Luoying Li Yuanyang Li Silong Chen Guangfu Xu Ding Yuan Chengfu Yuan | 2022 | Genes & Diseases2022，9，6： | 0 |
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