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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Meeting 24-h movement guidelines: Prevalence, correlates, and the relationships with overweight and obesity among Chinese children and adolescents显示文摘Background:Meeting 24-h movement guidelines by children and adolescents has been associated with improved indicators of health,although it has been under-studied in China.Hence,this study aimed to investigate the prevalence of meeting the 24-h movement guidelines,its correlates,and its relationships with body mass index in children and adolescents in China.Methods:Cross-sectional data from the 2017 Youth Study in China of 114,072 children and adolescents(mean age=13.75 years,49.18%boys)were used.Meeting 24-h movement guidelines(60 min of daily moderate-to-vigorous physical activity,2 h of daily leisure screen time,911 h and 810 h nightly sleep duration for 613-year-olds and 1417-year-olds,respectively)and height and weight of all participants were assessed.The prevalence of meeting the 24-h movement guidelines and World Health Organization weight status categories were determined.Generalized linear models were used to determine the correlates of meeting the 24-h movement guidelines and the relationships of meeting the 24-h movement guidelines with overweight(OW)and obesity(OB).Results:Only 5.12%of Chinese children and adolescents met the 24-h movement guidelines,and 22.44%were classified as OW/OB.Older children and adolescents were less likely to meet the 24-h movement guidelines.Parental education level and family income were positively related to meeting the 24-h movement guidelines.Children and adolescents meeting the 24-h movement guidelines showed lower odds ratios for OW/OB.Compared with participants meeting the 24-h movement guidelines,boys in 4th6th grades met none of the recommendations(OR=1.22,95%CI:1.061.40),met the screen time recommendation only(OR=1.13,95%CI:1.011.28),met the nightly sleep duration recommendation only(OR=1.14,95%CI:1.031.28),and had significantly higher odds ratios for OW/OB.Similar trends were observed for girls in 4th6th grades:meeting none of the guidelines(OR=1.35,95%CI:1.141.59),meeting sleep duration guidelines only(OR=1.23,95%CI:1.081.39),and meeting moderate-to-vigorous physical activity+nightly sleep duration guidelines(OR=1.24,95%CI:1.011.54).For girls in 7th9th grades,the following trend was observed:meeting none of the guidelines(OR=1.30,95%CI:1.011.67).Conclusion:Very few Chinese children and adolescents met the 24-h movement guidelines.Age(negatively correlated),parental education level,and family income(both positively correlated)were correlates of meeting the 24-h movement guidelines.Children and adolescents meeting the 24-h movement guidelines were more likely to have lower risks for OW/OB,especially in the youngest age group(Grades 46);and girls in the middle age group(Grades 79)were also more likely to have lower risks for OW/OB.Further research studies should explore additional correlates and determinants for meeting the 24-h movement guidelines.Also,future studies should use longitudinal or interventional designs to determine the relationships between meeting the 24-h movement guidelines and OW/OB and other health indicators,while taking sex and age differences into account. | Si-Tong Chen Yang Liu Mark S.Tremblay Jin-Tao Hong Yan Tang Zhen-Bo Cao Jie Zhuang Zheng Zhu Xueping Wu Lijuan Wang Yujun Cai Peijie Chen | 2021 | Journal of Sport and Health Science2021，10，3： | 12 |
| 3 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 4 | Estrogen upregulates MICA/B expression in human non-small cell lung cancer through the regulation of ADAM17显示文摘雌激素涉及支持肺癌症房间分割和转移。云母和 MICB 为 NKG2D 作为 ligands 工作,在生来的杀手(NK ) 上表示的重要 immunoreceptor 房间。然而,雌激素是否调整 MICA/B 表示并且影响肿瘤免疫者逃跑,仍然保持未知。在这研究,我们测量了非小的房间肺癌症(NSCLC ) 房间线与雌激素对待的云母, MICB 和 ADAM17in 的 mRNA 层次。LTEP-a2 和 A549 上的 MICA/B 的表面表示用流动 cytometry 被检测。我们证明 mRNA 和在肺腺癌房间线的 MICA/B 的能分泌的蛋白质层次是由 estradiol 的 upregulated。Estradiol 提高了 ADAM17 的表示,它与 MICA/B 的分泌物被联系。MICA/B downregulated 的这分泌物 NK92 房间的表面上的 NKG2D 受体并且损害了 NK 房间的细胞毒素的活动。Estradiol 提高了 ADAM17 的表示,它与 MICA/B 的分泌物被联系。而且,在 estradiol 和云母的表示的集中之间的重要关联在 NSCLC 病人的肿瘤纸巾被发现。因此,我们断定雌激素能通过 ADAM17 调整 MICA/B 的表示和分泌物,它帮助肺癌症房间逃离调停 NKG2D 的有免疫力的监视。 | Jing Ren Yunzhong Nie Mingming Lv Sunan Shen Ruijing Tang Yujun Xu Yayi Hou Shuli Zhao Tingting Wang | 2015 | Cellular & Molecular Immunology2015，12，6： | 6 |
