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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Significant risk and associated factors of active tuberculosis infection in Korean patients with inflammatory bowel disease using anti-TNF agents显示文摘AIM:To evaluate the incidence and risk factors of Korean tuberculosis(TB) infection in patients with inflammatory bowel disease(IBD) undergoing anti-TNF treatment.METHODS:The data of IBD patients treated with anti-TNFs in 13 tertiary referral hospitals located in the southeastern region of Korea were collected retrospectively.They failed to show response or were intolerant to conventional treatments,including steroids or immunomodulators.Screening measures for latent TB infection(LTBI)and the incidence and risk factors ofactive TB infection after treatment with anti-TNFs were identified.RESULTS:Overall,376 IBD patients treated with antiTNF agents were recruited(male 255,mean age of anti-TNF therapy 32.5±13.0 years);277 had Crohn’s disease,99 had ulcerative colitis,294 used infliximab,and 82 used adalimumab.Before anti-TNF treatment,screening tests for LTBI including an interferon gamma release assay or a tuberculin skin test were performed in 82.2%of patients.Thirty patients(8%)had LTBI.Sixteen cases of active TB infection including one TB-related mortality occurred during 801 personyears(PY)follow-up(1997.4 cases per 100000 PY)after anti-TNF treatment.LTBI(OR=5.76,95%CI:1.57-21.20,P=0.008)and WBC count<5000 mm3(OR=4.5,95%CI:1.51-13.44,P=0.007)during follow-up were identified as independently associated risk factors.CONCLUSION:Anti-TNFs significantly increase the risk of TB infection in Korean patients with IBD.The considerable burden of TB and marked immunosuppression might be attributed to this risk. | Eun Soo Kim Geun Am Song Kwang Bum Cho Kyung Sik Park Kyeong Ok Kim Byung Ik Jang Eun Young Kim Seong Woo Jeon Hyun Seok Lee Chang Heon Yang Yong Kook Lee Dong Wook Lee Sung Kook Kim Tae Oh Kim Jonghun Lee Hyung Wook Kim Sam Ryong Jee Seun Ja Park Hyun Jin Kim | 2015 | World Journal of Gastroenterology2015，21，11： | 5 |
| 3 | Serum prostate-specific antigen value adjusted for non-cancerous prostate tissue volume in patients undergoing radical prostatectomy: a new predictor of biochemical recurrence in localized or locally advanced prostate cancer显示文摘这研究的目的是调查为全部的肿瘤体积(PSA/tumor 体积) 调整的前列腺特定的抗原(PSA ) 价值和浆液 PSA 价值在激进的前列腺切除术以后作为病理学的调查结果和临床的结果的一个预言者为非癌的前列腺织物体积(NCPV )(PSA/NCPV ) 调整了的浆液的意义。407 个病人的临床、病理学的数据(中部的年龄:66.5 年;变化:41.8 鈥 ? 5.7 年) 回顾地被考察。中部的后续时期是 18.1 个月(范围:1.0 鈥 ? 07.8 个月) 。生物化学的复发被定义为可检测的 PSA 层次(比 0.2 ng ml 大 ? 1 ) 并且生物化学的复发的倍被花是第一次 PSA 变得可检测。在 multivariate 模型, PSA/NCPV 是囊外的扩展和积极外科的边缘的一个独立预言者(P < 0.05 ) ,但是 PSA/tumor 体积不。Kaplan 鈥揗e ier 曲线表明 PSA/NCPV 与生物化学的没有复发的幸存相关(P < 0.001;木头等级测试) 但是 PSA/tumor 体积(P=0.275;木头等级测试) 。PSA/NCPV 也是为 multivariate 考克斯上的生物化学的没有复发的幸存的一个重要独立预示的因素比例的危险分析(P=0.004,相对 risk=2.42 ) 。我们的调查结果建议 PSA/NCPV 与囊外的扩展和外科的边缘地位独立地被联系并且可以是在激进的前列腺切除术以后的 PSA 复发的一个独立预示的变量。 | Ja Hyeon Ku Kyung Chul Moon Sung Yong Cho Cheol Kwak Hyeon Hoe Kim | 2011 | Asian Journal of Andrology2011，13，2： | 3 |
| 4 | Effects of bamboo charcoal and bamboo vinegar as antibiotic alternatives on growth performance, immune responses and fecal microflora population in fattening pigs显示文摘 | Gyo Moon CHU Cheol Kyu JUNG Hoi Yun KIM Ji Hee HA Jong Hyun KIM Min Seob JUNG Shin Ja LEE Yuno SONG Rashid Ismael Hag IBRAHIM Jae Hyeon CHO Sung Sill LEE Young Min SONG | 2012 | Animal Science Journal2012，，2： | 2 |
| 5 | Factors Predictive of Adverse Events Following Endoscopic Papillary Large Balloon Dilation: Results from a Multicenter Series显示文摘 | Soo Jung Park Jin Hong Kim Jae Chul Hwang Ho Gak Kim Don Haeng Lee Seok Jeong Sang-Woo Cha Young Deok Cho Hong Ja Kim Jong Hyeok Kim Jong Ho Moon Sang-Heum Park Takao Itoi Hiroyuki Isayama Hirofumi Kogure Se Joon Lee Kyo Tae Jung Hye Sun Lee Todd H. Baron | 2013 | Digestive Diseases and Sciences2013，，4： | 2 |
