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| 1 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 2 | Hypoxia-induced resistance to cisplatin and doxorubicin in non-small cell lung cancer is inhibited by silencing of HIF-lalpha gene显示文摘 | Song Xianrang Liu Xianxi Chi Weiling | 2006 | Cancer Chemother Pharmacol2006，58，6： | 1 |
| 3 | A study on characteristic indexesof railway ballast bed underhigh-frequency radar显示文摘Purpose–In this paper,a high-frequency radar test system was used to collect the data of clean ballast bed and fouled ballast bed of ballasted tracks,respectively,for a quantitative evaluation of the condition of railway ballast bed.Design/methodology/approach–Based on original radar signals,the time–frequency characteristics of radar signals were analyzed,five ballast bed condition characteristic indexes were proposed,including the frequency domain integral area,scanning area,number of intersections with the time axis,number of timedomain inflection points and amplitude envelope obtained by Hilbert transform,and the effectiveness and sensitivity of the indexes were analyzed.Findings–The thickness of ballast bed tested at the sleep bottom by high-frequency radar is up to 55 cm,which meets the requirements of ballast bed detection.Compared with clean ballast bed,the values of the five indexes of fouled ballast bed are larger,and the five indexes could effectively show the condition of the ballast bed.The computational efficiency of amplitude envelope obtained by Hilbert transform is 140 s$km1,and the computational efficiency of other indexes is 5 s$km1.The amplitude envelopes obtained by Hilbert transform in the subgrade sections and tunnel sections are the most sensitive,followed by scanning area.The number of intersections with the time axis in the bridge sections was the most sensitive,followed by the scanning area.The scanning area can adapt to different substructures such as subgrade,bridges and tunnels,with high comprehensive sensitivity.Originality/value–The research can provide appropriate characteristic indexes from the high-frequency radar original signal to quantitatively evaluate ballast bed condition under different substructures. | Shilei Wang Zhan Peng Guixian Liu Weile Qiang Chi Zhang | 2023 | Railway Sciences2023，2，1： | 0 |
| 4 | Design strategies of performance-enhanced Se cathodes for Li-Se batteries and beyond显示文摘Lithium-selenium(Li-Se)batteries are deemed as an emerging high energy density electrochemical energy storage system owing to their high specific capacity and volume capacity.Prior to their practicality,a series of critical challenges from the Se cathode side need to be overcome including low reactivity of bulk Se,shuttle effect of intermediates,sluggish redox kinetics of polyselenides,and volume change etc.In this review,recent progress on design strategies of functional Se cathodes are comprehensively summarized and discussed.Following the significance and key challenges,various efficient functionalized strategies for Se cathodes are presented,encompassing covalent bonding,nanostructure construction,heteroatom doping,component hybridization,and solid solution formation.Specially,the universality of these functional strategies are successfully extended into Na-Se batteries,K-Se batteries,and Mg-Se batteries.At last,a brief summary is made and some perspectives are offered with the goal of guiding future research advances and further exploration of these strategies. | Weiling Qiu Xiang Long Huang Ye Wang Chi Feng Haining Ji Hua Kun Liu Shi Xue Dou Zhiming Wang | 2023 | Journal of Energy Chemistry2023，，1： | 0 |
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