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| 1 | Effects of feeding a diet containing Gymnema sylvestre extract: attenuating progression of obesity in C57BL/6J mice显示文摘Objective: To investigate the effect of Gymnema sylvestre extract(GS) on initial anti-obesity, liver injury, and glucose homeostasis induced by a high-fat diet(HFD). Methods: The dry powder of GS was extracted with methanol, and gymnemic acid was identified by high performance liquid chromatography as deacyl gymnemic acid. Male C57BL/6J mice that fed on either a normal diet, normal diet containing 1 g/kg GS(CON+GS) HFD, or HFD containing 1.0 g/kg GS(HFD+GS) for 4 weeks were used to test the initial anti-obesity effect of GS. Body weight gain and food intake, and serum levels about lipid and liver injury markers were measured. Histopathology of adipose tissue and liver stained with hematoxylin and eosin(H&E) and oil-red O were analyzed. After 4 weeks of GS extract feeding, intraperitoneal glucose tolerance test(IPGTT) was performed. Results: The methanol extracts of GS exerted significant anti-obesity effects in HFD+GS group. They decreased body weight gain, a lower food and energy efficiency ratio, and showed lower serum levels of total cholesterol(TC), triglyceride(TG), low-density lipoprotein(LDL)-cholesterol, very-low density lipoprotein(VLDL)-cholesterol and leptin compared with the HFD group. The decreases of abdominal as well as epididymal fat weight and adipocyte hypertrophy, lipid droplets in liver, and serum levels of aspartate aminotransferase(AST) and alanine transaminase(ALT) were also observed. The CON+GS group showed an effect of glucose homeostasis compared to the CON group. Conclusions: This study shows that GS provide the possibility as a key role in an initial anti-obesity effects feeding with a HFD. | Hyeon-Jeong Kim Seong-Ho Hong Seung-Hee Chang Sanghwa Kim Ah Young Lee Yoonjeong Jang Orkhonselenge Davaadamdin Kyeong-Nam Yu Ji-Eun Kim Myung-Haing Cho | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，5： | 3 |
| 2 | Perceived risk as a barrier to appropriate diagnosis of irritable bowel syndrome显示文摘AIM:To evaluate perceived risk,diagnostic testing,and acceptance of a diagnosis of irritable bowel syndrome(IBS)among the Korean laypersons.METHODS:We designed a conceptual framework to evaluate the health-seeking behavior of subjects based on a knowledge,attitude,and practice model.We developed a vignette-based questionnaire about IBS based on a literature review and focused group interviews.The vignette described a 40-year-old woman who meets the RomeⅢcriteria for IBS without red-flag signs.It was followed by questions about demographic characteristics,health behaviors,IBS symptoms,risk perception,perceived need for diagnostic tests,and acceptance of a positive diagnosis of IBS.Weplanned a nationwide survey targeting laypersons without IBS and between the ages of 20 and 69 years.Survey participants were selected by quota sampling stratified by gender,age,and nationwide location.A multivariate logistic model was constructed based on literature reviews,univariate analysis,and a stepwise selection method to investigate correlations between the perceived risk,need for diagnostic tests,and acceptance of a positive diagnosis.RESULTS:Of 2354 eligible households,1000 subjects completed the survey and 983 subjects were analyzed,excluding those who met symptom criteria for IBS.After reading the IBS vignette,the majority of subjects(86.8%)responded that the patient was at increased risk of severe disease.The most frequent concern was colon cancer(59.8%),followed by surgical condition(51.5%).Most