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| 1 | Physics-informed deep learning for incompressible laminar flows显示文摘Physics-informed deep learning has drawn tremendous interest in recent years to solve computational physics problems,whose basic concept is to embed physical laws to constrain/inform neural networks,with the need of less data for training a reliable model.This can be achieved by incorporating the residual of physics equations into the loss function.Through minimizing the loss function,the network could approximate the solution.In this paper,we propose a mixed-variable scheme of physics-informed neural network(PINN)for fluid dynamics and apply it to simulate steady and transient laminar flows at low Reynolds numbers.A parametric study indicates that the mixed-variable scheme can improve the PINN trainability and the solution accuracy.The predicted velocity and pressure fields by the proposed PINN approach are also compared with the reference numerical solutions.Simulation results demonstrate great potential of the proposed PINN for fluid flow simulation with a high accuracy. | Chengping Rao Hao Sun Yang Liu | 2020 | Theoretical & Applied Mechanics Letters2020，10，3： | 11 |
| 2 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 7 |
| 3 | Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘Objective: Germline alterations in the breast cancer susceptibility genes type 1 and 2, BRCA1 and BRCA2, predispose individuals to hereditary cancers, including breast, ovarian, prostate, pancreatic, and stomach cancers.Accumulating evidence suggests inherited genetic susceptibility to lung cancer.The present study aimed to survey the prevalence of pathogenic germline BRCA mutations(gBRCAm) and explore the potential association between gBRCAm and disease onset in Chinese advanced non-small cell lung cancer(NSCLC) patients.Methods: A total of 6,220 NSCLC patients were screened using capture-based ultra-deep targeted sequencing to identify patients harboring germline BRCA1/2 mutations.Results: Out of the 6,220 patients screened, 1.03%(64/6,220) of the patients harbored the pathogenic gB RCAm, with BRCA2 mutations being the most predominant mutations(49/64, 76.5%).Patients who developed NSCLC before 50 years of age were more likely to carry gBRCAm(P = 0.036).Among the patients harboring classic lung cancer driver mutations, those with concurrent gBRCAm were significantly younger than those harboring the wild-type gBRCA(P = 0.029).By contrast, the age of patients with or without concurrent gBRCAm was comparable to those of patients without the driver mutations(P = 0.972).In addition, we identified EGFR-mutant patients with concurrent gBRCAm who showed comparable progression-free survival but significantly longer overall survival(P = 0.002) compared to EGFR-mutant patients with wild-type germline BRCA.Conclusions: Overall, our study is the largest survey of the prevalence of pathogenic gBRCAm in advanced Chinese NSCLC patients.Results suggested a lack of association between germline BRCA status and treatment outcome of EGFR-TKI.In addition,results showed a positive correlation between pathogenic gB RCAm and an early onset of NSCLC. | Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu | 2019 | Cancer Biology & Medicine2019，16，3： | 4 |
| 4 | A Novel Duplex Low-temperature Chromizing Process at 500℃显示文摘在 500 °C 的一个优化低温度的渗铬过程经由由先锋血浆 nitriding 组成的一个双渗铬过程与 0.45 wt %碳在平凡的中等碳的钢上被认识到,并且跟随的盐洗澡 thermoreactive 免职和散开( TRD )有薄散开层的渗铬 process.CrN 层在下面被形成。双渗铬过程被光显微镜学(OM ) 学习,扫描电子显微镜学(SEM ) ,精力散 X 光检查光谱学(版本) , X 光检查衍射(XRD ) ,和传播电子显微镜学(TEM ) 。在 500 °C 的渗铬速度被增加更多的 Cr-Fe 粉末进盐洗澡成功地提高,这被发现,并且 CrN 层在厚度与一般水准 8.1 亩 m 以优先的氮化物混合物 layer.A CrN 层的成本形成了,在微坚硬的 1382 HV_( 0.01 )被双渗铬更为 24 h.Further 在 500 °C 在底层上形成, CrN 层由 nanocrystalline CrN 谷物组成了。 | Huiliang CAO Cuilan WU Jiangwen LIU Chengping LUO Ganfeng ZOU | 2007 | Journal of Materials Science & Technology2007，23，6： | 3 |
| 5 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
| 6 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