| 5 | Retrospect and prospect of Geographical Sciences in China: A comparison with the Strategic Directions for Geography in the USA显示文摘理解变化行星:为地理科学(UCP ) 的战略方向,出版了由国家研究委员会(美国) ,和它在职业地理学者的评价建议那大写和复数地理科学(GS ) 是为在为我们的很快变化的行星的更好的理解的下一十年的地理的战略方向。根据这些评价, UCP 过分地珍视技术和工具(任务) ,并且没对方法论(纪律) 给予许多注意。实际上,任务和纪律是地理翅膀,特别在大科学的时间。从 UCP 和它的注释的启发是应该在任务和学科之间被平衡的战略方向, GS 应该是一个纪律系统,方法论,和技术和工具的三维的构造,并且这个系统应该是基于科学精神的科学人性并且由人性指导。在最后 60 年期间,中国地理学者把自己奉献给 GS,包括实践和理论。显然,进步和眼界作为学科交差的 GS,地球表面科学(S 字) 和地理建设(GC ) 被建议。GS 的纪律系统是很复杂的,并且由象科学,技术,工程,和哲学的如此的人的知识领域构成。主要使命是研究户外,建筑群,和宏地球系统(不仅科学地,而且人性地) ,并且一重要方法论是质、量的工具(CIQQM ) 的全面集成。同时,在中国地理的另一个变化方向是人经济的地理(HEG ) 。 | SUN Jun PAN Yujun TANG Maolin WU Youde | 2013 | Journal of Geographical Sciences2013，23，6： | 4 |
| 6 | Fine mapping of qTGW10-20.8, a QTL having important contribution to grain weight variation in rice显示文摘Grain weight is one of themost important determinants of grain yield in rice.In this study,QTL analysis for grain weight,grain length,and grainwidthwas performed using populations derived from crosses between major parental lines of three-line indica hybrid rice.A total of 27 QTL for grain weight were detected using three recombinant inbred line populations derived from the crosses Teqing/IRBB lines,Zhenshan 97/Milyang 46,and Xieqingzao/Milyang 46.Of these,10 were found in only a single population and the other 17 in two or all three populations.Nine of the 17 common QTL were located in regions where no QTL associated with grain weight have been cloned and onewas selected for fine-mapping.Eight populations segregating in an isogenic background were derived from one F7 residual heterozygote of Teqing/IRBB52.The target QTL,qTGW10-20.8 controlling grain weight,grain length,and grain width,was localized to a 70.7-kb region flanked by InDel markers Te20811 and Te20882 on the long arm of chromosome 10.The QTL region contains seven annotated genes,ofwhich six encode proteins with known functional domains and one encodes a hypothetical protein.One of the genes,Os10g0536100 encoding the MIKC-type MADS-box protein OsMADS56,is the most likely candidate for qTGW10-20.8.These results provide a basis for cloning qTGW10-20.8,which has an important contribution to grain weight variation in rice. | Yujun Zhu Zhenhua Zhang Junyu Chen Yeyang Fan Tongmin Mou Shaoqing Tang Jieyun Zhuang | 2019 | The Crop Journal2019，7，5： | 2 |
| 7 | Prevalence and correlates of meeting the muscle-strengthening exercise recommendations among Chinese children and adolescents:Results from 2019 Physical Activity and Fitness in China—The Youth Study显示文摘Purpose This study aimed to describe the national prevalence of Chinese children and adolescents who met the World Health Organization muscle-strengthening exercise(MSE)recommendations and identify correlates of meeting the MSE recommendations.Methods Cross-sectional data from the 2019 Physical Activity and Fitness in China—The Youth Study,a nationally representative sample of Chinese children and adolescents(n=80,413;mean age=13.7 years;53.9%girls)and their parents,were analyzed.Children and adolescents who reported engaging≥3 days(up to 7 days)of MSE per week were classified as meeting the MSE recommendations.MSE,demographics,lifestyle behaviors(sport participation,moderate-to-vigorous physical activity,screen time,and sleep duration),exercise intention,peer and parental support,and parental MSE participation were assessed through self-reports.Logistic regression models were used to determine the correlates of meeting the MSE recommendations.The analyses were completed in 2020.Results Overall,39.3%of children and adolescents met the MSE recommendations.Girls,10th-12th graders,minorities,those from lower income households and those