subjects responded the patient needs diagnostic tests(97.2%).Colonoscopy was the most commonly required test(79.5%).Less than half of the respondents requested a stool examination(45.0%),blood test(40.7%),abdominal ultrasound(36.0%),or computed tomography(20.2%).The subjects who felt increased risk were more likely to see a need for colonoscopy[adjusted odds ratio(a OR)=2.10,95%CI:1.38-3.18].When asked about the positive diagnosis,the most frequent response was that'the patient would not be reassured'(65.7%).The increased risk perception group was less likely to be reassured by a positive diagnosis of IBS,compared to the other respondents(a OR=0.52,95%CI:0.34-0.78).CONCLUSION:For IBS diagnosis,increased risk perception is a possible barrier to the appropriate use of diagnostic tests and to the patient’s acceptance of a positive diagnosis. | Eunmi Ahn Ki Young Son Dong Wook Shin Min Kyu Han Hyejin Lee Ah Reum An Eun Ho Kim Be Long Cho | 2014 | World Journal of Gastroenterology2014，20，48： | 2 |
| 3 | Antioxidant and antimicrobial activities of leafy green vegetable extracts and their applications to meat product preservation显示文摘 | Sung-Jin Kim Ah Reum Cho Jaejoon Han | 2013 | Food Control2013，，1： | 2 |
| 4 | Methylation and microsatellite status and recurrence following adjuvant FOLFOX in colorectal cancer显示文摘 | Sae‐Won Han Hyun‐Jung Lee Jeong Mo Bae Nam‐Yun Cho Kyung‐Hun Lee Tae‐Yong Kim Do‐Youn Oh Seock‐Ah Im Yung‐Jue Bang Seung‐Yong Jeong Kyu Joo Park Jae‐Gahb Park Gyeong Hoon Kang Tae‐You Kim | 2012 | Int J Cancer2012，，9： | 2 |
| 5 | A case of hypereosinophilic syndrome presenting with intractable gastric ulcers显示文摘We report a rare case of hypereosinophilic syndrome(HES)presenting with intractable gastric ulcers.A 71-year-old man was admitted with epigastric pain.Initial endoscopic findings revealed multiple,active gastric ulcers in the gastric antrum.He underwent Helicobacter pylori(H pylori)eradication therapy followed by proton pump inhibitor(PPI)therapy.However,follow-up endoscopy at 4,6,10 and 14 mo revealed persistent multiple gastric ulcers without significant improvement.The proportion of his eosinophil count increased to 43%(total count:7903/mm 3).Abdominal-pelvic and chest computed tomography scans showed multiple small nodules in the liver and both lungs.The endoscopic biopsy specimen taken from the gastric antrum revealed prominent eosinophilic infiltration,and the liver biopsy specimen also showed eosinophilic infiltration in the portal tract and sinusoid.A bone marrow biopsy disclosed eosinophilic hyperplasia as well as increased cellularity of 70%.The patient was finally diagnosed with HES involving the stomach,liver,lung,and bone marrow.When gastric ulcers do not improve despite H pylori eradication and prolonged PPI therapy,infiltrative gastric disorders such as HES should be considered. | Tae Young Park Chang Hwan Choi Suh Yoon Yang InSoo Oh In-Do Song Hyun Woong Lee Hyung Joon Kim Jae Hyuk Do Sae Kyung Chang Ah Ra Cho Young Joo Cha | 2009 | World Journal of Gastroenterology2009，15，48： | 2 |
| 6 | Changes in a cerebellar peduncle lesion in a patient with Dandy-Walker malformation A diffusion tensor imaging study显示文摘We report a patient with severe ataxia due to Dandy-Walker malformation, who showed functional recovery over 10 months corresponding to a change in a cerebellar peduncle lesion. A 20-month-old female patient who was diagnosed with Dandy-Walker syndrome and six age- and sex-matched healthy control subjects were enrolled. The superior cerebellar peduncle, the middle cerebellar peduncle, and the inferior cerebellar peduncle were evaluated using