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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Measurements of rotor dynamic coefficients of hybrid bearings with (a) a plugged orifice, and (b) a worn land surface 显示文摘 | LAURANT F CHILDS D W | 2002 | ASME J Eng Gas Turbines Power2002，124，2： | 1 |
| 3 | Experimental investigation of drying shrinkage and creep of concrete using fibre-optic sensors 显示文摘 | Wong A C L Childs P A Terry W | 2007 | Advances in Structural Engineering2007，10，3： | 1 |
| 4 | Heme-oxygenase - 1 mRNA expression affects hemorrhagic shock-induced leukocyte adherence 显示文摘 | Moncure M Chen L Childs E W | 2003 | J Trauma2003，55，： | 1 |
| 5 | Polyamine-dependent gene expression显示文摘 | CHILDS A C MEHTA D J GERNER E W | 2003 | Cellular and Molecular Life Sciences2003，60，7： | 1 |
| 6 | Demonstration of significant abiotic iron isotope fractionation in nature显示文摘 | Bullen T D White A F Childs C W | 2001 | Geology2001，29，： | 1 |
| 7 | Experimental rotordynamic coefficient results for (a) a labyrinth seal with and without shunt injection and (b) a honeycomb seal显示文摘 | Soto E A Childs D W | 1999 | Journal of Engineering for Gas Turbines and Power1999，121，1： | 1 |
| 8 | Rotordynamic- coefficients and static (equilibrium loci and leakage ) characteristics for short, laminar-flow annular seals 显示文摘 | Childs D W Rodriguez L E Cullotta V | 2006 | Journal of Tribology2006，128，2： | 1 |
| 9 | Rotordynamic coefficients for a tooth-on- stator labyrinth gas seal at 70 bar supply pressures: measurements versus theory and comparisons to a hole-pattern stator seal 显示文摘 | Picardo A Childs D W | 2005 | ASME Journal of Engineering for Gas Turbines and Power2005，127，10： | 1 |
| 10 | Thermal Effects Liquid Oxygen Hydrostatic Journal Bearings 显示文摘 | Zhou Yang Luis San Andres Dara W Childs | 1996 | Tribology transactions1996，39，： | 1 |
| 11 | Assessment of primary cancers in growth hormone-treated adult hypopituitary patients:an analysis from the hypopituitary control and complications study (hypoccs)显示文摘 | Child C Zimmermann A Woodmansee W | | 0，，02： | 1 |
| 12 | Measurement versus predictions of rotordynamic coefficients of a hole-pattern gas seal with negative preswirl显示文摘 | Brown P D Childs D W | 2012 | Journal of Engineering for Gas Turbines and Power2012，134，12： | 1 |
| 13 | Influence of groove size on the static and rotordynamic characteristics of short, laminar-flow annular seals 显示文摘 | Childs D W Graviss M Rodriguez L E | 2007 | Journal of Tribology2007，129，2： | 1 |
| 14 | Global Cities and Developmental States : New York, Tokyo and Seoul显示文摘 | Child H Kim R J W | 2000 | Urban Studies2000，37，12： | 1 |
| 15 | Rare earth elements in ironmanganese concretions from some New Zealand soils显示文摘 | RANKIN P C CHILDS C W | 1976 | Chem Geol1976，，18： | 1 |
| 16 | Accuracy of diagnosis of persistent vegetative state显示文摘 | Childs N L Mercer W N Childs H W | 1993 | Neurology1993，43，8： | 1 |
| 17 | 查看详情显示文摘 | RHOADES W A CHILDS R L | | 0，，： | 1 |
| 18 | Rub-induced parametric excitation in rotors 显示文摘 | Childs D W | 1979 | Journal of Mechanical D esign1979，101，4： | 1 |
| 19 | Rare earth elements in ironmanganese concretions from some New Zealand soils显示文摘 | Rankin P C Childs C W | 1976 | Chem Geol1976，18，： | 1 |
| 20 | Assembly of nano-scale circular supramolecular arrays through π-π aggregation of arc-shapedhelicate units 显示文摘 | Childs L J Alcock N W Hannon M J | 2001 | Angew Chem Int Ed2001，40，： | 1 |
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