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| 1 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 7 |
| 2 | Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘Objective: Germline alterations in the breast cancer susceptibility genes type 1 and 2, BRCA1 and BRCA2, predispose individuals to hereditary cancers, including breast, ovarian, prostate, pancreatic, and stomach cancers.Accumulating evidence suggests inherited genetic susceptibility to lung cancer.The present study aimed to survey the prevalence of pathogenic germline BRCA mutations(gBRCAm) and explore the potential association between gBRCAm and disease onset in Chinese advanced non-small cell lung cancer(NSCLC) patients.Methods: A total of 6,220 NSCLC patients were screened using capture-based ultra-deep targeted sequencing to identify patients harboring germline BRCA1/2 mutations.Results: Out of the 6,220 patients screened, 1.03%(64/6,220) of the patients harbored the pathogenic gB RCAm, with BRCA2 mutations being the most predominant mutations(49/64, 76.5%).Patients who developed NSCLC before 50 years of age were more likely to carry gBRCAm(P = 0.036).Among the patients harboring classic lung cancer driver mutations, those with concurrent gBRCAm were significantly younger than those harboring the wild-type gBRCA(P = 0.029).By contrast, the age of patients with or without concurrent gBRCAm was comparable to those of patients without the driver mutations(P = 0.972).In addition, we identified EGFR-mutant patients with concurrent gBRCAm who showed comparable progression-free survival but significantly longer overall survival(P = 0.002) compared to EGFR-mutant patients with wild-type germline BRCA.Conclusions: Overall, our study is the largest survey of the prevalence of pathogenic gBRCAm in advanced Chinese NSCLC patients.Results suggested a lack of association between germline BRCA status and treatment outcome of EGFR-TKI.In addition,results showed a positive correlation between pathogenic gB RCAm and an early onset of NSCLC. | Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu | 2019 | Cancer Biology & Medicine2019，16，3： | 4 |
| 3 | Contrasting physical properties of the trilayer nickelates Nd4Ni3O10 and Nd4Ni3O8显示文摘We report the crystal structures and physical properties of trilayer nickelates Nd4Ni3O10and Nd4Ni3O8.Measurements of magnetization and electrical resistivity display contrasting behaviors in the two compounds.Nd4Ni3O10shows a paramagnetic metallic behavior with a metal-to-metal phase transition(T^*)at about 162 K,as revealed by both magnetic susceptibility and resistivity.Further magnetoresistance and Hall coefficient results show a negative magnetoresistance at low temperatures and the carrier type of Nd4Ni3O10is dominated by hole-type charge carriers.The significant enhancement of Hall coefficient and resistivity below T*suggests that effective charge carrier density decreases when cooling through the transition temperature.In contrast,Nd4Ni3O8 shows an insulating behavior.In addition,this compound shows a paramagnetic behavior with the similar magnetic moment as that of Nd4Ni3O10derived from the Curie-Weiss fitting.This may suggest that the magnetic moments in both systems are contributed by Nd^3+ ions.By applying pressures up to about 49 GPa,the insulating behavior is still present and becomes even stronger under a high pressure.Our results suggest that the different Ni configurations(Ni^1+/2+ or Ni^2+/3+)and the changes of coordination environment of Ni sites may account for the contrasting behaviors in trilayer nickelates Nd4Ni3O10and Nd4Ni3O8. | Qing Li ChengPing He XiYu Zhu Jin Si XinWei Fan Hai-Hu Wen | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，2： | 2 |
| 4 | Interface self‐reinforcing ability and antibacterial effect of natural chitosan modified polyvinyl chloride‐based wood flour composites显示文摘 | Kaimeng Xu Kaifu Li Tuhua Zhong Chengping Xie | 2014 | J. Appl. Polym. Sci2014，，3： | 2 |
| 5 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
| 6 | Clinical characteristics and prognostic significance of 92 cases ofpatients with primary mixed?histology lung cancer显示文摘 | Pengbo Deng Chengping Hu Lihua Zhou Yuanyuan Li Li Huang | 2013 | Molecular and Clinical Oncology2013，，5： | 1 |
| 7 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
| 8 | Erratum to Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘In the published article1,the affiliation for the first author,Xingshcng Hu,is'Department of Medical Oncology,Cancer Hospital,Chinese Academy of Medical Sciences',we would like to update it to'Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China'.We apologize for the errors and for any confusion it may have caused. | Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu | 2020 | Cancer Biology & Medicine2020，17，2： | 1 |
