|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Atmospheric deposition of PAHs,PCBs, and organochlorine pesticides to Corpus Christi Bay, Texas显示文摘 | Park J S Terry L W Sweet S | 2002 | Atmospheric Environment2002，36，： | 1 |
| 3 | Experimental investigation of drying shrinkage and creep of concrete using fibre-optic sensors 显示文摘 | Wong A C L Childs P A Terry W | 2007 | Advances in Structural Engineering2007，10，3： | 1 |
| 4 | A C/T single nucleotidepolymorphism at the tyrosine kinase domain of the insulin re-ceptor gene is associated with polycystic ovary syndrome 显示文摘 | Siegel S Futlerweit W Terry F | 2002 | Fertil Steril2002，78，6： | 1 |
| 5 | Pyrolytic Characteristics of Blended Coal and Woody Biomass 显示文摘 | Moghtaderi B Meesri C Terry F W | 2004 | Fuel2004，83，6： | 1 |
| 6 | Audits as a corporate governance mechanism: evidence from the German market 显示文摘 | Hollis A Terry D W | 2003 | Journal of In- ternational Accounting Research2003，，2： | 1 |
| 7 | Role of Plasma epinephrine in fasted exercising rats 显示文摘 | Terry L Winder W W Mitchell V M | 1985 | Am J Physiol Regulatory Integrative Comp Physiol1985，248，： | 1 |
| 8 | Stability and immunogenicity of empty particles of foot - and - mouth disease virus 显示文摘 | Rweye M M Terry G Oay T W F | 1979 | Arch Virol1979，56，： | 1 |
| 9 | Effect of diet on partial efficiency of acetate use for body tissue synthesis by mature cattle显示文摘 | Terry H F Reynolds P J Moe P W | 1979 | AnimSei1979，48，： | 1 |
| 10 | Social -Ecological Resilience to Coastal Disasters 显示文摘 | Nell Adger W Terry P Hughes Carl Folke | 2005 | Science2005，309，： | 1 |
| 11 | Vesicoureteral reflux treatment:the past,present and future显示文摘 | Terry W Hensle Amy L Grogg | 2007 | Current Medical Research and Opinion2007，23，4： | 1 |
| 12 | Diabetes and outcomes after radical prostatectomy:are results affected by obesity and race?Results from the shared equal-access regional cancer hospital database显示文摘 | Jayachandran J Aronson W Terris M | 2010 | Cancer Epidemiol Biomarkers Prev2010，1，19： | 1 |
| 13 | Changes of fermentation pathways of fecal microbial communities associated with d drug treatment that increases diatary starch in the human colon显示文摘 | MEYER J W TERRY L M YERRY S | 1999 | Appl Environ Microbiol1999，65，7： | 1 |
| 14 | CAI inhibits the growth of small cell lung cancer cells显示文摘 | Terry W Moody Jessica Chiles Elizabeth Moody Gregory J Sieczkiewicz Elise C Kohn | 2003 | Lung Cancer2003，，3： | 1 |
| 15 | SWOT analysis: it is time for a product recall 显示文摘 | Terry H Roy W | 1997 | Long Range Planning1997，30，1： | 1 |
| 16 | A computerized method of visual acuity testing显示文摘 | Roy W Beck Pamela S Moke Andrew H Turpin Frederick L Ferris John Paul SanGiovanni Chris A Johnson Eileen E Birch Danielle L Chandler Terry A Cox R.Clifford Blair Raymond T Kraker | 2003 | American Journal of Ophthalmology2003，，2： | 1 |
| 17 | Sensors and Actuators显示文摘 | Allen H V Terry S C De Bruin D W | 1989 | 20:153-1611989，20，： | 1 |
| 18 | A human- and male- specific protocadherin that acts through the wnt signaling pathway to induce neuroendocrine transdifferentiation of pros- tate cancer cells显示文摘 | Yang X Chen M W Terry S | 2005 | Cancer Res2005，65，12： | 1 |
| 19 | Inhibition of herpes simplex virus type I DNA polymerase by the natural product oosporein显示文摘 | Terry B J Liu C Cianci C W | 1992 | Journal of Antibiotics1992，45，2： | 1 |
| 20 | Determination of carbaryl in honeybees and pollen by HPLC显示文摘 | Terry D S Rocco A M George W H | 1986 | Chromatography1986，352，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员