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| 1 | A bioactive injectable self-healing anti-inflammatory hydrogel with ultralong extracellular vesicles release synergistically enhances motor functional recovery of spinal cord injury显示文摘The repair and motor functional recovery after spinal cord injury(SCI)remains a worldwide challenge.The inflammatory microenvironment is one of main obstacles on inhibiting the recovery of SCI.Using mesenchymal stem cells(MSCs)derived extracellular vesicles to replace MSCs transplantation and mimic cell paracrine secretions provides a potential strategy for microenvironment regulation.However,the effective preservation and controlled release of extracellular vesicles in the injured spinal cord tissue are still not satisfied.Herein,we fabricated an injectable adhesive anti-inflammatory F127-polycitrate-polyethyleneimine hydrogel(FE)with sustainable and long term extracellular vesicle release(FE@EVs)for improving motor functional recovery after SCI.The orthotopic injection of FE@EVs hydrogel could encapsulate extracellular vesicles on the injured spinal cord,thereby synergistically induce efficient integrated regulation through suppressing fibrotic scar formation,reducing inflammatory reaction,promoting remyelination and axonal regeneration.This study showed that combining extracellular vesicles into bioactive multifunctional hydrogel should have great potential in achieving satisfactory locomotor recovery of central nervous system diseases. | Chenggui Wang Min Wang Kaishun Xia Jingkai Wang Feng Cheng Kesi Shi Liwei Ying Chao Yu Haibin Xu Shining Xiao Chengzhen Liang Fangcai Li Bo Lei Qixin Chen | 2021 | Bioactive Materials2021，6，8： | 9 |
| 2 | Seismic performance of recycled concrete-filled square steel tube columns显示文摘An experimental study on the seismic performance of recycled concrete-filled square steel tube(RCFST) columns is carried out.Six specimens were designed and tested under constant axial compression and cyclic lateral loading.Two parameters, replacement percentage of recycled coarse aggregate(RCA) and axial compression level, were considered in the test.Based on the experimental data, the hysteretic loops, skeleton curves, ductility, energy dissipation capacity and stiffness degradation of RCFST columns were analyzed.The test results indicate that the failure modes of RCFST columns are the local buckling of the steel tube at the bottom of the columns, and the hysteretic loops are full and their shapes are similar to normal CFST columns.Furthermore, the ductility coefficient of all specimens are close to 3.0, and the equivalent viscous damping coefficient corresponding to the ultimate lateral load ranges from 0.323 to 0.360, which demonstrates that RCFST columns exhibit remarkable seismic performance. | Chen Zongping Jing Chenggui Xu Jinjun Zhang Xianggang | 2017 | Earthquake Engineering and Engineering Vibration2017，16，1： | 8 |
| 3 | Bounding surface plasticity model for stress-strain and grain-crushing behaviors of rockfill materials显示文摘Crushing of grains can greatly influence the strength,dilatancy,and stress-strain relationship of rockfill materials.The critical state line(CSL)in the void ratio versus mean effective stress plane was extended to the breakage critical state plane(BCSP).A state void-ratio-pressure index that incorporated the effect of grain crushing was proposed according to the BCSP.Rowe’s stress-dilatancy equation was modified by adding the breakage voidratio-pressure index,which was also incorporated into the formulations of the bounding stress ratio and plastic modulus.A BCSP-based bounding surface plasticity model was proposed to describe the state-dependent stressstrain behaviors and the evolution of grain crushing during shearing process of rockfill materials,and was shown to sufficiently capture the breakage phenomenon. | Yang Xiao Zengchun Sun Armin WStuedlein Chenggui Wang Zhijun Wu Zhichao Zhang | 2020 | Geoscience Frontiers2020，11，2： | 5 |