fractional anisotropy and the apparent diffusion coefficient. The patients' functional ambulation category was 0 at the initial visit, but improved to 2 at the follow-up evaluation, and Berg's balance scale score also improved from 0 to 7. Initial diffusion tensor tractography revealed that the inferior cerebellar peduncle was not detected, that the fractional anisotropy of the superior cerebellar peduncle and middle cerebellar peduncle decreased by two standard deviations below, and that the apparent diffusion coefficient increased by two standard deviations over normal control values. However, on follow-up diffusion tensor tractography, both inferior cerebellar peduncles could be detected, and the fractional anisotropy of superior cerebellar peduncle increased to within two standard deviations of normal controls. The functional improvement in this patient appeared to correspond to changes in these cerebellar peduncles. We believe that evaluating cerebellar peduncles using diffusion tensor imaging is useful in cases when a cerebellar peduncle lesion is suspected. | Ah Young Lee Sung Ho Jang Sang Seok Yeo Ensil Lee Yun Woo Cho Su Min Son | 2013 | Neural Regeneration Research2013，8，5： | 2 |
| 7 | Initial microbleeds at MR imaging can predict recurrent untra cerebral hemorrhage显示文摘 | Jeon SB Kang DW Cho AH | | 0，，： | 1 |
| 8 | Rapid appearance of new cerebral microbleeds after acute ischemic stroke显示文摘 | Jeon SB Kwon SU Cho AH | | 0，，： | 1 |
| 9 | Impaired kidney function andcerebral microbleeds in patients with acute ischemic stroke 显示文摘 | Cho AH Lee SB Han SJ | 2009 | Neurology2009，73，： | 1 |
| 10 | Rapid appearance of new cerebral microbleeds after acute ischemic stroke显示文摘 | Jeon SB Kwon SU Cho AH | 2009 | Neurology2009，73，： | 1 |
| 11 | Life-Threatening Anaphylactoid Re- action in an Acute lschemic Stroke Patient With Intravenous rt-PA Tlu'omlolysis, Followed by Successful lntra-Arterial Thmmbolysis 显示文摘 | Park IS Cho AH Lee SJ | 2008 | J Clin Neurol2008，，： | 1 |
| 12 | Rapid appearance of new cerebral microbleeds after acute ischemic stroke显示文摘 | Jeon SB Kwon SU Cho AH | 2009 | Neurology2009，73，20： | 1 |
| 13 | Bowel wall thickeningin patients with Crohn's disease:CT patternsand correlation with inflammatory activity显示文摘 | Choi D Jin Lee S Ah Cho Y | | 0，，01： | 1 |
| 14 | Bowel wall thickening in patients with Crohn ' s disease: C'T patterns and correlation with inflammatory activity显示文摘 | Choi D Jin Lee S Ah Cho Y | 2003 | Clin Radiol2003，58，1： | 1 |
| 15 | Antioxidant and antimic robial activities of various leafy herbal teas显示文摘 | Jungmin Oh Heonjoo Jo Ah Reum Cho | | 0，，31： | 1 |
| 16 | Classification of cultivation area of ginseng by near infrared spectroscopy and ICP- AES 显示文摘 | Young - ah Woo Chang - hee Cho Hyo - jin Kim Jong - soo Yang Ki - yong Seong | 2002 | Microchemical Journal2002，73，3： | 1 |
| 17 | Bowel wall thickening in patients with Crohn's disease:CT patterns and correlation with inflammatory activity显示文摘 | Choi D Jin Lee S Ah Cho Y | 2003 | Clin Radiol2003，58，1： | 1 |
| 18 | Rapid appearance of new cerebral microbleeds after acute ischemic stroke 显示文摘 | Jeon SB Kwon SU Cho AH | 2009 | Neurology2009，73，： | 1 |
| 19 | Impaired kidney function and cerebral microbleeds in patients with acute ischemic stroke 显示文摘 | Cho AH Lee SB Han SJ | 2009 | Neurology2009，73，： | 1 |
| 20 | Plas- mablastic lymphoma of the oral cavity in a human immunodeficien- cy virus -negative patient :A case report with literature review显示文摘 | So- Young Choi Young- Ah Cho Seong- Doo Hong | 2014 | Oral Maxillofacial Patho12014，117，2： | 1 |
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