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| 1 | Identity-aware convolutional neural networks for facial expression recognition显示文摘Facial expression recognition is a hot topic in computer vision, but it remains challenging due to the feature inconsistency caused by person-specific characteristics of facial expressions.To address such a challenge, and inspired by the recent success of deep identity network(Deep ID-Net) for face identification, this paper proposes a novel deep learning based framework for recognising human expressions with facial images. Compared to the existing deep learning methods, our proposed framework, which is based on multi-scale global images and local facial patches,can significantly achieve a better performance on facial expression recognition. Finally, we verify the effectiveness of our proposed framework through experiments on the public benchmarking datasets JAFFE and extended Cohn-Kanade(CK+). | Chongsheng Zhang Pengyou Wang Ke Chen Joni-Kristian Kamarainen | 2017 | Journal of Systems Engineering and Electronics2017，28，4： | 12 |
| 2 | FKF1 F-box protein promotes flowering in part by negatively regulating DELLA protein stability under long-day photoperiod in Arabidopsis^FA显示文摘FLAVIN-BINDING KELCH REPEAT F-BOX 1(FKF1)encodes an F-box protein that regulates photoperiod flowering in Arabidopsis under long-day conditions(LDs).Gibberellin(GA)is also important for regulating flowering under LDs.However,how FKF1 and the GA pathway work in concert in regulating flowering is not fully understood.Here,we showed that the mutation of FKF1 could cause accumulation of DELLA proteins,which are crucial repressors in GA signaling pathway,thereby reducing plant sensitivity to GA in flowering.Both in vitro and in vivo biochemical analyses demonstrated that FKF1 directly interacted with DELLA proteins.Furthermore,we showed that FKF1 promoted ubiquitination and degradation of DELLA proteins.Analysis of genetic data revealed that FKF1 acted partially through DELLAs to regulate flowering under LDs.In addition,DELLAs exerted a negative feedback on FKF1 expression.Collectively,these findings demonstrate that FKF1 promotes flowering partially by negatively regulating DELLA protein stability under LDs,and suggesting a potential mechanism linking the FKF1 to the GA signaling DELLA proteins. | Jindong Yan Xinmei Li Bingjie Zeng Ming Zhong Jiaxin Yang Piao Yang Xin Li Chongsheng He Jianzhong Lin Xuanming Liu Xiaoying Zhao | 2020 | Journal of Integrative Plant Biology2020，62，11： | 8 |
| 3 | Clinical study of IL-18 and NANOG gene polymorphisms in prostate cancer patients显示文摘Objective Recent studies have shown abnormal expression of NANOG and IL-18 to be related to cancer. However, the molecular mechanism by which IL-18 and NANOG gene polymorphisms are associated with prostate cancer is unclear. In this study, we examined whether IL-18 and NANOG gene polymorphisms and their interaction with prostate cancer-related risk factor are associated with the susceptibility to and clinicopathological development of prostate cancer among Chinese men.Methods Polymorphisms in the NANOG and IL-18 genes were evaluated for susceptibility in 120 patients with prostate cancer. The control group consisted of 125 samples from Chinese men. Genotyping was conducted using Taq Man allelic discrimination assays. Statistical analysis was performed using SPSS software. Results No association of NANOG and IL-18 gene polymorphisms and overall prostate cancer susceptibility was detected. The IL-18-607 CC genotype was significantly associated with a higher tumor grade(P = 0.025) and stage(P =0.001). The IL-18-137 GG genotype correlated with a higher tumor grade(P = 0.028) and stage(P = 0.008). The IL-18-137 G allele was significantly more frequent in patients with lymph node metastasis(P = 0.035). The IL-18-607 CC genotype was associated with distant metastasis(P = 0.025). However, no significant association was observed between NANOG polymorphisms and any clinicopathological feature. The Cox proportional hazard model showed that tumor grade and stage grouping were independent prognostic factors in IL-18, while IL-18 polymorphism was not. Polymorphism variants in the IL-18(IL-18-607 and IL-18-137) and NANOG(genotypes AC) genes might be associated with a worse prognosis of patients with prostate cancer.Conclusion NANOG may be associated with the early stages of prostate cancer carcinogenesis. IL-18 and NANOG gene polymorphisms may play a major role in the growth, invasion, and metastasis of prostate cancer. | Shaojun Nong Yangbo Guan Zhiwei Wang Zhongqing Wei Yueping Zhang Jian Ni Chongsheng He Limin Ma Shujun Zhou Wenguang Li | 2018 | Oncology and Translational Medicine2018，4，6： | 2 |