| 4 | Barley St#pe Mosaic Virus yb Interacts with Glycolate Oxidase and Inhibits Peroxisomal ROS Production to Facilitate Virus Infection显示文摘 | Meng Yang Zhenggang Li Kun Zhang Xuan Zhang Yongliang Zhang Xianbing Wang Chenggui Han Jialin Yu Kai Xu Dawei Li | 2018 | Molecular Plant2018，11，2： | 3 |
| 5 | Injectable kartogenin and apocynin loaded micelle enhances the alleviation of intervertebral disc degeneration by adipose-derived stem cell显示文摘Cell transplantation has been proved the promising therapeutic effects on intervertebral disc degeneration(IVDD).However,the increased levels of reactive oxygen species(ROS)in the degenerated region will impede the efficiency of human adipose-derived stem cells(human ADSCs)transplantation therapy.It inhibits human ADSCs proliferation,and increases human ADSCs apoptosis.Herein,we firstly devised a novel amphiphilic copolymer PEG-PAPO,which could self-assemble into a nanosized micelle and load lipophilic kartogenin(KGN),as a single complex(PAKM).It was an injectable esterase-responsive micelle,and showed controlled release ability of KGN and apocynin(APO).Oxidative stimulation promoted the esterase activity in human ADSCs,which accelerate degradation of esterase-responsive micelle.Compared its monomer,the PAKM micelle possessed better bioactivities,which were attributed to their synergistic effect.It enhanced the viability,autophagic activation(P62,LC3 II),ECM-related transcription factor(SOX9),and ECM(Collagen II,Aggrecan)maintenance in human ADSCs.Furthermore,it is demonstrated that the injection of PAKM with human ADSCs yielded higher disc height and water content in rats.Therefore,PAKM micelles perform promoting cell survival and differentiation effects,and may be a potential therapeutic agent for IVDD. | Chao Yu Dongdong Li Chenggui Wang Kaishun Xia Jingkai Wang Xiaopeng Zhou Liwei Ying Jiawei Shu Xianpeng Huang Haibin Xu Bin Han Qixin Chen Fangcai Li Jianbin Tang Chengzhen Liang Nigel Slater | 2021 | Bioactive Materials2021，6，10： | 3 |
| 6 | Generation of transgenic wheat resistant to wheat yellow mosaic virus and identification of gene silence induced by virus infection显示文摘The plasmid containing the promoter Actl, the coat protein (cp) gene of wheat yellow mosaic virus (WYMV) and the selectable bar gene, was delivered via particle bombardment, directly into immature embryos of a wheat culti-vars. PCR and PCR-RFLP were employed to screen the existence of the cp gene in T0 and T1 generations. Seeds from the positive T1 plants were sowed in fields heavily contaminated with WYMV to detect their resistance. In field trial of virus infection, one of the transgenic wheat lines, P8-T2, exhibited highly disease-resistance. Western blot and RT-PCR analysis showed that the expression level of cp gene in the resistant transgenic line was reduced greatly compared to those susceptible to WYMV infection. This provided evidence to presume that the resistance obtained by the transgenic wheat line was stimulated by the mechanism of the virus induced gene silencing. | DONG Jin HE Zhentian HAN Chenggui CHEN Xiulan ZHANG Lingdi LIU Weihua HAN Yuepeng WANG Jinrong ZHAI Yafeng YU Jialin LIU Yi XIAO Yueyan | 2002 | Chinese Science Bulletin2002，47，17： | 2 |
| 7 | In s itu opti cal microscope study of the shear-induced crystallization of isotactic polypropylene显示文摘 | Zhang Chenggui Hu Haiqing Wang Dujin | 2005 | Polymer2005，46，19： | 1 |
| 8 | Stochastic differential delay equations of population dynamics 显示文摘 | MAO Xuerong YUAN Chenggui ZOU Jiezhong | 2005 | Jour- nal of Mathematical Analysis and Applications2005，304，1： | 1 |
| 9 | Selective conversion of bio-oil to light olefins: Controlling catalytic cracking for maximum olefins显示文摘 | Feiyan Gong Zhi Yang Chenggui Hong Weiwei Huang Shen Ning Zhaoxia Zhang Yong Xu Quanxin Li | 2011 | Bioresource Technology2011，，19： | 1 |
| 10 | Forma tion of cylindrite structures in shear-induced crystallization of isotactic polypropylene at low shear rate 显示文摘 | Zhang Chenggui Hu Haiqing Wang Xiaohong | 2007 | Polymer2007，48，4： | 1 |
