|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis显示文摘AIM: To determine circulating and hepatic adiponectin in rodents with fatty liver disease or liver cirrhosis and investigate expression of the adiponectin receptors AdipoR1 on the mRNA and protein level and AdipoR2 on the mRNA level. METHODS: Fat fed rats were used as a model for fatty liver disease and bile duct ligation in mice to investigate cirrhotic liver. Expression of AdipoR1 and AdipoR2 mRNA was determined by real time RT-PCR. AdipoR1 protein was analysed by immunoblot. Adiponectin was measured by ELISA. RESULTS: Systemic adiponectin is reduced in fat- fed rats but is elevated in mice after bile duct ligation (BDL). Hepatic adiponectin protein is lower in steatotic liver but not in the liver of BDL-mice when compared to controls. Adiponectin mRNA was not detected in human liver samples or primary human hepatocytes nor in rat liver but recombinant adiponectin is taken up by isolated hepatocytes in-vitro. AdipoR1 mRNA and AdipoR1 protein levels are similar in the liver tissue of control and fat fed animals whereas AdipoR2 mRNA is induced. AdipoR2 mRNA and AdipoR1 mRNA and protein is suppressed in the liver of BDL-mice. CONCLUSION: Our studies show reduced circulating adiponectin in a rat model of fatty liver disease whereas circulating adiponectin is elevated in a mouse model of cirrhosis and similar fi ndings have been described in humans. Diminished hepatic expression of adiponectinreceptors was only found in liver cirrhosis. | Markus Neumeier Claus Hellerbrand Erwin Gbele Roland Buettner Cornelius Bollheimer Johanna Weigert Andreas Schffler Thomas S Weiss Monika Lichtenauer Jürgen Schlmerich Christa Buechler | 2006 | World Journal of Gastroenterology2006，12，34： | 4 |
| 2 | Endoscopic dilation of complete oesophageal obstructionswith a combined antegrade-retrograde rendezvoustechnique显示文摘AIM: To investigate the combined antegraderetrograde endoscopic rendezvous technique for complete oesophageal obstruction and the swallowing outcome.METHODS: This single-centre case series includes consecutive patients who were unable to swallow due to complete oesophageal obstruction and underwent combined antegrade-retrograde endoscopic dilation(CARD) within the last 10 years. The patients' demographic characteristics, clinical parameters, endoscopic therapy, adverse events, and outcomes were obtained retrospectively. Technical success was defined as effective restoration of oesophageal patency. Swallowing success was defined as either percutaneous endoscopic gastrostomy(PEG)-tube independency and/or relevant improvement of oral food intake, as assessed by the functional oral intake scale(FOIS)(≥ level 3).RESULTS: The cohort consisted of six patients [five males; mean age 71 years(range, 54-74)]. All but one patient had undergone radiotherapy for head and neck or oesophageal cancer. Technical success was achieved in five out of six patients. After discharge, repeated dilations were performed in all five patients. During follow-up(median 27 mo, range, 2-115), three patients remained PEG-tube dependent. Three of four patients achieved relevant improvement of swallowing(two patients: FOIS 6, one patient: FOIS 7). One patient developed mediastinal emphysema following CARD, without a need for surgery.CONCLUSION: The CARD technique is safe and a viable alternative to high-risk blind antegrade dilation in patients with complete proximal oesophageal obstruction. Although only half of the patients remained PEG-tube independent, the majority improved their ability to swallow. | Reto Bertolini Christa Meyenberger Paul Martin Putora Franziska Albrecht Martina Anja Broglie Sandro J Stoeckli Michael Christian Sulz | 2016 | World Journal of Gastroenterology2016，22，7： | 3 |