| 4 | Cloning and analysis of differentially expressed ESTs in swine muscle tissue显示文摘The obvious difference in muscle growth and meat quality traits exists between Chinese indigenous pig and exotic pigs. In order to study the reason of these phenotypic differences and search the potential gene related to growth and meat quality traits, silver-stained mRNA differential display technique was used to detect the difference with mRNA of loin-eye muscle tissue from matur-ity pigs of Lantang in Guangdong Province and Large Yorkshire. One of the newly discovered ex-pressed sequence tag (ESTsp3) was analyzed by using bioinformatic technique. The results showed: (1) nearly 2000 cDNA fragments were detected with 30 primer pairs, and 6 differentially expressed ESTs in the loin-eye muscle tissues from the two breeds were isolated and obtained. The differential fragments were cloned and sequenced. The all sequences were recorded in the GenBank. (2) The 786 bp fragment of ESTsp3 was obtained with in silico elongation system, the ORF analysis revealed that it existed as an 83 aa complete open reading frame, and the elongation sequences were verified by RT-PCR. The analysis of in silico expression profile showed that ESTsp3 is expressed in various growth stages and in most tissues and organs, such as soft tissue, skin, skeletal muscle and kidney, but with variant expression quantity. | LI Chongsheng CHEN Yaosheng WANG Chong LI Jiaqi | 2006 | Science China(Life Sciences)2006，49，4： | 2 |
| 5 | Significant association between IL-18 and OCT4 gene polymorphisms in susceptibility and clinical characteristics of prostate cancer显示文摘Objective Recent studies have shown abnormal expression of octamer-binding transcription factor 4(OCT4) and interleukin-18(IL-18) to be related to cancer. However, the molecular mechanisms by which the IL-18 and OCT4 gene polymorphisms are associated with prostate cancer remain unclear. In this study, we aimed to determine whether the presence of IL-18 and OCT4 polymorphisms were associated with size, grade, tumor, nodes and metastasis(TNM) stage, or survival in patients with prostate cancer.Methods Polymorphisms in OCT4 and IL-18 genes were evaluated to determine susceptibility to prostate cancer in 120 patients. A control group consisted of 125 Chinese participants. Genotyping was performed using TaqMan allelic discrimination assays, and statistical analysis was performed using SPSS. Results No association was found between OCT4 and IL-18 gene polymorphisms and prostate cancer susceptibility. For OCT4 AA and IL-18-607 CC genotypes, there was a significant association with higher tumor grade(P = 0.03 and P = 0.025) and stage(P = 0.04 and P = 0.001). The OCT4 and IL-18-137 GG genotype was correlated with higher tumor grade(P = 0.028) and stage(P = 0.008). Furthermore, OCT4 AA was significantly more frequent in patients with lymph node metastasis(P = 0.02) and distant metastasis(P = 0.01). The Cox proportional hazard model showed that tumor grade and stage grouping were independent prognostic factors but IL-18 and OCT4 polymorphisms were not. Conclusion The OCT4 gene may have a profound effect on prostate cancer risk. Polymorphism variants in the IL-18(IL-18-607 and IL-18-137) and OCT4 genes may be associated with poor prognoses for individuals with prostate cancer. | Shaojun Nong Yangbo Guan Zhiwei Wang Zhongqing Wei Yueping Zhang Jian Ni Chongsheng He Limin Ma Shujun Zhou Wenguang Li | 2019 | Oncology and Translational Medicine2019，5，3： | 2 |
| 6 | Integrated assessment on multi-temporal and multi-sensor combinations for reducing cloud obscuration of MODIS snow cover products of the Pacific Northwest USA显示文摘 | Yang Gao Hongjie Xie Tandong Yao Chongsheng Xue | 2010 | Remote Sensing of Environment2010，，8： | 1 |
| 7 | Applications of cha-otic oscillator in machinery fault diagnosis显示文摘 | Li Chongsheng Qu Liangsheng | 2007 | Me-chanical Systems and Signal Processing2007，21，： | 1 |
| 8 | Applications of chaotic oscillator in machinery fault diagnosis显示文摘 | Li Chongsheng Qu Liangsheng | 2007 | Mechanical Systems and Signal Processing2007，21，： | 1 |
| 9 | Oxidation behavior of high-strength FeCrAl alloys in a high-temperature supercritical carbon dioxide environment显示文摘The oxidation behavior of three high-strength FeCrAl alloys was investigated in supercritical carbon dioxide environment at 650 ℃. After exposure for 500 h, the weight gains of the FeCrAl alloys gradually decreased with increasing Al content. The oxide scales are primarily composed of α-Al_2O_3 and spinel oxides. With increasing Al content, the amount of α-Al_2O_3 increases and the C content decreased in the oxide scale and sub-scale matrix.Moreover, larger(Nb,Mo)C carbides formed in the sub-scale matrix and their number decreased with the increase of Al content. | Hongsheng Chen Sung Hwan Kim Chongsheng Long Chaewon Kim Changheui Jang | 2018 | Progress in Natural Science:Materials International2018，28，6： | 1 |