from families with lower parental education were less likely to meet the MSE recommendations.Children and adolescents who were proficient in≥2 sports were more likely to meet the MSE recommendations(adjusted odds ratio(aOR)=1.44,95%confidence interval(95%CI):1.26-1.65),as were those with more moderate-to-vigorous physical activity(aOR=1.57,95%CI:1.53-1.61).Additionally,children and adolescents with high exercise intention(aOR=1.60,95%CI:1.51-1.69),those whose parents met the adult MSE recommendations(aOR=1.46,95%CI:1.40-1.52),and those who received high peer(aOR=1.27,95%CI:1.20-1.34)and parental support(aOR=1.07,95%CI:1.04-1.12)were more likely to meet the MSE recommendations.Conclusion Less than two-fifths of Chinese children and adolescents met the World Health Organization MSE recommendations.The correlates identified in our study can help inform the development of school and community based strategies and policies to enhance participation in MSE and improve muscular fitness of all Chinese children and adolescents. | Fei Xin Zheng Zhu Sitong Chen Huan Chen Xiaoqing Hu Xiao Ma Kun Liang Yang Liu Lijuan Wang Yujun Cai Ang Chen Yan Tang | 2022 | Journal of Sport and Health Science2022，11，3： | 2 |
| 8 | Desiccation and crack-ing behaviour of clay layer from slurry state under wetting-drying cycles显示文摘 | Tang Chaosheng Cui Yujun Shi Bin | 2011 | Geoderma2011，166，1： | 1 |
| 9 | Study on the characteristics of ferroelectric electron emission显示文摘 | Qiuping Wang Yujun Feng Shuai Tang Zhuo Xu | 2011 | Ceramics International2011，，： | 1 |
| 10 | Desiccation and cracking behaviour of clay layer from slurry state under wetting-drying cycles显示文摘 | Tang Chaosheng Cui Yujun Shi Bin | 2011 | Geoderma2011，166，1： | 1 |
| 11 | Anti-cataract effects of Dajizhi(Euphorbium) eye drops on selenite-induced cataracts in rats显示文摘OBJECTIVE:To evaluate the effects of Dajizhi(Euphorbium)on selenite-induced cataracts.METHODS:Wistar rat pups were divided into 9 groups.Rats in group 1 were subcutaneously injected with saline,and rats in the other groups were injected with sodium-selenite.Every right eye was treated with 5μL eye drops 3 times per day,and the left eye received no treatment.The eyes of rats in group 3 were treated with pirenoxine;rats in groups 4,5,6,7,8 and 9 were respectively treated with Dajizhi(Euphorbium)(25 mg/m L),Dajizhi(Euphorbium)(5 mg/m L),Dajizhi(Euphorbium)methanol extract(25 mg/m L),Dajizhi(Euphorbium)methanol extract(5 mg/m L),euphol(25 mg/m L),euphol(5 mg/m L).Cataracts were observed by a slit lamp before and after treatment.Electroretinograms were acquired at set intervals.The morphological changes of the rat eyes were observed in vitro,and the levels of glutathione peroxidase(GSH-Px)and superoxide dismutase(SOD)in the lenses and aqueous humour were estimated at set intervals.RESULTS:Slit lamp examination showed decreased degrees of cataracts after administration of the different treatments.Morphological comparison showed that Dajizhi(Euphorbium)can reduce the turbidity of the lenses,meaning that Dajizhi(Euphorbium)has the anti-cataract effects.Low-concentration of Dajizhi(Euphorbium),its methanol extract and euphol treatment prevented the b-wave amplitudes of the electroretinograms from falling.Euphorbium treatment significantly restored GSH-Px and SOD levels in the lenses and aqueous humour,especially after 10 and 25 d of administration.Euphorbium may help lenses fight oxidative stress caused by selenite.CONCLUSION:The administration of Dajizhi(Euphorbium)can inhibit selenite-induced cataracts. | TANG Chengfang GAO Yang Gulibairemu Yusuyin MAO Yan LI Yujun WANG Yandong GU Zhengyi | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 1 |
| 12 | Experimental study on the swelling behavior ofbentonite claystone mixture 显示文摘 | WANG Qiong Anh Minh Tang CUI Yujun | 2012 | Engineering Geology2012，124，： | 1 |
| 13 | Water pol- lution risk simulation and prediction in the main canal of the South-to-North Water Transfer Projeet显示文摘 | TANG Caihong YI Yujun YANG Zhifeng | 2014 | Journal of Hydrol- ogy2014，519，： | 1 |
