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| 1 | Micromolar sodium fluoride mediates anti-osteoclastogenesis in Porphyromonas gingivalis-induced alveolar bone loss显示文摘Osteoclasts are bone-specific multinucleated cells generated by the differentiation of monocyte/macrophage lineage precursors.Regulation of osteoclast differentiation is considered an effective therapeutic approach to the treatment of bone-lytic diseases.Periodontitis is an inflammatory disease characterized by extensive bone resorption. In this study, we investigated the effects of sodium fluoride(Na F) on osteoclastogenesis induced by Porphyromonas gingivalis, an important colonizer of the oral cavity that has been implicated in periodontitis. Na F strongly inhibited the P. gingivalis-induced alveolar bone loss. That effect was accompanied by decreased levels of cathepsin K, interleukin(IL)-1β, matrix metalloproteinase 9(MMP9), and tartrate-resistant acid phosphatase,which were up-regulated during P. gingivalis-induced osteoclastogenesis. Consistent with the in vivo anti-osteoclastogenic effect,Na F inhibited osteoclast formation caused by the differentiation factor RANKL(receptor activator of nuclear factor kB ligand)and macrophage colony-stimulating factor(M-CSF). The RANKL-stimulated induction of the transcription factor nuclear factor of activated T cells(NFAT) c1 was also abrogated by Na F. Taken together, our data demonstrate that Na F inhibits RANKL-induced osteoclastogenesis by reducing the induction of NFATc1, ultimately leading to the suppressed expression of cathepsin K and MMP9.The in vivo effect of Na F on the inhibition of P. gingivalis-induced osteoclastogenesis strengthens the potential usefulness of Na F for treating periodontal diseases. | Ujjal K Bhawal Hye-Jin Lee Kazumune Arikawa Michiharu Shimosaka Masatoshi Suzuki Toshizo Toyama Takenori Sato Ryota Kawamata Chieko Taguchi Nobushiro Hamada Ikuo Nasu Hirohisa Arakawa Koh Shibutani | 2015 | International Journal of Oral Science2015，7，4： | 3 |
| 2 | Coumarin Glycosides of Glehnia littoralis Root and Rhizoma 显示文摘 | Junichi K Chieko O Toru I | 1998 | Chem Pharm Bull1998，46，9： | 1 |
| 3 | Influencing factors for dietary behaviors of patients with diabetic nephropathy显示文摘 | Kazuko S Chieko K Kenichi S | | 0，，01： | 1 |
| 4 | Comparative de- velopment of heavily asymmetric-cordate gametophytes of Anemi- a phyllitidis (Anemiaceae) focusing on mefistem behavior 显示文摘 | NAOKO T CHIEKO K NANA M 2012 | 2012 | J Plant Res2012，，3： | 1 |
| 5 | Liposomal Arg-Gly-Asp analogs effec- tively inhibit metastic BI6 melanoma colonization in murine lungs 显示文摘 | Naoto O Yoshihiro T Chieko K | 1996 | Life Sciences1996，58，24： | 1 |
| 6 | Effect of NKCP,a powder produced from dried culture filtrate of partially distilled Bacillus subtilis,on fluidity of blood显示文摘 | TETSUYA H CHIEKO T YUJI K | 2002 | Hemorheology and Related Research2002，5，1： | 1 |
| 7 | Coumarin glycosides of Glehnia fittoralis显示文摘 | Junichi K Chieko O Toru I | 1998 | Chem Pharm Buff1998，46，9： | 1 |
| 8 | Liposomal Arg-Gly- Asp analogs effectively inhibit metastic B16 melanoma colo- nization in routine lungs 显示文摘 | Naoto Ok Yoshihiro T Chieko K | 1996 | Life sciences1996，58，24： | 1 |
| 9 | Methotrexate-induced apoptosis in hepatocytes after hepatectomy显示文摘 | Kaoru K Chieko T Ikuyo T | 2002 | Eur J Pharmacol2002，438，12： | 1 |
| 10 | Association of IRF5 Polymorphisms With Systemic Lupus Erythcmatosus in a Japanese Population 显示文摘 | Aya K Chieko K Jun O ct al | 2008 | Arthritis & Rheumatism2008，58，3： | 1 |
| 11 | Effect of NKCP, a powder produced from dried culture filtrate of partially distilled Bacillus subtilis, on fluidity of blood 显示文摘 | Tetsuya H Chieko T Yuji K | 2002 | Hemorheology and Related Research2002，5，1： | 1 |
| 12 | Effect of NKCP,a powder produced from dried culture filtrate of partially distilled Bacillus subtilis,on fluidity of blood显示文摘 | Tetsuya H Chieko T Yuji K | 2002 | Hemorheol Related Res2002，5，1： | 1 |
| 13 | Enhanced expression of MCM proteins in cancer cells derivedfrom uterine cervix 显示文摘 | Yukio I Chieko K HTon-Ju K | 2003 | Eur J Bioehem2003，，： | 1 |
| 14 | Enhanced expression of MCM proteins in cancer cells derived from uterine cervix显示文摘 | ISAO O CHIEKO K | 2003 | Eur J Biochem2003，270，2： | 1 |
| 15 | Synthesis and properties of amphiphilic arm-or core-functionalized star shaped polymers显示文摘 | Shokyoku K Chieko K Satoru N | 2002 | Polymer Preprints2002，43，1： | 1 |
| 16 | Effect of NKCP, a powder produced from dried culture filtrate of partially distilled Bacillus subtilis, on fluidity of blood显示文摘 | Tetsuya H Chieko T Yuji K | 2002 | Hemorheology and Related Research2002，5，1： | 1 |
| 17 | Coumarins glycosides of Glehnia littoralis root and rhizoma 显示文摘 | Junichi K Chieko O Toru I | 1998 | Chem Pharm Bull1998，46，14： | 1 |
| 18 | Mechanism of pruritus and peracute death in mice induced by pseudorabies virus (PRV) infection显示文摘 | Hoirimi T Yasuhiro Y Chieko K | 1993 | J Vet Med Sci1993，55，： | 1 |
| 19 | Flow boiling of non- azeotropic mixture R32/R1234ze(E) in horizontal micro- fin tubes 显示文摘 | Chieko K Daisuke B Fumiya M | 2013 | International Journal of Refrigeration2013，36，8： | 1 |
| 20 | Coumarin glycosides of glehnia littoralis root and rhizoma显示文摘 | Junichi K Chieko O Toru Ishikawa | 1998 | Chem Pharm Bull1998，46，9： | 1 |
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