| 7 | Erratum to Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘In the published article1,the affiliation for the first author,Xingshcng Hu,is'Department of Medical Oncology,Cancer Hospital,Chinese Academy of Medical Sciences',we would like to update it to'Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China'.We apologize for the errors and for any confusion it may have caused. | Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu | 2020 | Cancer Biology & Medicine2020，17，2： | 1 |
| 8 | 显示文摘 | Chen Xianming Luo Chengping Liu Jiangwen | 2010 | Journal of Functional Materials2010，41，12： | 1 |
| 9 | 3D multipath planning for UAV based on network graph显示文摘According to the characteristic and the requirement of multipath planning,a new multipath planning method is proposed based on network.This method includes two steps:the construction of network and multipath searching.The construction of network proceeds in three phases:the skeleton extraction of the configuration space,the judgment of the cross points in the skeleton and how to link the cross points to form a network.Multipath searching makes use of the network and iterative penalty method (IPM) to plan multi-paths,and adjusts the planar paths to satisfy the requirement of maneuverability of unmanned aerial vehicle (UAV).In addition,a new height planning method is proposed to deal with the height planning of 3D route.The proposed algorithm can find multiple paths automatically according to distribution of terrain and threat areas with high efficiency.The height planning can make 3D route following the terrain.The simulation experiment illustrates the feasibility of the proposed method. | Xin Liu Chengping Zhou Mingyue Ding | 2011 | Journal of Systems Engineering and Electronics2011，22，4： | 1 |
| 10 | Effects of input method and display mode of situation map on early warning aircraft reconnaissance task performance with different information complexities显示文摘Early Warning Aircraft(EWA)are the main force for air detection and its Human-Machine Interface(HMI)should be designed to support task efficiency and safety.With the appli-cation of advanced input method and interface design in EWA,little is known about their actual usability in terms of human factors and ergonomics.The aim of this study was to investigate the effects of the input method and display mode of the situation map on EWA reconnaissance task performance with different information complexities.Eighteen participants attended a three-factor within-subject design experiment with input method(touch screen and mouse),display mode of the situation map(color and grayscale),and information complexity(high and low)as the inde-pendent variables.Participant behavior performance,subjective workload,heart rate/heart rate variability,and eye movements were recorded as the dependent variables.The results suggest that a touch screen requires greater task completion time and has greater physical demands than mouse operation;however,it also facilitates information processing by reducing the average fixation time.Color mode significantly decreases saccade counts compared to grayscale mode and is considered more appropriate for target search tasks as it induces less visual search load.High information complexity produces significant negative effects on behavior performance and subjective workload.It also has significant interaction effects with input method on fixation and saccade counts.The findings have implications in the optimization design of Human–Machine Interface for EWA task systems. | Chaoran LIANG Shuang LIU Xiaoru WANYAN Chengping LIU Xu XIAO Yuchen MIN | 2023 | Chinese Journal of Aeronautics2023，36，1： | 1 |
| 11 | Study on the formation mechanism of micro-arc oxidation coatings on magnesium显示文摘 | Chen Xianming Luo Chengping Liu Jiangwen | 2010 | Alloys Materials Science Forum2010，650，： | 1 |
| 12 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
| 13 | Multicomponent Reactions for Diverse Synthesis of N-Substituted and NH 1,4-Dihydropyridines显示文摘The multicomponent reactions of aldehydes,electron deficient alkynes and amines have been successfully per-formed to yield a number of symmetrical 2,6-unsubstituted 1,4-dihydropyridines(1,4-DHPs).This method has been found generally applicable for the synthesis of both N-substituted and N-unsubstituted 1,4-DHPs by employing secondary amine to activate the alkyne component via enaminoester intermediates.The present method runs through an enamine type activation,which is different from the known approach employing AcOH as solvent. | Jieping Wan Youyi Zhou Yunyun Liu Zheng Fang Chengping Wen | 2014 | Chinese Journal of Chemistry2014，32，3： | 0 |
