|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Examining the Transparency of Gallium-Doped Zinc Oxide for Photovoltaic Applications 显示文摘 | Wong L M Chiam S Y Huang J Q | 2011 | Solar Energy Materials & Solar Cells2011，95，8： | 1 |
| 2 | Dynamic Analysis of Flexible Bodies Using Extended Bond Graphs显示文摘 | Chiaming Y Glenn Y M | 1994 | ASME Journal of Dynamic Systems Measurement and Control1994，116，1： | 1 |
| 3 | Dynamic analysis of flexible bodies using extended bond graphs显示文摘 | Chiaming Y Glenn Y M | 1994 | ASME Journal of Dynamic Systems Measurement and Control1994，116，1： | 1 |
| 4 | Dynamic Analysis of Flexible Bodies Using Extended Bond Graphs显示文摘 | Chiaming Y Glenn Y M | 1994 | ASME Journal of Dynamic Systems Measurement and Control1994，116，1： | 1 |
| 5 | Physical and cognitive domains of the instrumental activities of daily living:validation in a multiethnic population of Asian older adults显示文摘 | Ng TP Niti M Chiam PC | 2006 | J Gerontol A Biol Sci Med Sci2006，61，72： | 1 |
| 6 | Serve combined immunodeficiency caused by a splicing abnormality of the CD3δ gene显示文摘 | Hidetoshi T Akihiko N Chiam M | 2005 | Euopean Joumal of pediatrics2005，164，31： | 1 |
| 7 | Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus显示文摘BACKGROUND Circulating microRNAs(miRNAs)are potential biomarkers for many diseases.However,they can originate from non-disease specific sources,such as blood cells,and compromise the investigations for miRNA biomarkers.While small extracellular vesicles(sEVs)have been suggested to provide a purer source of circulating miRNAs for biomarkers discovery,the most suitable blood sample for sEV miRNA biomarker studies has not been defined.AIM To compare the mi RNA profiles between matched serum and plasma s EV preparations to determine their suitability for biomarker studies.METHODS Matched serum and plasma samples were obtained from 10 healthy controls and10 patients with esophageal adenocarcinoma.s EV isolates were prepared from serum and plasma using Exo Quick TM and quantified using Nano Sight.RNA was extracted from s EV preparations with the mi RNeasy Serum/Plasma kit and profiled using the Taqman Openarray q PCR.The overall mi RNA content and theexpression of specific mi RNAs of reported vesicular and non-vesicular origins were compared between serum and plasma s EV preparations.The diagnostic performance of a previously identified multi-mi RNA biomarker panel for esophageal adenocarcinoma was also compared.RESULTS The overall mi RNA content was higher in plasma s EV preparations(480 mi RNAs)and contained 97.5%of the mi RNAs found in the serum s EV preparations(412 mi RNAs).The expression of commonly expressed mi RNAs was highly correlated(Spearman’s R=0.87,P<0.0001)between the plasma and serum s EV preparations,but was consistently higher in the plasma s EV preparations.Specific blood-cell mi RNAs(hsa-mi R-223-3 p,hsa-mi R-451 a,mi R-19 b-3 p,hsa-mi R-17-5 p,hsa-mi R-30 b-5 p,hsa-mi R-106 a-5 p,hsa-mi R-150-5 p and hsa-mi R-92 a-3 p)were expressed at 2.7 to 9.6 fold higher levels in the plasma s EV preparations compared to serum s EV preparations(P<0.05).In plasma s EV preparations,the percentage of protein-associated mi RNAs expressed at relatively higher levels(Ct 20-25)was greater than serum s EV preparations(50%vs 31%).While the percentage of vesicle-associated mi RNAs expressed at relatively higher levels was greater in the serum s EV preparations than plasma s EV preparations(70%vs 44%).A 5-mi RNA biomarker panel produced a higher cross validated accuracy for discriminating