| 3 | Glucocorticoid receptor gene haplotype structure and steroid therapy outcome in IBD patients显示文摘AIM: To study whether the glucocorticoid receptor (GR/ NR3C1) gene haplotypes influence the steroid therapy outcome in inflammatory bowel disease (IBD). METHODS: We sequenced all coding exons and flanking intronic sequences of the NR3C1 gene in 181 IBD patients, determined the single nucleotide polymorphisms, and predicted the NR3C1 haplotypes. Furthermore, we investigated whether certain NR3C1 haplotypes are significantly associated with steroid therapy outcomes. RESULTS: We detected 13 NR3C1 variants, which led to the formation of 17 different haplotypes with a certainty of > 95% in 173 individuals. The three most commonly occurring haplotypes were included in the association analysis of the influence of haplotype on steroid therapy outcome or IBD activity. None of the NR3C1 haplotypes showed statistically signifi cant association with glucocorticoid therapy success. CONCLUSION: NR3C1 haplotypes are not related to steroid therapy outcome. | Jessica Mwinyi Christa Wenger Jyrki J Eloranta Gerd A Kullak-Ublick | 2010 | World Journal of Gastroenterology2010，16，31： | 2 |
| 4 | Trends in heavy metal concentrations in the Western and Central Baltic Sea waters detected by using empirical orthogonal functions analysis显示文摘 | Dippner J W Christa P | 2004 | Journal of Marine Systems2004，，46： | 1 |
| 5 | Molecular epidemiology of avian pathogenic Escherichia coli (APEC) isolated from colisepticemia in poultry显示文摘 | Traute J Sabine K | 2004 | Veterinary Microbiolog2004，104，： | 1 |
| 6 | Collaborative commerce for non-technical industries:Is it worth the investment?显示文摘 | Cynthia J M Mahesh S R | 2004 | International Journal of Information Management2004，24，5： | 1 |
| 7 | 14-3-3 proteins and plant development显示文摘 | Hrvoje Fulgosi Jürgen Soll Simone de Faria Maraschin Henrie A.A.J. Korthout Mei Wang Christa Testerink | 2002 | Plant Molecular Biology2002，，6： | 1 |
| 8 | Ganeration of bioactive peprides by biological libraries显示文摘 | Christa M Alois J | 2007 | Journal of Chromatography B2007，7，3： | 1 |
| 9 | Using remotely-sensed estimates of soil moisture to infer soil texture and hydraulic properties across a semi-arid watershed 显示文摘 | JOSEPH A SANTANELLO J CHRISTA D | 2007 | Remote Sensing of Environment2007，110，1： | 1 |
| 10 | Nitric oxide is induced by wounding and influences jasmonic acid signaling in Arabidopsis thaliana显示文摘 | Xi Huang Kurt Stettmaier Christa Michel Peter Hutzler Martin J. Mueller J?rg Durner | 2004 | Planta2004，，6： | 1 |
| 11 | Nitric oxide is induced by wounding and influences jasmonic acid signaling in Arabidopsis thaliana显示文摘 | Xi Huang Kurt Stettmaier Christa Michel Peter Hutzler Martin J. Mueller J?rg Durner | 2004 | Planta2004，，6： | 1 |
| 12 | Enhanced expression of 14-3-3 protein in reactive astrocytes in Creutzfeldt-Jakob disease brains显示文摘 | Yasuhiro K Ichiro A Christa J | 2004 | Acta Neurophthol2004，108，： | 1 |
| 13 | Overexpression of glutamine synthetase in human primary liver cancer显示文摘 | Christa L Simon M T Flinois J P Gebhardl R Brechot C Lasserre C | 1994 | Gastroenterology1994，106，： | 1 |
| 14 | Analysis of cyanobacterial pigments and proteins by electrophoretic and chromatographic methods显示文摘 | CHRISTA L COLYER CHRISTOPHER S KINKADE PERTTI J VISKARI | 2005 | Anal Bioanal Chem2005，382，： | 1 |
| 15 | Rapid light curves: a new fluorescence method to assess the state of the photosynthetic apparatus 显示文摘 | CHRISTA C WHITE A J | 1999 | Pho tosynth Res1999，59，： | 1 |
| 16 | Adiponectin isoforms: a potential therapeutic target in rheumatoid arthritis?显示文摘 | Klaus W Frommer Andreas Sch?ffler Christa Büchler Jürgen Steinmeyer Markus Rickert Stefan Rehart Fabia Brentano Steffen Gay Ulf Müller-Ladner Elena Neumann | 2012 | Annals of the Rheumatic Diseases2012，，10： | 1 |
| 17 | Lymphocytic hypophysitis associated with dacryoadenitis - an autoimmunologically mediated syndrome显示文摘 | Antonia M J Clemens S Christa F | 1999 | Arch Ophthalmol1999，117，： | 1 |
| 18 | Sex differences in concentrations of exhaled nitric oxide and plasma nitrate显示文摘 | Bemd J Johannes K Christa M | 1996 | Life Sci1996，58，： | 1 |
| 19 | Nitric oxide is induced by wounding and influences jasmonic acid signaling in Arabidopsis thaliana显示文摘 | Xi Huang Kurt Stettmaier Christa Michel Peter Hutzler Martin J. Mueller J?rg Durner | 2004 | Planta2004，，6： | 1 |
| 20 | Adiponectin reduces connective tissue growth factor in human hepatocytes which is already induced in non-fibrotic non-alcoholic steatohepatitis显示文摘 | Roland Walter Josef Wanninger Sabrina Bauer Kristina Eisinger Markus Neumeier Thomas S. Weiss Thomas Amann Claus Hellerbrand Andreas Sch?ffler Jürgen Sch?lmerich Christa Buechler | 2011 | Experimental and Molecular Pathology2011，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员