|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Could wastewater analysis be a useful tool for China?——A review显示文摘Analysing wastewater samples is an innovative approach that overcomes many limitations of traditional surveys to identify and measure a range of chemicals that were consumed by or exposed to people living in a sewer catchment area. First conceptualised in 2001, much progress has been made to make wastewater analysis(WWA) a reliable and robust tool for measuring chemical consumption and/or exposure. At the moment, the most popular application of WWA, sometimes referred as sewage epidemiology, is to monitor the consumption of illicit drugs in communities around the globe, including China. The approach has been largely adopted by law enforcement agencies as a device to monitor the temporal and geographical patterns of drug consumption. In the future, the methodology can be extended to other chemicals including biomarkers of population health(e.g. environmental or oxidative stress biomarkers, lifestyle indicators or medications that are taken by different demographic groups) and pollutants that people are exposed to(e.g. polycyclic aromatic hydrocarbons,perfluorinated chemicals, and toxic pesticides). The extension of WWA to a huge range of chemicals may give rise to a field called sewage chemical-information mining(SCIM) with unexplored potentials. China has many densely populated cities with thousands of sewage treatment plants which are favourable for applying WWA/SCIM in order to help relevant authorities gather information about illicit drug consumption and population health status. However, there are some prerequisites and uncertainties of the methodology that should be addressed for SCIM to reach its full potential in China. | Jianfa Gao Jake O'Brien Foon Yin Lai Alexander L.N.van Nuijs Jun He Jochen F.Mueller Jingsha Xu Phong K.Thai | 2015 | Journal of Environmental Sciences2015，27，1： | 4 |
| 2 | Safety of endovascular therapy for symptomatic intracranial artery stenosis:a national prospective registry显示文摘Introduction The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown.The Clinical Registration Trial of Intracranial Stenting for Patients with Symptomatic Intracranial Artery Stenosis(CRTICAS)was a prospective,multicentre,real-world registry designed to assess these outcomes and the impact of centre experience.Methods 1140 severe,symptomatic intracranial arterial stenosis(ICAS)patients treated with endovascular therapy were included from 26 centres,further divided into three groups according to the annual centre volume of intracranial angioplasty and stent placement procedures over 2 years:(1)high volume for≥25 cases/year;(2)moderate volume for 10–25 cases/year and(3)low volume for<10 cases/year.Results The rate of 30-day stroke,transient ischaemic attack or death was 9.7%(111),with 5.4%,21.1%and 9.7%in high-volume,moderate-volume and low-volume centres,respectively(p<0.05).Multivariable logistic regression confirmed high-volume centres had a significantly lower primary endpoint compared with moderate-volume centres(OR=0.187,95%CI:0.056 to 0.627;p≤0.0001),while moderate-volume and low-volume centres showed no significant difference(p=0.8456).Conclusion Compared with the preceding randomised controlled trials,this real-world,prospective,multicentre registry shows a lower complication rate of endovascular treatment for symptomatic ICAS.Non-uniform utilisation in endovascular technology,institutional experience and patient selection in different volumes of centres may have an impact on overall safety of this treatment. | Yabing Wang Tao Wang Adam Andrew Dmytriw Kun Yang Liqun Jiao Huaizhang Shi Jie Lu Tianxiao Li Yujie Huang Zhenwei Zhao Wei Wu Jieqing Wan Qinjian Sun Bo Hong Yongli Li Liyong Zhang Jianfeng Chu Qiong Cheng Yiling Cai Pengfei Wang Qi Luo Hua Yang Baijing Dong Yang Zhang Jun Zhao Zuoquan Chen Wei Li Xiaoxin Bai Weiwen He Xueli Cai Maimai Ti Osama O Zaidat | 2022 | Stroke & Vascular Neurology2022，7，2： | 3 |
