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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Trogocytosis of CD80 and CD86 by induced regulatory 7 cells显示文摘 | Peng Gu Julia Fang Gao Cheryl A D'Souza Aleksandra Kowalczyk Kuang-Yen Chou Li Zhang | 2012 | Cellular & Molecular Immunology2012，9，2： | 7 |
| 3 | Diabetes nurse case management and motivational interviewing for change ( DYNAMIC ): Results of a 2‐year randomized controlled pragmatic trial (糖尿病护士病例管理以及促进改变的动机性会谈(DYNAMIC):一项为期2年的实用随机对照研究)显示文摘 | Robert A. Gabbay Raquel M. A?el‐Tiangco Cheryl Dellasega David T. Mauger Alan Adelman Deborah H.A. Van Horn | 2013 | Journal of Diabetes2013，，： | 3 |
| 4 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 2 |
| 5 | Solitary fibrous tumor: Histological and immunohistochemical spectrum of benign and malignant variants presenting at different sites显示文摘 | Cheryl A Hanau Markku Miettinen | 1995 | Human Pathology1995，，4： | 2 |
| 6 | Analysis for perfluorocarboxylic acids/anions in surface waters and precipitation using GC-MS and analysis of PFOA from large-volume samples显示文摘 | Brian F Scott Cheryl A Moody | | 0，，： | 1 |
| 7 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 1 |
| 8 | A Review of Ocean Acidification and America’s Response显示文摘 | Logan Cheryl A | 2010 | Bioscience2010，，10： | 1 |
| 9 | Electroless Copper Plating A Review:Part Ⅱ 显示文摘 | Cheryl A Decket | 1995 | Plat Surf Finish1995，，2： | 1 |
| 10 | BaleCytokine stimulation of pregnancyassociated plasma protein A expression in human coronary artery smooth muscle cells: inhibition by resveratrol显示文摘 | Cheryl A Conover K Laurie K | 2006 | J Am Physiol Cell Physiol2006，290，： | 1 |
| 11 | Designing measurements to assess case management outeomes显示文摘 | Magdalena A Cheryl N | 2002 | Lippincott'' s case management2002，7，6： | 1 |
| 12 | The use of the elevated plus maze as an assay of anxiety-related behavior in rodents显示文摘 | Alieia A Waif Cheryl A Frye | 2007 | Nature Protocols2007，2，2： | 1 |
| 13 | On transitive Cayley graphs of groups and semigroups显示文摘 | A V Kelarev Cheryl E Praeger | 2003 | European Journal of Combinatorics2003，24，： | 1 |
| 14 | Implications of the structure of cementitious wastes containing Pb(Ⅱ),Cd(Ⅱ),As(Ⅴ),and Cr(Ⅵ) on the leaching of metals显示文摘 | CHERYL E H ROSE A DONIA B | 2004 | Cem Concr Res2004，34，7： | 1 |
| 15 | Targeted disruption of the pregnancy - associated plasma protein - A gene is associated with diminished smooth muscle cell response to insulin - like growth factor - I and resistance to neointimal hyperplasia after vascular in- jury显示文摘 | Simari ZT Conover RD Cheryl A | 2006 | Endocrinology2006，147，12： | 1 |
| 16 | Nicotine concentrations with electronic cigarette use: effects of sex and flavor显示文摘 | Cheryl A Oncken Mark D Litt Lynn D McLaughlin | 2015 | Nicotine and Tobacco Research2015，17，4： | 1 |
| 17 | MicroRNA expression and identification of putative miRNA targets in ovarian cancer 显示文摘 | Neetu D Cheryl A Tian L | 2008 | PLoS ONE2008，3，6： | 1 |
| 18 | Acute and sublethal of ammonia on striped bass and hybrid striped bass 显示文摘 | James B O Cheryl A G | 1991 | Journal of the World Aquaculture Society1991，24，1： | 1 |
| 19 | Bilingual Education Program Models:A Frameworkfor Understanding显示文摘 | Cheryl A R | 1995 | Bilingual Research Journal Summer/Fall1995，，19： | 1 |
| 20 | Pregnancy-associated plasma proteinA as a marker of acute coronary syndromes显示文摘 | Cheryl A Conover CA Overgaard MT | 2001 | N Engl J Med2001，345，： | 1 |
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