| 6 | 强化降压对高血压患者左心室肥厚的影响显示文摘目前尚不清楚超出推荐值的强化降压是否更能降低高血压患者的左心室肥厚(left ventricular hypertrophy,LVH)发生风险,以及LVH风险降低能否解释强化降压的益处。Soliman等纳入收缩压干预试验(systolic blood pressure intervention,SPRINT)中患有高血压但无糖尿病的8164例受试者(平均年龄67.9岁,女性35.3%,31.2%为非洲裔), | 刘莉 叶鹏 Soliman EZ Ambrosius WT Cushman WC Zhang ZM Bates JT Neyra JA Carson TY Tamariz L Ghazi L Cho ME Shapiro BP He J Fine LJ Lewis CE SPRINT Research Study Group | 2017 | 中华高血压杂志2017，25，6： | 2 |
| 7 | Missed synchronous gastric neoplasm with endoscopic submucosal dissection for gastric neoplasm: Experience in our hospital显示文摘 | Hyung Hun Kim Eun Ju Cho Eunji Noh Seok Reyol Choi Seun Ja Park Moo In Park Won Moon | 2012 | Digestive Endoscopy2012，，1： | 2 |
| 8 | Dehydro -ct -lapachone isolated from Catalpa ovata stems: activity against plant pathogenic fungi 显示文摘 | JUN YOUNG CHO HAE YOUNG K/M GYUNG JA CHOI | 2006 | Pest Management Science2006，62，： | 1 |
| 9 | The Efficacy and Safety of Photoselective Vaporization of the Prostate with a Potassium-titanyl-phosphate Laser for Symptomatic Benign Prostatic Hyperplasia according to Prostate Size:2-Year Surgical Outcomes显示文摘 | Hyung Suk Kim Min Chul Cho Ja Hyeon Ku | | 0，，： | 1 |
| 10 | Imaging correlation of the degree of degenerative IA-5 spondylolisthesis with the corresponding amount of facet fluid 显示文摘 | Cho BY Murovie JA Park J | 2009 | J Neurosurg Spine2009，11，5： | 1 |
| 11 | Synthesis of new trifluoromethylated 1,3-oxazolecarboxanolides and their fungicidal activities显示文摘 | HOH-GYU HAHN SANG WON LEE SU YEOUL BAE HEDUCK MAH GYUNG JA CHOI KWANG YUN CHO | | 0，，01： | 1 |
| 12 | Fibrous hamartoma at a- trophic congenital pseudoarthrosis of the tibia is not osteo- genie but osteoelastogenic显示文摘 | Cho T J Seo JB Kim JA | 2007 | Transactions Orthop Res Soe( San Diego CA)2007，32，： | 1 |
| 13 | Total mismatch:negative diffusion-weighted imaging but extensive perfusion defect in acute stroke显示文摘 | Cho TH Hermier M Alawneh JA | 2009 | Stroke2009，40，： | 1 |
| 14 | Use of 3′-deoxy-3′-[18F]fluorothymidine PET to monitor early responses to radiation therapy in murine SCCVII tumors显示文摘 | You-Jung Yang Jin-Sook Ryu Seog-Young Kim Seung Jun Oh Ki Chun Im Heuiran Lee Sang-wook Lee Kyung Ja Cho Gi-Jeong Cheon Dae Hyuk Moon | 2006 | European Journal of Nuclear Medicine and Molecular Imaging2006，，4： | 1 |
| 15 | Elevation of CRABP-I in the cerebrospinal fluid of patients with Moyamoya disease显示文摘 | Kim SK Yoo JI Cho BK Hong SJ Kim YK Moon JA | 2003 | Stroke2003，34，12： | 1 |
| 16 | Telomere length, TERT and shelterin complex proteins in hepatocellular carcinomas expressing “stemness”-related markers显示文摘 | Haeryoung Kim Jeong Eun Yoo Jai Young Cho Bong-Kyeong Oh Yoo-Seok Yoon Ho-Seong Han Hye Seung Lee Ja June Jang Sook Hyang Jeong Jin Wook Kim Young Nyun Park | 2013 | Journal of Hepatology2013，，： | 1 |
| 17 | Positional vertigo: as occurs across all age groups显示文摘 | Cho EI White JA | 2011 | Otolaryngol Clin North Am2011，44，2： | 1 |
| 18 | Visceral pseudoaneurysms due to panereatic pseudocysts: rare but lethal complications of pancreatitis 显示文摘 | Cart JA Cho J Shepard AS | 2000 | J Vase Surg2000，32，8： | 1 |
| 19 | Carcinoma ex-pleomorphic of the nasal cavity:a report of two case显示文摘 | Kyung JA Cho MD Adel K | 1995 | J laryngol Otol1995，109，： | 1 |
| 20 | Rice Os ACDR1(Oryza sativa accelerated cell death and resistance 1)is a potential positive regulator of fungal disease resistance显示文摘 | Kim JA Cho K Singh R | 2009 | Molecules and Cells2009，28，5： | 1 |
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