| 10 | Plug the clinical treatment of cerebral thrombosis observation 显示文摘 | Wang Chongsheng ya-bo wang | 2000 | Journal of cardiac re- habilitation medicine journal2000，，1： | 1 |
| 11 | Two regularity criteria for the 3D MHD equations显示文摘 | CAO Chongsheng WU Jiahong | | 0，，09： | 1 |
| 12 | Applications of chaotic oscillator in machinery fault diagnosis显示文摘 | Chongsheng Li Liangsheng Qu | 2005 | Mechanical Systems and Signal Processing2005，，1： | 1 |
| 13 | Applications of chaotic oscillator in machinery fault diagnosis显示文摘 | Chongsheng Li Liangsheng Qu | 2007 | Mechanical Systems and Signal Processing2007，27，25： | 1 |
| 14 | Cycle Slip Detection and Repair for Undifferenced GPS Observations Under High Ionospheric Activity显示文摘 | Cai Chongsheng Liu Zhizhao Xia Pengfei | 2013 | GPS Solutions2013，17，2： | 1 |
| 15 | Virtual Gluino Correction to the Decay Z→bb显示文摘We computed the O(αs)virtual gluino correction to the process Z→bb in the minimal supersymmetric standard model,and investigated the dependence of the process on gluino and squark masses.For some values of masses,the correction implies about 7%-12%additional decrease of the ratio Г(Z→bb)/Г(Z→hadrons)relative to the standard model expectation. | LI Chongsheng HU Bingquan | 1992 | Chinese Physics Letters1992，9，6： | 0 |
| 16 | Transcriptome-wide profiling of RNA N^(4)-cytidine acetylation in Arabidopsis thaliana and Oryza sativa显示文摘Acetylation of N^(4)-cytidine(ac^(4)C)has recently been discovered as a novel modification of mRNA.RNA ac^(4)C modification has been shown to be a key regulator of RNA stability,RNA translation,and the thermal stress response.However,its existence in eukaryotic mRNAs is still controversial.In plants,the existence,distribution pattern,and potential function of RNA ac^(4)C modification are largely unknown.Here we report the presence of ac^(4)C in the mRNAs of both Arabidopsis thaliana and rice(Oryza sativa).By comparing two ac^(4)C sequencing methods,we found that RNA immunoprecipitation and sequencing(acRIP-seq),but not ac^(4)C sequencing,was suitable for plant RNA ac^(4)C sequencing.We present transcriptome-wide atlases of RNA ac^(4)C modification in A.thaliana and rice mRNAs obtained by acRIP-seq.Analysis of the distribution of RNA ac^(4)C modifications showed that ac^(4)C is enriched near translation start sites in rice mRNAs and near translation start sites and translation end sites in Arabidopsis mRNAs.The RNA ac^(4)C modification level is positively correlated with RNA half-life and the number of splicing variants.Similar to that in mammals,the translation efficiency of ac^(4)C target genes is significantly higher than that of other genes.Our in vitro translation results confirmed that RNA ac^(4)C modification enhances translation efficiency.We also found that RNA ac^(4)C modification is negatively correlated with RNA structure.These results suggest that ac^(4)C is a conserved mRNA modification in plants that contributes to RNA stability,splicing,translation,and secondary structure formation. | Bin Li Donghao Li Linjun Cai Qiting Zhou Cong Liu Jianzhong Lin Yixing Li Xiaoying Zhao Li Li Xuanming Liu Chongsheng He | 2023 | Molecular Plant2023，16，6： | 0 |
| 17 | Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients显示文摘Primary ciliary dyskinesia(PCD)is a highly heterogeneous recessive inherited disorder.FAP54,the homolog of CFAP54 in Chlamydomonas reinhardtii,was previously demonstrated as the C1d projection of the central microtubule apparatus of flagella.A Cfap54 knockout mouse model was then reported to have PCD-relevant phenotypes.Through whole-exome sequencing,compound heterozygous variants c.2649_2657delinC(p.E883Dfs*47)and c.7312_7313insCGCAGGCTGAATTCTTGG(p.T2438delinsTQAEFLA)in a new suspected PCD-relevant gene,CFAP54,were identified in an individual with PCD.Two missense variants,c.4112A>C(p.E1371A)and c.6559C>T(p.P2187S),in CFAP54 were detected in another unrelated patient.In this study,a minigene assay was conducted on the frameshift mutation showing a reduction in mRNA expression.In addition,a CFAP54 in-frame variant knock-in mouse model was established,which recapitulated the typical symptoms of PCD,including hydrocephalus,infertility,and mucus accumulation in nasal sinuses.Correspondingly,two missense variants were deleterious,with a dramatic reduction in mRNA abundance from bronchial tissue and sperm.The identification of PCD-causing variants of CFAP54 in two unrelated patients with PCD for the first time provides strong supportive evidence that CFAP54 is a new PCD-causing gene.This study further helps expand the disease-associated gene spectrum and improve genetic testing for PCD diagnosis in the future. | Xinyue Zhao Haijun Ge Wenshuai Xu Chongsheng Cheng Wangji Zhou Yan Xu Junping Fan Yaping Liu Xinlun Tian Kai-Feng Xu Xue Zhang | 2023 | Frontiers of Medicine2023，17，6： | 0 |