| 14 | Discovery of a new nontoxic cuprate superconducting system Ga-Ba-Ca-Cu-O显示文摘Superconductivity is observed in a new nontoxic cuprate system Ga-Ba-Ca-Cu-O,with T_c=82 K for Ga Ba_2Ca_5Cu_6O_(14+δ)(Ga-1256)and T_c=116 K probably for Ga Ba_2Ca_3Cu_4O_(10+δ)(Ga-1234)or Ga Ba_2Ca_2Cu_3O_(8+δ)(Ga-1223),respectively.All compounds are fabricated by solid state reaction method under high pressure and high temperature.Samples are characterized by resistivity,magnetization and X-ray diffraction(XRD)measurements.The temperature dependence of magnetization measured in both zero-field-cooled and field-cooled processes on one sample(S1)shows two superconducting transitions at about 82 K and113 K.The estimated shielding fraction for the phase with T_cof 82 K is about 67%,while the fraction for another phase with T_(c )of 113 K is quite small.The XRD Rietveld refinement for S1 indicates two main phases existing in the sample,Ga-1256 with fraction of about 58%and non-superconducting Ca_(0.85)Cu O_2with fraction of about 42%respectively.Thus,we can conclude the superconducting phase with transition temperature of 82 K is due to Ga-1256.The resistivity measurement also confirms the superconductivity for S1,and the resistivity reaches zero at about 82 K.The temperature dependence of magnetization for another sample(S2)shows much higher superconducting shielding fraction for the phase with T_cof 116 K,which may be a promising prospective for the synthesis of Ga-1234 or Ga-1223 phase. | Yue Zhang Wenhao Liu Jin Si Xiyu Zhu Chengping He Haonan Zhao Hai-Hu Wen | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，9： | 0 |
| 15 | Treatment Effects of Integrated TCM and Western Medicine Treatment Scheme on COVID-19: A Single-armed Clinical Trial显示文摘Backgroud:The outbreak of COVID-19 has brought unprecedented perils to human health and raised public health concerns in more than two hundred countries.Safe and effective treatment scheme is needed urgently.Objective:To evaluate the effects of integratedTCM and western medicine treatment scheme on COVID-19.Methods:A single-armed clinical trial was carried out in Hangzhou Xixi Hospital,an affiliated hospital with Zhejiang Chinese Medical University.102 confirmed cases were screened out from 725 suspected cases and 93 of them were treated with integrated TCM and western medicine treatment scheme.Results:83 cases were cured,5 cases deteriorated,and 5 cases withdrew from the study.No deaths were reported.The mean relief time of fever,cough,diarrhea,and fatigue were(4.78±4.61)days,(7.22±4.99)days,(5.28±3.39)days,and(5.28±3.39)days,respectively.It took(14.84±5.50)days for SARS-CoV-2 by nucleic acid amplification-based testing to turn negative.Multivariable cox regression analysis revealed that age,BMI,PISCT,BPC,AST,CK,BS,and UPRO were independent risk factors for COVID-19 treatment.Conclusion:Our study suggested that integrated TCM and western medicine treatment scheme was effective for COVID-19. | Jianfeng Bao Zhijun Xie Shourong Liu Lin Huang Jing Sun Yujun Tang Haiping Chen Jianjiang Qi Jianchun Guo Liangbin Miao Zhaoyi Li Hui Yang Yi Zhang Zhiyu Li Yuan Xu Shengyou Lin Yunhao Xun Li Zhang Jie Bao Zhaobin Cai Jinsong Huang Chengping Wen | 2021 | Clinical Complementary Medicine and Pharmacology2021，1，1： | 0 |
