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	题名	作者	年代	出处	被引量
1	Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib显示文摘Background:Cancer-associated fibroblasts(CAFs)play an important role in the induction of chemo-resistance.This study aimed to clarify the mechanism underlying CAF-mediated resistance to two tyrosine kinase inhibitors(TKIs),sorafenib and lenvatinib,and to identify a novel therapeutic target for overcoming TKI resistance in hepatocellular carcinoma(HCC).Methods:We performed a systematic integrative analysis of publicly available gene expression datasets and whole-transcriptome sequencing data from 9 pairs of CAFs and para-cancer fibroblasts isolated from human HCC and para-tumor tissues,respectively,to identify key molecules that might induce resistance to TKIs.We then performed in vitro and in vivo experiments to validate selected targets and related mechanisms.The associations of plasma secreted phosphoprotein 1(SPP1)expression levels before sorafenib/lenvatinib treatment with progression-free survival(PFS)and overall survival(OS)of 54 patients with advanced HCC were evaluated using Kaplan-Meier and Cox regression analysis.Results:Bioinformatic analysis identified CAF-derived SPP1 as a candidate molecule driving TKI resistance.SPP1 inhibitors reversed CAF-induced TKI resistance in vitro and in vivo.CAF-derived SPP1 activated rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase(MAPK)and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)through the integrin-protein kinase C-alpha(PKCα)signaling pathway and promoted epithelial-to-mesenchymal transition(EMT).A high plasma SPP1 level before TKI treatment was identified as an independent predictor of poor PFS(P=0.026)and OS(P=0.047)in patients with advanced HCC after TKI treatment.Conclusions:CAF-derived SPP1 enhances TKI resistance in HCC via bypass activation of oncogenic signals and EMT promotion.Its inhibition represents a promising therapeutic strategy against TKI resistance inHCC.Moreover,plasma SPP1 level before TKI treatment represents a potential biomarker for treatment response prediction.	JungWoo Eun Jung Hwan Yoon Hye Ri Ahn Seokhwi Kim Young Bae Kim Su Bin Lim Won Park TaeWook Kang Geum Ok Baek Moon Gyeong Yoon Ju A Son Ji HyangWeon Soon Sun Kim Hyo Jung Cho Jae Youn Cheong	2023	Cancer Communications2023，43，4：	2
2	Resonances and interference effects on the effective electronic coupling in electron transfer显示文摘	Roitberg A E Mujica V Ratner M A	1994	J Photochem Photobiol A:Chem1994，82，：	1
3	A review of the optical properties of biological tissues显示文摘	Cheong W F Prahl S A Welch A J	1990	IEEE J Quantum Electron1990，26，：	1
4	Oviductal microsomal epoxide hydrolase(EPHX1) reduces reactive oxygen species (ROS)level and enhances preimplantation mouse embryo development 显示文摘	CHEONG A W Y LEE Y L LIU W M	2009	Biol Reprod2009，81，：	1
5	Reverse nearest neighbor queries in fixed dimension显示文摘	Cheong O Vigneron A Yon J	2011	Int J Comput Geometry Appl2011，21，2：	1
6	Effect of impact angle and velocity on the fragment size distribution of glass spheres显示文摘	Cheong Y S Salman A D Hounslow M J	2003	Powder Technology2003，138，：	1
7	Physical characterization of particulate matter and ambient meteorological parameters at different indooroutdoor locations in Singapore 显示文摘	Gupta A Cheong K W	2007	Building and Environment2007，42，：	1
8	Discrete store-operatedcalcium influx into an intracellular compartment in rabbit arteriolarsmooth muscle显示文摘	Flemming R Cheong A Dedman AM	2002	J-Physiol2002，543，：	1
9	Structural basis of the heterodimerization of the MST and RASSF SARAH domains in the Hippo signalling pathway显示文摘	Hwang E Cheong HK Ul Mushtaq A	2014	Acta Crystallogr D Biol Crystallogr2014，70，7：	1
10	The coefficient of restitution of different representative types of granules 显示文摘	Mangwandi C Cheong Y S Adams M J Hounslow M J Salman A D	2007	Chemical Engineering Science2007，62，12：	1
11	Application of recyclable ionic liquid-supported imidazolidinone catalyst inenantioselective D iels-A lder reaction显示文摘	Shen Z L Cheong H L Lai Y C et a l	2012	Green Chem2012，14，：	1
12	An assessment of a new diagnostic indirect enzyme immunoassay for the detection of anti-Mycoplama pneumoniae IgM显示文摘	Cimolai N Cheong A	1996	Am J Clinical Pathol1996，105，：	1
13	A QTL located on chro mosome 4A associated with dormancy in white and red grained wheats of diverse origin 显示文摘	Mares D Mrva K Cheong J et a l	2005	Theoretical and Ap- plied Genetics2005，111，7：	1
14	Epidemic reemergence in adaptive complex networks 显示文摘	Zhou J Xiao G Cheong S A Fu X Wong L Ma S Cheng T	2012	Physical Review E2012，85，03：	1
15	From the Archives of the AFIP: neoplasms of the urinary blad der: radiologic pathologic correlation显示文摘	Wong You Cheong J J Woodward P J Manning M A	2006	Radiographics2006，26，2：	1
16	Multiferroics: Past, present,and future 显示文摘	Spaldin N A Cheong S W Ramesh R	2010	Physics Today2010，63，10：	1
17	An assessment of a new diagnostic indirect enzyme immunoassay for the detection of anti-mycoplasma pneumoniae IgM显示文摘	CIMOLAI N CHEONG A C H	1996	Am J Clin Pathol1996，105，：	1
18	A review of the optical properties of biological tissues显示文摘	Cheong W F Prahl S A Welch A J	1990	IEEE J Quantum Electron1990，26，12：	1
19	Effect of impact angle and velocity on the fragment size distribution of glass spheres显示文摘	CHEONG Y S SALMAN A D HOUNSLOW M J	2003	Powder Technology2003，，12：	1
20	The Influence of Preparation Conditions on the Surface Area of Zirconia显示文摘	G K CHUAH S JAENICKE S A CHEONG K S CHAN	1996	Appl Catal A : General1996，145，：	1

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