| 11 | Left to right extracardial shunt to control hemorrhage of ascending aorta and left ventricle: A report of 3 cases显示文摘 | LIU CHENGGUI ( 刘成硅 ) YANG CHENGYUAN(杨辰垣) ZHANG KAILUN(张凯伦) | 1998 | J Tongji Med Univ1998，18，： | 1 |
| 12 | Simple electronic circuit model for diversity-induced resonance显示文摘 | Chenggui Yao Meng Zhan | 2010 | Physics Letters A2010，，24： | 1 |
| 13 | Numerical solutions of stochastic differential delay equations with Jumps显示文摘 | JACOB N WANG Yongting YUAN Chenggui | 2009 | Stoch Anal Appl2009，，27： | 1 |
| 14 | Convergence of the Euler-Maruyama method for stochastic differential equations with Mark-ovian switching 显示文摘 | YUAN Chenggui MAO Xuerong | 2004 | Mathematics Computers in Simulation2004，，64： | 1 |
| 15 | Wheat yellow mosaic virus widely occurring in wheat in China显示文摘 | Han Chenggui Li Dawei Xing Yiming | 2000 | Plant Disease2000，84，： | 1 |
| 16 | Elevated serum my- eloperoxidase activities are significantly associated with the preva- lence of ACS and high LDL-C levels in CHD patients显示文摘 | Chenggui L Guoming X Wenfang I-I | 2012 | J Ather- oscler Thromb2012，19，5： | 1 |
| 17 | Exploration on Separation of Periplaneta Americana Small Peptides with Tricine-SDS-PAGE System显示文摘[Objective] This study aimed to explore a Tricine-SDS-PAGE method for separation and purification of Periplaneta Americana small peptides. [Method] By comparing the separation effects of three types of gels with different ratios on P. Americana small peptides, an appropriate Tricine-SDS-PAGE method for separation of small peptides was established. [Result] Standard low molecular weight Marker was preliminarily separated to a certain extent with polyacrylamide gel electrophoresis, while the sample mixture was not separated due to the different levels of aggregation in separating gel, spacer gel and stacking gel. [Conclusion] More appropriate polyacrylamide gel electrophoresis separation method or other better separation methods were to be further explored for separating peptide mixture with smaller molecular weight. | Shaohui WU Xiumei WU Chenggui ZHANG Guangmin DONG Guangming LIU | 2012 | Agricultural Biotechnology2012，1，2： | 1 |
| 18 | Ore-forming age and tectonic setting of the Linjiasandaogou gold deposit in the Liaodong Peninsula,northeast China:constraints from geochronology and geochemistry显示文摘The Linjiasandaogou gold deposit is located in the Qingchengzi Orefield,North China Craton,China,and has not attracted many studies.We present geochronological,whole-rock geochemical,and Sr–Nd–Hf isotopic data to constrain the age and tectonic setting of the mineralization.U–Pb dating of zircon from pre-and post-ore dikes indicates the Linjiasandaogou Au deposit formed at ca.227–226 Ma.The granite porphyry(ca.227 Ma)and quartz diorite porphyry(ca.228 Ma),which are slightly older than the mineralization,have(;Sr/;Sr)i-=0.7127–0.7162,εNd(t)=–13.7 to–17.0,andεHf(t)=–14.6 to–16.9,and display enrichment in light rare earth elements and large ion lithophile elements and depletion in high field strength elements.Two lamprophyres(226 and225 Ma),which are slightly younger than the mineralization,have higher(;Sr/;Sr)i(0.7165–0.7216),negativeεNd(t)(–11.2 to–14.3)andεHf(t)(–15.6 to–18.6)values,and are enriched in light rare earth elements but depleted in high field strength elements(Nb and Ta).The geochemical characteristics of the granitoid and lamprophyres indicate a lower crustal and enriched mantle source,respectively.We infer that the Linjiasandaogou Au deposit formed in a postcollisional tectonic setting,following the collision between the North China,Yangtze craton,and Central Asian Orogeny in Triassic. | Xiaofeng Yao Tingjie Yan Zhicheng Lü Chenggui Lin Kuifeng Mi Shenghui Li Yang Li Wange Du | 2022 | Acta Geochimica2022，41，2： | 1 |
| 19 | Research on a MCOP algorithm for optimized path显示文摘 | Qin Yong Wang Yukun Zhao Chenggui | 2006 | Journal of Information & Computational Science2006，3，4： | 1 |
| 20 | Asymptotic stability in distribution of stochastic differential equations with markovian switching显示文摘 | Mao Xuerong | 2003 | Stoch Proc Appl2003，103，： | 1 |
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