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| 1 | MELD score,insulin-like growth factor 1 and cytokines on bone density in end-stage liver disease显示文摘AIM:To determine the contributions of insulin-like growth factor 1 (IGF-1),cytokines and liver disease severity to bone mineral density in patients pre-transplantation.METHODS:Serum IGF-1,tumor necrosis factor-α (TNFα) and interleukin 6 (IL-6) were measured and the Model for End-Stage Liver Disease (MELD) score calculated in 121 adult patients referred to a single centre for liver transplantation.Bone mineral density (BMD) of the lumbar spine and femoral neck were assessed via dual energy X-ray absorptiometry.Demographics,liver disease etiology,medication use and relevant biochemistry were recorded.RESULTS:A total of 117 subjects were included,with low BMD seen in 68.6%,irrespective of disease etiol-ogy.In multivariable analysis,low body mass index (BMI),increased bone turnover and low IGF-1 were independent predictors of low spinal bone density.At the hip,BMI,IGF-1 and vitamin D status were predictive.Despite prevalent elevations of TNFα and IL-6,levels did not correlate with degree of bone loss.The MELD score failed to predict low BMD in this pre-transplant population.CONCLUSION:Osteopenia/osteoporosis is common in advanced liver disease.Low serum IGF-1 is weakly predictive but serum cytokine and MELD score fail to predict the severity of bone disease. | Rebecca Mitchell Jill McDermid Mang M Ma Constance L Chik | 2011 | World Journal of Hepatology2011，3，6： | 5 |
| 2 | Correctly identifying the microsomic fetus improving ultrasonography - based prediction显示文摘 | Soko(R) Chik L Dombrowski MP | 2000 | Am J Obstet Gynecol2000，186，： | 1 |
| 3 | Precise gaussian distribution functions of maternal serum alpha-fetoprotein and free beta-subunit of human chorionic gonadotropin for trisomy 21 screening:Improved accuracy for patient counseling显示文摘 | Chik L Spencer K Johnson Mp | 1997 | Am J Obstet Gynecol1997，177，： | 1 |
| 4 | Diagnosis and management of hyperprolactinemia显示文摘 | Omar Serri Constance L Chik | 2003 | CMAJ2003，169，： | 1 |
| 5 | Nonlinear pre fire and post fire analysis of steel frames显示文摘 | CHIK I CHAN S L ZHA X X | 2008 | Engineering Structures2008，27，11： | 1 |
| 6 | Diagnosis and management of hyperprolaetinemia显示文摘 | Serri O Chik C L Ur E | 2003 | CMAJ2003，169，6： | 1 |
| 7 | Mitogen-activated protein kinase phosphatase-1 (MKP-1) preferentially dephosphory lates p42/44MAPK but not p38MAPK in rat pinealoeytes 显示文摘 | Price D M Wloka M T Chik C L | 2007 | JNeurochem2007，101，6： | 1 |
| 8 | Cell surface protein glycosy-lation in cancer显示文摘 | Christiansen MN’Chik J Lee L | 2014 | Proteomics2014，14，45： | 1 |
| 9 | The role of the agouti gene in the yellow obese syndrome显示文摘 | Miltenberger R J Mynatt R L Wilkinson J E Woy- chik R P | 1997 | J Nutr1997，127，： | 1 |
| 10 | Cell surface protein glycosy-lation in cancer显示文摘 | Christiansen MN Chik J Lee L | 2014 | Proteomics2014，14，45： | 1 |
| 11 | Saussurea involucrata: a review of the botany, phytochemistry and ethnopharma- cology of a rare traditional herbal medicine显示文摘 | Chik WI Zhu L Fan LL | 2015 | J Ethno- pharmacology2015，168，20： | 1 |
| 12 | Diagnosis and management of hyperprolactinemia 显示文摘 | Omar Serri Constance L Chik | 2003 | CMAJ2003，169，： | 1 |
| 13 | Pituitary adenylate cyclase-activating p eptide stimulates cyclic AMP accumulation in UMR 106 osteoblast-like cells 显示文摘 | Kovacs C S Chik C L Li B | 1996 | J Endocrinol1996，149，： | 1 |
| 14 | What affects fetal pulmonary maturtion during diabetic pregnancy? 显示文摘 | FerrionKM Gross TL Sokol RJ Chik L | 1984 | Am J Obstet Gynecol1984，150，： | 1 |
| 15 | Cell surface protein glycosylation in cancer显示文摘 | Christiansen MN Chik J Lee L | 2014 | Proteomics2014，14，45： | 1 |
| 16 | Precise Gaussian distribution functions of maternal serum α-fetoprotein and free β-subunit of human chorionic gonadotrnpin for trisomy 21 screening:improved accuracy for patient counseling显示文摘 | Chik L Spencer K Johnson MP | 1997 | Am J Obstet Gynecol1997，177，4： | 1 |
| 17 | Perfectionism and treatment outcome in obsessive--compulsive disorder显示文摘 | Chik H M Whittal M L O'neill M L | 2008 | Cognitive Therapy and Research2008，32，5： | 1 |
| 18 | Precise gaussian distribution functions of maternal serum -fetoprotein and free -subunit of human chorionic gonadotropin for trisomy 21,screening:improved accuracy for patient counseling显示文摘 | Chik L Spencer K Johnson MP | 1997 | Am J Obstet Gynecol1997，177，4： | 1 |
| 19 | White Matter andCerebral Metabolite Changes in Children Undergoing Treatment for Acute Lymphoblastic Leukemia: Longitudinal Study with MR Imaging and 1H MR Spectroscopyl 显示文摘 | Chu W CW Chik KW Chan (L etal | 2003 | Radiology2003，229，3： | 1 |
| 20 | Precise Gaussian distribution functions of maternal serum a-fetoprotein and free 15 -subunit of human chorionic gonadotropin for trisomy 21 screening:improved accuracy for patient counseling显示文摘 | Chik L Spencer K Johnson MP | 1997 | Am J Obstet Gynecol1997，177，4： | 1 |
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