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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Suppression of Fas-mediate apoptosis by mitogen-activated kinase signaling显示文摘 | Chow SC Elo 1 | 1998 | J Immunol1998，28，： | 1 |
| 3 | Plate fixation for crescentic metatarsal osteotomy in the treatment of hallux valgus: an eight- year followup study显示文摘 | Chow FY Lui TH Kwok KW | 2008 | Foot Ankle Int2008，29，1： | 1 |
| 4 | Diagnostic and thera- peutic evaluation of 111 in-vinorelbine-liposomes in a human colorectal carcinoma HT-29/luc-hearing animal model显示文摘 | Chow TH Lin YY Hwang JJ | 2008 | Nu- clMedBiol2008，35，5： | 1 |
| 5 | Diagnostic and therapeutic evaluation of 111 In-vinorelbine-liposomes in a human coloreetal carcinoma HT-29/luc-bearing animal model 显示文摘 | Chow TH Lin YY Hwang J J | 2008 | Nucl Med Biol2008，35，5： | 1 |
| 6 | Scleroderma renal crisis sine scleroderma during pregnancy显示文摘 | Mok CC Kwan TH Chow L | 2003 | Scand J Rheumatol2003，32，1： | 1 |
| 7 | The importance of skin biopsy in the diverse clinical manifestations of disseminated candidiasis 显示文摘 | Tseng JT Chow JM Tsai TH | 2010 | Int J Infect Dis2010，14，3： | 1 |
| 8 | Effect of insulin-like growth factor blockade on hyperoxia-induced lung injury显示文摘 | Kim TH Chow YH Gill SE | 2012 | Am J Respir Cell Mol Biol2012，47，3： | 1 |
| 9 | Suppression of Fas/APO-1-mediated apoptosis by mitogen-activated kinase signaling显示文摘 | Holmstrom TH Chow SC Elo I | 1998 | J Immunol1998，160，6： | 1 |
| 10 | Comparison of radiologic and arthroscopic diagnoses of distal tibiofibular syndesmosis disruption in acute ankle fracture显示文摘 | Lui TH Ip K Chow HT | | 0，，11： | 1 |
| 11 | Arthroscopy-assisted correct of hallux valgus deformity显示文摘 | Lui TH Chan KB Chow HT | 2008 | Arthroscopy2008，24，8： | 1 |
| 12 | Arthroscopy- assisted correct of hallux valgus deformity显示文摘 | Lui TH Chan KB Chow HT | 2008 | Arthroscopy2008，24，8： | 1 |
| 13 | Comparison of radiologic and arthroscopic diagnoses of distal tibioibular syndesmosis disruption in acute ankle fracture显示文摘 | Lui TH Ip K Chow HT | 2005 | Arthroscopy2005，21，11： | 1 |
| 14 | Arthroscopy - assisted correct of hallux valgus deformity 显示文摘 | Lui TH Chan KB Chow HT | 2008 | Arthroscopy2008，24，8： | 1 |
| 15 | Comparison of radiologic and arthroscopie diagnoses of distal tibiofibular syndesmosis disruption in acute ankle fracture显示文摘 | Lui TH Ip K Chow HT | 2005 | Arthroscopy2005，11，： | 1 |
| 16 | Arthroscopy-assisted correction of hallux valgus deformity显示文摘 | Lui TH Chan KB Chow HT | | 0，，： | 1 |
| 17 | Involvement of multiple proteases during Fas mediated apoptosis in T lymphocytes 显示文摘 | Chow SC Weis M Kass GE Holmstrom TH Erikssm JE Orrenius S | 1995 | FEBS Lett1995，364，2： | 1 |
| 18 | Diagnostic and therapeutic evaluation of 111 in-vinorelbine-liposomes in a human colorectal carcinoma HT-29/luc-bearing animal model显示文摘 | Chow TH Lin YY Hwang JJ | | 0，，05： | 1 |
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