| 3 | Electrochemical Lithium Storage Performance of Molten Salt Derived V_(2)SnC MAX Phase显示文摘MAX phases are gaining attention as precursors of two-dimensional MXenes that are intensively pursued in applications for electrochemical energy storage.Here,we report the preparation of V_(2)SnC MAX phase by the molten salt method.V_(2)SnC is investigated as a lithium storage anode,showing a high gravimetric capacity of 490 mAh g−1 and volumetric capacity of 570 mAh cm^(−3) as well as superior rate performance of 95 mAh g^(−1)(110 mAh cm^(−3))at 50 C,surpassing the ever-reported performance of MAX phase anodes.Sup-ported by operando X-ray diffraction and density functional theory,a charge storage mechanism with dual redox reaction is proposed with a Sn-Li(de)alloying reaction that occurs at the edge sites of V_(2)SnC particles where Sn atoms are exposed to the electrolyte followed by a redox reaction that occurs at V_(2)C layers with Li.This study offers promise of using MAX phases with M-site and A-site elements that are redox active as high-rate lithium storage materials. | Youbing Li Guoliang Ma Hui Shao Peng Xiao Jun Lu Jin Xu Jinrong Hou Ke Chen Xiao Zhang Mian Li Per OÅPersson Lars Hultman Per Eklund Shiyu Du Zhifang Chai Zhengren Huang Na Jin Jiwei Ma Ying Liu Zifeng Lin Qing Huang | 2021 | Nano-Micro Letters2021，13，10： | 2 |
| 4 | LMP2-DC Vaccine Elicits Specific EBV-LMP2 Response to Effectively Improve Immunotherapy in Patients with Nasopharyngeal Cancer显示文摘Objective To evaluate the safety and effectiveness of a vaccine based on latent membrane protein 2(LMP2)modified dendritic cells(DCs)that boosts specific responses of cytotoxic T lymphocytes(CTLs)to LMP2 before and after intradermal injection in patients with nasopharyngeal carcinoma(NPC).Methods DCs were derived from peripheral blood monocytes of patients with NPC.We prepared LMP2-DCs infected by recombinant adenovirus vector expressing LMP2(rAd-LMP2).NPC patients were immunized with 2×105 LMP2-DCs by intradermal injection at week 0 and after the second and fourth weeks.Specific responses to LMP2 were detected by enzyme-linked immunospot(ELISPOT)assay at week 0 and at the fifth and eighth weeks.Local clinicians performed the follow-up and tracking of patients.Results We demonstrated that DCs derived from monocytes displayed typical DC morphologies;the expression of LMP2 in the LMP2-DCs vaccine was confirmed by immunocytochemical assay.Twenty-nine patients with NPC were enrolled in this clinical trial.The LMP2-DCs vaccine was well tolerated in all of the patients.Boosted responses to LMP2 peptide sub-pools were observed in 18 of the 29 patients with NPC.The follow-up data of 29 immunized patients from April,2010 to April 2015 indicated a five-year survival rate of 94.4%in responders and 45.5%in non-responders.Conclusion In this pilot study,we demonstrated that the LMP2-DCs vaccine is safe and effective in patients with NPC.Specific CTLs responses to LMP2 play a certain role in controlling and preventing the recurrence and metastasis of NPC,which warrants further clinical testing. | ZENG Yi SI Yong Feng LAN Gui Ping WANG Zhan ZHOU Ling TANG Min Zhong SJ O`Brien LAN Jiao ZHOU Xiang Yang WANG Yong Li TANG Juan ZHOU Zhi Xiang DU Hai Jun LIN Hui | 2020 | Biomedical and Environmental Sciences2020，33，11： | 2 |