| 16 | Nickel-Catalyzed Cross-Electrophile Coupling of Triazine Esters with Aryl Bromides显示文摘Cross-electrophile coupling of triazine esters with aryl bromides could be facilely accomplished by employing nickel as catalyst,magnesium as metal mediator,and lithium chloride as additive.The reactions proceeded efficiently in THF at room temperature through C—O bond activation to afford an array of structurally different diaryl ketones in moderate to good yields with wide functional group tolerance.Control experiments showed that nickel,magnesium,lithium chloride,and THF are all indispensable for the good performance of the coupling reaction.Preliminary mechanistic exploration indicated that in situ formed arylmagnesium reagent by the insertion of magnesium into aryl bromide might serve as the key intermediate of the cross-coupling.The method which avoids the utilization of moisture-labile and relatively difficult-to-obtain organometallics is step-economical,cost-efficient,and operationally simple,potentially serving as an attractive alternative to documented methods. | Xiang Liu Cai-Yu He Hao-Nan Yin Chengping Miao Xue-Qiang Chu Weidong Rao Hao Xu Xiaocong Zhou Zhi-Liang Shen | 2023 | Chinese Journal of Chemistry2023，41，24： | 0 |
| 17 | Pressure induced color change and evolution of metallic behavior in nitrogen-doped lutetium hydride显示文摘By applying pressures up to 42 GPa on the nitrogen-doped lutetium hydride(LuH2_(±x)N_(y)),we have found a gradual change of color from dark-blue to pink-violet in the pressure region of about 12 to 21 GPa.The temperature dependence of resistivity under pressures up to 50.5 GPa shows progressively optimized metallic behavior with pressure.Interestingly,in the pressure region for the color change,a clear decrease of resistivity is observed with the increase of pressure,which is accompanied by a clear increase of the residual resistivity ratio(RRR).Fitting to the low temperature resistivity gives exponents of about 2,suggesting a Fermi-liquid behavior in the low temperature region.The general behavior in a wide temperature region suggests that the electron-phonon scattering is still the dominant one.The magnetoresistance up to 9 T in the state under a pressure of 50.5 GPa shows an almost negligible effect,which suggests that the electric conduction in the pink-violet state is dominated by a single band.It is highly desired to have theoretical efforts in understanding the evolution of color and resistivity in this interesting system. | Ying-Jie Zhang Xue Ming Qing Li Xiyu Zhu Bo Zheng Yuecong Liu Chengping He Huan Yang Hai-Hu Wen | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 0 |
| 18 | B1-cell-produced anti-phosphatidylserine antibodies contribute to lupus nephritis development via TLR-mediated Syk activation显示文摘Autoantibodies produced by B cells play a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE). However, both the cellular source of antiphospholipid antibodies and their contributions to the development of lupus nephritis (LN) remain largely unclear. Here, we report a pathogenic role of anti-phosphatidylserine (PS) autoantibodies in the development of LN. Elevated serum PS-specific IgG levels were measured in model mice and SLE patients, especially in those with LN. PS-specific IgG accumulation was found in the kidney biopsies of LN patients. Both transfer of SLE PS-specific IgG and PS immunization triggered lupus-like glomerular immune complex deposition in recipient mice. ELISPOT analysis identified B1a cells as the main cell type that secretes PS-specific IgG in both lupus model mice and patients. Adoptive transfer of PS-specific B1a cells accelerated the PS-specific autoimmune response and renal damage in recipient lupus model mice, whereas depletion of B1a cells attenuated lupus progression. In culture, PS-specific B1a cells were significantly expanded upon treatment with chromatin components, while blockade of TLR signal cascades by DNase I digestion and inhibitory ODN 2088 or R406 treatment profoundly abrogated chromatin-induced PS-specific IgG secretion by lupus B1a cells. Thus, our study has demonstrated that the anti-PS autoantibodies produced by B1 cells contribute to lupus nephritis development. Our findings that blockade of the TLR/Syk signaling cascade inhibits PS-specific B1-cell expansion provide new insights into lupus pathogenesis and may facilitate the development of novel therapeutic targets for the treatment of LN in SLE. | Kongyang Ma Wenhan Du Shiyun Wang Fan Xiao Jingyi Li Jie Tian Yida Xing Xiaodan Kong Ke Rui Rencai Qin Xiaoxia Zhu Jing Wang Cainan Luo Haijing Wu Yun Zhang Chengping Wen Lan He Dongzhou Liu Hejian Zou Qianjin Lu Lijun Wu Liwei Lu | 2023 | Cellular & Molecular Immunology2023，20，8： | 0 |
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