patients with esophageal adenocarcinoma from healthy controls using serum s EV preparations compared with plasma s EV preparations(AUROC 0.80 vs 0.54,P<0.05).CONCLUSION Although plasma s EV preparations contained more mi RNAs than serum s EV preparations,they also contained more mi RNAs from non-vesicle origins.Serum appears to be more suitable than plasma for s EV mi RNAs biomarkers studies. | Karen Chiam George C Mayne Tingting Wang David I Watson Tanya S Irvine Tim Bright Lorelle T Smith Imogen A Ball Joanne M Bowen Dorothy M Keefe Sarah K Thompson Damian J Hussey | 2020 | World Journal of Gastroenterology2020，26，20： | 1 |
| 8 | 6-weekly bevacizumab versus 4-weekly ranibizumab for neovascular age-related macular degeneration:a 2-year outcome显示文摘AIM: To compare visual acuity and central macular thickness(CMT) changes in neovascular age-related macular degeneration patients treated with either 6weekly bevacizumab regimen or 4 weekly ranibizumab on an as required basis.·METHODS: Patients made an informed choice between bevacizumab 1.25 mg or ranibizumab 0.5 mg. The selected treatment was administered in the first 3 visits.Bevacizumab patients were followed-up 6 weekly and ranibizumab 4 weekly. Retreatment criteria was based on the reduction of >5 letters in the best-corrected visual acuity(BCVA), the presence of retinal fluid on optical coherence tomography(OCT) or new retinal haemorrhage.·RESULTS: Visual acuity at 2y bevacizumab patients gained 7. 0 letters and ranibizumab 9. 2( P = 0. 31, 95 %CI-6.4 to 2.0). At 2y 86% of bevacizumab and 94%ranibizumab patients had not lost 15 letters or more(P =0.13). Mean CMT decreased at 2y bevacizumab by 146 μm,ranibizumab 160 μm(P =0.72). Mean number of injections was at 2y bevacizumzb 11.9, ranibizumab 10.3(P =0.023).· CONCLUSION: Bevacizumab 6 weekly on an as required basis was not demonstrably non-inferior to ranibizumab 4 weekly pro re nata(prn) in terms of BCVA and change in CMT. In the bevacizumab group, one more injection was required in the second year compared to the ranibizumab group. | Patrick J Chiam Vivian W Ho Nicholas M Hickley Venkat Kotamarthi | 2016 | International Journal of Ophthalmology(English edition)2016，9，4： | 1 |
| 9 | Physical and cognitive domains of the Instrumental Activities of Daily Living : validation in a multiethnic popu- lation of Asian older adults 显示文摘 | Ng TP Niti M Chiam PC | 2006 | J Gerontol A Biol Sci Med Sci2006，61，7： | 1 |
| 10 | Oncogenic osteomalacia-hy-pophosphataemic spectrum from ' benignancy ' to ' malignancy'显示文摘 | Chiam P Tan H C Bee Y M | 2013 | Bone2013，53，1： | 1 |
| 11 | GSTP1 DNA methylation and expression status is indicative of 5-aza-2'-deoxycytidine efficacy in human prostate cancer cells显示文摘 | CHIAM K CENTENERA M M BUTLER LM | 2011 | PIoS One2011，6，25： | 1 |
| 12 | Role of oxygen for highly conducting and transparent gallium-doped zinc oxide electrode deposited at room temperature显示文摘 | WONGL M CHIAM S Y HUANG J Q | | 0，，02： | 1 |
| 13 | Dynamic Analysis of Flexible Bodies U-sing Extended Bond Graphs显示文摘 | Chiaming Y Glenn Y M | 1994 | ASME Journal of Dynamic Systems Measurement and Control1994，116，1： | 1 |
| 14 | Comparative analysis and study of ionized metal plasma (IMP)-Cu and chemical vapor deposition (CVD)-Cu on diffusion barrier properties of IMP-TaN on SiO2显示文摘 | LEE Y K KHIN M L KIM J H THOMAS O CHIAM S Y LEE K | 2000 | Materials Science and Engineering B2000，77，： | 1 |
| 15 | 查看详情显示文摘 | Chiaming W Tungyou L Russel C Bruce I C Andris M D | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员