| 14 | Magnetic field driving gradient effects on the micro structure in amorphous-nanoerystalline cobalt alloy rib bons 显示文摘 | Tang Zhaowei Song Yujun Sun Qiangqiang | 2012 | Nanoscale2012，4，2： | 1 |
| 15 | Desiccation and cracking behaviour of clay layer from slurry state under wetting-drying cycles显示文摘 | Tang Chaosheng Cui Yujun Shi Bin | 2011 | Geoderma2011，，： | 1 |
| 16 | Experiment evidence on the temperature dependence of desiccation cracking behavior of clayer soils显示文摘 | Tang Chaosheng Cui Yujun Tang Anh-Minh | 2010 | Engineering Geology2010，，： | 1 |
| 17 | State tracking model reference adaptive control for switched nonlinear systems with linear uncertain parameters显示文摘为适应控制(MRAC ) 为未知参数线性地在出现的交换非线性的系统的一个类被考虑的引用建模。当在不同分系统的向量和不明确的向量被不同向量变量个别地估计,在每个分系统的线性不明确的参数能被表示。更改法律被设计以便参数评价将结冰直到它的相应分系统是活跃的。为分系统的控制器被给保证在任意的切换下面追踪的 asymptotic 状态。二个例子被举验证建议方法。 | Xia WANG Jun ZHAO Yujun TANG | 2012 | 控制理论与应用(英文版)2012，10，3： | 1 |
| 18 | Aggregation-induced emission:Red and near-infrared organic light-emitting diodes显示文摘Red and near-infrared(NIR)organic light-emitting diodes(OLED)have gained remarkable interest due to their numerous applications.However,the construction of highly emissive emitters is hampered by the energy-gap law and aggregation-caused quenching(ACQ)effect.Whereas,aggregationinduced emission(AIE)materials could avoid the undesirable ACQ effect and emit bright light in aggregated state,which is one class of the most promising materials to fabricate high-performance OLED with a high external quantum efficiency and low efficiency roll-off.This review summarizes recent advances in red and NIR OLED with AIE property,including the traditional fluorescence,thermally activated delayed fluorescence,and hybridized local and charge transfer compounds.Meanwhile,the emphasis attention is paid to the molecular design principles,as well as the molecular structure-photophysical characteristics.We also briefly further outlook the challenges and perspective of red and NIR AIE luminogens. | Liangjing Tu Yujun Xie Zhen Li Benzhong Tang | 2021 | SmartMat2021，2，3： | 1 |
| 19 | Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis显示文摘Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease affecting both upper and lower motor neurons(MNs)with large unmet medical needs.Multiple pathological mechanisms are considered to contribute to the progression of ALS,including neuronal oxidative stress and mitochondrial dysfunction.Honokiol(HNK)has been reported to exert therapeutic effects in several neurologic disease models including ischemia stroke,Alzheimer’s disease and Parkinson’s disease.Here we found that honokiol also exhibited protective effects in ALS disease models both in vitro and in vivo.Honokiol improved the viability of NSC-34 motor neuron-like cells that expressed the mutant G93A SOD1 proteins(SOD1-G93A cells for short).Mechanistical studies revealed that honokiol alleviated cellular oxidative stress by enhancing glutathione(GSH)synthesis and activating the nuclear factor erythroid 2-related factor 2(NRF2)-antioxidant response element(ARE)pathway.Also,honokiol improved both mitochondrial function and morphology via fine-tuning mitochondrial dynamics in SOD1-G93A cells.Importantly,honokiol extended the lifespan of the SOD1-G93A transgenic mice and improved the motor function.The improvement of antioxidant capacity and mitochondrial function was further confirmed in the spinal cord and gastrocnemius muscle in mice.Overall,honokiol showed promising preclinical potential as a multiple target drug for ALS treatment. | Yujun Zhou Jingshu Tang Jiaqi Lan Yong Zhang Hongyue Wang Qiuyu Chen Yuying Kang Yang Sun Xinhong Feng Lei Wu Hongtao Jin Shizhong Chen Ying Peng | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 1 |
| 20 | Numerical analysis of tunnel reinforcing influences on failure process of surrounding rock under explosive stress waves显示文摘 | ZU0 YUJUN TANG CHUNAN ZHU WANCHENG | 2008 | Journal of Central South University of Technology:English Edition2008，15，5： | 1 |
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