| 9 | Construction and Characterization of a Streptococcus suis Serotype 2 Recombinant Expressing Enhanced Green Fluorescent Protein 显示文摘 | Tao Chen QH Zhaolong Li Wei Zhang Chengping Lu Huochun Yao | 2012 | PloS one2012，7，7： | 1 |
| 10 | Face stability of shield tunnels considering a kinematically admissible velocity field of soil arching显示文摘Existing mechanism of simulating soil movement at tunnel face is generally based on the translational or rotational velocity field,which is,to some extent,different from the real soil movement in the arching zone.Numerical simulations are carried out first to investigate the characteristics of the velocity distribution at tunnel face and above tunnel vault.Then a new kinematically admissible velocity field is proposed to improve the description of the soil movement according to the results of the numerical simulation.Based on the proposed velocity field,an improved failure mechanism is constructed adopting the spatial discretization technique,which takes into account soil arching effect and plastic deformation within soil mass.Finally,the critical face pressure and the proposed mechanism are compared with the results of the numerical simulation,existing analytical studies and experimental tests to verify the accuracy and improvement of the presented method.The proposed mechanism can serve as an alternative approach for the face stability analysis. | Wei Li Chengping Zhang Dingli Zhang Zijian Ye Zhibiao Tan | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，2： | 1 |
| 11 | Bronchial Fistula: Rare Complication of Treatment with Anlotinib显示文摘Background and objective Anlotinib is a newly developed small molecule multiple receptor tyrosine kinase(RTK) inhibitor that was approved for the treatment of patients with lung cancer in China. We aim to report 3 cases of rare complication of anlotinib-bronchial fistula(BF) during the treatment of lung cancer patients and summarize the possible causes.Methods We collected three patients who developed BF due to anlotinib treatment, and conducted a search of Medline and Pub Med for medical literature published between 2018 and 2020 using the following search terms: 'anlotinib,' 'lung cancer,' and 'fistula.'Results Our literature search produced two case reports(three patients) which, in addition to our three patients. We collated the patients’ clinical characteristics including demographic information, cancer type, imaging features, treatment received, risk factors for anlotinib related BF, and treatment-related outcomes. The six patients shared some common characteristics: advanced age, male, concurrent infection symptoms, diabetes mellitus(DM), advanced squamous cell and small cell lung cancers, centrally located tumors, tumor measuring ≥5 cm in longest diameter, and newly formed tumor cavitation after multi-line treatment especially after receiving radiotherapy. Fistula types included broncho-pericardial fistula, broncho-pleural fistula, and esophagotracheobronchial fistula. Six patients all died within 6 months.Conclusion Although anlotinib is relatively safe, it is still necessary to pay attention to the occurrence of BF, a rare treatment side effect that threatens the quality of life and overall survival of patients. Anlotinib, therefore, requires selective use and close observation of high-risk patients. | Pengbo DENG Chengping HU Yuanyuan LI Liming CAO Huaping YANG Min LI Jian AN Juan JIANG Qihua GU | 2020 | 中国肺癌杂志2020，23，10： | 1 |
| 12 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
| 13 | Face stability analysis of a shield tunnel excavated along inclined strata显示文摘The horizontally layered or even inclined strata are often encountered in practical shield tunneling.The influence of inclined strata on face stability of shield tunnels is not fully investigated by the existing studies.This paper adopts both theoretical analysis and numerical simulation to carry out research on face stability in inclined strata.The spatial discretization technique is adopted to construct a threedimensional(3D)kinematic failure mechanism considering intersection between inclined soil interface and tunnel face.An analytical solution for critical support pressure is obtained.Besides,the critical support pressure and 3D kinematic mechanism are compared with numerical results to verify accuracy and effectiveness of analytical model.The influences of dip and position of inclined strata on face stability are thoroughly studied.The proposed failure mechanism can serve as a reference for face stability analysis in inclined strata. | Wei Li Chengping Zhang Shiqin Tu Wen Chen Mengshuo Ma | 2023 | Underground Space2023，，6： | 0 |
