|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Synthetic biology: a new approach to stud bioloaical pattern formation显示文摘 | Chenli Liu Xiongfei Fu Jian-Dong Huang | 2013 | Frontiers of Electrical and Electronic Engineering in China2013，8，4： | 4 |
| 2 | Construction of precise support vector machine based models for predicting promoter strength显示文摘原核生物的倡导者力量的预言不仅在生命科学的基本研究而且在合成生物学的应用方面基于它的顺序是很重要的。许多进展被做了为力量预言造量的模型,特别象人工的神经网络(ANN ) 那样的机器学习方法的介绍显著地有改进预言精确性。作为最重要的机器学习方法之一,支持向量机器(SVM ) 是更强大的听说从小样品数据集并且这样的知识想了处于这个问题工作。证实这的方法,我们构造了基于的 SVM 到份量上的模型预言倡导者力量。100 个倡导者序列和力量价值的一个图书馆随机被划分成二数据集,包括为模型训练和为模型测试的一个测试集合(10 个序列) 的一个训练集合(10 个序列) 。结果显示的结果有训练的尺寸的增加的预言表演增加设定,并且最好的表演在 90 的尺寸被完成,这定序。在模型参数的优化以后,一个高效的模型最后被训练,与为适合训练集合的一个高摆平的关联系数( R 2> 0.99 )并且测试集合( R 2> 0.98 ),哪个比我们的以前的工作获得的 ANN 的好。我们的结果表明基于 SVM 的模型的结论能为倡导者力量的量的预言被采用。 | Hailin Meng Yingfei Ma Guoqin Mai Yong Wang Chenli Liu | 2017 | Frontiers of Electrical and Electronic Engineering in China2017，5，1： | 2 |
| 3 | Low rate of pre-exposure prophylaxis and post-exposure prophylaxis uptake and high prevalence of transmitted drug resistance among newly diagnosed primary HIV infections in Shenzhen, China: a real-world retrospective study显示文摘Background: Understanding the characteristics of newly diagnosed primary human deficiency virus-1 (HIV-1) infection in the context of the post-antiretroviral therapy era and HIV drug prophylaxis is essential for achieving the new target of 95-95-95-95 by 2025. This study reported the characteristics of newly diagnosed primary HIV-1 infection in Shenzhen.Methods: This is a real-world retrospective study. Eighty-seven newly diagnosed primary HIV-1-infected patients were recruited from January 2021 to March 2022 at the Third People’s Hospital of Shenzhen. Demographic, epidemiological, diagnostic, drug resistance, and medical data were described and analyzed.Results: Overall, 96.6% (84/87) of the newly identified primary HIV-1-infected patients were male, including 88.5% (77/87) men have sex with men (MSM), with a median age of 29.0 years (Q_(1)-Q_(3): 24.0-34.0 years);of these, 85.1% (74/87) reported high-risk sexual behaviors with casual partners. The rate of condom usage was only 28.7% (25/87). The overall rate of pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) was 8.0% (7/87, including 4 PrEP and 3 PEP cases) around the potential exposure, although 41.4% of the patients had prior awareness of such interventions. Moreover, only 19.5% (17/87) had previously used PrEP or PEP. Of those, 58.8% (10/17) of the patients obtained drugs from the internet, and only 35.3% (6/17) reported good compliance. A total of 54.0% (47/87) of subjects were diagnosed by the HIV nucleic acid test. Acute retroviral syndrome appeared in 54.0% (47/87) of patients. The prevalence of transmitted drug resistance (TDR) mutation was 33.9% (19/56), including 6 (10.7%) against nucleoside reverse transcriptase inhibitor (NRTI) plus non-nucleoside reverse transcriptase inhibitor (NNRTI), 8 (14.3%) against NNRTI, and 5 (8.9%) against protease inhibitor (PI) only.Conclusions: Owing to the low utilization rate and incorrect usage of PrEP and PEP, massive efforts are needed to promote HIV-preventive strategies in the MSM population. The extremely high prevalence of TDR mutation in this population implies the need for future pretreatment drug resistance surveillance. | Qiaoli Peng Xiaoning Liu Xian Tang Qiuyue Zhang Jin Zhao Chenli Zheng Fang Zhao Yang Zhou Lukun Zhang Liqin Sun Haitao Zhang Xinyun Jia Ying Song Tingzhi Cao Siyuan Wang Man Rao Zhiwei Chen Hui Wang Yun He | 2022 | Chinese Medical Journal2022，135，22： | 1 |
