2篇
您的检索式：作者名="Chengnan Yin"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Quantification of pesticide residues on plastic mulching films in typical farmlands of the North China显示文摘Plastic debris as new pollutants attracts much attention in the recent years.The plastic mulching films is one of the most important plastic debirs source in the environment.The aim of this work was to investigate the current status of pesticide residues on the plastic mulching films.Based on the QuEChERS method,multi-residue methods for detection of pesticide residues with gas chromatography tandem mass spectrum(GC-MS)and high performance liquid chromatography tandem mass spectrum(HPLC-MS)were developed for the analysis of the pesticides residues in plastic film and soil samples from Tianjin,Hebei and Shandong.The total concentrations of pesticide residues were in the range of 86.4-22213.2 ng/g in plastic film debris,which was about 20 times higher than that in soil(9.3—535.3 ng/g).Residual level of pesticides varied greatly in different samples.The historical usage and recent application of pesticides were the main sources for pesticide residues on plastic films and soil.In short,plastic mulching films could act as a sink for pesticides in farmland and the ubiquitous pesticide residues on plastic films should draw more attention. | Baoyuan Guo Jiao Meng Xinyu Wang Chengnan Yin Weiyu Hao Baiwen Ma Zhang Tao | 2020 | Frontiers of Environmental Science & Engineering2020，14，1： | 0 |
| 2 | Brain-targeted polymersome codelivery of siRNA and temozolomide for effective glioblastoma chemo-RNAi synergistic therapy显示文摘Temozolomide (TMZ) is a clinically approved drug for glioblastoma (GBM) therapy. However, as a result of methylguanine-DNA-methyltransferase (MGMT), which is able to repair damaged DNA-damage repairing, TMZ usually yields unsatisfactory therapeutic effects. Small interfering RNA (siRNA) is a potential alteration tool for sensitivity of TMZ by targeting DNA repair enzymes. However, a suitable TMZ and siRNA codelivery system that can effectively and actively co-deliver siRNA/TMZ into the brain tumor is lacking. In this study, we constructed an angiopep-2 decorated polymersomal delivery system to co-deliver TMZ/siRNA for synergistic GBM therapy. This targeted polymersomal nanomedicine not only enhanced the circulation time of siRNA/TMZ in blood but also improved their blood-brain barrier (BBB) crossing and GBM targeting ability. Moreover, when we co-administered siRNAs specific to retinoblastoma binding protein 4 (RBBP4) together with TMZ in GBM cells, these RBBP4- specific siRNA (siRBBP4) modulated the sensitivity of TMZ by regulating MGMT, and thus showed a powerful synergistic anti-tumor effect. We demonstrated that angiopep-2 decorated polymersomal siRBBP4/TMZ co-loaded nanomedicines are capable of inhibiting tumor growth and significantly improved life expectancy of orthotropic GBM bearing mice. Overall, our study suggests that such a polymersomal TMZ/siRNA codelivery system provides a robust and potent nanoplatform for targeted GBM chemo-RNAi therapy. | Meng Zheng Chengnan Yan Qingshan Yang Feiyan Zhu Qiuli Du Xue Xia Marco Morsch Albert Lee Jinglong Yin Yan Zou Bingyang Shi | 2022 | ChemPhysMater2022，1，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员