| 14 | Theanine improves the function of dendritic cells via the downregulation of cyclooxygenase-2 expression显示文摘 | Lei Mingsheng Zuo Jianhong Li Min Gu Qihua Hu Chengping | 2014 | Chinese Medical Journal2014，，8： | 0 |
| 15 | Treatment Effects of Integrated TCM and Western Medicine Treatment Scheme on COVID-19: A Single-armed Clinical Trial显示文摘Backgroud:The outbreak of COVID-19 has brought unprecedented perils to human health and raised public health concerns in more than two hundred countries.Safe and effective treatment scheme is needed urgently.Objective:To evaluate the effects of integratedTCM and western medicine treatment scheme on COVID-19.Methods:A single-armed clinical trial was carried out in Hangzhou Xixi Hospital,an affiliated hospital with Zhejiang Chinese Medical University.102 confirmed cases were screened out from 725 suspected cases and 93 of them were treated with integrated TCM and western medicine treatment scheme.Results:83 cases were cured,5 cases deteriorated,and 5 cases withdrew from the study.No deaths were reported.The mean relief time of fever,cough,diarrhea,and fatigue were(4.78±4.61)days,(7.22±4.99)days,(5.28±3.39)days,and(5.28±3.39)days,respectively.It took(14.84±5.50)days for SARS-CoV-2 by nucleic acid amplification-based testing to turn negative.Multivariable cox regression analysis revealed that age,BMI,PISCT,BPC,AST,CK,BS,and UPRO were independent risk factors for COVID-19 treatment.Conclusion:Our study suggested that integrated TCM and western medicine treatment scheme was effective for COVID-19. | Jianfeng Bao Zhijun Xie Shourong Liu Lin Huang Jing Sun Yujun Tang Haiping Chen Jianjiang Qi Jianchun Guo Liangbin Miao Zhaoyi Li Hui Yang Yi Zhang Zhiyu Li Yuan Xu Shengyou Lin Yunhao Xun Li Zhang Jie Bao Zhaobin Cai Jinsong Huang Chengping Wen | 2021 | Clinical Complementary Medicine and Pharmacology2021，1，1： | 0 |
| 16 | Highly efficient recovery of waste LiNi_(x)Co_(y)Mn_(z)O_(2) cathode materials using a process involving pyrometallurgy and hydrometallurgy显示文摘Substantial environmental and economic benefits can be achieved by recycling used lithium-ion batteries. Hydrometallurgy is often employed to recover waste LiNi_(x)Co_(y)Mn_(z)O_(2) cathode materials. As Ni, Co and Mn are transition metals, they exhibit similar properties;therefore, separating them is difficult. Thus, most researchers have focused on leaching processes, while minimal attention has been devoted to the separation of valuable metals from waste LiNi_(x)Co_(y)Mn_(z)O_(2) cathode materials. Herein, we propose an environment-friendly, gentle process involving the usage of pyrometallurgy and hydrometallurgy to gradually leach valuable metals and effectively separate them. Interestingly, Li is recovered through a reduction roasting and water leaching process using natural graphite powder, Ni and Co are recovered through ammonia leaching and extraction processes and Mn is recovered through acid leaching and evaporation–crystallization processes. Results show that ~87% Li, 97.01% Co, 97.08% Ni and 99% Mn can be leached using water, ammonia and acid leaching processes. The result obtained using the response surface methodology shows that the concentration of (NH4)2SO3 is a notable factor affecting the leaching of transition metals. Under optimal conditions, ~97.01% Co, 97.08% Ni and 0.64% Mn can be leached out. The decomposition of LiNi_(x)Co_(y)Mn_(z)O_(2) is a two-step process. This study provides valuable insights to develop an environment-friendly, gentle leaching process for efficiently recycling valuable metals, which is vital for the lithium-ion battery recycling industry. | Tianwei Zhang Juanye Dao Jinsong Wang Yuzhong Guo Rundong Wan Chengping Li Xian Zhou Zhengfu Zhang | 2024 | Frontiers of Environmental Science & Engineering2024，18，2： | 0 |
| 17 | Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis显示文摘Systemic lupus erythematosus(SLE),a severe autoimmune disorder,is characterized by systemic inflammatory response,autoantibody accumulation and damage to organs.The dysregulation of double-negative(DN)T cells is considered as a crucial commander during SLE.Neddylation,a significant type of protein post-translational modification(PTM),has been well-proved to regulate T cell-mediated immune response.However,the function of neddylation in SLE is still unknown.Here,we reported that neddylation inactivation with MLN4924,a specific inhibitor of NEDD8-activating enzyme E1(NAE1),or genetic abrogation of Ube2m in T cells decreased DN T cell accumulation and attenuated murine lupus development.Further investigations revealed that inactivation of neddylation blocked Bim ubiquitination degradation and