| 4 | Salvianolic acid B inhibits Aβ fibril formation and disaggregates preformed fibrils and protects against Aβ-induced cytotoxicty显示文摘 | Siva Sundara Kumar Durairajan Qiuju Yuan Lixia Xie Wing-Sai Chan Wan-Fung Kum Irene Koo Chenli Liu Youqiang Song Jian-Dong Huang William L. Klein Min Li | 2007 | Neurochemistry International2007，，4： | 1 |
| 5 | Enabling technology and core theory of synthetic biology显示文摘Synthetic biology provides a new paradigm for life science research(“build to learn”)and opens the future journey of biotechnology(“build to use”).Here,we discuss advances of various principles and technologies in the mainstream of the enabling technology of synthetic biology,including synthesis and assembly of a genome,DNA storage,gene editing,molecular evolution and de novo design of function proteins,cell and gene circuit engineering,cell-free synthetic biology,artificial intelligence(AI)-aided synthetic biology,as well as biofoundries.We also introduce the concept of quantitative synthetic biology,which is guiding synthetic biology towards increased accuracy and predictability or the real rational design.We conclude that synthetic biology will establish its disciplinary system with the iterative development of enabling technologies and the maturity of the core theory. | Xian-En Zhang Chenli Liu Junbiao Dai Yingjin Yuan Caixia Gao Yan Feng Bian Wu Ping Wei Chun You Xiaowo Wang Tong Si | 2023 | Science China(Life Sciences)2023，66，8： | 1 |
| 6 | Hunting field:insights on distribution pattern of bacteria and immune cells in solid tumors显示文摘Bacterial cancer therapy,which was first applied in the clinic in 1868,has regained attention owing to the recent progress made in synthetic biology.Considering their easily manipulated genomes,preferential accumulation in tumors,and penetration abilities,bacteria have shown great therapeutic potential in tumor treatment. | Yang Li Yuqi Wang Xuefei Li Chenli Liu | 2021 | National Science Review2021，8，5： | 1 |
| 7 | Does the eclipse limit bacterial nucleoid complexity and cell width?显示文摘Cell size of bacteria M is related to 3 temporal parameters:chromosome replication time C,period from replication-termination to subsequent division D,and doubling time t.Steady-state,bacillary cells grow exponentially by extending length L only,but their constant width W is larger at shorter t‘s or longer C's,in proportion to the number of chromosome replication positions n(?C/t),at least in Escherichia coli and Salmonella typhimurium.Extending C by thymine limitation of fast-growing thyA mutants result in continuous increase of M,associated with rising W,up to a limit before branching.A set of such puzzling observations is qualitatively consistent with the view that the actual cell mass(or volume)at the time of replication-initiation Mi(or Vi),usually relatively constant in growth at varying t0s,rises with time under thymine limitation of fast-growing,thymine-requiring E.coli strains.The hypothesis will be tested that presumes existence of a minimal distance lmin between successive moving replisomes,translated into the time needed for a replisome to reach lmin before a newreplication-initiation at oriC is allowed,termed Eclipse E.Preliminary analysis of currently available data is inconsistent with a constant E under all conditions,hence other explanations andways to test themare proposed in an attempt to elucidate these and other results.The complex hypothesis takes into account much of what is currently known about Bacterial Physiology:the relationships between cell dimensions,growth and cycle parameters,particularly nucleoid structure,replication and position,and themode of peptidoglycan biosynthesis.Further experiments arementioned that are necessary to test the discussed ideas and hypotheses. | Arieh Zaritsky Avinoam Rabinovitch Chenli Liu Conrad L.Woldringh | 2017 | Synthetic and Systems Biotechnology2017，2，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员