| 18 | 血清白细胞介素-18和NO活性在前列腺癌患者的临床价值(英文)显示文摘Objective:The aim of the study was to estimate the clinical value of serum interleukin-18(IL-18)and nitric oxide(NO)activities in patients with prostate cancer.Methods:The 50 patients with prostate cancer and 25 control subjects were measured in serum IL-18 by enzyme-linked immunosorbent assay(ELISA)and nitrate+nitrite level by an index of NO generation.Results:Serum IL-18 and nitrate+nitrite levels were significantly higher in patients with prostate cancer when compared to the control subjects(P<0.05).Serum IL-18 level was significantly higher in patients with stages B,C and D when compared to patients with stage A(P<0.05).Serum IL-18 level was significantly higher in the metastatic patients compared with the nonmetastatic patients(P<0.01).There was no difference in serum nitrate and nitrite level between metastatic and nonmetastatic patients(P>0.05).The serum IL-18 and nitrate and nitrite levels decreased after patients underwent surgical resection.Conclusion:Serum IL-18 level may be a useful marker to predict prognosis of patients with prostate cancer after surgery.Long-term follow-up is required to clarify this hypothesis. | Shaojun Nong Yueping Zhang Chongsheng He Bin Cheng Shujun Zhou Wenguang Li Limin Ma You Wu | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，12： | 0 |
| 19 | 白细胞介素-18基因607和137多态性在前列腺癌临床特性的影响(英文)显示文摘Objective: The aim of this study was to determine whether the presence of IL-18 polymorphisms -137 G/C and -607 A/C was associated with grade, clinical stage, and survival in patients with prostate cancer. Methods: The study cohort included 126 patients with prostate cancer. Control group consisted of 125 samples from Chinese population. Genomic DNA was extracted from EDTA-anticoagulated peripheral blood leukocytes by the salting-out method. The genotyping of the two IL-18 polymorphisms was performed using predesigned TaqMan SNP Genotyping Assays. Results: The studied IL-18 gene polymorphisms did not influence susceptibility to prostate cancer in the analyzed group of patients (IL-18-607, P = 0.342; IL-18-137 P = 0.715) but may contribute to disease onset and aggressiveness. IL-18-607 CC genotype was significantly associated with higher tumor grade (P = 0.025) and stage (P = 0.001). IL-18-137 GG genotype was correlated with higher tumor grade (P = 0.018) and stage (P = 0.007). The Cox proportional hazard model showed that tuumor grade and stage grouping were independent prognostic factors but IL-18 polymorphism was not. Polymorphism variants in the IL-18 gene (IL-18-607 and IL-18-137) may be associated with a worse prognosis for prostate cancer. Conclusion: High levels of IL-18 production may play a major role in the growth, invasion and metastasis of prostate cancer. | Shaojun Nong Yueping Zhang Bin Cheng Chongsheng He Limin Ma Shujun Zhou Wenguang Li | 2013 | The Chinese-German Journal of Clinical Oncology2013，12，4： | 0 |
| 20 | Power allocation for collaborative transmission in LTE-Advanced显示文摘Collaborative transmission among evolved Node-Bs(eNBs)is one of the promising techniques for LTE-Advanced to provide broader coverage and higher spectral efficiency.The interference among multi-cell transmission can be mitigated by joint precoding,such as multi-cell block diagonalization(BD)at cooperative eNBs.The major difference between multi-cell and single-cell transmission is that the power constraint has to be considered on a per-eNB basis.To satisfy per-eNB power constraint(PePC),a simplified power allocation algorithm for the multi-cell BD based collaborative transmission is proposed in this paper.The algorithm provides a power allocation coefficient matrix for BD to meet PePC.Simulation results demonstrate that the proposed algorithm has a near-optimal performance with simplicity. | Jing JIN Chongsheng LIN Qixing WANG Hongwen YANG Yafeng WANG | 2011 | Frontiers of Electrical and Electronic Engineering in China2011，6，4： | 0 |
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