maintained Bim level in DN T cells,contributing to the apoptosis of the accumulated DN T cells in lupus mice.Then double knockout(KO)lupus-prone mice(Ube2m-/-Bim-/-lpr)were generated and results showed that loss of Bim reduced Ube2m deficiency-induced apoptosis in DN T cells and reversed the alleviated lupus progression.Our findings identified that neddylation inactivation promoted Bim-mediated DN T cell apoptosis and attenuated lupus progression.Clinically,we also found that in SLE patients,the proportion of DN T cells was raised and their apoptosis was reduced.Moreover,compared to healthy groups,SLE patients exhibited decreased Bim levels and elevated Cullin1 neddylation levels.Meantime,the inhibition of neddylation induced Bim-dependent apoptosis of DN T cells isolated from SLE patients.Altogether,our findings provide the direct evidence about the function of neddylation during lupus,suggesting a promising therapeutic approach for this disease. | Yun Zhang Lijun Du Chenxi Wang Zhangsheng Jiang Qingchi Duan Yiping Li Zhijun Xie Zhixing He Yi Sun Lin Huang Liwei Lu Chengping Wen | 2024 | Signal Transduction and Targeted Therapy2024，9，2： | 0 |
| 18 | Pressure induced color change and evolution of metallic behavior in nitrogen-doped lutetium hydride显示文摘By applying pressures up to 42 GPa on the nitrogen-doped lutetium hydride(LuH2_(±x)N_(y)),we have found a gradual change of color from dark-blue to pink-violet in the pressure region of about 12 to 21 GPa.The temperature dependence of resistivity under pressures up to 50.5 GPa shows progressively optimized metallic behavior with pressure.Interestingly,in the pressure region for the color change,a clear decrease of resistivity is observed with the increase of pressure,which is accompanied by a clear increase of the residual resistivity ratio(RRR).Fitting to the low temperature resistivity gives exponents of about 2,suggesting a Fermi-liquid behavior in the low temperature region.The general behavior in a wide temperature region suggests that the electron-phonon scattering is still the dominant one.The magnetoresistance up to 9 T in the state under a pressure of 50.5 GPa shows an almost negligible effect,which suggests that the electric conduction in the pink-violet state is dominated by a single band.It is highly desired to have theoretical efforts in understanding the evolution of color and resistivity in this interesting system. | Ying-Jie Zhang Xue Ming Qing Li Xiyu Zhu Bo Zheng Yuecong Liu Chengping He Huan Yang Hai-Hu Wen | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 0 |
| 19 | B1-cell-produced anti-phosphatidylserine antibodies contribute to lupus nephritis development via TLR-mediated Syk activation显示文摘Autoantibodies produced by B cells play a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE). However, both the cellular source of antiphospholipid antibodies and their contributions to the development of lupus nephritis (LN) remain largely unclear. Here, we report a pathogenic role of anti-phosphatidylserine (PS) autoantibodies in the development of LN. Elevated serum PS-specific IgG levels were measured in model mice and SLE patients, especially in those with LN. PS-specific IgG accumulation was found in the kidney biopsies of LN patients. Both transfer of SLE PS-specific IgG and PS immunization triggered lupus-like glomerular immune complex deposition in recipient mice. ELISPOT analysis identified B1a cells as the main cell type that secretes PS-specific IgG in both lupus model mice and patients. Adoptive transfer of PS-specific B1a cells accelerated the PS-specific autoimmune response and renal damage in recipient lupus model mice, whereas depletion of B1a cells attenuated lupus progression. In culture, PS-specific B1a cells were significantly expanded upon treatment with chromatin components, while blockade of TLR signal cascades by DNase I digestion and inhibitory ODN 2088 or R406 treatment profoundly abrogated chromatin-induced PS-specific IgG secretion by lupus B1a cells. Thus, our study has demonstrated that the anti-PS autoantibodies produced by B1 cells contribute to lupus nephritis development. Our findings that blockade of the TLR/Syk signaling cascade inhibits PS-specific B1-cell expansion provide new insights into lupus pathogenesis and may facilitate the development of novel therapeutic targets for the treatment of LN in SLE. | Kongyang Ma Wenhan Du Shiyun Wang Fan Xiao Jingyi Li Jie Tian Yida Xing Xiaodan Kong Ke Rui Rencai Qin Xiaoxia Zhu Jing Wang Cainan Luo Haijing Wu Yun Zhang Chengping Wen Lan He Dongzhou Liu Hejian Zou Qianjin Lu Lijun Wu Liwei Lu | 2023 | Cellular & Molecular Immunology2023，20，8： | 0 |
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