| 5 | 2004年加拿大预防血透病人医院血流感染的成本-效益分析显示文摘目的:血液透析相关的血流感染是一个严重的公共健康问题,因为加拿大的血液透析病人从1996年到2005翻了一番。本研究目的在于确定加拿大医院血流感染的成本,估算在综合性医院中建立感染控制项目的成本,并进行成本-效益分析。材料与方法:用加拿大医院感染监测项目的数据来估算医院血流感染的发生率。用加拿大健康信息所数据来估算2004年加拿大平均一次血流感染住院的额外成本。建立和维护一个感染控制项目的成本用美国疾病预防与控制中心1985年的成本换算为2004年的加拿大成本来估算。假设感染控制项目能降低医院血流感染病例的20%~30%。结果:2004年的加拿大15278名血液透析病人中估计共有2524人发生血流感染。全年用于治疗血流感染的成本估计为4901万加元。医院血流感染预防和人力资源的总投资成本为815万加元。建立医院感染控制项目后能带来1452万加元的医疗成本节约。效益成本比在1.0:1到1.8:1之间。结论:本研究提供的证据表明,如果医院感染控制项目能降低20%~30%的感染,该项目的经济效益将远超过增加的成本。医院感染控制项目将带来双重效益:节约货币成本的同时改善医疗质量。 | Zhiyong Hong MD DrPH Jun Wu PhD Crystal O'Leary BHSc Clem Tisdell James Gomes Shi-Wu Wen Howard Njoo 李洪超 | 2010 | 中国药物经济学2010，，1： | 2 |
| 6 | Free bending vibration of a multi-step rotor显示文摘 | Jun O S Kim J O | 1999 | Journal of Sound and Vibration1999，224，4： | 1 |
| 7 | Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia显示文摘 | Masashi Ikeda Yoshio Yamanouchi Yoko Kinoshita Tsuyoshi Kitajima Reiji Yoshimura Shuji Hashimoto Michael C O&rsquor Donovan Jun Nakamura Norio Ozaki Nakao Iwata | 2008 | Pharmacogenomics2008，，10： | 1 |
| 8 | Roles of bHLH genes in neural stem cell differentiation显示文摘 | Ryoichiro K Toshiyuki O Jun Hatakeyama | 2005 | Exp Cell Res2005，306，： | 1 |
| 9 | Cyclophosphamide inhibits the development of diabetes in the diabetes-prone BB rat 显示文摘 | Sobel D O Ahvazi B Jun H S | 2000 | Diabetologia2000，43，8： | 1 |
| 10 | Latch-up characteristics of a lateral trench gate conductivity modulated power transistor 显示文摘 | CAI Jun SIN J K O | 1998 | Journal of University of Science and Technology of China1998，29，4： | 1 |
| 11 | Effect of heat and moisture exchanger(HME)positioning on inspiratory gas humidification显示文摘 | Daisuke I Jun O Masaj N | 2006 | BMC Pulm Med2006，6，： | 1 |
| 12 | Enhanced level of anthocyanin leads to increased salt tolerance in arabidopsis PAP1-D plants upon sucrose treatment显示文摘 | Jee E O Young H K Jun H K | 2011 | Korean Soc2011，54，1： | 1 |
| 13 | Polymerization of aqueous lactic acid to prepare high molecular weight poly(lactic acid) by chain extending with hexamethylone diisocyannate显示文摘 | Kim B O Jun H S | 1995 | Poly Bull1995，35，4： | 1 |
| 14 | AdpA,a Central Transcriptional Regulator in the A-Factor Regulatory Cascade That Leads to Morphological Development and Secondary Metabolism in Streptomyces griseus显示文摘 | Haruka Y Jun K | 2005 | Biosci Biotechnol Biochem2005，69，3： | 1 |
| 15 | Polymerization ofaqueous lactic acid to prepare high molecular weightpoly(lactic acid)by chain-extending with hexamethylenediisocyanate显示文摘 | WOO S I KIM B O JUN H S | 1995 | Polym Bull1995，35，4： | 1 |
| 16 | A novel route to three-dimensionally ordered macroporous polymers by electron irradiation of polymer colloids显示文摘 | Cho S O Jun H Y Ahn S K | 2005 | Adv Mater2005，17，1： | 1 |
| 17 | Analytic thermogravimetry to determine the effect of surface modification on dispersion of NdFeB fillers 显示文摘 | Joshua U O | 1999 | J Mater Res1999，14，7： | 1 |
| 18 | Inhibition of BAD Phosphorylation Either at Serine 112 via Extracellular Signalregulated Protein Kinase Cascade or at Serine 136 via Akt Cascade Sensitizes Human Ovarian Cancer Cells to Cisplatin显示文摘 | Jun H Masahide O Hirohisa K | 2000 | Cancer Res2000，60，： | 1 |
| 19 | Biorthogonal wavelet space:Parametrization and factorization 显示文摘 | Howard L Jun T Raymond O | 2001 | Society for Industrial and Applied Mathematics2001，33，1： | 1 |
| 20 | Polymerization of aqueous lactic acid to prepare high molecular weight poly (lactic acid) by chain-extending with hexamethylene diisocyanate显示文摘 | Woo S I Kim B O Jun H S | 1995 | Polymer Bulletin1995，35，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员