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| 1 | CD24 expression predicts distant metastasis in extrahepatic bile duct cancer显示文摘AIM: To evaluate the prognostic significance of CD24 expression in patients undergoing adjuvant chemoradiotherapy for extrahepatic bile duct (EHBD) cancer. METHODS: Eighty-four patients with EHBD cancer who underwent curative resection followed by adjuvant chemoradiotherapy were enrolled in this study. Postoperative radiotherapy was delivered to the tumor bed and regional lymph nodes up to a median of 40 Gy (range: 40-56 Gy). All patients also received fluoropyrimidine chemotherapy for radiosensitization during radiotherapy. CD24 expression was assessed with immunohistochemical staining on tissue microarray. Clinicopathologic factors as well as CD24 expression were evaluated in multivariate analysis for clinical outcomes including loco-regional recurrence, distant metastasisfree and overall survival. RESULTS: CD24 was expressed in 36 patients (42.9%). CD24 expression was associated with distant metastasis, but not with loco-regional recurrence nor with overall survival. The 5-year distant metastasis-free survival rates were 55.1% and 29.0% in patients with negative and positive expression, respectively (P=0.0100). On multivariate analysis incorporating N stage, histologic differentiation and CD24 expression, N stage was the only significant factor predicting distant metastasis-free survival (P=0.0089), while CD24 expression had borderline significance (P=0.0733). In subgroup analysis, CD24 expression was significantly associated with 5-year distant metastasis-free survival in node-positive patients (38.4% with negative expression vs 0% with positive expression, P=0.0110), but not in nodenegative patients (62.0% with negative expression vs 64.0% with positive expression,P=0.8599). CONCLUSION: CD24 expression was a significant predictor of distant metastasis for patients undergoing curative resection followed by adjuvant chemoradiotherapy especially for node-positive EHBD cancer. | Kyubo Kim Hye Sook Min Eui Kyu Chie Jin-Young Jang Sun Whe Kim Sae-Won Han Do-Youn Oh Seock-Ah Im Tae-You Kim Yung-Jue Bang Ja-June Jang Sung W Ha | 2013 | World Journal of Gastroenterology2013，19，9： | 2 |
| 2 | Acquisition behavior of a first order digital phase-locked loop显示文摘 | W C Lindsey C M Chie | 1981 | IEEE transactions on communication1981，26，： | 1 |
| 3 | Epidemiological analysis of factors influencing an episode of exertional rhabdomyolysis in high school students显示文摘 | Lin H Chie W Lien H | | 0，，03： | 1 |
| 4 | Epidemiological analysis of factors influencing an episode of exertional rhabdomyolysis in high school students显示文摘 | Lin H Chie W Lien H | 2006 | Am J Sports Medd2006，34，3： | 1 |
| 5 | Quality of life in patients of nasopharyngeal carcinoma: validation of the Taiwan Chinese version of the EORTC QLQ-C30 and the EORTC QLQ-H&N35 显示文摘 | Chie W C Hong R L Lai C C | 2003 | Qual Life Res2003，12，1： | 1 |
| 6 | A novel method for evaluation of improved survival trend for common cancer: Early detection or improvement of medical care显示文摘 | Chie W C Chang Y H Chen H H | 2007 | J Eval Clin Pract2007，13，1： | 1 |
| 7 | Treatment outcome of an giocentric T-cell and NK/T-cell lymphoma, nasal type: radio therapy versus chemoradiotherapy显示文摘 | Kim K Chie E K Kim C W | 2005 | Jpn J Clin Oncol2005，35，1： | 1 |
| 8 | Fractionated photothermolysis:the Fraxel 1550nm glass fiber laser treatment显示文摘 | CHIE R J KRIDEL R W | 2007 | Facial Plast Surg Clin North Am2007，15，2： | 1 |
| 9 | Comparison of relaxation of techniques, routine blood pressure measurements, and selt-earning packages in hypertension control显示文摘 | Yen L L Patrick W K Chie W C | 1996 | Prey Med1996，25，3： | 1 |
| 10 | Absence of symptom and intact liver function are positive prognosticators for patients undergoing radiotherapy for lymph node metastasis from hepatocellular carcinoma显示文摘 | Kim K Chie EK Kim W | | 0，，03： | 1 |
| 11 | Treatment outcome ofangiocentric T-cell and NK/T-cell lymphoma, nasal type: radiotherapy versus chemoradiotherapy显示文摘 | Kim K Chie E K Kim C W | 2005 | Jpn J Clin Oncol2005，35，1： | 1 |
| 12 | Age at any full-term pregnancy and breast cancer risk 显示文摘 | Chie W Hsieh CC Newcomb PA | 2000 | Am J Epidemiol2000，151，7： | 1 |
| 13 | Quality of life (QQL) among community dwelling older people in Taiwan measured by the CASP-19, an index to capture Q~L in old age 显示文摘 | Wu T Chie W Kuo K | 2013 | Arch Gerontol Geriatr2013，57，2： | 1 |
| 14 | Epidemiological analysis of factors influencing an episode of exertional rhabdomyolysis in high school students显示文摘 | Lin H Chie W Lien H | 2006 | Am J Sports Med2006，34，： | 1 |
| 15 | Quality of life of lung cancer patients:Vali-dation of the Taiwan Chinese version of the EORTC QLQ-C30 and QLQ-LCl3显示文摘 | Chie W C Yang C H | | 0，，01： | 1 |
| 16 | Clinical and psychometric validation of the EORTC QLQCR29 questionnaire module to assess health-related quality of life in patients with colorectal cancer显示文摘 | WHISTANCE R N CONROY T CHIE W | 2009 | Eur J Cancer2009，45，17： | 1 |
| 17 | Friction characteristics of water,R-134a,and air in small tubes显示文摘 | CHIE Y Y JIUNN C W HSIN C T | 2003 | Microscale Thermophysical Engineering2003，7，4： | 1 |
| 18 | A survey of digital phaselocked loops 显示文摘 | LINDSEY W C CHIE C M | 1981 | Proceedings of IEEE1981，69，4： | 1 |
| 19 | Application of a unified Jacobian-Torsor model for tolerance analysis 显示文摘 | Desrochers A Chie W Laperriere L | 2003 | Journal of Computing and Information Science in Engineering2003，3，3： | 1 |
| 20 | Absence of symptom and intact liver function are positive prognosticators for patients undergoing radiotherapy for lymph node metastasis from hepatocellular carcinoma显示文摘 | Kim K Chie EK Kim W | 2010 | Int J Radiat Oncol Biol Phys2010，78，3： | 1 |
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