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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | A new techniques for measuring coupling coefficients and 3-D capacitance characterization of floating gate devices 显示文摘 | Choi W L Kim D M | 1994 | IEEE Trans ED1994，41，12： | 3 |
| 3 | Environm-ental applications of semiconductor photocatalysis显示文摘 | Hoffmann M R Martin S T Choi W | 1995 | Chem Rev1995，95，1： | 2 |
| 4 | Evaluation of seismic performance of multistory building structures based on the equivalent responses 显示文摘 | LEE D G CHOI W H CHEONG M C | 2006 | Engineering Structures2006，28，6： | 1 |
| 5 | Polymer-polymer miscibility study for plastic gradient index optical fiber 显示文摘 | LEE B CHOI W Y WALKER J K | 2000 | Polym Eng Sci2000，40，9： | 1 |
| 6 | Ruthenium Bipyridyl Complex-sensitized Dechlorination of in Aqueous Mieellar Solutions under Visible Light显示文摘 | CHO Y PARK Y CHOI W Y | 2008 | Journal of Industrial and Engineering Chemistry2008，14，： | 1 |
| 7 | 显示文摘 | Choi W B Chung D S Kang J H | 1999 | Applied Physics Letters1999，75，20： | 1 |
| 8 | Digital inkjet printing for chitosan-treated cotton fabric显示文摘 | P S R Choi C W M Yuen S K A Ku | 2005 | Fibers and Polymers2005，6，3： | 1 |
| 9 | Bank Relationships and the Value Relevance of the Income Statement: Evidence from Income-statement Conservatism显示文摘 | Choi W | 2007 | Journal of Business Finance & Accounting2007，34，78： | 1 |
| 10 | Intranasal endoscopic diagnosis and treatment in congenital nasolacrimal duct obstruction显示文摘 | CHOI W C KIM K S PARK T K | 2002 | Ophthalmic Surg Lasers2002，33，4： | 1 |
| 11 | The role of metal ion dopants in quantum-sized TiO2:correlation between photoreactivity and charge cartier recombination dynamics 显示文摘 | Choi W Termin A Hoffmann M R | 1994 | J Phys Chem1994，98，13： | 1 |
| 12 | Inhibition of tyrosinase and lipoxygenase activities by resveratrol and its derivatives from seeds of Paeonia lactiflora显示文摘 | Kim H J Ha S C Choi S W | 2002 | Nutraceuticals and Food2002，7，4： | 1 |
| 13 | 显示文摘 | Cho Y Choi W Lee C H | 2001 | Environ Sei Teehnol2001，35，5： | 1 |
| 14 | Speed control of a permanent magnet synchronous motor with a torque observer: a fuzzy approach显示文摘 | Jung J W Kim T H Choi H H | 2010 | IET Control Theory and Applications2010，4，12： | 1 |
| 15 | The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference显示文摘 | CHOI D S CASCINI M G MAILLIARD W | 2004 | Nat Neurosci2004，7，8： | 1 |
| 16 | Simultaneous and synergistic conversion of dyes and geavy metal ions in aqueous TiO2 suspensions under visible - light illumination 显示文摘 | Kyung H Lee J Choi W | 2005 | Environ Sci Technol2005，39，： | 1 |
| 17 | Compact ultra - wideband printed antenna with band-rejection characteristic 显示文摘 | Choi W Chung K Jung J | 2005 | Electronic letters2005，41，18： | 1 |
| 18 | Relation between glass transition and melting of PEO-sah complexes 显示文摘 | KIM Y W LEE W CHOI B K | 2000 | Eleetrochlmica Aeta2000，45，： | 1 |
| 19 | Spinal involvement of hematopoietic malignancies and metastasis: differentiation using MR imaging显示文摘 | Kim H J Ryu K N Choi W S | 1999 | Clin Imaging1999，23，2： | 1 |
| 20 | XML-Based Network Management for IP Networks 显示文摘 | CHOI Mijung JAMES W H JU H T | 2003 | ETRI Journal2003，25，6： | 1 |
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